{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:07:27Z","timestamp":1790615247840,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"General project, Institutional science foundation of the First Affiliated Hospital of Xi\u2019an Jiaotong University","award":["2014YK23"],"award-info":[{"award-number":["2014YK23"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s40618-017-0626-x","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T05:57:13Z","timestamp":1487915833000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center"],"prefix":"10.1007","volume":"40","author":[{"given":"Y.","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"626_CR1","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s40618-016-0505-x","volume":"39","author":"L Bartalena","year":"2016","unstructured":"Bartalena L, Chiovato L, Vitti P (2016) Management of hyperthyroidism due to Graves\u2019 disease: frequently asked questions and answers (if any). J Endocrinol Invest 39:1105\u20131114. doi:\n10.1007\/s40618-016-0505-x","journal-title":"J Endocrinol Invest"},{"key":"626_CR2","doi-asserted-by":"publisher","first-page":"4549","DOI":"10.1210\/jc.2012-2802","volume":"97","author":"HB Burch","year":"2012","unstructured":"Burch HB, Burman KD, Cooper DS (2012) A 2011 survey of clinical practice patterns in the management of Graves\u2019 disease. J Clin Endocrinol Metab 97:4549\u20134558. doi:\n10.1210\/jc.2012-2802","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1089\/105072504323150787","volume":"14","author":"J Tajiri","year":"2004","unstructured":"Tajiri J, Noguchi S (2004) Antithyroid drug-induced agranulocytosis: special reference to normal white blood cell count agranulocytosis. Thyroid 14:459\u2013462. doi:\n10.1089\/105072504323150787","journal-title":"Thyroid"},{"key":"626_CR4","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1056\/NEJMra042972","volume":"352","author":"DS Cooper","year":"2005","unstructured":"Cooper DS (2005) Antithyroid drugs. N Engl J Med 352:905\u2013917. doi:\n10.1056\/NEJMra042972","journal-title":"N Engl J Med"},{"key":"626_CR5","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1089\/thy.2005.15.292","volume":"15","author":"J Tajiri","year":"2005","unstructured":"Tajiri J, Noguchi S (2005) Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? Thyroid 15:292\u2013297. doi:\n10.1089\/thy.2005.15.292","journal-title":"Thyroid"},{"key":"626_CR6","doi-asserted-by":"publisher","first-page":"E49","DOI":"10.1210\/jc.2011-2221","volume":"97","author":"N Watanabe","year":"2012","unstructured":"Watanabe N, Narimatsu H, Noh JY, Yamaguchi T, Kobayashi K, Kami M, Kunii Y, Mukasa K, Ito K, Ito K (2012) Antithyroid drug-induced hematopoietic damage: a retrospective cohort study of agranulocytosis and pancytopenia involving 50,385 patients with Graves\u2019 disease. J Clin Endocrinol Metab 97:E49\u2013E53. doi:\n10.1210\/jc.2011-2221","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR7","doi-asserted-by":"publisher","first-page":"4776","DOI":"10.1210\/jc.2013-2569","volume":"98","author":"H Nakamura","year":"2013","unstructured":"Nakamura H, Miyauchi A, Miyawaki N, Imagawa J (2013) Analysis of 754 cases of antithyroid drug-induced agranulocytosis over 30 years in Japan. J Clin Endocrinol Metab 98:4776\u20134783. doi:\n10.1210\/jc.2013-2569","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR8","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1210\/jc.2015-4274","volume":"101","author":"SL Andersen","year":"2016","unstructured":"Andersen SL, Olsen J, Laurberg P (2016) Antithyroid drug side effects in the population and in pregnancy. J Clin Endocrinol Metab 101:1606\u20131614. doi:\n10.1210\/jc.2015-4274","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0300-2977(98)00065-5","volume":"53","author":"WW Roeloffzen","year":"1998","unstructured":"Roeloffzen WW, Verhaegh JJ, van Poelgeest AE, Gansevoort RT (1998) Fever or a soar throat after start of antithyroidal drugs? A medical emergency. Neth J Med 53:113\u2013117. doi:\n10.1016\/S0300-2977(98)00065-5","journal-title":"Neth J Med"},{"key":"626_CR10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/qjmed\/92.8.455","volume":"92","author":"WH Sheng","year":"1999","unstructured":"Sheng WH, Hung CC, Chen YC, Fang CT, Hsieh SM, Chang SC, Hsieh WC (1999) Antithyroid-drug-induced agranulocytosis complicated by life-threatening infections. QJM 92:455\u201346112","journal-title":"QJM"},{"key":"626_CR11","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s40618-016-0477-x","volume":"39","author":"SA Rivkees","year":"2016","unstructured":"Rivkees SA (2016) Controversies in the management of Graves\u2019 disease in children. J Endocrinol Invest 39:1247\u20131257. doi:\n10.1007\/s40618-016-0477-x","journal-title":"J Endocrinol Invest"},{"key":"626_CR12","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s40618-014-0136-z","volume":"37","author":"M Marino","year":"2014","unstructured":"Marino M, Latrofa F, Menconi F, Chiovato L, Vitti P (2014) An update on the medical treatment of Graves\u2019 hyperthyroidism. J Endocrinol Invest 37:1041\u20131048. doi:\n10.1007\/s40618-014-0136-z","journal-title":"J Endocrinol Invest"},{"key":"626_CR13","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1089\/thy.2015.0439","volume":"26","author":"J Yang","year":"2016","unstructured":"Yang J, Zhu YJ, Zhong J, Zhang J, Weng WW, Liu Z, Xu Q, Dong M (2016) Characteristics of antithyroid drug-induced agranulocytosis in patients with hyperthyroidism: a retrospective analysis of 114 cases in a single institution in China involving 9690 patients referred for radioiodine treatment over 15 years. Thyroid 26:627\u2013633. doi:\n10.1089\/thy.2015.0439","journal-title":"Thyroid"},{"key":"626_CR14","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3803\/EnM.2015.30.4.475","volume":"30","author":"HK Kim","year":"2015","unstructured":"Kim HK, Yoon JH, Jeon MJ, Kim TY, Shong YK, Lee MJ, Kim BH, Kim IJ, Joung JY, Kim SW, Chung JH, Kang HC (2015) Characteristics of Korean patients with antithyroid drug-induced agranulocytosis: a multicenter study in Korea. Endocrinol Metab 30:475\u2013480. doi:\n10.3803\/EnM.2015.30.4.475","journal-title":"Endocrinol Metab"},{"key":"626_CR15","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1089\/thy.2013.0476","volume":"24","author":"S Kobayashi","year":"2014","unstructured":"Kobayashi S, Noh JY, Mukasa K, Kunii Y, Watanabe N, Matsumoto M, Ohye H, Suzuki M, Yoshihara A, Iwaku K, Sugino K, Ito K (2014) Characteristics of agranulocytosis as an adverse effect of antithyroid drugs in the second or later course of treatment. Thyroid 24:796\u2013801. doi:\n10.1089\/thy.2013.0476","journal-title":"Thyroid"},{"key":"626_CR16","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF03344959","volume":"17","author":"M Meyer-Gessner","year":"1994","unstructured":"Meyer-Gessner M, Benker G, Lederbogen S, Olbricht T, Reinwein D (1994) Antithyroid drug-induced agranulocytosis: clinical experience with ten patients treated at one institution and review of the literature. J Endocrinol Invest 17:29\u201336. doi:\n10.1007\/BF03344959","journal-title":"J Endocrinol Invest"},{"key":"626_CR17","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.2169\/internalmedicine.51.7845","volume":"51","author":"J Yang","year":"2012","unstructured":"Yang J, Zhong J, Zhou LZ, Hong T, Xiao XH, Wen GB (2012) Sudden onset agranulocytosis and hepatotoxicity after taking methimazole. Intern Med 51:2189\u20132192. doi:\n10.2169\/internalmedicine.51.7845","journal-title":"Intern Med"},{"key":"626_CR18","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.4158\/EP11339.CR","volume":"18","author":"P Mutharasan","year":"2012","unstructured":"Mutharasan P, Oatis W, Kwaan H, Molitch M (2012) Delayed anithyroid drug-induced agranulocytosis. Endocr Pract 18:e69\u2013e72. doi:\n10.4158\/EP11339.CR","journal-title":"Endocr Pract"},{"key":"626_CR19","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1001\/archinte.1990.00390150107020","volume":"150","author":"J Tajiri","year":"1990","unstructured":"Tajiri J, Noguchi S, Murakami T, Murakami N (1990) Antithyroid drug-induced agranulocytosis. The usefulness of routine white blood cell count monitoring. Arch Intern Med 150:621\u2013624. doi:\n10.1001\/archinte.1990.00390150107020","journal-title":"Arch Intern Med"},{"key":"626_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1089\/thy.1999.9.29","volume":"9","author":"S Fukata","year":"1999","unstructured":"Fukata S, Kuma K, Sugawara M (1999) Granulocyte colony-stimulating factor (G-CSF) does not improve recovery from antithyroid drug-induced agranulocytosis: a prospective study. Thyroid 9:29\u201331. doi:\n10.1089\/thy.1999.9.29","journal-title":"Thyroid"},{"key":"626_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/qjmed\/94.8.423","volume":"94","author":"E Andres","year":"2001","unstructured":"Andres E, Kurtz JE, Perrin AE, Dufour P, Schlienger JL, Maloisel F (2001) Haematopoietic growth factor in antithyroid-drug-induced agranulocytosis. QJM 94:423\u2013428. doi:\n10.1093\/qjmed\/94.8.423","journal-title":"QJM"},{"key":"626_CR22","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1089\/thy.2008.0364","volume":"19","author":"K Takata","year":"2009","unstructured":"Takata K, Kubota S, Fukata S, Kudo T, Nishihara E, Ito M, Amino N, Miyauchi A (2009) Methimazole-induced agranulocytosis in patients with Graves\u2019 disease is more frequent with an initial dose of 30\u00a0mg daily than with 15\u00a0mg daily. Thyroid 19:559\u2013563. doi:\n10.1089\/thy.2008.0364","journal-title":"Thyroid"},{"key":"626_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1089\/thy.2010.0417","volume":"21","author":"RS Bahn Chair","year":"2011","unstructured":"Bahn Chair RS, Burch HB, Cooper DS, Garber JR, Greenlee MC, Klein I, Laurberg P, McDougall IR, Montori VM, Rivkees SA, Ross DS, Sosa JA, Stan MN (2011) Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid 21:593\u2013646. doi:\n10.1089\/thy.2010.0417","journal-title":"Thyroid"},{"key":"626_CR24","first-page":"242","volume":"30","author":"CH Huang","year":"2007","unstructured":"Huang CH, Li KL, Wu JH, Wang PN, Juang JH (2007) Antithyroid drug-induced agranulocytosis: report of 13 cases. Chang Guang Med J 30:242\u2013248","journal-title":"Chang Guang Med J"},{"key":"626_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1089\/thy.1993.3.305","volume":"3","author":"MS Balkin","year":"1993","unstructured":"Balkin MS, Buchholtz M, Ortiz J, Green AJ (1993) Propylthiouracil (PTU)-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF). Thyroid 3:305\u2013309. doi:\n10.1089\/thy.1993.3.305","journal-title":"Thyroid"},{"key":"626_CR26","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/S1726-4901(09)70402-2","volume":"72","author":"MT Sun","year":"2009","unstructured":"Sun MT, Tsai CH, Shih KC (2009) Antithyroid drug-induced agranulocytosis. J Chin Med Assoc 72:438\u2013441. doi:\n10.1016\/S1726-4901(09)70402-2","journal-title":"J Chin Med Assoc"},{"key":"626_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1507\/endocrj.49-29","volume":"49","author":"WX Dai","year":"2002","unstructured":"Dai WX, Zhang JD, Zhan SW, Xu BZ, Jin H, Yao Y, Xin WC, Bai Y (2002) Retrospective analysis of 18 cases of antithyroid drug (ATD)-induced agranulocytosis. Endocr J 49:29\u201333. doi:\n10.1507\/endocrj.49-29","journal-title":"Endocr J"},{"key":"626_CR28","first-page":"168","volume":"14","author":"KL Li","year":"1991","unstructured":"Li KL, Huang HS, Wang PW, Lin JD, Juang JH, Liu RT, Huang BY, Huang MJ. (1991) Agranulocytosis associated with anti-thyroid drug in patients with Graves\u2019 thyrotoxicosis\u2013report of 11 cases. Chang Guang Med J 14:168\u2013173.","journal-title":"Chang Guang Med J"},{"key":"626_CR29","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1210\/jc.2007-0141","volume":"92","author":"M Abalovich","year":"2007","unstructured":"Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ, Stagnaro-Green A (2007) Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 92:S1\u2013S47. doi:\n10.1210\/jc.2007-0141","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR30","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1089\/thy.2011.2106.ed1","volume":"21","author":"S Yamashita","year":"2011","unstructured":"Yamashita S, Amino N, Shong YK (2011) The American Thyroid Association and American Association of Clinical Endocrinologists hyperthyroidism and other causes of thyrotoxicosis guidelines: viewpoints from Japan and Korea. Thyroid 21:577\u2013580. doi:\n10.1089\/thy.2011.2106.ed1","journal-title":"Thyroid"},{"key":"626_CR31","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"26","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN, Walter MA (2016) 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid 26:1343\u20131421. doi:\n10.1089\/thy.2016.0229","journal-title":"Thyroid"},{"key":"626_CR32","first-page":"876","volume":"46","author":"Chinese Endocrinology Association","year":"2007","unstructured":"Chinese Endocrinology Association (2007) Management guideline of thyroid disease in China: hyperthyroidism. Zhonghua Nei Ke Za Zhi 46:876\u2013882 (in Chinese)","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"626_CR33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000367990","volume":"3","author":"J Robinson","year":"2014","unstructured":"Robinson J, Richardson M, Hickey J, James A, Pearce SH, Ball SG, Quinton R, Morris M, Miller M, Perros P (2014) Patient knowledge of antithyroid drug-induced agranulocytosis. Eur Thyroid J 3:245\u2013251. doi:\n10.1159\/000367990","journal-title":"Eur Thyroid J"},{"key":"626_CR34","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1210\/jcem.77.5.7521347","volume":"77","author":"H Tamai","year":"1993","unstructured":"Tamai H, Mukuta T, Matsubayashi S, Fukata S, Komaki G, Kuma K, Kumagai LF, Nagataki S (1993) Treatment of methimazole-induced agranulocytosis using recombinant human granulocyte colony-stimulating factor (rhG-CSF). J Clin Endocrinol Metab 77:1356\u20131360. doi:\n10.1210\/jcem.77.5.7521347","journal-title":"J Clin Endocrinol Metab"},{"key":"626_CR35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/BF03349180","volume":"29","author":"J Jakucs","year":"2006","unstructured":"Jakucs J, Pocsay G (2006) Successful treatment of methimazole-induced severe aplastic anemia with recombinant human granulocyte colony-stimulating factor and high-dosage steroids. J Endocrinol Invest 29:74\u201377. doi:\n10.1007\/BF03349180","journal-title":"J Endocrinol Invest"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-017-0626-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0626-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0626-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T10:45:45Z","timestamp":1497005145000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-017-0626-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,24]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["626"],"URL":"https:\/\/doi.org\/10.1007\/s40618-017-0626-x","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,24]]}}}