{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:51:56Z","timestamp":1789210316619,"version":"build-2803163510"},"reference-count":160,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1007\/s40618-017-0627-9","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T14:01:08Z","timestamp":1488376868000},"page":"789-802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP)"],"prefix":"10.1007","volume":"40","author":[{"given":"Sofia","family":"Leka-Emiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kanaka-Gantenbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,1]]},"reference":[{"key":"627_CR1","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1210\/er.2002-0019","volume":"24","author":"AS Parent","year":"2003","unstructured":"Parent AS, Teilmann G, Juul A, Skakkebaek NE, Toppari J, Bourguignon JP (2003) The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev 24:668\u2013693","journal-title":"Endocr Rev"},{"key":"627_CR2","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1210\/jc.2008-0981","volume":"93","author":"ZK Gajdos","year":"2008","unstructured":"Gajdos ZK, Butler JL, Henderson KD, He C, Supelak PJ, Egyud M, Price A, Reich D, Clayton PE, Le Marchand L, Hunter DJ, Henderson BE, Palmert MR, Hirschhorn JN (2008) Association studies of common variants in 10 hypogonadotropic hypogonadism genes with age at menarche. J Clin Endocrinol Metab 93:4290\u20134298","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1096-7192(03)00107-0","volume":"80","author":"MR Palmert","year":"2003","unstructured":"Palmert MR, Hirschhorn JN (2003) Genetic approaches to stature, pubertal timing, and other complex traits. Mol Genet Metab 80:1\u201310","journal-title":"Mol Genet Metab"},{"key":"627_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1002\/ajhb.20039","volume":"16","author":"EW Demerath","year":"2004","unstructured":"Demerath EW, Towne B, Chumlea WC, Sun SS, Czerwinski SA, Remsberg KE, Siervogel RM (2004) Recent decline in age at menarche: the Fels Longitudinal Study. Am J Hum Biol 16:453\u2013457","journal-title":"Am J Hum Biol"},{"issue":"Suppl 3","key":"627_CR5","doi-asserted-by":"publisher","first-page":"S172","DOI":"10.1542\/peds.2007-1813D","volume":"121","author":"SY Euling","year":"2008","unstructured":"Euling SY, Herman-Giddens ME, Lee PA, Selevan SG, Juul A, Sorensen TI, Dunkel L, Himes JH, Teilmann G, Swan SH (2008) Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 121(Suppl 3):S172\u2013S191","journal-title":"Pediatrics"},{"key":"627_CR6","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1056\/NEJM196904172801606","volume":"280","author":"L Zacharias","year":"1969","unstructured":"Zacharias L, Wurtman RJ (1969) Age at menarche. Genetic and environmental influences. N Engl J Med 280:868\u2013875","journal-title":"N Engl J Med"},{"key":"627_CR7","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/03014467700002401","volume":"4","author":"S Fischbein","year":"1977","unstructured":"Fischbein S (1977) Intra-pair similarity in physical growth of monozygotic and of dizygotic twins during puberty. Ann Hum Biol 4:417\u2013430","journal-title":"Ann Hum Biol"},{"key":"627_CR8","first-page":"739","volume":"67","author":"J Kaprio","year":"1995","unstructured":"Kaprio J, Rimpel\u00e4 A, Winter T, Viken RJ, Rimpel\u00e4 M, Rose RJ (1995) Common genetic influences on BMI and age at menarche. Hum Biol 67:739\u2013753","journal-title":"Hum Biol"},{"key":"627_CR9","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1210\/jcem.86.6.7603","volume":"86","author":"MR Palmert","year":"2001","unstructured":"Palmert MR, Boepple PA (2001) Variation in the timing of puberty: clinical spectrum and genetic investigation. J Clin Endocrinol Metab 86:2364\u20132368","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR10","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/ajpa.20106","volume":"128","author":"B Towne","year":"2005","unstructured":"Towne B, Czerwinski SA, Demerath EW, Blangero J, Roche AF, Siervogel RM (2005) Heritability of age at menarche in girls from the Fels Longitudinal Study. Am J Phys Anthropol 128:210\u2013219","journal-title":"Am J Phys Anthropol"},{"key":"627_CR11","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s10519-007-9161-4","volume":"37","author":"SM Van den Berg","year":"2007","unstructured":"Van den Berg SM, Boomsma DI (2007) The familial clustering of age at menarche in extended twin families. Behav Genet 37:661\u2013667","journal-title":"Behav Genet"},{"key":"627_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1136\/adc.70.2.116","volume":"70","author":"NA Bridges","year":"1994","unstructured":"Bridges NA, Christopher JA, Hindmarsh PC, Brook CG (1994) Sexual precocity: sex incidence and aetiology. Arch Dis Child 70:116\u2013118","journal-title":"Arch Dis Child"},{"key":"627_CR13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/00008480-200008000-00020","volume":"12","author":"MC Lebrethon","year":"2000","unstructured":"Lebrethon MC, Bourguignon JP (2000) Management of central isosexual precocity: diagnosis, treatment, outcome. Curr Opin Pediatr 12:394\u2013399","journal-title":"Curr Opin Pediatr"},{"key":"627_CR14","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1210\/jcem.84.2.5533","volume":"84","author":"KO Klein","year":"1999","unstructured":"Klein KO (1999) Precocious puberty: who has it? Who should be treated? J Clin Endocrinol Metab 84:411\u2013414","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1034\/j.1600-0463.2001.d01-107.x","volume":"109","author":"PA Lee","year":"2001","unstructured":"Lee PA, Guo SS, Kulin HE (2001) Age of puberty: data from the United States of America. APMIS 109:81\u201388","journal-title":"APMIS"},{"key":"627_CR16","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1046\/j.0300-0664.2001.01490.x","volume":"56","author":"CJ Partsch","year":"2002","unstructured":"Partsch CJ, Heger S, Sippell WG (2002) Management and outcome of central precocious puberty. Clin Endocrinol (Oxf) 56:129\u2013148.","journal-title":"Clin Endocrinol"},{"key":"627_CR17","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","volume":"358","author":"JC Carel","year":"2008","unstructured":"Carel JC, Leger J (2008) Clinical practice. Precocious puberty. N Engl J Med 358:2366\u20132377","journal-title":"N Engl J Med"},{"key":"627_CR18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0022-3476(86)80767-3","volume":"108","author":"OH Pescovitz","year":"1986","unstructured":"Pescovitz OH, Comite F, Hench K, Barnes K, McNemar A, Foster C, Kenigsberg D, Loriaux DL, Cutler GB Jr (1986) The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr 108:47\u201354","journal-title":"J Pediatr"},{"key":"627_CR19","first-page":"313","volume-title":"The neurobiology of puberty","author":"EK Neely","year":"1995","unstructured":"Neely EK (1995) A multicenter trial of depot leuprolide for central precocious puberty. In: Plant TM, Lee PA (eds) The neurobiology of puberty. J Endocrinol Ltd, Bristol, pp\u00a0313\u2013318"},{"key":"627_CR20","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1515\/JPEM.2000.13.S1.765","volume":"13","author":"D Mul","year":"2000","unstructured":"Mul D, Oostdijk W, Otten BJ, Rouw\u00e9 C, Jansen M, Delemarre-van de Waal HA, Waelkens JJ, Drop SL (2000) Final height after gonadotrophin releasing hormone agonist treatment for central precocious puberty: the Dutch experience. J Pediatr Endocrinol Metab 13:765\u2013772","journal-title":"J Pediatr Endocrinol Metab"},{"key":"627_CR21","first-page":"4480","volume":"84","author":"MR Palmert","year":"1999","unstructured":"Palmert MR, Mansfield MJ, Crowley WF Jr, Crigler JF Jr, Crawford JD, Boepple PA (1999) Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab 84:4480\u20134488","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"627_CR22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/humupd\/7.3.292","volume":"7","author":"CJ Partsch","year":"2001","unstructured":"Partsch CJ, Sippell WG (2001) Pathogenesis and epidemiology of precocious puberty. Effects of exogenous oestrogens. Hum Reprod Update 7(3):292\u2013302","journal-title":"Hum Reprod Update"},{"key":"627_CR23","unstructured":"Grumbach MM, Styne DM (1998) Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR (eds), Williams\u2019 textbook of endocrinology. 9th ad. W.B. Saunders Ca, Philadelphia, 1509\u20131625"},{"key":"627_CR24","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1210\/jcem-52-3-488","volume":"52","author":"B Sherman","year":"1981","unstructured":"Sherman B, Wallace R, Bean J, Schlabaugh L (1981) Relationship of body weight to menarcheal and menopausal age: implications for breast cancer risk. J Clin Endocrinol Metab 52:488\u2013493","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/ajcn\/64.1.18","volume":"64","author":"FJ van Lenthe","year":"1996","unstructured":"van Lenthe FJ, Kemper CG, van Mechelen W (1996) Rapid maturation in adolescence results in greater obesity in adulthood: the Amsterdam Growth and Health Study. Am J Clin Nutr 64:18\u201324","journal-title":"Am J Clin Nutr"},{"key":"627_CR26","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1038\/ng.714","volume":"42","author":"CE Elks","year":"2010","unstructured":"Elks CE, Perry JR, Sulem P et al (2010) Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 42:1077\u20131085","journal-title":"Nat Genet"},{"key":"627_CR27","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa021293","volume":"348","author":"AS Hamilton","year":"2003","unstructured":"Hamilton AS, Mack TM (2003) Puberty and genetic susceptibility to breast cancer in a case-control study in twins. N Engl J Med 348:2313\u20132322","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"627_CR28","doi-asserted-by":"publisher","first-page":"S218","DOI":"10.1542\/peds.2007-1813G","volume":"121","author":"MS Golub","year":"2008","unstructured":"Golub MS, Collman GW, Foster PM et al (2008) Public health implications of altered puberty timing. Pediatrics 121(Suppl 3):S218\u2013S230","journal-title":"Pediatrics"},{"key":"627_CR29","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1210\/jc.2008-1522","volume":"94","author":"S Iuliano-Burns","year":"2009","unstructured":"Iuliano-Burns S, Hopper J, Seeman E (2009) The age of puberty determines sexual dimorphism in bone structure: a male\/female co-twin control study. J Clin Endocrinol Metab 94:1638\u20131643","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR30","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1210\/jc.2003-030361","volume":"89","author":"L \u2018de Vries","year":"2004","unstructured":"\u2018de Vries L, Kauschansky A, Shohat M, Phillip M (2004) Familial central precocious puberty suggests autosomal dominant inheritance. J Clin Endocrinol Metab 89:1794\u20131800","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR31","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mce.2011.05.019","volume":"346","author":"MG Teles","year":"2011","unstructured":"Teles MG, Silveira LF, Tusset C, Latronico AC (2011) New genetic factors implicated in human GnRH-dependent precocious puberty: the role of kisspeptin system. Mol Cell Endocrinol 346:84\u201390","journal-title":"Mol Cell Endocrinol"},{"key":"627_CR32","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1542\/peds.2005-0012","volume":"116","author":"G Teilmann","year":"2005","unstructured":"Teilmann G, Pedersen CB, Jensen TK, Skakkebaek NE, Juul A (2005) Prevalence and incidence of precocious pubertal development in Denmark: an epidemiologic study based on national registries. Pediatrics 116:1323\u20131328","journal-title":"Pediatrics"},{"key":"627_CR33","first-page":"521","volume":"19","author":"SB Seminara","year":"1998","unstructured":"Seminara SB, Hayes FJ, Crowley WF Jr (1998) Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and kallmann\u2019s syndrome): pathophysiological and genetic considerations. Endocr Rev 19:521\u2013539","journal-title":"Endocr Rev"},{"key":"627_CR34","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nrendo.2009.177","volume":"5","author":"SD Bianco","year":"2009","unstructured":"Bianco SD, Kaiser UB (2009) The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol 5:569\u2013576","journal-title":"Nat Rev Endocrinol"},{"key":"627_CR35","doi-asserted-by":"publisher","first-page":"10972","DOI":"10.1073\/pnas.1834399100","volume":"100","author":"N de Roux","year":"2003","unstructured":"de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E (2003) Hypogonadotropic hypogonadism due to loss of function of the kiss1-derived peptide receptor gpr54. Proc Natl Acad Sci U S A 100:10972\u201310976","journal-title":"Proc Natl Acad Sci U S A"},{"key":"627_CR36","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1056\/NEJMoa035322","volume":"349","author":"SB Seminara","year":"2003","unstructured":"Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O\u2019Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH (2003) The gpr54 gene as a regulator of puberty. N Engl J Med 349:1614\u20131627","journal-title":"N Engl J Med"},{"key":"627_CR37","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.fertnstert.2005.08.044","volume":"85","author":"B Bhagavath","year":"2006","unstructured":"Bhagavath B, Pdolsky RH, Ozata M, Bolu E, Bick DP, Kulharya A et al (2006) Clinical and molecular characterization of a large sample of patients with hypogonadotropic hypogonadism. Fertil Steril 85:706\u2013713","journal-title":"Fertil Steril"},{"key":"627_CR38","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1159\/000098147","volume":"84","author":"AK Topaloglu","year":"2006","unstructured":"Topaloglu AK, Lu ZL, Farooqi IS, Mungan NO, Yuksel B, O\u2019Rahilly S, Millar RP (2006) Molecular genetic analysis of normosmic hypogonadotropic hypogonadism in a Turkish population: identification and detailed functional characterization of a novel mutation in the gonadotropin-releasing hormone receptor gene. Neuroendocrinology 84:301\u2013308","journal-title":"Neuroendocrinology"},{"key":"627_CR39","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1055\/s-2007-984743","volume":"25","author":"GY B\u00e9d\u00e9carrats","year":"2007","unstructured":"B\u00e9d\u00e9carrats GY, Kaiser UB (2007) Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med 25:368\u2013378","journal-title":"Semin Reprod Med"},{"key":"627_CR40","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1210\/jc.2010-1676","volume":"96","author":"R Nimri","year":"2011","unstructured":"Nimri R, Lebenthal Y, Lazar L, Chevrier L, Phillip M, Bar M, Hernandez-Mora E, de Roux N, Gat-Yablonski G (2011) A novel loss-of-function mutation in GPR54\/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family. J Clin Endocrinol Metab 96:536\u2013545","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR41","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1056\/NEJMoa073443","volume":"358","author":"MG Teles","year":"2008","unstructured":"Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC (2008) A gpr54-activating mutation in a patient with central precocious puberty. N Engl J Med 358:709\u2013715","journal-title":"N Engl J Med"},{"key":"627_CR42","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.1210\/jc.2009-2421","volume":"95","author":"LG Silveira","year":"2010","unstructured":"Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC (2010) Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab 95:2276\u20132280","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR43","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1056\/NEJMoa1302160","volume":"368","author":"AP Abreu","year":"2013","unstructured":"Abreu AP, Dauber A, Macedo DB et al (2013) Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med 368:2467\u20132475","journal-title":"N Engl J Med"},{"key":"627_CR44","doi-asserted-by":"publisher","first-page":"E647","DOI":"10.1210\/jc.2013-4084","volume":"99","author":"N Settas","year":"2014","unstructured":"Settas N, Dacou-Voutetakis C, Karantza M, Kanaka-Gantenbein C, Chrousos GP, Voutetakis A (2014) Central precocious puberty in a girl and early puberty in her brother caused by a novel mutation in the MKRN3 gene. J Clin Endocrinol Metab 99:E647\u2013E651","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"627_CR45","doi-asserted-by":"publisher","first-page":"E1097","DOI":"10.1210\/jc.2013-3126","volume":"99","author":"DB Macedo","year":"2014","unstructured":"Macedo DB, Abreu AP, Reis AC, Montenegro LR, Dauber A, Beneduzzi D, Cukier P, Silveira LF, Teles MG, Carroll RS, Guerra Junior G, Guaragna Filho G, Gucev Z, Arnhold IJ, de Castro M, Moreira AC, Martinelli CE Jr, Hirschhorn JN, Mendonca BB, Brito VN, Antonini SR, Kaiser UB, Latronico AC (2014) Central Precocious Puberty that appears to be sporadic caused by Paternally inherited mutations in the imprinted GENE makorin ring finger 3. J Clin Endocrinol Metab 99(6):E1097\u2013E1103","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR46","doi-asserted-by":"publisher","first-page":"5257","DOI":"10.1210\/endo.140.11.7139","volume":"140","author":"KL Keen","year":"1999","unstructured":"Keen KL, Burich AJ, Mitsushima D, Kasuya E, Terasawa E (1999) Effects of pulsatile infusion of the GABA(A) receptor blocker bicuculline on the onset of puberty in female rhesus monkeys. Endocrinology 140:5257\u20135266","journal-title":"Endocrinology"},{"key":"627_CR47","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1210\/jc.2005-2657","volume":"91","author":"VN Brito","year":"2006","unstructured":"Brito VN, Mendonca BB, guilhoto LM, Freitas KC, Arnhold IJ, Latronico AC (2006) Allelic variants of the gamma-aminobutyric acid-A receptor alpha1-subunit gene (GABRA1) are not associated with idiopathic gonadotropin-dependent precocious puberty in girls with and without electroencephalographic abnormalities. J Clin Endocrinol Metab 91:2432\u20132436","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR48","first-page":"111","volume":"22","author":"E Terasawa","year":"2001","unstructured":"Terasawa E, Fernandez DL (2001) Neurobiological mechanisms of the onset of puberty in primates. Endocr Rev 22:111\u2013151","journal-title":"Endocr Rev"},{"key":"627_CR49","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.fertnstert.2006.07.1519","volume":"87","author":"KC Freitas","year":"2007","unstructured":"Freitas KC, Ryan G, Brito VN, Tao YX, Costa EM, Mendonca BB, Segaloff D, Latronico AC (2007) Molecular analysis of the neuropeptide y1 receptor gene in human idiopathic gonadotropin-dependent precocious puberty and isolated hypogonadotropic hypogonadism. Fertil Steril 87:627\u2013634","journal-title":"Fertil Steril"},{"key":"627_CR50","doi-asserted-by":"publisher","first-page":"11349","DOI":"10.1523\/JNEUROSCI.3328-05.2005","volume":"25","author":"SK Han","year":"2005","unstructured":"Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE (2005) Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349\u201311356","journal-title":"J Neurosci"},{"key":"627_CR51","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.tem.2004.05.010","volume":"15","author":"ML Gottsch","year":"2004","unstructured":"Gottsch ML, Clifton DK, Steiner RA (2004) Galanin-like peptide as a link in the integration of metabolism and reproduction. Trends Endocrinol Metab 15:215\u2013221","journal-title":"Trends Endocrinol Metab"},{"key":"627_CR52","doi-asserted-by":"publisher","first-page":"4073","DOI":"10.1210\/en.2004-0431","volume":"145","author":"ML Gottsch","year":"2004","unstructured":"Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA (2004) A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073\u20134077","journal-title":"Endocrinology"},{"key":"627_CR53","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.bbrc.2004.05.185","volume":"320","author":"H Matsui","year":"2004","unstructured":"Matsui H, Takatsu Y, Kumano S, Matsumoto H, Ohtaki T (2004) Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun 320:383\u2013388","journal-title":"Biochem Biophys Res Commun"},{"key":"627_CR54","doi-asserted-by":"publisher","first-page":"6609","DOI":"10.1210\/jc.2005-1468","volume":"90","author":"WS Dhillo","year":"2005","unstructured":"Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, Murphy KG, Badman MK, McGowan BM, Amber V, Patel S, Ghatei MA, Bloom SR (2005) Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 90:6609\u20136615","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR55","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1365-2826.2005.01357.x","volume":"17","author":"S Messager","year":"2005","unstructured":"Messager S (2005) Kisspeptin and its receptor: new gatekeepers of puberty. J Neuroendocrinol 17:687\u2013688","journal-title":"J Neuroendocrinol"},{"key":"627_CR56","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1210\/en.2004-1353","volume":"146","author":"VM Navarro","year":"2005","unstructured":"Navarro VM, Castellano JM, Fernandez-Fernandez R, Tovar S, Roa J, Mayen A, Barreiro ML, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2005) Effects of KiSS-1 peptide, the natural ligand of GPR54, on follicle-stimulating hormone secretion in the rat. Endocrinology 146:1689\u20131697","journal-title":"Endocrinology"},{"key":"627_CR57","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1073\/pnas.0409822102","volume":"102","author":"M Shahab","year":"2005","unstructured":"Shahab M, Mastronardi C, Seminara SB, Crowley WF, Ojeda SR, Plant TM (2005) Increased hypothalamic gpr54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A 102:2129\u20132134","journal-title":"Proc Natl Acad Sci U S A"},{"key":"627_CR58","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1507\/endocrj.K10E-073","volume":"57","author":"JM Ko","year":"2010","unstructured":"Ko JM, Lee HS, Hwang JS (2010) KISS1 gene analysis in Korean girls with central precocious puberty: a polymorphism, p.P110T, suggested to exert a protective effect. Endocr J 57:701\u2013709","journal-title":"Endocr J"},{"key":"627_CR59","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.mce.2011.12.014","volume":"351","author":"L Huijbregts","year":"2012","unstructured":"Huijbregts L, Roze C, Bonafe G, Houang M, Le Bouc Y, Carel JC, Leger J, Alberti P, de Roux N (2012) DNA polymorphisms of the KiSS1 3\u2032 Untranslated region interfere with the folding of a G-rich sequence into G-quadruplex. Mol Cell Endocrinol 351:239\u2013248","journal-title":"Mol Cell Endocrinol"},{"key":"627_CR60","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000107511","volume":"86","author":"X Luan","year":"2007","unstructured":"Luan X, Yu H, Wei X, Zhou Y, Wang W, Li P, Gan X, Wei D, Xiao J (2007) GPR54 polymorphisms in Chinese girls with central precocious puberty. Neuroendocrinology 86:77\u201383","journal-title":"Neuroendocrinology"},{"key":"627_CR61","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1530\/EJE-07-0061","volume":"157","author":"X Luan","year":"2007","unstructured":"Luan X, Zhou Y, Wang W, Yu H, Li P, Gan X, Wei D, Xiao J (2007) Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girls. Eur J Endocrinol 157:113\u2013118","journal-title":"Eur J Endocrinol"},{"key":"627_CR62","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1186\/1756-0500-4-363","volume":"4","author":"J Tommiska","year":"2011","unstructured":"Tommiska J, S\u00f8rensen K, Aksglaede L et al (2011) LIN28B, LIN28A, KISS1, and KISS1R in idiopathic central precocious puberty. BMC Res Notes 4:363","journal-title":"BMC Res Notes"},{"key":"627_CR63","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1515\/jpem-2013-0080","volume":"27","author":"M Krstevska-Konstantinova","year":"2014","unstructured":"Krstevska-Konstantinova M, Jovanovska J, Tasic VB, Montenegro LR, Beneduzzi D, Silveira LF, Gucev ZS (2014) Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty. J Pediatr Endocrinol Metab 27:199\u2013201","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"3","key":"627_CR64","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000356913","volume":"81","author":"S Leka-Emiri","year":"2014","unstructured":"Leka-Emiri S, Louizou E, Kambouris M, Chrousos G, De Roux N, Kanaka-Gantenbein C (2014) Absence of GPR54 and TACR3 mutations in sporadic cases of idiopathic central precocious puberty. Horm Res Paediatr 81(3):177\u2013181","journal-title":"Horm Res Paediatr"},{"key":"627_CR65","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/ng.385","volume":"41","author":"C He","year":"2009","unstructured":"He C, Kraft P, Chen C, Buring JE, Par\u00e9 G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI (2009) Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet 41:724\u2013728","journal-title":"Nat Genet"},{"issue":"6","key":"627_CR66","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/ng.382","volume":"41","author":"KK Ong","year":"2009","unstructured":"Ong KK, Elks CE, Li S, Zhao JH, Luan J, Andersen LB, Bingham SA, Brage S, Smith GD, Ekelund U, Gillson CJ, Glaser B, Golding J, Hardy R, Khaw KT, Kuh D, Luben R, Marcus M, McGeehin MA, Ness AR, Northstone K, Ring SM, Rubin C, Sims MA, Song K, Strachan DP, Vollenweider P, Waeber G, Waterworth DM, Wong A, Deloukas P, Barroso I, Mooser V, Loos RJ, Wareham NJ (2009) Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet 41(6):729\u2013733","journal-title":"Nat Genet"},{"key":"627_CR67","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/ng.386","volume":"41","author":"JR Perry","year":"2009","unstructured":"Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G, McArdle PF, Smith AV, Aspelund T, Bandinelli S, Boerwinkle E, Cherkas L, Eiriksdottir G, Estrada K, Ferrucci L, Folsom AR, Garcia M, Gudnason V, Hofman A, Karasik D, Kiel DP, Launer LJ, van Meurs J, Nalls MA, Rivadeneira F, Shuldiner AR, Singleton A, Soranzo N, Tanaka T, Visser JA, Weedon MN, Wilson SG, Zhuang V, Streeten EA, Harris TB, Murray A, Spector TD, Demerath EW, Uitterlinden AG, Murabito JM (2009) Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet 41:648\u2013650","journal-title":"Nat Genet"},{"issue":"3","key":"627_CR68","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1159\/000342212","volume":"78","author":"AP Silveira-Neto","year":"2012","unstructured":"Silveira-Neto AP, Leal LF, Emerman AB, Henderson KD, Piskounova E, Henderson BE, Gregory RI, Silveira LF, Hirschhorn JN, Nguyen TT, Beneduzzi D, Tusset C, Reis AC, Brito VN, Mendonca BB, Palmert MR, Antonini SR, Latronico AC (2012) Absence of functional LIN28B mutations in a large cohort of patients with idiopathic central precocious puberty. Horm Res Paediatr 78(3):144\u2013150","journal-title":"Horm Res Paediatr"},{"issue":"3","key":"627_CR69","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1172\/JCI119172","volume":"99","author":"RS Ahima","year":"1997","unstructured":"Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS (1997) Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 99(3):391\u2013395","journal-title":"J Clin Invest"},{"issue":"5296","key":"627_CR70","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1126\/science.275.5296.88","volume":"275","author":"FF Chehab","year":"1997","unstructured":"Chehab FF, Mounzih K, Lu R, Lim ME (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275(5296):88\u201390","journal-title":"Science"},{"issue":"6","key":"627_CR71","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1210\/endo-98-6-1359","volume":"98","author":"RS Swerdloff","year":"1976","unstructured":"Swerdloff RS, Batt RA, Bray GA (1976) Reproductive hormonal function in the genetically obese (ob\/ob) mouse. Endocrinology 98(6):1359\u20131364","journal-title":"Endocrinology"},{"issue":"2","key":"627_CR72","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1530\/jrf.0.0640363","volume":"64","author":"RA Batt","year":"1982","unstructured":"Batt RA, Everard DM, Gillies G, Wilkinson M, Wilson CA, Yeo TA (1982) Investigation into the hypogonadism of the obese mouse (genotype ob\/ob). J Reprod Fertil 64(2):363\u2013371","journal-title":"J Reprod Fertil"},{"issue":"12","key":"627_CR73","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ejmg.2012.09.003","volume":"55","author":"PH Su","year":"2012","unstructured":"Su PH, Yang SF, Yu JS, Chen SJ, Chen JY (2012) A polymorphism in the leptin receptor gene at position 223 is associated with growth hormone replacement therapy responsiveness in idiopathic short stature and growth hormone deficiency patients. Eur J Med Genet 55(12):682\u2013687","journal-title":"Eur J Med Genet"},{"issue":"3","key":"627_CR74","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1002\/cne.20626","volume":"489","author":"SJ Krajewski","year":"2005","unstructured":"Krajewski SJ, Anderson MJ, Iles-Shih L, Chen KJ, Urbanski HF, Rance NE (2005) Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J Comp Neurol 489(3):372\u2013386","journal-title":"J Comp Neurol"},{"key":"627_CR75","doi-asserted-by":"publisher","first-page":"5752","DOI":"10.1210\/en.2007-0961","volume":"148","author":"RL Goodman","year":"2007","unstructured":"Goodman RL, Lehman MN, Smith JT, Coolen LM, de Oliveira CV, Jafarzadehshirazi MR, Pereira A, Iqbal J, Caraty A, Ciofi P, Clarke IJ (2007) Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin a and neurokinin b. Endocrinology 148:5752\u20135760","journal-title":"Endocrinology"},{"key":"627_CR76","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1590\/S0004-27302012000900008","volume":"56","author":"C Tusset","year":"2012","unstructured":"Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendon\u00e7a BB, Kaiser UB, Latronico AC (2012) Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. Arq Bras Endocrinol Metabol 56:646\u2013652","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"627_CR77","first-page":"645","volume":"26","author":"HS Lee","year":"2013","unstructured":"Lee HS, Park HK, Kim KH, Ko JH, Kim YJ, Yi KH, Hwang JS (2013) Estrogen receptor gene analysis in girls with central precocious puberty. J Pediatr Endocrinol Metab 26:645\u2013649","journal-title":"J Pediatr Endocrinol Metab"},{"key":"627_CR78","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1111\/j.1365-2826.2008.01812.x","volume":"21","author":"C Garcia-Rudaz","year":"2009","unstructured":"Garcia-Rudaz C, Deng V, Matagne V, Ronnekleiv OK, Bosch M, Han V, Percy AK, Ojeda SR (2009) FXYD1, a modulator of Na, K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability. J Neuroendocrinol 21:108\u2013122","journal-title":"J Neuroendocrinol"},{"key":"627_CR79","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1172\/JCI31752","volume":"117","author":"S Heger","year":"2007","unstructured":"Heger S, Mastronardi C, Dissen GA, Lomniczi A, Cabrera R, Roth CL, Jung H, Galimi F, Sippell W, Ojeda SR (2007) Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis. J Clin Invest 117:2145\u20132154","journal-title":"J Clin Invest"},{"key":"627_CR80","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ymeth.2009.06.004","volume":"49","author":"GA Dissen","year":"2009","unstructured":"Dissen GA, Lomniczi A, Neff TL, Hobbs TR, Kohama SG, Kroenke CD, Galimi F, Ojeda SR (2009) In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles. Methods 49:70\u201377","journal-title":"Methods"},{"key":"627_CR81","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1159\/000354643","volume":"80","author":"P Cukier","year":"2013","unstructured":"Cukier P, Wright H, Rulfs T, Silveira LF, Teles MG, Mendonca BB, Arnhold IJ, Heger S, Latronico AC, Ojeda SR, Brito VN (2013) Molecular and gene network analysis of thyroid transcription factor 1 (TTF1) and enhanced at puberty (EAP1) genes in patients with GnRH-dependent pubertal disorders. Horm Res Paediatr 80:257\u2013266","journal-title":"Horm Res Paediatr"},{"issue":"5","key":"627_CR82","doi-asserted-by":"publisher","first-page":"e932","DOI":"10.1542\/peds.2008-2491","volume":"123","author":"L Aksglaede","year":"2009","unstructured":"Aksglaede L, S\u00f8rensen K, Petersen JH, Skakkebaek NE, Juul A (2009) Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 123(5):e932\u2013e939","journal-title":"Pediatrics"},{"issue":"3","key":"627_CR83","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/000336325","volume":"77","author":"K S\u00f8rensen","year":"2012","unstructured":"S\u00f8rensen K, Mouritsen A, Aksglaede L, Hagen CP, Mogensen SS, Juul A (2012) Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Paediatr 77(3):137\u2013145","journal-title":"Horm Res Paediatr"},{"key":"627_CR84","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","volume":"341","author":"DJ Barker","year":"1993","unstructured":"Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS (1993) Fetal nutrition and cardiovascular disease in adult life. Lancet 341:938\u2013941","journal-title":"Lancet"},{"key":"627_CR85","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1001\/archpedi.1964.02080060497011","volume":"107","author":"HK Silver","year":"1964","unstructured":"Silver HK (1964) Asymmetry, short stature, and variations in sexual development. A syndrome of congenital malformations. Am J Dis Child 107:495\u2013515","journal-title":"Am J Dis Child"},{"key":"627_CR86","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000472189","volume":"4","author":"DJ Tomkins","year":"1996","unstructured":"Tomkins DJ, Roux AF, Waye J, Freeman VC, Cox DW, Whelan DT (1996) Maternal uniparental isodisomy of human chromosome 14 associated with a paternal t(13q14q) and precocious puberty. Eur J Hum Genet 4:153\u2013159","journal-title":"Eur J Hum Genet"},{"key":"627_CR87","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0022-3476(99)70282-9","volume":"134","author":"S Fokstuen","year":"1999","unstructured":"Fokstuen S, Ginsburg C, Zachmann M, Schinzel A (1999) Maternal uniparental disomy 14 as a cause of intrauterine growth retardation and early onset of puberty. J Pediatr 134:689\u2013695","journal-title":"J Pediatr"},{"key":"627_CR88","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1126\/science.169.3943.397","volume":"169","author":"RE Frisch","year":"1970","unstructured":"Frisch RE, Revelle R (1970) Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169:397\u2013399","journal-title":"Science"},{"key":"627_CR89","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/adc.46.249.695","volume":"46","author":"RE Frisch","year":"1971","unstructured":"Frisch RE, Revelle R (1971) Height and weight at menarche and a hypothesis of menarche. Arch Dis Child 46:695\u2013701","journal-title":"Arch Dis Child"},{"key":"627_CR90","first-page":"469","volume":"45","author":"RE Frisch","year":"1973","unstructured":"Frisch RE, Revelle R, Cook S (1973) Components of weight at menarche and the initiation of the adolescent growth spurt in girls: estimated total water, lean body weight and fat. Hum Biol 45:469\u2013483","journal-title":"Hum Biol"},{"key":"627_CR91","first-page":"181","volume":"9","author":"WA Wattigney","year":"1999","unstructured":"Wattigney WA, Srinivasan SR, Chen W, Greenlund KJ, Berenson GS (1999) Secular trend of earlier onset of menarche with increasing obesity in black and white girls: the Bogalusa Heart Study. Ethn Dis 9:181\u2013189","journal-title":"Ethn Dis"},{"key":"627_CR92","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1136\/adc.64.3.383","volume":"64","author":"O Stark","year":"1989","unstructured":"Stark O, Peckham CS, Moynihan C (1989) Weight and age at menarche. Arch Dis Child 64:383\u2013387","journal-title":"Arch Dis Child"},{"key":"627_CR93","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/oxfordjournals.aje.a115738","volume":"132","author":"J Moisan","year":"1990","unstructured":"Moisan J, Meyer F, Gingras S (1990) A nested case-control study of the correlates of early menarche. Am J Epidemiol 132:953\u2013961","journal-title":"Am J Epidemiol"},{"key":"627_CR94","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1093\/oxfordjournals.aje.a116850","volume":"138","author":"H Merzenich","year":"1993","unstructured":"Merzenich H, Boeing H, Wahrendorf J (1993) Dietary fat and sports activity as determinants for age at menarche. Am J Epidemiol 138:217\u2013224","journal-title":"Am J Epidemiol"},{"key":"627_CR95","first-page":"1827","volume":"83","author":"G Van den Berghe","year":"1998","unstructured":"Van den Berghe G, de Zegher F, Bouillon R (1998) Clinical review 95: acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 83:1827\u20131834","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR96","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1001\/jama.1992.03480090092034","volume":"267","author":"GP Chrousos","year":"1992","unstructured":"Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244\u20131252","journal-title":"JAMA"},{"key":"627_CR97","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.1210\/jcem.84.12.6177","volume":"84","author":"N Georgopoulos","year":"1999","unstructured":"Georgopoulos N, Markou K, Theodoropoulou A, Paraskevopoulou P, Varaki L, Kazantzi Z, Leglise M, Vagenakis AG (1999) Growth and pubertal development in elite female rhythmic gymnasts. J Clin Endocrinol Metab 84:4525\u20134530","journal-title":"J Clin Endocrinol Metab"},{"key":"627_CR98","first-page":"913","volume":"28","author":"M Wierson","year":"1993","unstructured":"Wierson M, Long PJ, Forehand RL (1993) Toward a new understanding of early menarche: the role of environmental stress in pubertal timing. Adolescence 28:913\u2013924","journal-title":"Adolescence"},{"key":"627_CR99","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/eurpub\/ckv153","volume":"26","author":"J Le Moal","year":"2016","unstructured":"Le Moal J, Sharpe RM, J\u03d5rgensen N, Levine H, Jurewicz J, Mendiola J, Swan SH, Virtanen H, Christin-Ma\u00eetre S, Cordier S, Toppari J, Hanke W, HURGENT Network (2016) Toward a multi-country monitoring system of reproductive health in the context of endocrine disrupting chemical exposure. Eur J Public Health 26:76\u201383","journal-title":"Eur J Public Health"},{"key":"627_CR100","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1530\/EJE-11-0876","volume":"166","author":"F Deng","year":"2012","unstructured":"Deng F, Tao FB, Liu DY, Xu YY, Hao JH, Sun Y, Su PY (2012) Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty. Eur J Endocrinol 166:803\u2013809","journal-title":"Eur J Endocrinol"},{"key":"627_CR101","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1093\/humrep\/16.5.1020","volume":"16","author":"M Krstevska-Konstantinova","year":"2001","unstructured":"Krstevska-Konstantinova M, Charlier C, Craen M, Du Caju M, Heinrichs C, de Beaufort C, Plomteux G, Bourguignon JP (2001) Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides. Hum Reprod 16:1020\u20131026","journal-title":"Hum Reprod"},{"key":"627_CR102","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1006\/gcen.1997.7013","volume":"109","author":"EJ Clark","year":"1998","unstructured":"Clark EJ, Norris DO, Jones RE (1998) Interactions of gonadal steroids and pesticides (DDT, DDE) on gonaduct growth in larval tiger salamanders, Ambystoma tigrinum. Gen Comp Endocrinol 109:94\u2013105","journal-title":"Gen Comp Endocrinol"},{"key":"627_CR103","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3109\/15376516.2016.1158894","volume":"26","author":"AD Bulu\u015f","year":"2016","unstructured":"Bulu\u015f AD, A\u015fci A, Erkekoglu P, Balci A, Andiran N, Ko\u00e7er-G\u00fcm\u00fc\u015fel B (2016) The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. Toxicol Mech Methods 26:493\u2013500","journal-title":"Toxicol Mech Methods"},{"key":"627_CR104","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1210\/er.2009-0005","volume":"30","author":"AE Oakley","year":"2009","unstructured":"Oakley AE, Clifton DK, Steiner RA (2009) Kisspeptin signaling in the brain. Endocr Rev 30:713\u2013743","journal-title":"Endocr Rev"},{"key":"627_CR105","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.mce.2009.12.003","volume":"324","author":"SR Ojeda","year":"2010","unstructured":"Ojeda SR, Dubay C, Lomniczi A et al (2010) Gene networks and the neuroendocrine regulation of puberty. Mol Cell Endocrinol 324:3\u201311","journal-title":"Mol Cell Endocrinol"},{"key":"627_CR106","first-page":"1621","volume-title":"The Physiology of Reproduction. 2","author":"C Kordon","year":"1994","unstructured":"Kordon C, Drouva SV, de la Escalera M, Weiner RI (1994) Role of classi and peptide neuromediators in the neuroendocrine regulation of luteinizing hormona and prolactin. In: knobil E, Neil JD (eds) The Physiology of Reproduction. 2, vol\u00a01. Raven Press, New York, pp\u00a01621\u20131681"},{"key":"627_CR107","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/B978-012532104-4\/50077-9","volume-title":"Hormones, Brain and Behavior, vol4","author":"SR Ojeda","year":"2002","unstructured":"Ojeda SR, Terasawa E (2002) Neuroendocrine regulation of puberty. In: Pfaff D, Arnild A, Etgen A, Fahabach S, Moss R, Rubin R (eds) Hormones, Brain and Behavior, vol\u00a04. Elsevier, New York, pp\u00a0589\u2013659"},{"key":"627_CR108","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1080\/07853890310005164","volume":"35","author":"SR Ojeda","year":"2003","unstructured":"Ojeda SR, Prevot V, Heger S, Lomniczi A, Dziedzic B, Mungenast A (2003) Glia-to-neuron signaling and the neuroendocrine control of female puberty. Ann Med 35:244\u2013255","journal-title":"Ann Med"},{"key":"627_CR109","first-page":"2177","volume-title":"The Physiology of Reproduction. 3","author":"TM Plant","year":"2006","unstructured":"Plant, TM, Witchel, SF (2006) Puberty in nonhuman primates and humans. In: Neil JD (ed) The Physiology of Reproduction. 3. Academic Press\/Elsevier, San Diego,p\u00a02177\u20132230"},{"key":"627_CR110","first-page":"2061","volume-title":"The Physiology of reproduction. 3","author":"SR Ojeda","year":"2006","unstructured":"Ojeda, SR, Skinner, MK (2006) Puberty in the rat. In: Neil JD (ed) The Physiology of reproduction. 3. Academic Press\/Elsevier, San Diego, p\u00a02061\u20132126"},{"key":"627_CR111","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1210\/en.2005-1282","volume":"147","author":"HM Dungan","year":"2006","unstructured":"Dungan HM, Clifton DK, Steiner RA (2006) Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 147:1154\u20131158","journal-title":"Endocrinology"},{"key":"627_CR112","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/ng.306","volume":"41","author":"AK Topaloglu","year":"2009","unstructured":"Topaloglu AK, Reimann F, Guclu M, Yalin AS, Kotan LD, Porter KM, Serin A, Mungan NO, Cook JR, Ozbek MN, Imamoglu S, Akalin NS, Yuksel B, O\u2019Rahilly S, Semple RK (2009) Tac3 and tacr3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin b in the central control of reproduction. Nat Genet 41:354\u2013358","journal-title":"Nat Genet"},{"key":"627_CR113","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1210\/me.2002-0163","volume":"16","author":"RA DeFazio","year":"2002","unstructured":"DeFazio RA, Heger S, Ojeda SR, Moenter SM (2002) Activation of A-type gamma-aminobutyric acid receptors excites gonadotropin-releasing hormone neurons. Mol Endocrinol 16:2872\u20132891","journal-title":"Mol Endocrinol"},{"key":"627_CR114","doi-asserted-by":"publisher","first-page":"5374","DOI":"10.1210\/en.2005-0788","volume":"146","author":"SM Moenter","year":"2005","unstructured":"Moenter SM, DeFazio RA (2005) Endogenous gamma-aminobutyric acid can excite gonadotropin-releasing hormone neurons. Endocrinology 146:5374\u20135379","journal-title":"Endocrinology"},{"key":"627_CR115","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1365-2826.2005.01398.x","volume":"18","author":"B Dudas","year":"2006","unstructured":"Dudas B, Merchenthaler I (2006) Three-dimensional representation of the neurotransmitter systems of the human hypothalamus: inputs of the gonadotrophin hormone-releasing hormone neuronal system. J Neuroendocrinol 18:79\u201395","journal-title":"J Neuroendocrinol"},{"key":"627_CR116","doi-asserted-by":"publisher","first-page":"11859","DOI":"10.1523\/JNEUROSCI.1569-09.2009","volume":"29","author":"VM Navarro","year":"2009","unstructured":"Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA (2009) Regulation of gonadotropin-releasing hormone secretion by kisspeptin\/dynorphin\/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 29:11859\u201311866","journal-title":"J Neurosci"},{"key":"627_CR117","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1210\/en.2007-1765","volume":"149","author":"FJ Ebling","year":"2008","unstructured":"Ebling FJ, Luckman SM (2008) RFAmide-related peptide: another sexy peptide? Endocrinology 149:899\u2013901","journal-title":"Endocrinology"},{"key":"627_CR118","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1210\/en.2008-1623","volume":"150","author":"E Ducret","year":"2009","unstructured":"Ducret E, Anderson GM, Herbison AE (2009) RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology 150:2799\u20132804","journal-title":"Endocrinology"},{"key":"627_CR119","doi-asserted-by":"publisher","first-page":"4958","DOI":"10.1210\/en.2008-0316","volume":"149","author":"EM Gibson","year":"2008","unstructured":"Gibson EM, Humber SA, Jain S, Williams WP 3rd, Zhao S, Bentley GE, Tsutsui K, Kriegsfeld LJ (2008) Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology 149:4958\u20134969","journal-title":"Endocrinology"},{"key":"627_CR120","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1365-2826.2010.02018.x","volume":"22","author":"K Tsutsui","year":"2010","unstructured":"Tsutsui K, Bentley GE, Kriegsfeld LJ, Osugi T, Seong JY, Vaudry H (2010) Discovery and evolutionary history of gonadotrophin-inhibitory hormone and kisspeptin: new key neuropeptides controlling reproduction. J Neuroendocrinol 22:716\u2013727","journal-title":"J Neuroendocrinol"},{"key":"627_CR121","first-page":"41","volume-title":"The Onset of Puberty in Perspective","author":"SR Ojeda","year":"2000","unstructured":"Ojeda SR, MA YJ, Dziedzic B, Prevot V (2000) Astrocyte-neuron signalling and the onset of female puberty. In: Bourguignon J-P, Plant TM (eds) The Onset of Puberty in Perspective. Elsevier Science, Amsterdam, pp\u00a041\u201357"},{"key":"627_CR122","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/978-0-387-79492-1_19","volume-title":"Astrocytes in (patho) physiology of the nervous system","author":"A Lomniczi","year":"2009","unstructured":"Lomniczi A, Ojeda SR (2009) A role for glial cells of the neuroendocrine brain in the central control of female sexual development. In: Parpura V, Haydon P (eds) Astrocytes in (patho) physiology of the nervous system. Springer, NY, pp\u00a0487\u2013511"},{"key":"627_CR123","doi-asserted-by":"publisher","first-page":"4927","DOI":"10.1210\/en.2007-0078","volume":"148","author":"R Lapatto","year":"2007","unstructured":"Lapatto R, Pallais JC, Zhang D, Chan YM, Mahan A, Cerrato F, Le WW, Hoffman GE, Seminara SB (2007) Kiss1-\/- mice exhibit more variable hypogonadism than Gpr54-\/- mice. Endocrinology 148:4927\u20134936","journal-title":"Endocrinology"},{"key":"627_CR124","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/j.1365-2826.2009.01892.x","volume":"21","author":"J Clarkson","year":"2009","unstructured":"Clarkson J, d\u2019Anglemont de Tassigny X, Colledge WH, Caraty A, Herbison AE (2009) Distribution of kisspeptin neurones in the adult female mouse brain. J Neuroendocrinol 21:673\u2013682","journal-title":"J Neuroendocrinol"},{"key":"627_CR125","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1375\/1369052042335278","volume":"7","author":"L Eaves","year":"2004","unstructured":"Eaves L, Silberg J, Foley D, Bulik C, Maes H, Erkanli A, Angold A, Costello EJ, Worthman C (2004) Genetic and environmental influences on the relative timing of pubertal change. Twin Res 7:471\u201381","journal-title":"Twin Res"},{"key":"627_CR126","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1210\/en.2004-0543","volume":"145","author":"TD Krewson","year":"2004","unstructured":"Krewson TD, Supelak PJ, Hill AE, Singer JB, Lander ES, Nadeau JH, Palmert MR (2004) Chromosomes 6 and 13 harbor genes that regulate pubertal timing in mouse chromosome substitution strains. Endocrinology 145:4447\u20134451","journal-title":"Endocrinology"},{"key":"627_CR127","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1210\/endo.142.6.8261","volume":"142","author":"SB Seminara","year":"2001","unstructured":"Seminara SB, Crowley WF Jr (2001) Perspective: the importance of genetic defects in humans in elucidating the complexities of the hypothalamic-pituitary-gonadal axis. Endocrinology 142:2173\u20132177","journal-title":"Endocrinology"},{"key":"627_CR128","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/ng.383","volume":"41","author":"P Sulem","year":"2009","unstructured":"Sulem P, Gudbjartsson DF, Rafnar T, Holm H, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Alexandersen P, Feenstra B, Boyd HA, Aben KK, Verbeek AL, Roeleveld N, Jonasdottir A, Styrkarsdottir U, Steinthorsdottir V, Karason A, Stacey SN, Gudmundsson J, Jakobsdottir M, Thorleifsson G, Hardarson G, Gulcher J, Kong A, Kiemeney LA, Melbye M, Christiansen C, Tryggvadottir L, Thorsteinsdottir U, Stefansson K (2009) Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nat Genet 41:734\u2013738","journal-title":"Nat Genet"},{"key":"627_CR129","doi-asserted-by":"publisher","first-page":"5147","DOI":"10.1210\/en.2007-0634","volume":"148","author":"CL Roth","year":"2007","unstructured":"Roth CL, Mastronardi C, Lomniczi A, Wright H, Cabrera R, Mungenast AE, Heger S, Jung H, Dubay C, Ojeda SR (2007) Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty. Endocrinology 148:5147\u20135161","journal-title":"Endocrinology"},{"key":"627_CR130","first-page":"114","volume":"69","author":"AS Parent","year":"2008","unstructured":"Parent AS, Matagne V, Westphal M, Heger S, Ojeda S, Jung H (2008) Gene expression profiling of hypothalamic hamartomas: a search for genes associated with central precocious puberty. Horm Res 69:114\u2013123","journal-title":"Horm Res"},{"key":"627_CR131","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","volume":"88","author":"EG Moss","year":"1997","unstructured":"Moss EG, Lee RC, Ambros V (1997) The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell 88:637\u2013646","journal-title":"Cell"},{"key":"627_CR132","unstructured":"Matagne V, Ramaswamy S, Lomniczi A, Plant TM, Ojeda SR (2009) Hypothalamic expression of a gene cluster encoding transcriptional repressors and maping to chromosome 19 is developmentally regulated and linked to sexual maturation in the rhesus monkey Program No 703. 9, 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience"},{"key":"627_CR133","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/gb-2003-4-10-231","volume":"4","author":"R Urrutia","year":"2003","unstructured":"Urrutia R (2003) KRAB-containing zinc-finger repressor proteins. Genome Biol 4:231","journal-title":"Genome Biol"},{"key":"627_CR134","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1101\/gr.5391806","volume":"16","author":"MJ Vogel","year":"2006","unstructured":"Vogel MJ, Guelen L, de Wit E, Peric-Hupkes D, Lod\u00e9n M, Talhout W, Feenstra M, Abbas B, Classen AK, van Steensel B (2006) Human heterochromatin proteins form large domains containing KRAB-ZNF genes. Genome Res 16:1493\u20131504","journal-title":"Genome Res"},{"key":"627_CR135","unstructured":"Lomniczi A, Loche A, Ojeda SR (2010) Epigenetic regulation of female puberty. 4oth Ann Mtg Society for neuroscience. pp 13\u201317"},{"key":"627_CR136","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1016\/j.tcb.2006.09.003","volume":"16","author":"KF Kelly","year":"2006","unstructured":"Kelly KF, Daniel JM (2006) POZ for effect\u2013POZ-ZF transcription factors in cancer and development. Trends Cell Biol 16:578\u2013587","journal-title":"Trends Cell Biol"},{"key":"627_CR137","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.tcb.2008.02.005","volume":"18","author":"C K\u00f6hler","year":"2008","unstructured":"K\u00f6hler C, Villar CB (2008) Programming of gene expression by Polycomb group proteins. Trends Cell Biol 18:236\u2013243","journal-title":"Trends Cell Biol"},{"issue":"10","key":"627_CR138","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/nrn2731","volume":"10","author":"JA Simon","year":"2009","unstructured":"Simon JA, Kingston RE (2009) Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 10(10):697\u2013708","journal-title":"Nat Rev Mol Cell Biol"},{"key":"627_CR139","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/ng.445","volume":"41","author":"AK Classen","year":"2009","unstructured":"Classen AK, Bunker BD, Harvey KF, Vaccari T, Bilder D (2009) A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet 41:1150\u20131155","journal-title":"Nat Genet"},{"key":"627_CR140","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/ng.414","volume":"41","author":"AM Martinez","year":"2009","unstructured":"Martinez AM, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G (2009) Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet 41:1076\u20131082","journal-title":"Nat Genet"},{"key":"627_CR141","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1056\/NEJMra023075","volume":"349","author":"JG Herman","year":"2003","unstructured":"Herman JG, Baylin SB (2003) Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042\u20132054","journal-title":"N Engl J Med"},{"key":"627_CR142","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1126\/science.286.5439.481","volume":"286","author":"AP Wolffe","year":"1999","unstructured":"Wolffe AP, Matzke MA (1999) Epigenetics: regulation through repression. Science 286:481\u2013486","journal-title":"Science"},{"key":"627_CR143","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.tig.2004.06.009","volume":"20","author":"HT Bjornsson","year":"2004","unstructured":"Bjornsson HT, Fallin MD, Feinberg AP (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet 20:350\u2013358","journal-title":"Trends Genet"},{"key":"627_CR144","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/ng1089","volume":"33","author":"R Jaenisch","year":"2003","unstructured":"Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33:245\u201354.","journal-title":"Nat Genet"},{"key":"627_CR145","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1126\/science.1063127","volume":"293","author":"T Jenuwein","year":"2001","unstructured":"Jenuwein T, Allis CD (2001) Translating the histone code. Science 293:1074\u20131080","journal-title":"Science"},{"key":"627_CR146","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693\u2013705","journal-title":"Cell"},{"key":"627_CR147","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.cell.2006.12.038","volume":"128","author":"I Garcia-Bassets","year":"2007","unstructured":"Garcia-Bassets I, Kwon YS, Telese F, Prefontaine GG, Hutt KR, Cheng CS, Ju BG, Ohgi KA, Wang J, Escoubet-Lozach L, Rose DW, Glass CK, Fu XD, Rosenfeld MG (2007) Histone methylation-dependent mechanisms impose ligand dependency for gene activation by nuclear receptors. Cell 128:505\u2013518","journal-title":"Cell"},{"issue":"6","key":"627_CR148","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.neuron.2007.02.022","volume":"53","author":"CA Miller","year":"2007","unstructured":"Miller CA, Sweatt JD (2007) Covalent modification of DNA regulates memory formation. Neuron 53(6):857\u201369. (Erratum in: Neuron. 59:1051)","journal-title":"Neuron"},{"key":"627_CR149","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nature06640","volume":"452","author":"S Kangaspeska","year":"2008","unstructured":"Kangaspeska S, Stride B, M\u00e9tivier R, Polycarpou-Schwartz M, Ibberson D, Carmouche RP, Benes V, Gannon F, Reid G (2008) Transient cyclical methylation of promoter DNA. Nature 452:112\u2013115","journal-title":"Nature"},{"key":"627_CR150","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature06544","volume":"452","author":"R M\u00e9tivier","year":"2008","unstructured":"M\u00e9tivier R, Gallais R, Tiffoche C, Le P\u00e9ron C, Jurkowska RZ, Carmouche RP, Ibberson D, Barath P, Demay F, Reid G, Benes V, Jeltsch A, Gannon F, Salbert G (2008) Cyclical DNA methylation of a transcriptionally active promoter. Nature 452:45\u201350. (Erratum in: Nature 463(7279):384)","journal-title":"Nature"},{"key":"627_CR151","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1126\/science.1147674","volume":"319","author":"B Perillo","year":"2008","unstructured":"Perillo B, Ombra MN, Bertoni A, Cuozzo C, Sacchetti S, Sasso A, Chiariotti L, Malorni A, Abbondanza C, Avvedimento EV (2008) DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science 319:202\u2013206","journal-title":"Science"},{"key":"627_CR152","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.molcel.2008.03.022","volume":"30","author":"K Subramanian","year":"2008","unstructured":"Subramanian K, Jia D, Kapoor-Vazirani P, Powell DR, Collins RE, Sharma D, Peng J, Cheng X, Vertino PM (2008) Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell 30:336\u2013347","journal-title":"Mol Cell"},{"key":"627_CR153","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1038\/nn.2172","volume":"11","author":"S Shen","year":"2008","unstructured":"Shen S, Sandoval J, Swiss VA, Li J, Dupree J, Franklin RJ, Casaccia-Bonnefil P (2008) Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency. Nat Neurosci 11:1024\u20131034","journal-title":"Nat Neurosci"},{"key":"627_CR154","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","volume":"134","author":"Y Nakahata","year":"2008","unstructured":"Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134:329\u2013340","journal-title":"Cell"},{"key":"627_CR155","doi-asserted-by":"publisher","first-page":"12815","DOI":"10.1523\/JNEUROSCI.3331-09.2009","volume":"29","author":"MM McCarthy","year":"2009","unstructured":"McCarthy MM, Auger AP, Bale TL, De Vries GJ, Dunn GA, Forger NG, Murray EK, Nugent BM, Schwarz JM, Wilson ME (2009) The epigenetics of sex differences in the brain. J Neurosc 29:12815\u201312823","journal-title":"J Neurosc"},{"issue":"2","key":"627_CR156","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.yhbeh.2012.09.013","volume":"64","author":"A Lomniczi","year":"2013","unstructured":"Lomniczi A, Wright H, Castellano JM, Sonmez K, Ojeda SR (2013) A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates. Horm Behav 64(2):175\u2013186","journal-title":"Horm Behav"},{"issue":"2","key":"627_CR157","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nrendo.2013.233","volume":"10","author":"SR Ojeda","year":"2014","unstructured":"Ojeda SR, Lomniczi A (2014) Puberty in 2013: Unravelling the mystery of puberty. Nat Rev Endocrinol 10(2):67\u201369","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"627_CR158","doi-asserted-by":"publisher","first-page":"R131","DOI":"10.1530\/JME-14-0315","volume":"54","author":"AP Abreu","year":"2015","unstructured":"Abreu AP, Macedo DB, Brito VN, Kaiser UB, Latronico AC (2015) A new pathway in the control of the initiation of puberty: the MKRN3 gene. J Mol Endocrinol 54(3):R131\u20139","journal-title":"J Mol Endocrinol"},{"issue":"4","key":"627_CR159","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","volume":"128","author":"BE Bernstein","year":"2007","unstructured":"Bernstein BE, Meissner A, Lander ES (2007) The mammalian epigenome. Cell 23;128(4):669\u201381","journal-title":"Cell"},{"issue":"1\u20132","key":"627_CR160","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cell.2012.01.003","volume":"148","author":"TA Rando","year":"2012","unstructured":"Rando TA, Chang HY (2012) Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell 148(1\u20132):46\u201357","journal-title":"Cell"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-017-0627-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0627-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0627-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T15:28:07Z","timestamp":1719070087000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-017-0627-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":160,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["627"],"URL":"https:\/\/doi.org\/10.1007\/s40618-017-0627-9","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,1]]},"assertion":[{"value":"21 January 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}