{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:18:44Z","timestamp":1791217124773,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T00:00:00Z","timestamp":1509408000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s40618-017-0782-z","type":"journal-article","created":{"date-parts":[[2017,10,31]],"date-time":"2017-10-31T10:25:25Z","timestamp":1509445525000},"page":"583-590","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Modulatory effects of alpha-lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients"],"prefix":"10.1007","volume":"41","author":[{"given":"A. D.","family":"Genazzani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Della Casa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Prati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Napolitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Manzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Despini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Simoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,10,31]]},"reference":[{"key":"782_CR1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH et al (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97:28\u201338","journal-title":"Fertil Steril"},{"key":"782_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4172\/2161-1017.1000140","volume":"3","author":"AD Genazzani","year":"2014","unstructured":"Genazzani AD, Despini G, Santagni S, Prati S, Rattighieri E, Chierchia E, Simoncini T (2014) Effects of a combination of alpha lipoic acid and myo-inositol on insulin dynamics in overweight\/obese patients with PCOS. Endocrinol Metab Synd 3:3. \n                        https:\/\/doi.org\/10.4172\/2161-1017.1000140","journal-title":"Endocrinol Metab Synd"},{"key":"782_CR3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2217\/WHE.10.43","volume":"6","author":"AD Genazzani","year":"2010","unstructured":"Genazzani AD, Ricchieri F, Lanzoni C (2010) Use of metformin in the treatment of polycystic ovary syndrome. Womens Health (Lond) 6:577\u2013593","journal-title":"Womens Health (Lond)"},{"key":"782_CR4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.rbmo.2016.08.024","volume":"33","author":"AD Genazzani","year":"2016","unstructured":"Genazzani AD (2016) Inositol as putative integrative treatment for PCOS. Reprod BioMed Online 33:770\u2013780","journal-title":"Reprod BioMed Online"},{"key":"782_CR5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s40618-016-0570-1","volume":"40","author":"FM Mario","year":"2017","unstructured":"Mario FM, Graff SK, Spritzer PM (2017) Habitual physical activity is associated with improved anthropometric and androgenic profile in PCOS: a cross-sectional study. J Endocrinol Invest 40:377\u2013384","journal-title":"J Endocrinol Invest"},{"key":"782_CR6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3109\/09513590.2010.500818","volume":"26","author":"AD Genazzani","year":"2010","unstructured":"Genazzani AD, Chierchia E, Rattighieri E, Santagni S, Casarosa E et al (2010) Metformin administration restores allopregnanolone response to adrenocorticotropic hormone (ACTH) stimulation in overweight hyperinsulinemic patients with PCOS. Gynecol Endocrinol 26:684\u2013689","journal-title":"Gynecol Endocrinol"},{"key":"782_CR7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.fertnstert.2003.05.020","volume":"81","author":"AD Genazzani","year":"2004","unstructured":"Genazzani AD, Battaglia C, Malavasi B, Strucchi C, Tortolani F, Gamba O (2004) Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril 81:114\u2013119","journal-title":"Fertil Steril"},{"key":"782_CR8","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/bmj.327.7421.951","volume":"327","author":"JM Lord","year":"2003","unstructured":"Lord JM, Flight IH, Norman RJ (2003) Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327:951\u2013953","journal-title":"BMJ"},{"key":"782_CR9","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2337\/diacare.29.02.06.dc05-1070","volume":"29","author":"JP Baillargeon","year":"2006","unstructured":"Baillargeon JP, Diamanti-Kandarakis E, Ostlund RE Jr, Apridonidze T, Iuorno MJ et al (2006) Altered d-chiro-inositol urinary clearance in women with polycystic ovary syndrome. Diabetes Care 29:300\u2013305","journal-title":"Diabetes Care"},{"key":"782_CR10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/09513590801893232","volume":"24","author":"AD Genazzani","year":"2008","unstructured":"Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VM (2008) Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol 24:139\u2013144","journal-title":"Gynecol Endocrinol"},{"key":"782_CR11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/09513590.2014.897321","volume":"30","author":"AD Genazzani","year":"2014","unstructured":"Genazzani AD, Santagni S, Rattighieri E, Chierchia E, Despini G, Marini G, Prati A, Simoncini T (2014) Modulatory role of d-chiro-inositol (DCI) on LH and insulin secretion in obese PCOS patients. Gynecol Endocrinol 30:438\u2013443","journal-title":"Gynecol Endocrinol"},{"key":"782_CR12","first-page":"1","volume":"20","author":"S Dinicola","year":"2014","unstructured":"Dinicola S, Chiu TTY, Unfer V, Carlomagno G, Bizzarri M (2014) The rationale of the myo-inositol and d-chiro-inositol combined treatment for polycystic ovary syndrome. J Clin Pharmacol 20:1\u201314","journal-title":"J Clin Pharmacol"},{"key":"782_CR13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbrc.2005.05.035","volume":"332","author":"WJ Lee","year":"2005","unstructured":"Lee WJ, Song KH, Koh EH, Won JC, Kim HS et al (2005) Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle. Biochem Biophys Res Commun 332:885\u2013891","journal-title":"Biochem Biophys Res Commun"},{"key":"782_CR14","doi-asserted-by":"crossref","first-page":"C1395","DOI":"10.1152\/ajpcell.00115.2007","volume":"293","author":"QW Shen","year":"2007","unstructured":"Shen QW, Zhu MJ, Tong J, Ren J, Du M (2007) Ca2+\/calmodulindependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes. Am J Physiol Cell Physiol 293:C1395\u2013C1403","journal-title":"Am J Physiol Cell Physiol"},{"key":"782_CR15","doi-asserted-by":"publisher","unstructured":"Gomes MB, Negrato CA (2014) Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr 6(1):80. doi:\n                        10.1186\/1758-5996-6-80","DOI":"10.1186\/1758-5996-6-80"},{"key":"782_CR16","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/474561","author":"A Scaramuzza","year":"2015","unstructured":"Scaramuzza A, Giani E, Radaelli F, Ungheri S, Macedoni M, Giudici V, Bosetti A, Ferrari M, Zuccotti GV (2015) Alpha-Lipoic acid and antioxidant diet help to improve endothelial dysfunction in adolescents with type 1 diabetes: a pilot study. J Diabetes Res. \n                        https:\/\/doi.org\/10.1155\/2015\/474561\n                        \n                     (Article ID 474561)","journal-title":"J Diabetes Res"},{"issue":"2","key":"782_CR17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1177\/193229681000400218","volume":"4","author":"U Masharani","year":"2010","unstructured":"Masharani U, Gjerde C, Evans JL, Youngren JF, Goldfine ID (2010) Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome. J Diabetes Sci Technol 4(2):359\u2013364","journal-title":"J Diabetes Sci Technol"},{"key":"782_CR18","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1590\/S0004-27302008000900010","volume":"52","author":"IR Madeira","year":"2008","unstructured":"Madeira IR, Carvalho CN, Gazolla FM, de Matos HJ, Borges MA et al (2008) Cut-off point for Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index established from Receiver Operating Characteristic (ROC) curve in the detection of metabolic syndrome in overweight prepubertal children. Arq Bras Endocrinol Metabol 52:1466\u20131473","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"782_CR19","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3109\/09513590.2012.685205","volume":"28","author":"AD Genazzani","year":"2012","unstructured":"Genazzani AD, Prati A, Santagni S, Ricchieri F, Chierchia E et al (2012) Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecol Endocrinol 28:969\u2013973","journal-title":"Gynecol Endocrinol"},{"key":"782_CR20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1210\/jcem-72-6-1220","volume":"72","author":"AD Genazzani","year":"1991","unstructured":"Genazzani AD, Petraglia F, Benatti R, Montanini V, Algeri I et al (1991) Luteinizing hormone (LH) secretory burst duration is independent from LH, prolactin, or gonadal steroid plasma levels in amenorrheic women. J Clin Endocrinol Metab 72:1220\u20131225","journal-title":"J Clin Endocrinol Metab"},{"key":"782_CR21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1590\/S0004-27302009000200020","volume":"53","author":"B Geloneze","year":"2009","unstructured":"Geloneze B, Vasques AC, Stabe CF, Pareja JC, Rosado LE et al (2009) HOMA1-IR and HOMA2-IR indexes in identifying insulin resistance and metabolic syndrome: Brazilian Metabolic Syndrome Study (BRAMS). Arq Bras Endocrinol Metabol 53:281\u2013287","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"782_CR22","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3109\/09513590.2012.685205","volume":"28","author":"AD Genazzani","year":"2012","unstructured":"Genazzani AD, Ricchieri F, Prati A, Santagni S, Chierchia E, Rattighieri E, Campedelli A, Simoncini T, Artini PG (2012) Differential insulin response to myo-inositol administration in obese PCOS patients. Gynecol Endocrinol 28:969\u2013973","journal-title":"Gynecol Endocrinol"},{"key":"782_CR23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0014-5793(01)02469-3","volume":"498","author":"T Morikawa","year":"2001","unstructured":"Morikawa T, Yasuno R, Wada H (2001) Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria. FEBS Lett 498:16\u201321","journal-title":"FEBS Lett"},{"key":"782_CR24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.2337\/db08-0473","volume":"58","author":"I Padmalayam","year":"2009","unstructured":"Padmalayam I, Hasham S, Saxena U, Pillarisetti S (2009) Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance. Diabetes 58:600\u2013608","journal-title":"Diabetes"},{"key":"782_CR25","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.2337\/diabetes.51.7.2074","volume":"51","author":"N Musi","year":"2002","unstructured":"Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P et al (2002) Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 51:2074\u20132081","journal-title":"Diabetes"},{"key":"782_CR26","doi-asserted-by":"crossref","first-page":"R145","DOI":"10.1530\/EJE-16-1063","volume":"177","author":"D Macut","year":"2017","unstructured":"Macut D, Bo\u017ei\u0107-Anti\u0107 I, Bjeki\u0107-Macut J, Tziomalos K (2017) Polycystic ovary syndrome and nonalcoholic fatty liver disease. Eur J Endocrinol 177:R145\u2013R158","journal-title":"Eur J Endocrinol"},{"key":"782_CR27","doi-asserted-by":"publisher","first-page":"727","DOI":"10.2337\/dc10-1991","volume":"34","author":"JC Bae","year":"2011","unstructured":"Bae JC, Rhee EJ, Lee WY, Park SE, Park CY, Oh KW, Park SW, Kim SW (2011) Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study. Diabetes Care 34:727\u2013729. \n                        https:\/\/doi.org\/10.2337\/dc10-1991","journal-title":"Diabetes Care"},{"key":"782_CR28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/09513590.2012.743020","volume":"29","author":"PG Artini","year":"2013","unstructured":"Artini PG, Di Berardino OM, Papini F et al (2013) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study. Gynecol Endocrinol 29:375\u2013379","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"782_CR29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/09513590.2014.964640","volume":"31","author":"Z Kamenov","year":"2015","unstructured":"Kamenov Z, Kolarov G, Gateva A, Carlomagno G, Genazzani AD (2015) Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Gynecol Endocrinol 31(2):131\u2013135","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"782_CR30","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/09513590.2015.1014784","volume":"31","author":"A Cianci","year":"2015","unstructured":"Cianci A, Panella M, Fichera M, Falduzzi C, Bartolo M, Caruso S (2015) d-chiro-inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS. Gynecol Endocrinol 31(6):483\u2013486","journal-title":"Gynecol Endocrinol"},{"key":"782_CR31","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1210\/en.2010-1353","volume":"152","author":"RM Thomas","year":"2011","unstructured":"Thomas RM, Nechamen CA, Mazurkiewicz JE, Ulloa-Aguirre A, Dias JA (2011) The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization. Endocrinology 152:1691\u20131701","journal-title":"Endocrinology"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-017-0782-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0782-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0782-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T07:26:50Z","timestamp":1523863610000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-017-0782-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,31]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["782"],"URL":"https:\/\/doi.org\/10.1007\/s40618-017-0782-z","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,31]]}}}