{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:43:18Z","timestamp":1780105398301,"version":"3.54.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T00:00:00Z","timestamp":1509753600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Dong-A ST Co., LTD"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s40618-017-0786-8","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T08:07:01Z","timestamp":1509782821000},"page":"475-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Recombinant growth hormone therapy for prepubertal children with idiopathic short stature in Korea: a phase III randomized trial"],"prefix":"10.1007","volume":"41","author":[{"given":"J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.-K.","family":"Suh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Y.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-S.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Y.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2913-059X","authenticated-orcid":false,"given":"S. Y.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-W.","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.-K.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,4]]},"reference":[{"key":"786_CR1","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1210\/jc.2008-0509","volume":"93","author":"P Cohen","year":"2008","unstructured":"Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, Chernausek SD, Savage MO, Wit JM (2008) Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab 93:4210\u20134217","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ghir.2007.11.004","volume":"18","author":"JM Wit","year":"2008","unstructured":"Wit JM, Clayton PE, Rogol AD, Savage MO, Saenger PH, Cohen P (2008) Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm IGF Res 18:89\u2013110","journal-title":"Growth Horm IGF Res"},{"key":"786_CR3","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1056\/NEJMcp060828","volume":"354","author":"MM Lee","year":"2006","unstructured":"Lee MM (2006) Clinical practice. Idiopathic short stature. N Engl J Med 354:2576\u20132582","journal-title":"N Engl J Med"},{"key":"786_CR4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1067\/S0022-3476(03)00246-4","volume":"143","author":"TA Wilson","year":"2003","unstructured":"Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P (2003) Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 143:415\u2013421","journal-title":"J Pediatr"},{"key":"786_CR5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000145016","volume":"70","author":"R Padidela","year":"2008","unstructured":"Padidela R, Camacho-Hubner C, Attie KM, Savage MO (2008) Abnormal growth in noonan syndrome: genetic and endocrine features and optimal treatment. Horm Res 70:129\u2013136","journal-title":"Horm Res"},{"issue":"Suppl 3","key":"786_CR6","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.4103\/2230-8210.84852","volume":"15","author":"VS Ayyar","year":"2011","unstructured":"Ayyar VS (2011) History of growth hormone therapy. Indian J Endocrinol Metab 15(Suppl 3):S162\u2013S165","journal-title":"Indian J Endocrinol Metab"},{"key":"786_CR7","unstructured":"Food and Drug Administration (2003) FDA approves Humatrope for non-growth hormone deficient short stature. \n                        http:\/\/www.fda.gov\/ohrms\/dockets\/ac\/03\/transcripts\/3957t1.doc\n                        \n                    . Accessed 1 May 2017"},{"key":"786_CR8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1001\/archpedi.156.3.230","volume":"156","author":"BS Finkelstein","year":"2002","unstructured":"Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L (2002) Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis. Arch Pediatr Adolesc Med 156:230\u2013240","journal-title":"Arch Pediatr Adolesc Med"},{"key":"786_CR9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000452150","volume":"86","author":"A Grimberg","year":"2016","unstructured":"Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH, Drug, Therapeutics C, Ethics Committee of the Pediatric Endocrine S (2016) Guidelines for growth hormone and insulin-like growth factor-I treatment in children and adolescents: Growth hormone deficiency, idiopathic short stature, and primary insulin-like growth factor-I Deficiency. Horm Res Paediatr 86:361\u2013397","journal-title":"Horm Res Paediatr"},{"key":"786_CR10","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1210\/jc.2004-2513","volume":"90","author":"SF Kemp","year":"2005","unstructured":"Kemp SF, Kuntze J, Attie KM, Maneatis T, Butler S, Frane J, Lippe B (2005) Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature. J Clin Endocrinol Metab 90:5247\u20135253","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ghir.2007.11.003","volume":"18","author":"JM Wit","year":"2008","unstructured":"Wit JM, Reiter EO, Ross JL, Saenger PH, Savage MO, Rogol AD, Cohen P (2008) Idiopathic short stature: management and growth hormone treatment. Growth Horm IGF Res 18:111\u2013135","journal-title":"Growth Horm IGF Res"},{"key":"786_CR12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3349\/ymj.2014.55.1.53","volume":"55","author":"HS Kim","year":"2014","unstructured":"Kim HS, Yang SW, Yoo HW, Suh BK, Ko CW, Chung WY, Lee KH, Hwang JS, Ji HJ, Ahn H, Kim DH (2014) Efficacy of short-term growth hormone treatment in prepubertal children with idiopathic short stature. Yonsei Med J 55:53\u201360","journal-title":"Yonsei Med J"},{"key":"786_CR13","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1056\/NEJM199902183400702","volume":"340","author":"RL Hintz","year":"1999","unstructured":"Hintz RL, Attie KM, Baptista J, Roche A (1999) Effect of growth hormone treatment on adult height of children with idiopathic short stature. Genentech Collaborative Group. N Engl J Med 340:502\u2013507","journal-title":"N Engl J Med"},{"key":"786_CR14","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1210\/jc.2003-031457","volume":"89","author":"EW Leschek","year":"2004","unstructured":"Leschek EW, Rose SR, Yanovski JA, Troendle JF, Quigley CA, Chipman JJ, Crowe BJ, Ross JL, Cassorla FG, Blum WF, Cutler GB Jr, Baron J (2004) Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 89:3140\u20133148","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR15","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1210\/jc.2008-0707","volume":"93","author":"K Albertsson-Wikland","year":"2008","unstructured":"Albertsson-Wikland K, Aronson AS, Gustafsson J, Hagenas L, Ivarsson SA, Jonsson B, Kristrom B, Marcus C, Nilsson KO, Ritzen EM, Tuvemo T, Westphal O, Aman J (2008) Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J Clin Endocrinol Metab 93:4342\u20134350","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1687-9856-2011-6","volume":"2011","author":"PA Lee","year":"2011","unstructured":"Lee PA, Germak J, Gut R, Khutoryansky N, Ross J (2011) Identification of factors associated with good response to growth hormone therapy in children with short stature: results from the ANSWER Program(R). Int J Pediatr Endocrinol 2011:6","journal-title":"Int J Pediatr Endocrinol"},{"key":"786_CR17","first-page":"53","volume":"68","author":"MB Ranke","year":"2007","unstructured":"Ranke MB, Lindberg A, Price DA, Darendeliler F, Albertsson-Wikland K, Wilton P, Reiter EO, Kigs International Board (2007) Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature. Horm Res 68:53\u201362","journal-title":"Horm Res"},{"key":"786_CR18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpeds.2004.08.055","volume":"146","author":"JM Wit","year":"2005","unstructured":"Wit JM, Rekers-Mombarg LT, Cutler GB, Crowe B, Beck TJ, Roberts K, Gill A, Chaussain JL, Frisch H, Yturriaga R, Attanasio AF (2005) Growth hormone (GH) treatment to final height in children with idiopathic short stature: evidence for a dose effect. J Pediatr 146:45\u201353","journal-title":"J Pediatr"},{"key":"786_CR19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000354126","volume":"80","author":"DR Counts","year":"2013","unstructured":"Counts DR, Silverman LA, Geffner ME, Rajicic N, Hey-Hadavi J, Thornton PS, Wajnrajch MP, ISS Study Grp (2013) A four-year, open-label, multi-center, randomized, two-arm study of genotropin (R) in patients with idiopathic short stature: comparison of an individualized, target-driven treatment regimen to standard dosing of genotropin (R)\u2014analysis of two-year data. Horm Res Paediatr 80:242\u2013251","journal-title":"Horm Res Paediatr"},{"key":"786_CR20","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1210\/jc.2004-2543","volume":"90","author":"CA Quigley","year":"2005","unstructured":"Quigley CA, Gill AM, Crowe BJ, Robling K, Chipman JJ, Rose SR, Ross JL, Cassorla FG, Wolka AM, Wit JM, Rekers-Mombarg LT, Cutler GB Jr (2005) Safety of growth hormone treatment in pediatric patients with idiopathic short stature. J Clin Endocrinol Metab 90:5188\u20135196","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR21","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s40618-015-0418-0","volume":"39","author":"M Cappa","year":"2016","unstructured":"Cappa M, Iughetti L, Loche S, Maghnie M, Vottero A, GeNe SIS, National Board on behalf of the GeNeSIS Italian Investigators (2016) Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study. J Endocrinol Invest 39:667\u2013677","journal-title":"J Endocrinol Invest"},{"key":"786_CR22","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1210\/jc.2011-1995","volume":"97","author":"JC Carel","year":"2012","unstructured":"Carel JC, Ecosse E, Landier F, Meguellati-Hakkas D, Kaguelidou F, Rey G, Coste J (2012) Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. J Clin Endocrinol Metab 97:416\u2013425","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR23","first-page":"3115","volume":"83","author":"P Saenger","year":"1998","unstructured":"Saenger P, Attie KM, DiMartino-Nardi J, Hintz R, Frahm L, Frane JW (1998) Metabolic consequences of 5-year growth hormone (GH) therapy in children treated with GH for idiopathic short stature. Genentech Collaborative Study Group. J Clin Endocrinol Metab 83:3115\u20133120","journal-title":"J Clin Endocrinol Metab"},{"key":"786_CR24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/jc.2005-0891","volume":"91","author":"BJ Crowe","year":"2006","unstructured":"Crowe BJ, Rekers-Mombarg LT, Robling K, Wolka AM, Cutler GB Jr, Wit JM (2006) Effect of growth hormone dose on bone maturation and puberty in children with idiopathic short stature. J Clin Endocrinol Metab 91:169\u2013175","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-017-0786-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0786-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-017-0786-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T01:06:14Z","timestamp":1520989574000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-017-0786-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["786"],"URL":"https:\/\/doi.org\/10.1007\/s40618-017-0786-8","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,4]]}}}