{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:04:43Z","timestamp":1777111483530,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T00:00:00Z","timestamp":1544227200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81670722"],"award-info":[{"award-number":["No. 81670722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NO.81471004"],"award-info":[{"award-number":["NO.81471004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s40618-018-0990-1","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T07:42:46Z","timestamp":1544254966000},"page":"843-850","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The MAGI2 gene polymorphism rs2160322 is associated with Graves\u2019 disease but not with Hashimoto\u2019s thyroiditis"],"prefix":"10.1007","volume":"42","author":[{"given":"X.","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,8]]},"reference":[{"issue":"10047","key":"990_CR1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","volume":"388","author":"S Leo De","year":"2016","unstructured":"De Leo S, Lee SY, Braverman LE (2016) Hyperthyroidism. Lancet 388(10047):906\u2013918. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(16)00278-6","journal-title":"Hyperthyroidism. Lancet"},{"issue":"11","key":"990_CR2","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s40618-014-0136-z","volume":"37","author":"M Marino","year":"2014","unstructured":"Marino M, Latrofa F, Menconi F, Chiovato L, Vitti P (2014) An update on the medical treatment of Graves\u2019 hyperthyroidism. J Endocrinol Investig 37(11):1041\u20131048. \n                    https:\/\/doi.org\/10.1007\/s40618-014-0136-z","journal-title":"J Endocrinol Investig"},{"issue":"6","key":"990_CR3","doi-asserted-by":"publisher","first-page":"R241","DOI":"10.1530\/EJE-14-0047","volume":"170","author":"G Effraimidis","year":"2014","unstructured":"Effraimidis G, Wiersinga WM (2014) Mechanisms in endocrinology: autoimmune thyroid disease: old and new players. Eur J Endocrinol 170(6):R241\u2013R252. \n                    https:\/\/doi.org\/10.1530\/EJE-14-0047","journal-title":"Eur J Endocrinol"},{"issue":"16","key":"990_CR4","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1056\/NEJMra1510030","volume":"375","author":"TJ Smith","year":"2016","unstructured":"Smith TJ, Hegedus L (2016) Graves\u2019 Disease. The New England journal of medicine 375(16):1552\u20131565. \n                    https:\/\/doi.org\/10.1056\/NEJMra1510030","journal-title":"The New England journal of medicine"},{"key":"990_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0910-4","author":"A Jabrocka-Hybel","year":"2018","unstructured":"Jabrocka-Hybel A, Skalniak A, Piatkowski J, Turek-Jabrocka R, Vyhouskaya P, Ludwig-Slomczynska A, Machlowska J, Kapusta P, Malecki M, Pach D, Trofimiuk-Muldner M, Lizis-Kolus K, Hubalewska-Dydejczyk A (2018) How much of the predisposition to Hashimoto\u2019s thyroiditis can be explained based on previously reported associations? J Endocrinol Investig. \n                    https:\/\/doi.org\/10.1007\/s40618-018-0910-4\n                    \n                  \n                           (Epub ahead of print)","journal-title":"J Endocrinol Investig"},{"issue":"3","key":"990_CR6","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s40618-014-0214-2","volume":"38","author":"M Marino","year":"2015","unstructured":"Marino M, Latrofa F, Menconi F, Chiovato L, Vitti P (2015) Role of genetic and non-genetic factors in the etiology of Graves\u2019 disease. J Endocrinol Investig 38(3):283\u2013294. \n                    https:\/\/doi.org\/10.1007\/s40618-014-0214-2","journal-title":"J Endocrinol Investig"},{"issue":"4\u20135","key":"990_CR7","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.autrev.2014.01.013","volume":"13","author":"F Menconi","year":"2014","unstructured":"Menconi F, Marcocci C, Marino M (2014) Diagnosis and classification of Graves\u2019 disease. Autoimmun Rev 13(4\u20135):398\u2013402. \n                    https:\/\/doi.org\/10.1016\/j.autrev.2014.01.013","journal-title":"Autoimmun Rev"},{"key":"990_CR8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1146\/annurev-pathol-012513-104713","volume":"9","author":"Y Tomer","year":"2014","unstructured":"Tomer Y (2014) Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics. Annu Rev Pathol 9:147\u2013156. \n                    https:\/\/doi.org\/10.1146\/annurev-pathol-012513-104713","journal-title":"Annu Rev Pathol"},{"issue":"Database issue","key":"990_CR9","doi-asserted-by":"publisher","first-page":"D447","DOI":"10.1093\/nar\/gku1003","volume":"43","author":"D Szklarczyk","year":"2015","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, Kuhn M, Bork P, Jensen LJ, von Mering C (2015) STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43(Database issue):D447\u2013D452. \n                    https:\/\/doi.org\/10.1093\/nar\/gku1003","journal-title":"Nucleic Acids Res"},{"issue":"55","key":"990_CR10","doi-asserted-by":"publisher","first-page":"6930","DOI":"10.1038\/onc.2008.344","volume":"27","author":"S Tsukita","year":"2008","unstructured":"Tsukita S, Yamazaki Y, Katsuno T, Tamura A, Tsukita S (2008) Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27(55):6930\u20136938. \n                    https:\/\/doi.org\/10.1038\/onc.2008.344","journal-title":"Oncogene"},{"issue":"3","key":"990_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.imbio.2012.05.016","volume":"218","author":"SA Rebuffat","year":"2013","unstructured":"Rebuffat SA, Kammoun-Krichen M, Charfeddine I, Ayadi H, Bougacha-Elleuch N, Peraldi-Roux S (2013) IL-1beta and TSH disturb thyroid epithelium integrity in autoimmune thyroid diseases. Immunobiology 218(3):285\u2013291. \n                    https:\/\/doi.org\/10.1016\/j.imbio.2012.05.016","journal-title":"Immunobiology"},{"issue":"2","key":"990_CR12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/1756-185X.12663","volume":"19","author":"TJ Fang","year":"2016","unstructured":"Fang TJ, Lin CH, Lin YZ, Li RN, Ou TT, Wu CC, Tsai WC, Yen JH (2016) F11R mRNA expression and promoter polymorphisms in patients with rheumatoid arthritis. Int J Rheum Dis 19(2):127\u2013133. \n                    https:\/\/doi.org\/10.1111\/1756-185X.12663","journal-title":"Int J Rheum Dis"},{"issue":"2","key":"990_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1093\/rheumatology\/kem321","volume":"47","author":"H Miyagawa","year":"2008","unstructured":"Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T (2008) Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. Rheumatology 47(2):158\u2013164. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/kem321","journal-title":"Rheumatology"},{"issue":"1","key":"990_CR14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s10620-017-4857-7","volume":"63","author":"E Noren","year":"2018","unstructured":"Noren E, Mellander MR, Almer S, Soderman J (2018) Genetic variation and gene expression levels of tight junction genes indicates relationships between PTEN as well as MAGI1 and microscopic colitis. Dig Dis Sci 63(1):105\u2013112. \n                    https:\/\/doi.org\/10.1007\/s10620-017-4857-7","journal-title":"Dig Dis Sci"},{"issue":"1","key":"990_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12876-017-0620-y","volume":"17","author":"E Noren","year":"2017","unstructured":"Noren E, Almer S, Soderman J (2017) Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease. BMC Gastroenterol 17(1):68. \n                    https:\/\/doi.org\/10.1186\/s12876-017-0620-y","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"990_CR16","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/ibd.20611","volume":"15","author":"DP McGovern","year":"2009","unstructured":"McGovern DP, Taylor KD, Landers C, Derkowski C, Dutridge D, Dubinsky M, Ippoliti A, Vasiliauskas E, Mei L, Mengesha E, King L, Pressman S, Targan SR, Rotter JI (2009) MAGI2 genetic variation and inflammatory bowel disease. Inflamm Bowel Dis 15(1):75\u201383. \n                    https:\/\/doi.org\/10.1002\/ibd.20611","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"990_CR17","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1530\/JME-15-0144","volume":"55","author":"N Yan","year":"2015","unstructured":"Yan N, Meng S, Song RH, Qin Q, Wang X, Yao Q, Jiang Y, Jiang W, Shi L, Xu J, Zhang J (2015) Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease. J Mol Endocrinol 55(3):209\u2013218. \n                    https:\/\/doi.org\/10.1530\/JME-15-0144","journal-title":"J Mol Endocrinol"},{"issue":"7","key":"990_CR18","doi-asserted-by":"publisher","first-page":"12280","DOI":"10.3390\/ijms150712280","volume":"15","author":"N Yan","year":"2014","unstructured":"Yan N, Meng S, Zhou J, Xu J, Muhali FS, Jiang W, Shi L, Shi X, Zhang J (2014) Association between STAT4 gene polymorphisms and autoimmune thyroid diseases in a Chinese population. Int J Mol Sci 15(7):12280\u201312293. \n                    https:\/\/doi.org\/10.3390\/ijms150712280","journal-title":"Int J Mol Sci"},{"issue":"1","key":"990_CR19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12020-011-9510-1","volume":"41","author":"J Yang","year":"2012","unstructured":"Yang J, Qin Q, Yan N, Zhu YF, Li C, Yang XJ, Wang X, Pandey M, Hou P, Zhang JA (2012) CD40 C\/T(\u22121) and CTLA-4 A\/G(49) SNPs are associated with autoimmune thyroid diseases in the Chinese population. Endocrine 41(1):111\u2013115. \n                    https:\/\/doi.org\/10.1007\/s12020-011-9510-1","journal-title":"Endocrine"},{"key":"990_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2018.05.002","author":"AT Gabrielson","year":"2018","unstructured":"Gabrielson AT, Sartor RA, Hellstrom WJG (2018) The impact of thyroid disease on sexual dysfunction in men and women. Sex Med Rev. \n                    https:\/\/doi.org\/10.1016\/j.sxmr.2018.05.002","journal-title":"Sex Med Rev"},{"issue":"7","key":"990_CR21","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S2213-8587(17)30402-3","volume":"6","author":"S Leo De","year":"2018","unstructured":"De Leo S, Pearce EN (2018) Autoimmune thyroid disease during pregnancy. Lancet Diabetes Endocrinol 6(7):575\u2013586. \n                    https:\/\/doi.org\/10.1016\/S2213-8587(17)30402-3","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2","key":"990_CR22","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12020-012-9703-2","volume":"42","author":"DS McLeod","year":"2012","unstructured":"McLeod DS, Cooper DS (2012) The incidence and prevalence of thyroid autoimmunity. Endocrine 42(2):252\u2013265. \n                    https:\/\/doi.org\/10.1007\/s12020-012-9703-2","journal-title":"Endocrine"},{"issue":"3","key":"990_CR23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1093\/ajcp\/aqw111","volume":"146","author":"J Goldstein","year":"2016","unstructured":"Goldstein J, Goyal R, Roland JT, Gellert LL, Clark PE, Hameed O, Giannico GA (2016) MAGI-2 is a sensitive and specific marker of prostatic adenocarcinoma: a comparison with AMACR. Am J Clin Pathol 146(3):294\u2013302. \n                    https:\/\/doi.org\/10.1093\/ajcp\/aqw111","journal-title":"Am J Clin Pathol"},{"issue":"33","key":"990_CR24","doi-asserted-by":"publisher","first-page":"21105","DOI":"10.1074\/jbc.273.33.21105","volume":"273","author":"K Hirao","year":"1998","unstructured":"Hirao K, Hata Y, Ide N, Takeuchi M, Irie M, Yao I, Deguchi M, Toyoda A, Sudhof TC, Takai Y (1998) A novel multiple PDZ domain-containing molecule interacting with N-methyl-d-aspartate receptors and neuronal cell adhesion proteins. J Biol Chem 273(33):21105\u201321110. \n                    https:\/\/doi.org\/10.1074\/jbc.273.33.21105","journal-title":"J Biol Chem"},{"issue":"16","key":"990_CR25","doi-asserted-by":"publisher","first-page":"7092","DOI":"10.1128\/MCB.25.16.7092-7106.2005","volume":"25","author":"RJ Ingham","year":"2005","unstructured":"Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O\u2019Donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T (2005) WW domains provide a platform for the assembly of multiprotein networks. Mol Cell Biol 25(16):7092\u20137106. \n                    https:\/\/doi.org\/10.1128\/MCB.25.16.7092-7106.2005","journal-title":"Mol Cell Biol"},{"issue":"4","key":"990_CR26","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1093\/jb\/mvv009","volume":"157","author":"S Nagashima","year":"2015","unstructured":"Nagashima S, Kodaka M, Iwasa H, Hata Y (2015) MAGI2\/S-SCAM outside brain. J Biochem 157(4):177\u2013184. \n                    https:\/\/doi.org\/10.1093\/jb\/mvv009","journal-title":"J Biochem"},{"issue":"8","key":"990_CR27","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1073\/pnas.97.8.4233","volume":"97","author":"X Wu","year":"2000","unstructured":"Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE (2000) Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Proc Natl Acad Sci USA 97(8):4233\u20134238. \n                    https:\/\/doi.org\/10.1073\/pnas.97.8.4233","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"990_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2007.07.027","volume":"467","author":"Y Hu","year":"2007","unstructured":"Hu Y, Li Z, Guo L, Wang L, Zhang L, Cai X, Zhao H, Zha X (2007) MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells. Arch Biochem Biophys 467(1):1\u20139. \n                    https:\/\/doi.org\/10.1016\/j.abb.2007.07.027","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"990_CR29","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1530\/eje.0.1490215","volume":"149","author":"S Tedelind","year":"2003","unstructured":"Tedelind S, Ericson LE, Karlsson JO, Nilsson M (2003) Interferon-gamma down-regulates claudin-1 and impairs the epithelial barrier function in primary cultured human thyrocytes. Eur J Endocrinol 149(3):215\u2013221. \n                    https:\/\/doi.org\/10.1530\/eje.0.1490215","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"990_CR30","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.autrev.2014.08.025","volume":"13","author":"A Antonelli","year":"2014","unstructured":"Antonelli A, Ferrari SM, Corrado A, Franceschini SS, Gelmini S, Ferrannini E, Fallahi P (2014) Extra-ocular muscle cells from patients with Graves\u2019 ophthalmopathy secrete alpha (CXCL10) and beta (CCL2) chemokines under the influence of cytokines that are modulated by PPARgamma. Autoimmun Rev 13(11):1160\u20131166. \n                    https:\/\/doi.org\/10.1016\/j.autrev.2014.08.025","journal-title":"Autoimmun Rev"},{"issue":"3","key":"990_CR31","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1210\/jcem.83.3.4626","volume":"83","author":"M Nilsson","year":"1998","unstructured":"Nilsson M, Husmark J, Bjorkman U, Ericson LE (1998) Cytokines and thyroid epithelial integrity: interleukin-1alpha induces dissociation of the junctional complex and paracellular leakage in filter-cultured human thyrocytes. J Clin Endocrinol Metab 83(3):945\u2013952. \n                    https:\/\/doi.org\/10.1210\/jcem.83.3.4626","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"990_CR32","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1681\/ASN.2016121356","volume":"28","author":"N Shirata","year":"2017","unstructured":"Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Oliva Trejo JA, Miyake T, Yamada H, Campbell KN, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K (2017) Glomerulosclerosis induced by deficiency of membrane-associated guanylate kinase inverted 2 in kidney podocytes. J Am Soc Nephrol JASN 28(9):2654\u20132669. \n                    https:\/\/doi.org\/10.1681\/ASN.2016121356","journal-title":"J Am Soc Nephrol JASN"},{"issue":"2","key":"990_CR33","doi-asserted-by":"publisher","first-page":"439","DOI":"10.3892\/ijmm.2013.1411","volume":"32","author":"X Li","year":"2013","unstructured":"Li X, Li Z, Li N, Qi J, Fan K, Yin P, Zhao C, Liu Y, Yao W, Cai X, Wang L, Zha X (2013) MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. Int J Mol Med 32(2):439\u2013447. \n                    https:\/\/doi.org\/10.3892\/ijmm.2013.1411","journal-title":"Int J Mol Med"},{"key":"990_CR34","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1749-6632.2002.tb04337.x","volume":"968","author":"C Eng","year":"2002","unstructured":"Eng C (2002) Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis. Ann N Y Acad Sci 968:213\u2013221","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"990_CR35","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.jamcollsurg.2006.12.037","volume":"204","author":"SD Larson","year":"2007","unstructured":"Larson SD, Jackson LN, Riall TS, Uchida T, Thomas RP, Qiu S, Evers BM (2007) Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k\/Akt pathway. J Am Coll Surg 204(5):764\u2013773. \n                    https:\/\/doi.org\/10.1016\/j.jamcollsurg.2006.12.037","journal-title":"J Am Coll Surg"},{"issue":"7","key":"990_CR36","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.ejmg.2017.04.010","volume":"60","author":"F Guaraldi","year":"2017","unstructured":"Guaraldi F, Di Nardo G, Tarani L, Bertelli L, Susca FC, Bagnulo R, Resta N (2017) Association of autoimmune thyroiditis and celiac disease with juvenile polyposis due to 10q23.1q23.31 deletion: Potential role of PI3K\/Akt pathway dysregulation. Eur J Med Genet 60(7):380\u2013384. \n                    https:\/\/doi.org\/10.1016\/j.ejmg.2017.04.010","journal-title":"Eur J Med Genet"},{"issue":"6","key":"990_CR37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/msphere.00305-17","volume":"2","author":"L Grossman","year":"2017","unstructured":"Grossman L, Chang C, Dai J, Nikitin PA, Jima DD, Dave SS, Luftig MA (2017) Epstein-Barr virus induces adhesion receptor CD226 (DNAM-1) expression during primary B-cell transformation into lymphoblastoid cell lines. mSphere 2(6):115\u2013123. \n                    https:\/\/doi.org\/10.1128\/msphere.00305-17","journal-title":"mSphere"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-018-0990-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-018-0990-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-018-0990-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T19:12:54Z","timestamp":1575745974000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-018-0990-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,8]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["990"],"URL":"https:\/\/doi.org\/10.1007\/s40618-018-0990-1","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,8]]},"assertion":[{"value":"27 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiment was approved by the ethics committee of Jinshan Hospital of Fudan University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was signed in both the patient group and the control group. All subjects in this experiment were voluntary and did not receive any financial compensation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}