{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:15:02Z","timestamp":1789388102762,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"RICERCA FINALIZZATA 2010","award":["RF-2010-2318911"],"award-info":[{"award-number":["RF-2010-2318911"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s40618-019-01086-7","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T10:03:03Z","timestamp":1564048983000},"page":"101-107","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity"],"prefix":"10.1007","volume":"43","author":[{"given":"C.","family":"Luordi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Maddaloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pedicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Zampetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"D\u2019Onofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-6041","authenticated-orcid":false,"given":"R.","family":"Buzzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"1086_CR1","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s13679-018-0320-0","volume":"7","author":"S Weihrauch-Bl\u00fcher","year":"2018","unstructured":"Weihrauch-Bl\u00fcher S, Wiegand S (2018) Risk factors and implications of childhood obesity. Curr Obes Rep 7:254\u2013259. \nhttps:\/\/doi.org\/10.1007\/s13679-018-0320-0","journal-title":"Curr Obes Rep"},{"key":"1086_CR2","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41574-018-0002-8","volume":"14","author":"KS Steinbeck","year":"2018","unstructured":"Steinbeck KS, Lister NB, Gow ML, Baur LA (2018) Treatment of adolescent obesity. Nat Rev Endocrinol 14:331\u2013344. \nhttps:\/\/doi.org\/10.1038\/s41574-018-0002-8","journal-title":"Nat Rev Endocrinol"},{"key":"1086_CR3","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13052-018-0525-6","volume":"44","author":"G Valerio","year":"2018","unstructured":"Valerio G, Maffeis C, Saggese G et al (2018) Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics. Ital J Pediatr 44:88. \nhttps:\/\/doi.org\/10.1186\/s13052-018-0525-6","journal-title":"Ital J Pediatr"},{"key":"1086_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3134","author":"HCH Ho","year":"2019","unstructured":"Ho HCH, Maddaloni E, Buzzetti R (2019) Risk factors and predicitve biomarkers of early cardiovascular disease in obese youth. Diabetes Metab Res Rev. \nhttps:\/\/doi.org\/10.1002\/dmrr.3134","journal-title":"Diabetes Metab Res Rev"},{"key":"1086_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.appet.2015.03.028","volume":"93","author":"JA Yanovski","year":"2015","unstructured":"Yanovski JA (2015) Pediatric obesity: an introduction. Appetite 93:3\u201312. \nhttps:\/\/doi.org\/10.1016\/j.appet.2015.03.028","journal-title":"Appetite"},{"key":"1086_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-018-0534-x","author":"N Namazi","year":"2018","unstructured":"Namazi N, Djalalinia S, Mahdavi-Gorabi A et al (2018) Association of wrist circumference with cardio-metabolic risk factors: a systematic review and meta-analysis. Eat Weight Disord. \nhttps:\/\/doi.org\/10.1007\/s40519-018-0534-x","journal-title":"Eat Weight Disord"},{"key":"1086_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.044","author":"E Maddaloni","year":"2016","unstructured":"Maddaloni E, Cavallari I, De Pascalis M et al (2016) Relation of body circumferences to cardiometabolic disease in overweight-obese subjects. Am J Cardiol. \nhttps:\/\/doi.org\/10.1016\/j.amjcard.2016.06.044","journal-title":"Am J Cardiol"},{"key":"1086_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/cob.12171","volume":"7","author":"WP Jayawardene","year":"2017","unstructured":"Jayawardene WP, Lohrmann D, Dickinson S et al (2017) Clinical measures of obesity and cumulative cardiometabolic risk in adolescents. Clin Obes 7:11\u201321. \nhttps:\/\/doi.org\/10.1111\/cob.12171","journal-title":"Clin Obes"},{"key":"1086_CR9","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1590\/1984-0462\/;2017;35;3;00013","volume":"35","author":"TMB de Quadros","year":"2017","unstructured":"de Quadros TMB, Gordia AP, Silva LR (2017) Anthropometry and clustered cardiometabolic risk factors in young people: a systematic review. Rev Paul Pediatr 35:340\u2013350. \nhttps:\/\/doi.org\/10.1590\/1984-0462\/;2017;35;3;00013","journal-title":"Rev Paul Pediatr"},{"key":"1086_CR10","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1161\/CIRCULATIONAHA.110.012898","volume":"123","author":"M Capizzi","year":"2011","unstructured":"Capizzi M, Leto G, Petrone A et al (2011) Wrist circumference is a clinical marker of insulin resistance in overweight and obese children and adolescents. Circulation 123:1757\u20131762. \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.012898","journal-title":"Circulation"},{"key":"1086_CR11","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-4684-2622-9_3","volume-title":"Hum Growth","author":"N Cameron","year":"1978","unstructured":"Cameron N (1978) The methods of auxological anthropometry. Hum Growth. Springer, Boston, pp 35\u201390"},{"key":"1086_CR12","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1038\/oby.2012.81","volume":"20","author":"DS Freedman","year":"2012","unstructured":"Freedman DS, Thornton JC, Pi-Sunyer FX et al (2012) The body adiposity index (hip circumference \u00f7 height 1.5) is not a more accurate measure of adiposity than is bmi, waist circumference, or hip circumference. Obesity 20:2438\u20132444. \nhttps:\/\/doi.org\/10.1038\/oby.2012.81","journal-title":"Obesity"},{"key":"1086_CR13","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1136\/bmj.320.7244.1240","volume":"320","author":"TJ Cole","year":"2000","unstructured":"Cole TJ, Bellizzi MC, Flegal KM, Dietz WH (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 320:1240\u20131243. \nhttps:\/\/doi.org\/10.1136\/bmj.320.7244.1240","journal-title":"BMJ"},{"key":"1086_CR14","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12887-015-0366-z","volume":"15","author":"F Bacopoulou","year":"2015","unstructured":"Bacopoulou F, Efthymiou V, Landis G et al (2015) Waist circumference, waist-to-hip ratio and waist-to-height ratio reference percentiles for abdominal obesity among Greek adolescents. BMC Pediatr 15:50. \nhttps:\/\/doi.org\/10.1186\/s12887-015-0366-z","journal-title":"BMC Pediatr"},{"key":"1086_CR15","doi-asserted-by":"publisher","first-page":"425","DOI":"10.3345\/kjp.2016.59.11.425","volume":"59","author":"E-G Yoo","year":"2016","unstructured":"Yoo E-G (2016) Waist-to-height ratio as a screening tool for obesity and cardiometabolic risk. Korean J Pediatr 59:425\u2013431. \nhttps:\/\/doi.org\/10.3345\/kjp.2016.59.11.425","journal-title":"Korean J Pediatr"},{"key":"1086_CR16","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.clinimag.2006.02.004","volume":"30","author":"J Nyland","year":"2006","unstructured":"Nyland J, Fried A, Maitra R et al (2006) Wrist circumference is related to patellar tendon thickness in healthy men and women. Clin Imaging 30:335\u2013338. \nhttps:\/\/doi.org\/10.1016\/j.clinimag.2006.02.004","journal-title":"Clin Imaging"},{"key":"1086_CR17","doi-asserted-by":"publisher","first-page":"e0156646","DOI":"10.1371\/journal.pone.0156646","volume":"11","author":"G Campagna","year":"2016","unstructured":"Campagna G, Zampetti S, Gallozzi A et al (2016) Excellent intra and inter-observer reproducibility of wrist circumference measurements in obese children and adolescents. PLoS One 11:e0156646. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0156646","journal-title":"PLoS One"},{"key":"1086_CR18","first-page":"e53","volume":"8","author":"R Hazani","year":"2008","unstructured":"Hazani R, Engineer NJ, Cooney D, Wilhelmi BJ (2008) Anatomic landmarks for the first dorsal compartment. Eplasty 8:e53","journal-title":"Eplasty"},{"key":"1086_CR19","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cuor.2005.02.008","volume":"19","author":"R Srinivas Reddy","year":"2005","unstructured":"Srinivas Reddy R, Compson J (2005) (i) Examination of the wrist\u2014surface anatomy of the carpal bones. Curr Orthop 19:171\u2013179. \nhttps:\/\/doi.org\/10.1016\/j.cuor.2005.02.008","journal-title":"Curr Orthop"},{"key":"1086_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-87410-2","volume-title":"Manual of arthroscopic surgery","author":"MJ Strobel","year":"2002","unstructured":"Strobel MJ (2002) Manual of arthroscopic surgery. Springer, Berlin Heidelberg"},{"key":"1086_CR21","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS et al (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412\u2013419","journal-title":"Diabetologia"},{"key":"1086_CR22","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","volume":"22","author":"M Matsuda","year":"1999","unstructured":"Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462\u20131470. \nhttps:\/\/doi.org\/10.2337\/diacare.22.9.1462","journal-title":"Diabetes Care"},{"key":"1086_CR23","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1007\/s00125-014-3172-5","volume":"57","author":"A Viitasalo","year":"2014","unstructured":"Viitasalo A, Lakka TA, Laaksonen DE et al (2014) Validation of metabolic syndrome score by confirmatory factor analysis in children and adults and prediction of cardiometabolic outcomes in adults. Diabetologia 57:940\u2013949. \nhttps:\/\/doi.org\/10.1007\/s00125-014-3172-5","journal-title":"Diabetologia"},{"key":"1086_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/obr.12242","volume":"16","author":"Y Bai","year":"2015","unstructured":"Bai Y, Sun Q (2015) Macrophage recruitment in obese adipose tissue. Obes Rev 16:127\u2013136. \nhttps:\/\/doi.org\/10.1111\/obr.12242","journal-title":"Obes Rev"},{"key":"1086_CR25","doi-asserted-by":"publisher","first-page":"191","DOI":"10.2147\/DMSO.S182406","volume":"12","author":"O Gruzdeva","year":"2019","unstructured":"Gruzdeva O, Borodkina D, Uchasova E et al (2019) Leptin resistance: underlying mechanisms and diagnosis. Diabetes Metab Syndr Obes 12:191\u2013198. \nhttps:\/\/doi.org\/10.2147\/DMSO.S182406","journal-title":"Diabetes Metab Syndr Obes"},{"key":"1086_CR26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/jpi.12257","volume":"59","author":"K Szewczyk-Golec","year":"2015","unstructured":"Szewczyk-Golec K, Wo\u017aniak A, Reiter RJ (2015) Inter-relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity. J Pineal Res 59:277\u2013291. \nhttps:\/\/doi.org\/10.1111\/jpi.12257","journal-title":"J Pineal Res"},{"key":"1086_CR27","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1203\/01.PDR.0000147728.62185.21","volume":"57","author":"R Buzzetti","year":"2005","unstructured":"Buzzetti R, Petrone A, Caiazzo AM et al (2005) PPAR-gamma2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity. Pediatr Res 57:138\u2013140. \nhttps:\/\/doi.org\/10.1203\/01.PDR.0000147728.62185.21","journal-title":"Pediatr Res"},{"key":"1086_CR28","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1038\/oby.2006.172","volume":"14","author":"A Petrone","year":"2006","unstructured":"Petrone A, Zavarella S, Caiazzo A et al (2006) The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity. Obesity (Silver Spring) 14:1498\u20131504. \nhttps:\/\/doi.org\/10.1038\/oby.2006.172","journal-title":"Obesity (Silver Spring)"},{"key":"1086_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/nu11020454","author":"G Fr\u00fchbeck","year":"2019","unstructured":"Fr\u00fchbeck G, Catal\u00e1n V, Rodr\u00edguez A et al (2019) Adiponectin\u2013leptin ratio is a functional biomarker of adipose tissue inflammation. Nutrients. \nhttps:\/\/doi.org\/10.3390\/nu11020454","journal-title":"Nutrients"},{"key":"1086_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1210\/er.2017-00253","volume":"39","author":"GA Bray","year":"2018","unstructured":"Bray GA, Heisel WE, Afshin A et al (2018) The science of obesity management: an endocrine society scientific statement. Endocr Rev 39:79\u2013132. \nhttps:\/\/doi.org\/10.1210\/er.2017-00253","journal-title":"Endocr Rev"},{"key":"1086_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41440-017-0006-0","volume":"41","author":"S Zampetti","year":"2018","unstructured":"Zampetti S, Campagna G, Lucantoni F et al (2018) Wrist circumference is associated with increased systolic blood pressure in children with overweight\/obesity. Hypertens Res 41:193\u2013197. \nhttps:\/\/doi.org\/10.1038\/s41440-017-0006-0","journal-title":"Hypertens Res"},{"key":"1086_CR32","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.amjcard.2018.02.057","volume":"121","author":"S Zampetti","year":"2018","unstructured":"Zampetti S, Campagna G, Leto G et al (2018) Relation between wrist circumference and left ventricular structure in overweight children. Am J Cardiol 121:1624\u20131628. \nhttps:\/\/doi.org\/10.1016\/j.amjcard.2018.02.057","journal-title":"Am J Cardiol"},{"key":"1086_CR33","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000479510","volume":"88","author":"S Bussler","year":"2017","unstructured":"Bussler S, Penke M, Flemming G et al (2017) Novel insights in the metabolic syndrome in childhood and adolescence. Horm Res Paediatr 88:181\u2013193. \nhttps:\/\/doi.org\/10.1159\/000479510","journal-title":"Horm Res Paediatr"},{"key":"1086_CR34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1475-2840-7-17","volume":"7","author":"JC Eisenmann","year":"2008","unstructured":"Eisenmann JC (2008) On the use of a continuous metabolic syndrome score in pediatric research. Cardiovasc Diabetol 7:17. \nhttps:\/\/doi.org\/10.1186\/1475-2840-7-17","journal-title":"Cardiovasc Diabetol"},{"key":"1086_CR35","doi-asserted-by":"publisher","first-page":"954","DOI":"10.3945\/jn.109.118737","volume":"140","author":"A Bosy-Westphal","year":"2010","unstructured":"Bosy-Westphal A, Booke C-A, Bl\u00f6cker T et al (2010) Measurement site for waist circumference affects its accuracy as an index of visceral and abdominal subcutaneous fat in a Caucasian population. J Nutr 140:954\u2013961. \nhttps:\/\/doi.org\/10.3945\/jn.109.118737","journal-title":"J Nutr"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01086-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-019-01086-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01086-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T23:40:08Z","timestamp":1595547608000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-019-01086-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,25]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1086"],"URL":"https:\/\/doi.org\/10.1007\/s40618-019-01086-7","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,25]]},"assertion":[{"value":"17 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethical Committee of Bambino Ges\u00f9 Children\u2019s Hospital in Rome.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the parents or guardians of the children included in this study, in accordance with the principles of the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}