{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:23:41Z","timestamp":1779909821678,"version":"3.53.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s40618-019-01100-y","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T08:02:45Z","timestamp":1566460965000},"page":"197-207","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-5731","authenticated-orcid":false,"given":"V.","family":"Gasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Roncoroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zavattaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ghigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maccario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Grottoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"1100_CR1","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.1365-2265.1992.tb02347.x","volume":"37","author":"RC Cuneo","year":"1992","unstructured":"Cuneo RC, Salomon F, McGauley GA, S\u00f6nksen PH (1992) The growth hormone deficiency syndrome in adults. Clin Endocrinol (Oxf) 37:387\u2013397","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1100_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","volume":"336","author":"T Ros\u00e9n","year":"1990","unstructured":"Ros\u00e9n T, Bengtsson BA (1990) Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336:285\u2013288","journal-title":"Lancet"},{"key":"1100_CR3","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1210\/jc.2003-031601","volume":"89","author":"J Svensson","year":"2004","unstructured":"Svensson J, Bengtsson BA, Ros\u00e9n T, Od\u00e9n A, Johannsson G (2004) Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy. J Clin Endocrinol Metab 89:3306\u20133312","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","volume":"46","author":"B B\u00fclow","year":"1997","unstructured":"B\u00fclow B, Hagmar L, Mikoczy Z, Nordstr\u00f6m CH, Erfurth EM (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol (Oxf) 46:75\u201381","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1100_CR5","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/0140-6736(92)92892-J","volume":"340","author":"V Markussis","year":"1992","unstructured":"Markussis V, Beshyah SA, Fisher C, Sharp P, Nicolaides AN, Johnston DG (1992) Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults. Lancet 340:1188\u20131192","journal-title":"Lancet"},{"key":"1100_CR6","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1046\/j.1365-2265.1999.00695.x","volume":"50","author":"R Abs","year":"1999","unstructured":"Abs R, Bengtsson BA, Hernberg-St\u00e2hl E, Monson JP, Tauber JP, Wilton P, W\u00fcster C (1999) GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safety. Clin Endocrinol (Oxf) 50:703\u2013713","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9 Suppl","key":"1100_CR7","first-page":"52","volume":"31","author":"SM Webb","year":"2008","unstructured":"Webb SM (2008) Measurements of quality of life in patients with growth hormone deficiency. J Endocrinol Invest 31(9 Suppl):52\u201355","journal-title":"J Endocrinol Invest"},{"key":"1100_CR8","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1210\/jc.2011-0179","volume":"96","author":"ME Molitch","year":"2011","unstructured":"Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML, Endocrine Society (2011) Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96:1587\u20131609","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR9","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1007\/BF03349263","volume":"31","author":"A Giustina","year":"2008","unstructured":"Giustina A, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E, Casanueva F, Colao A, Lamberts S, Sheppard M, Melmed S, Pituitary Society; European Neuroendocrine Association (2008) Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults. J Endocrinol Invest 31:820\u2013838","journal-title":"J Endocrinol Invest"},{"issue":"9 Suppl","key":"1100_CR10","first-page":"75","volume":"31","author":"M Losa","year":"2008","unstructured":"Losa M, Gatti E, Rossini A, Lanzi R (2008) Replacement therapy with growth hormone and pituitary tumor recurrence: the relevance of the problem. J Endocrinol Invest 31(9 Suppl):75\u201378","journal-title":"J Endocrinol Invest"},{"key":"1100_CR11","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s40618-014-0179-1","volume":"38","author":"E Brignardello","year":"2015","unstructured":"Brignardello E, Felicetti F, Castiglione A, Fortunati N, Matarazzo P, Biasin E, Sacerdote C, Ricardi U, Fagioli F, Corrias A, Arvat E (2015) GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution. J Endocrinol Invest 38:171\u2013176","journal-title":"J Endocrinol Invest"},{"key":"1100_CR12","doi-asserted-by":"publisher","first-page":"P1","DOI":"10.1530\/EJE-15-0873","volume":"174","author":"DB Allen","year":"2016","unstructured":"Allen DB, Backeljauw P, Bidlingmaier M, Biller BM, Boguszewski M, Burman P, Butler G, Chihara K, Christiansen J, Cianfarani S et al (2016) GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. Eur J Endocrinol 174:P1\u2013P9","journal-title":"Eur J Endocrinol"},{"key":"1100_CR13","first-page":"1919","volume":"84","author":"A Colao","year":"1999","unstructured":"Colao A, Di Somma C, Pivonello R, Loche S, Aimaretti G, Cerbone G, Faggiano A, Corneli G, Ghigo E, Lombardi G (1999) Bone loss is correlated to the severity of growth hormone deficiency in adult patients with hypopituitarism. J Clin Endocrinol Metab 84:1919\u20131924","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR14","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1210\/jcem.84.4.5605","volume":"84","author":"A Colao","year":"1999","unstructured":"Colao A, Cerbone G, Pivonello R, Aimaretti G, Loche S, Di Somma C, Faggiano A, Corneli G, Ghigo E, Lombardi G (1999) The growth hormone (GH) response to the arginine plus GH-releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency. J Clin Endocrinol Metab 84:1277\u20131282","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR15","doi-asserted-by":"publisher","first-page":"3950","DOI":"10.1210\/jcem.84.11.6112","volume":"84","author":"A Colao","year":"1999","unstructured":"Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte AM, Nicolai E, Lucci R, Salvatore M, Lombardi G (1999) Impaired cardiac performance in elderly patients with growth hormone deficiency. J Clin Endocrinol Metab 84:3950\u20133955","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR16","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1210\/er.2007-0036","volume":"29","author":"A Giustina","year":"2008","unstructured":"Giustina A, Mazziotti G, Canalis E (2008) Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 29:535\u2013559","journal-title":"Endocr Rev"},{"key":"1100_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1530\/eje.1.02179","volume":"155","author":"R Abs","year":"2006","unstructured":"Abs R, Feldt-Rasmussen U, Mattsson AF, Monson JP, Bengtsson BA, G\u00f3th MI, Wilton P, Koltowska-H\u00e4ggstr\u00f6m M (2006) Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults\u2013a KIMS database analysis. Eur J Endocrinol 155:79\u201390","journal-title":"Eur J Endocrinol"},{"key":"1100_CR18","first-page":"3693","volume":"85","author":"G Aimaretti","year":"2000","unstructured":"Aimaretti G, Baffoni C, Bellone S, Di Vito L, Corneli G, Arvat E, Benso L, Camanni F, Ghigo E (2000) Retesting young adults with childhood-onset growth hormone (GH) deficiency with GH-releasing-hormone-plus-arginine test. J Clin Endocrinol Metab 85:3693\u20133699","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR19","first-page":"82","volume":"82","author":"AF Attanasio","year":"1997","unstructured":"Attanasio AF, Lamberts SW, Matranga AM, Birkett MA, Bates PC, Valk NK, Hilsted J, Bengtsson BA, Strasburger CJ (1997) Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Adult Growth Hormone Deficiency Study Group. J Clin Endocrinol Metab 82:82\u201388","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR20","first-page":"1671","volume":"77","author":"G Amato","year":"1993","unstructured":"Amato G, Carella C, Fazio S, La Montagna G, Cittadini A, Sabatini D, Marciano-Mone C, Sacc\u00e1 L, Bellastella A (1993) Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab 77:1671\u20131676","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR21","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1111\/j.1365-2796.1992.tb00613.x","volume":"232","author":"AG Johansson","year":"1992","unstructured":"Johansson AG, Burman P, Westermark K, Ljunghall S (1992) The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I. J Intern Med 232:447\u2013452","journal-title":"J Intern Med"},{"key":"1100_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF00298715","volume":"52","author":"RG Bing-You","year":"1993","unstructured":"Bing-You RG, Denis MC, Rosen CJ (1993) Low bone mineral density in adults with previous hypothalamic-pituitary tumors: correlations with serum growth hormone responses to GH-releasing hormone, insulin-like growth factor I, and IGF binding protein 3. Calcif Tissue Int 52:183\u2013187","journal-title":"Calcif Tissue Int"},{"key":"1100_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/BF03346389","volume":"31","author":"G Aimaretti","year":"2008","unstructured":"Aimaretti G, Boschetti M, Corneli G, Gasco V, Valle D, Borsotti M, Rossi A, Barreca A, Fazzuoli L, Ferone D, Ghigo E, Minuto F (2008) Normal age-dependent values of serum insulin growth factor-I: results from a healthy Italian population. J Endocrinol Invest 31:445\u2013459","journal-title":"J Endocrinol Invest"},{"key":"1100_CR24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.ghir.2005.06.018","volume":"15","author":"R Abs","year":"2005","unstructured":"Abs R, Mattsson AF, Bengtsson BA, Feldt-Rasmussen U, G\u00f3th MI, Koltowska-H\u00e4ggstr\u00f6m M, Monson JP, Verhelst J, Wilton P, KIMS Study Group (2005) Isolated growth hormone (GH) deficiency in adult patients: baseline clinical characteristics and responses to GH replacement in comparison with hypopituitary patients. A sub-analysis of the KIMS database. Growth Horm IGF Res 15:349\u2013359","journal-title":"Growth Horm IGF Res"},{"key":"1100_CR25","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S1043-2760(00)00268-X","volume":"11","author":"PV Carroll","year":"2000","unstructured":"Carroll PV, Christ ER, S\u00f6nksen PH (2000) Growth hormone replacement in adults with growth hormone deficiency: assessment of current knowledge. Trends Endocrinol Metab 11:231\u2013238","journal-title":"Trends Endocrinol Metab"},{"key":"1100_CR26","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1530\/acta.0.1290195","volume":"129","author":"T Ros\u00e9n","year":"1993","unstructured":"Ros\u00e9n T, Ed\u00e9n S, Larson G, Wilhelmsen L, Bengtsson BA (1993) Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh) 129:195\u2013200","journal-title":"Acta Endocrinol (Copenh)"},{"key":"1100_CR27","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1365-2265.2001.01320.x","volume":"55","author":"TA Abdu","year":"2001","unstructured":"Abdu TA, Neary R, Elhadd TA, Akber M, Clayton RN (2001) Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clin Endocrinol (Oxf) 55:209\u2013216","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1100_CR28","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1210\/jcem.87.3.8336","volume":"87","author":"A Colao","year":"2002","unstructured":"Colao A, di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G (2002) The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 87:1088\u20131093","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1530\/EJE-12-0807","volume":"168","author":"R Abs","year":"2013","unstructured":"Abs R, Mattsson AF, Thunander M, Verhelst J, G\u00f3th MI, Wilton P, Ko\u0142towska-H\u00e4ggstr\u00f6m M, Luger A (2013) Prevalence of diabetes mellitus in 6050 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis. Eur J Endocrinol 168:297\u2013305","journal-title":"Eur J Endocrinol"},{"key":"1100_CR30","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1530\/EJE-11-0599","volume":"165","author":"J Verhelst","year":"2011","unstructured":"Verhelst J, Mattsson AF, Luger A, Thunander M, G\u00f3th MI, Koltowska-H\u00e4ggstr\u00f6m M, Abs R (2011) Prevalence and characteristics of the metabolic syndrome in 2479 hypopituitary patients with adult-onset GH deficiency before GH replacement: a KIMS analysis. Eur J Endocrinol 165:881\u2013889","journal-title":"Eur J Endocrinol"},{"key":"1100_CR31","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12020-015-0738-z","volume":"52","author":"G Mazziotti","year":"2016","unstructured":"Mazziotti G, Doga M, Frara S, Maffezzoni F, Porcelli T, Cerri L, Maroldi R, Giustina A (2016) Incidence of morphometric vertebral fractures in adult patients with growth hormone deficiency. Endocrine 52:103\u2013110","journal-title":"Endocrine"},{"key":"1100_CR32","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-015001","author":"LA Hopstock","year":"2017","unstructured":"Hopstock LA, B\u00f8naa KH, Eggen AE, Grimsgaard S, Jacobsen BK, L\u00f8chen ML, Mathiesen EB, Nj\u00f8lstad I, Wilsgaard T (2017) Longitudinal and secular trends in total cholesterol levels and impact of lipid-lowering drug use among Norwegian women and men born in 1905-1977 in the population-based Troms\u00f8 study 1979-2016. BMJ Open. \nhttps:\/\/doi.org\/10.1136\/bmjopen-2016-015001","journal-title":"BMJ Open"},{"key":"1100_CR33","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0021-9150(87)90094-3","volume":"68","author":"KM Anderson","year":"1987","unstructured":"Anderson KM, Wilson PW, Garrison RJ, Castelli WP (1987) Longitudinal and secular trends in lipoprotein cholesterol measurements in a general population sample. The Framingham Offspring Study. Atherosclerosis 68:59\u201366","journal-title":"Atherosclerosis"},{"key":"1100_CR34","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1210\/jc.2007-0275","volume":"92","author":"A Garg","year":"2007","unstructured":"Garg A, Simha V (2007) Update on dyslipidemia. J Clin Endocrinol Metab 92:1581\u20131589","journal-title":"J Clin Endocrinol Metab"},{"key":"1100_CR35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.2174\/1874192401105010076","volume":"5","author":"CV Rizos","year":"2011","unstructured":"Rizos CV, Elisaf MS, Liberopoulos EN (2011) Effects of thyroid dysfunction on lipid profile. Open Cardiovasc Med J 5:76\u201384","journal-title":"Open Cardiovasc Med J"},{"key":"1100_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/575840","author":"M Peppa","year":"2011","unstructured":"Peppa M, Betsi G, Dimitriadis G (2011) Lipid abnormalities and cardiometabolic risk in patients with overt and subclinical thyroid disease. J Lipids. \nhttps:\/\/doi.org\/10.1155\/2011\/575840","journal-title":"J Lipids"},{"key":"1100_CR37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1530\/eje.1.01967","volume":"153","author":"G Corneli","year":"2005","unstructured":"Corneli G, Di Somma C, Baldelli R, Rovere S, Gasco V, Croce CG, Grottoli S, Maccario M, Colao A, Lombardi G, Ghigo E, Camanni F, Aimaretti G (2005) The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. Eur J Endocrinol 153:257\u2013264","journal-title":"Eur J Endocrinol"},{"key":"1100_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2017.05.013","volume":"122","author":"G Seravalle","year":"2017","unstructured":"Seravalle G, Grassi G (2017) Obesity and hypertension. Pharmacol Res 122:1\u20137","journal-title":"Pharmacol Res"},{"key":"1100_CR39","first-page":"237","volume":"10","author":"F Samadian","year":"2016","unstructured":"Samadian F, Dalili N, Jamalian A (2016) Lifestyle modifications to prevent and control hypertension. Iran J Kidney Dis 10:237\u2013263","journal-title":"Iran J Kidney Dis"},{"key":"1100_CR40","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.phrs.2017.10.003","volume":"128","author":"C Cuspidi","year":"2018","unstructured":"Cuspidi C, Tadic M, Grassi G, Mancia G (2018) Treatment of hypertension: the ESH\/ESC guidelines recommendations. Pharmacol Res 128:315\u2013321","journal-title":"Pharmacol Res"},{"key":"1100_CR41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.numecd.2011.11.001","volume":"22","author":"G Muscogiuri","year":"2012","unstructured":"Muscogiuri G, Sorice GP, Ajjan R, Mezza T, Pilz S, Prioletta A, Scragg R, Volpe SL, Witham MD, Giaccari A (2012) Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis 22:81\u201387","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1100_CR42","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s12020-014-0167-4","volume":"46","author":"M Ghosh","year":"2014","unstructured":"Ghosh M, Majumdar SR (2014) Antihypertensive medications, bone mineral density, and fractures: a review of old cardiac drugs that provides new insights into osteoporosis. Endocrine 46:397\u2013405","journal-title":"Endocrine"},{"key":"1100_CR43","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-017-0888-0","author":"JI Barzilay","year":"2017","unstructured":"Barzilay JI, Davis BR, Pressel SL, Ghosh A, Puttnam R, Margolis KL, Whelton PK (2017) The impact of antihypertensive medications on bone mineral density and fracture risk. Curr Cardiol Rep. \nhttps:\/\/doi.org\/10.1007\/s11886-017-0888-0","journal-title":"Curr Cardiol Rep"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-019-01100-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01100-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:20:36Z","timestamp":1597965636000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-019-01100-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1100"],"URL":"https:\/\/doi.org\/10.1007\/s40618-019-01100-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"13 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from the individual participant included in the study","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}