{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:04:59Z","timestamp":1775340299727,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s40618-019-01144-0","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T07:03:11Z","timestamp":1573542191000},"page":"595-600","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["\u201cBlock-and-replace\u201d treatment in Graves\u2019 disease: experience in a cohort of pediatric patients"],"prefix":"10.1007","volume":"43","author":[{"given":"M. C.","family":"Vigone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Peroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Di Frenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4781-6715","authenticated-orcid":false,"given":"S.","family":"Mora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Barera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"1144_CR1","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1530\/eje.0.1300565","volume":"130","author":"L Lavard","year":"1994","unstructured":"Lavard L, Ranl\u00f8v I, Perrild H, Andersen O, Jacobsen BB (1994) Incidence of juvenile thyrotoxicosis in Denmark, 1982\u20131988. A nationwide study. Eur J Endocrinol. 130:565\u2013568. https:\/\/doi.org\/10.1530\/eje.0.1300565","journal-title":"Eur J Endocrinol."},{"key":"1144_CR2","doi-asserted-by":"publisher","first-page":"e481","DOI":"10.1542\/peds.2007-1535","volume":"121","author":"NS Glaser","year":"2008","unstructured":"Glaser NS, Styne DM, Organization of Pediatric Endocrinologists of Northern California Collaborative Graves\u2019 Disease Study Group (2008) Predicting the likelihood of remission in children with Graves\u2019 disease: a prospective, multicenter study. Pediatrics 121:e481\u2013e488. https:\/\/doi.org\/10.1542\/peds.2007-1535","journal-title":"Pediatrics"},{"key":"1144_CR3","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1089\/thy.1997.7.755","volume":"7","author":"DI Shulman","year":"1997","unstructured":"Shulman DI, Muhar I, Jorgensen EV, Diamond FB, Bercu BB, Root AW (1997) Autoimmune hyperthyroidism in prepubertal children and adolescents: comparison of clinical and biochemical features at diagnosis and responses to medical therapy. Thyroid. 7:755\u2013760. https:\/\/doi.org\/10.1089\/thy.1997.7.755","journal-title":"Thyroid."},{"key":"1144_CR4","doi-asserted-by":"publisher","first-page":"3817","DOI":"10.1210\/jc.2008-0842","volume":"93","author":"F Kaguelidou","year":"2008","unstructured":"Kaguelidou F, Alberti C, Castanet M, Guitteny MA, Czernichow P, L\u00e9ger J, French Childhood Graves\u2019 Disease Study Group (2008) Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. J Clin Endocrinol Metab 93:3817\u20133826. https:\/\/doi.org\/10.1210\/jc.2008-0842","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR5","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1210\/jcem.85.10.6922","volume":"85","author":"L Lazar","year":"2000","unstructured":"Lazar L, Kalter-Leibovici O, Pertzelan A, Weintrob N, Josefsberg Z, Phillip M (2000) Thyrotoxicosis in prepubertal children compared with pubertal and postpubertal patients. J Clin Endocrinol Metab 85:3678\u20133682. https:\/\/doi.org\/10.1210\/jcem.85.10.6922","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/ncpendmet0068","volume":"2","author":"AP Weetman","year":"2006","unstructured":"Weetman AP (2006) Graves\u2019 hyperthyroidism: how long should antithyroid drug therapy be continued to achieve remission? Nat Clin Pract Endocrinol Metab 2:2\u20133. https:\/\/doi.org\/10.1038\/ncpendmet0068","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"1144_CR7","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/S0929-693X(98)80052-3","volume":"5","author":"J Boiko","year":"1998","unstructured":"Boiko J, L\u00e9ger J, Raux-Demay MC, Cabrol S, Le Bouc Y, Czernichow P (1998) Basedow disease in children: clinical and evolutive aspects. Arch Pediatr 5:722\u2013730. https:\/\/doi.org\/10.1016\/S0929-693X(98)80052-3","journal-title":"Arch Pediatr"},{"key":"1144_CR8","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1210\/jcem.82.6.3986","volume":"82","author":"NS Glaser","year":"1997","unstructured":"Glaser NS, Styne DM (1997) Predictors of early remission of hyperthyroidism in children. J Clin Endocrinol Metab 82:1719\u20131726. https:\/\/doi.org\/10.1210\/jcem.82.6.3986","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR9","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/S0031-3955(16)37011-0","volume":"37","author":"D Zimmerman","year":"1990","unstructured":"Zimmerman D, Gan-Gaisano M (1990) Hyperthyroidism in children and adolescents. Pediatr Clin North Am 37:1273\u20131295. https:\/\/doi.org\/10.1016\/S0031-3955(16)37011-0","journal-title":"Pediatr Clin North Am"},{"key":"1144_CR10","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1210\/jcem-60-5-1019","volume":"60","author":"JI Hamburger","year":"1985","unstructured":"Hamburger JI (1985) Management of hyperthyroidism in children and adolescents. J Clin Endocrinol Metab 60:1019\u20131024. https:\/\/doi.org\/10.1210\/jcem-60-5-1019","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR11","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s40618-016-0177-x","volume":"39","author":"SA Rivkees","year":"2016","unstructured":"Rivkees SA (2016) Controversies in the management of Grave\u2019s disease in children. J Endocrinol Invest 39:1247\u20131257. https:\/\/doi.org\/10.1007\/s40618-016-0177-x","journal-title":"J Endocrinol Invest"},{"key":"1144_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1210\/jc.2011-1944","volume":"97","author":"J L\u00e9ger","year":"2012","unstructured":"L\u00e9ger J, Gelwane G, Kaguelidou F, Benmerad M, Alberti C, French Childhood Graves\u2019 Disease Study Group (2012) Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves\u2019 disease: national long-term cohort study. J Clin Endocrinol Metab 97:110\u2013119. https:\/\/doi.org\/10.1210\/jc.2011-1944","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR13","doi-asserted-by":"publisher","first-page":"R59","DOI":"10.1530\/EJE-16-0938","volume":"177","author":"J L\u00e9ger","year":"2017","unstructured":"L\u00e9ger J, Carel JC (2017) Management of endocrine disease: arguments for the prolonged use of antithyroid drugs in children with Graves\u2019 disease. Eur J Endocrinol 177:R59\u2013R67. https:\/\/doi.org\/10.1530\/EJE-16-0938","journal-title":"Eur J Endocrinol"},{"key":"1144_CR14","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000223414","volume":"71","author":"F Kaguelidou","year":"2009","unstructured":"Kaguelidou F, Carel JC, L\u00e9ger J (2009) Graves\u2019 disease in childhood: advances in management with antithyroid drug therapy. Horm Res 71:310\u2013317. https:\/\/doi.org\/10.1159\/000223414","journal-title":"Horm Res"},{"key":"1144_CR15","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1089\/thy.2016.0229","volume":"26","author":"DS Ross","year":"2016","unstructured":"Ross DS, Burch HB, Cooper DS, Greenlee MC, Laurberg P, Maia AL, Rivkees SA, Samuels M, Sosa JA, Stan MN et al (2016) 2016 American thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 26:1343\u20131421. https:\/\/doi.org\/10.1089\/thy.2016.0229","journal-title":"Thyroid."},{"key":"1144_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1530\/eje.1.01993","volume":"153","author":"P Abraham","year":"2005","unstructured":"Abraham P, Avenell A, Park CM et al (2005) A systematic review of drug therapy for Graves\u2019 hyperthyroidism. Eur J Endocrinol 153:489\u2013498. https:\/\/doi.org\/10.1530\/eje.1.01993","journal-title":"Eur J Endocrinol"},{"key":"1144_CR17","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1530\/eje.1.02169","volume":"154","author":"S Razvi","year":"2006","unstructured":"Razvi S, Vaidya B, Perros P, Pearce SH (2006) What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves\u2019 disease. Eur J Endocrinol 154:783\u2013786. https:\/\/doi.org\/10.1530\/eje.1.02169","journal-title":"Eur J Endocrinol"},{"key":"1144_CR18","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1007\/s40618-018-0918-9","volume":"41","author":"E Masiello","year":"2018","unstructured":"Masiello E, Veronesi G, Gallo D, Premoli P, Bianconi E, Rosetti S, Cusini C, Sabatino J, Ippolito S, Piantanida E, Tanda ML, Chiovato L, Wiersinga Bartalena L (2018) Antithyroid drug treatment for Grave\u2019s disease: baseline predictive models of relapse after treatment for a patient-tailored management. J Endocrinol Invest 41:1425\u20131432. https:\/\/doi.org\/10.1007\/s40618-018-0918-9","journal-title":"J Endocrinol Invest"},{"key":"1144_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003420.pub4","author":"P Abraham","year":"2010","unstructured":"Abraham P, Avenell A, McGeoch SC, Clark LF, Bevan JS (2010) Antithyroid drug regimen for treating Graves\u2019 hyperthyroidism. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD003420.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"1144_CR20","doi-asserted-by":"crossref","unstructured":"Ranke MB (2003) Diagnostics of endocrine function in children and adolescents. In: Basel, Karger, 2003, pp 93\u2013106. Diagnostic Tests of Thyroid Function in Children and Adolescents","DOI":"10.1159\/000073546"},{"key":"1144_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.beem.2013.08.008","volume":"28","author":"J Leger","year":"2014","unstructured":"Leger J, Kaguelidou F, Alberti C, Carel JC (2014) Graves\u2019 disease in children. Best Pract Res Clin Endocrinol Metab 28:233\u2013243. https:\/\/doi.org\/10.1016\/j.beem.2013.08.008","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1144_CR22","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1530\/eje.1.02295","volume":"155","author":"P Laurberg","year":"2006","unstructured":"Laurberg P (2006) Remission of Graves\u2019 disease during anti-thyroid drug therapy. Time to reconsider the mechanism? Eur J Endocrinol 155:783\u2013786. https:\/\/doi.org\/10.1530\/eje.1.02295","journal-title":"Eur J Endocrinol"},{"key":"1144_CR23","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1210\/jcem-57-3-563","volume":"57","author":"JH Romaldini","year":"1983","unstructured":"Romaldini JH, Bromberg N, Werner RS, Tanaka LM, Rodrigues HF, Werner MC, Farah CS, Reis LC (1983) Comparison of effects of high and low dosage regimens of antithyroid drugs in the management of Graves\u2019 hyperthyroidism. J Clin Endocrinol Metab 57:563\u2013570. https:\/\/doi.org\/10.1210\/jcem-57-3-563","journal-title":"J Clin Endocrinol Metab"},{"key":"1144_CR24","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/eje.0.1310125","volume":"131","author":"SW Kuo","year":"1994","unstructured":"Kuo SW, Huang WS, Hu CA, Liao WK, Fung TC, Wu SY (1994) Effect of thyroxine administration on serum thyrotropin receptor antibody and thyroglobulin levels in patients with Graves\u2019 hyperthyroidism during antithyroid drug therapy. Eur J Endocrinol 131:125\u2013130","journal-title":"Eur J Endocrinol"},{"key":"1144_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1136\/adc.78.3.207","volume":"78","author":"TD Cheetham","year":"1998","unstructured":"Cheetham TD, Hughes IA, Barnes ND et al (1998) Treatment of hyperthyroidism in young people. Arch Dis Child 78:207\u2013209. https:\/\/doi.org\/10.1136\/adc.78.3.207","journal-title":"Arch Dis Child"},{"key":"1144_CR26","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1056\/NEJM199104043241403","volume":"324","author":"K Hashizume","year":"1991","unstructured":"Hashizume K, Ichikawa K, Sakurai A, Suzuki S, Takeda T, Kobayashi M, Miyamoto T, Arai M, Nagasawa T (1991) Administration of thyroxine in treated Graves\u2019 disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med 324:947\u2013953. https:\/\/doi.org\/10.1056\/NEJM199104043241403","journal-title":"N Engl J Med"},{"key":"1144_CR27","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s4618-017-0626-x","volume":"40","author":"Y He","year":"2017","unstructured":"He Y, Li J, Zheng J, Khan Z, Qiang W, Gao F, Zhao Y, Shi B (2017) Emphasis on the early diagnosis of antithyroid drug-induced agranulocytosis: retrospective analysis over 16 years at one Chinese center. J Endocrinol Invest 40:733\u2013740. https:\/\/doi.org\/10.1007\/s4618-017-0626-x","journal-title":"J Endocrinol Invest"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01144-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-019-01144-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01144-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:53:00Z","timestamp":1605055980000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-019-01144-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["1144"],"URL":"https:\/\/doi.org\/10.1007\/s40618-019-01144-0","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"7 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors do not have conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional regulations and with the 1964 Helsinki declaration and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from parents or legal guardians of all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}