{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:23Z","timestamp":1791434243691,"version":"4.3.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1007\/s40618-019-01162-y","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T14:03:26Z","timestamp":1577109806000},"page":"677-682","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hypercalciuria: its value as a predictive risk factor for nephrolithiasis in asymptomatic primary hyperparathyroidism?"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0277-1648","authenticated-orcid":false,"given":"F.","family":"Saponaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cetani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Mazoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Apicella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Di Giulio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Carlucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Scalese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Pardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Borsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Bilezikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Marcocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"1162_CR1","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1056\/nejmcp1106636","volume":"365","author":"C Marcocci","year":"2011","unstructured":"Marcocci C, Cetani F (2011) Clinical practice: primary hyperparathyroidism. N Engl J Med 365:2389\u20132397. https:\/\/doi.org\/10.1056\/nejmcp1106636","journal-title":"N Engl J Med"},{"key":"1162_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2015.03.015","author":"C Marcocci","year":"2015","unstructured":"Marcocci C, Saponaro F (2015) Epidemiology, pathogenesis of primary hyperparathyroidism: Current data. Ann Endocrinol (Paris). https:\/\/doi.org\/10.1016\/j.ando.2015.03.015","journal-title":"Ann Endocrinol (Paris)"},{"key":"1162_CR3","doi-asserted-by":"publisher","first-page":"16033","DOI":"10.1038\/nrdp.2016.33","volume":"2","author":"JP Bilezikian","year":"2016","unstructured":"Bilezikian JP, Cusano NE, Khan AA et al (2016) Primary hyperparathyroidism. Nat Rev Dis Prim 2:16033. https:\/\/doi.org\/10.1038\/nrdp.2016.33","journal-title":"Nat Rev Dis Prim"},{"key":"1162_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrendo.2017.104","volume":"14","author":"MD Walker","year":"2018","unstructured":"Walker MD, Silverberg SJ (2018) Primary hyperparathyroidism. Nat Rev Endocrinol 14:115\u2013125. https:\/\/doi.org\/10.1038\/nrendo.2017.104","journal-title":"Nat Rev Endocrinol"},{"key":"1162_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1318-1","author":"F Saponaro","year":"2018","unstructured":"Saponaro F, Marcocci C, Cacciatore F et al (2018) Clinical profile of juvenile primary hyperparathyroidism: a prospective study. Endocrine. https:\/\/doi.org\/10.1007\/s12020-017-1318-1","journal-title":"Endocrine"},{"key":"1162_CR6","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1210\/jc.2014-1413","volume":"99","author":"JP Bilezikian","year":"2014","unstructured":"Bilezikian JP, Brandi ML, Eastell R et al (2014) Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the fourth international workshop. J Clin Endocrinol Metab 99:3561\u20133569. https:\/\/doi.org\/10.1210\/jc.2014-1413","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1760","author":"SJ Silverberg","year":"2009","unstructured":"Silverberg SJ, Lewiecki EM, Mosekilde L et al (2009) Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jc.2008-1760","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374602-3.00040-7","author":"MJ Favus","year":"2010","unstructured":"Favus MJ (2010) Hypercalciuria. Osteoporos Men. https:\/\/doi.org\/10.1016\/B978-0-12-374602-3.00040-7","journal-title":"Osteoporos Men"},{"key":"1162_CR9","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3160","author":"JM Suh","year":"2008","unstructured":"Suh JM, Cronan JJ, Monchik JM (2008) Primary hyperparathyroidism: Is there an increased prevalence of renal stone disease? Am J Roentgenol. https:\/\/doi.org\/10.2214\/AJR.07.3160","journal-title":"Am J Roentgenol"},{"key":"1162_CR10","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1210\/jc.2014-3708","volume":"100","author":"C Cipriani","year":"2015","unstructured":"Cipriani C, Biamonte F, Costa AG et al (2015) Prevalence of kidney stones and vertebral fractures in primary hyperparathyroidism using imaging technology. J Clin Endocrinol Metab 100:1309\u20131315. https:\/\/doi.org\/10.1210\/jc.2014-3708","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.01.028","author":"AD Berger","year":"2009","unstructured":"Berger AD, Wu W, Eisner BH et al (2009) Patients with primary hyperparathyroidism\u2014why do some form stones? J Urol. https:\/\/doi.org\/10.1016\/j.juro.2009.01.028","journal-title":"J Urol"},{"key":"1162_CR12","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s40620-016-0329-y","volume":"29","author":"G Gambaro","year":"2016","unstructured":"Gambaro G, Croppi E, Coe F et al (2016) Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement. J Nephrol 29:715\u2013734. https:\/\/doi.org\/10.1007\/s40620-016-0329-y","journal-title":"J Nephrol"},{"key":"1162_CR13","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1046\/j.1365-2265.2003.01696.x","volume":"58","author":"F Cetani","year":"2003","unstructured":"Cetani F, Pardi E, Borsari S et al (2003) Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation. Clin Endocrinol (Oxf) 58:199\u2013206. https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01696.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1162_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0931-8","author":"G Viccica","year":"2016","unstructured":"Viccica G, Cetani F, Vignali E et al (2016) Impact of vitamin D deficiency on the clinical and biochemical phenotype in women with sporadic primary hyperparathyroidism. Endocrine. https:\/\/doi.org\/10.1007\/s12020-016-0931-8","journal-title":"Endocrine"},{"key":"1162_CR15","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med. https:\/\/doi.org\/10.7326\/0003-4819-150-9-200905050-00006","journal-title":"Ann Intern Med"},{"key":"1162_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-018-0879-z","author":"F Saponaro","year":"2018","unstructured":"Saponaro F, Cetani F, Repaci A et al (2018) Clinical presentation and management of patients with primary hyperparathyroidism in Italy. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-018-0879-z","journal-title":"J Endocrinol Invest"},{"key":"1162_CR17","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/07435800.2018.1431275","volume":"43","author":"YKD Tay","year":"2018","unstructured":"Tay YKD, Liu M, Bandeira L et al (2018) Occult urolithiasis in asymptomatic primary hyperparathyroidism. Endocr Res 43:106\u2013115. https:\/\/doi.org\/10.1080\/07435800.2018.1431275","journal-title":"Endocr Res"},{"key":"1162_CR18","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1210\/jc.2018-00923","volume":"103","author":"H Ejlsmark-Svensson","year":"2018","unstructured":"Ejlsmark-Svensson H, Bislev LS, Rolighed L et al (2018) Predictors of renal function and calcifications in primary hyperparathyroidism: a nested case-control study. J Clin Endocrinol Metab 103:3574\u20133583. https:\/\/doi.org\/10.1210\/jc.2018-00923","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR19","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.4158\/EP14074.OR","volume":"20","author":"S Cassibba","year":"2014","unstructured":"Cassibba S, Pellegrino M, Gianotti L et al (2014) Silent renal stones in primary hyperparathyroidism: prevalence and clinical features. Endocr Pract 20:1137\u20131142. https:\/\/doi.org\/10.4158\/EP14074.OR","journal-title":"Endocr Pract"},{"key":"1162_CR20","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00423-016-1520-2","volume":"402","author":"A Selberherr","year":"2017","unstructured":"Selberherr A, H\u00f6rmann M, Prager G et al (2017) \u201cSilent\u201d kidney stones in \u201casymptomatic\u201d primary hyperparathyroidism\u2014a comparison of multidetector computed tomography and ultrasound. Langenbeck\u2019s Arch Surg 402:289\u2013293. https:\/\/doi.org\/10.1007\/s00423-016-1520-2","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"1162_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90346-F","author":"SJ Silverberg","year":"1990","unstructured":"Silverberg SJ, Shane E, Jacobs TP et al (1990) Nephrolithiasis and bone involvement in primary hyperparathyroidism. Am J Med. https:\/\/doi.org\/10.1016\/0002-9343(90)90346-F","journal-title":"Am J Med"},{"key":"1162_CR22","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/BF03345354","volume":"28","author":"S Corbetta","year":"2005","unstructured":"Corbetta S, Baccarelli A, Aroldi A et al (2005) Risk factors associated to kidney stones in primary hyperparathyroidism. J Endocrinol Invest 28:122\u2013128","journal-title":"J Endocrinol Invest"},{"key":"1162_CR23","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.1210\/jc.2014-1415","volume":"99","author":"SJ Silverberg","year":"2014","unstructured":"Silverberg SJ, Clarke BL, Peacock M et al (2014) Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the fourth international workshop. J Clin Endocrinol Metab 99:3580\u20133594. https:\/\/doi.org\/10.1210\/jc.2014-1415","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80051-1","author":"JA Soreide","year":"1996","unstructured":"Soreide JA, Van Heerden JA, Grant CS et al (1996) Characteristics of patients surgically treated for primary hyperparathyroidism with and without renal stones. Surgery. https:\/\/doi.org\/10.1016\/S0039-6060(96)80051-1","journal-title":"Surgery"},{"issue":"9","key":"1162_CR25","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s40618-019-01025-6","volume":"42","author":"B Madeo","year":"2019","unstructured":"Madeo B, De Vincentis S, Kara E, Vescini F, Trenti T, Guaraldi G, Rochira V (2019) Reliability of calcium-phosphorus (Ca\/P) ratio as a new, accurate and inexpensive tool in the diagnosis of some Ca-P disorders. J Endocrinol Invest 42(9):1041\u20131049. https:\/\/doi.org\/10.1007\/s40618-019-01025-6","journal-title":"J Endocrinol Invest"},{"key":"1162_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.01.016","author":"MA Elkoushy","year":"2014","unstructured":"Elkoushy MA, Yu AX, Tabah R et al (2014) Determinants of urolithiasis before and after parathyroidectomy in patients with primary hyperparathyroidism. Urology. https:\/\/doi.org\/10.1016\/j.urology.2014.01.016","journal-title":"Urology"},{"key":"1162_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002708","author":"GC Curhan","year":"2008","unstructured":"Curhan GC, Taylor EN (2008) 24-h uric acid excretion and the risk of kidney stones. Kidney Int. https:\/\/doi.org\/10.1038\/sj.ki.5002708","journal-title":"Kidney Int"},{"key":"1162_CR28","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1210\/jc.2011-0569","volume":"96","author":"L Rejnmark","year":"2011","unstructured":"Rejnmark L, Vestergaard P, Mosekilde L (2011) Nephrolithiasis and renal calcifications in primary hyperparathyroidism. J Clin Endocrinol Metab 96:2377\u20132385. https:\/\/doi.org\/10.1210\/jc.2011-0569","journal-title":"J Clin Endocrinol Metab"},{"key":"1162_CR29","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00240-007-0096-2","volume":"35","author":"CV Odvina","year":"2007","unstructured":"Odvina CV, Sakhaee K, Heller HJ et al (2007) Biochemical characterization of primary hyperparathyroidism with and without kidney stones. Urol Res 35:123\u2013128. https:\/\/doi.org\/10.1007\/s00240-007-0096-2","journal-title":"Urol Res"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01162-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-019-01162-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-01162-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:37:22Z","timestamp":1608597442000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-019-01162-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["1162"],"URL":"https:\/\/doi.org\/10.1007\/s40618-019-01162-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]},"assertion":[{"value":"28 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has been approved by the appropriate institutional and\/or national research ethics committee and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human research"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}