{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:47:43Z","timestamp":1793155663189,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003062","name":"Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TTU-2015-5672"],"award-info":[{"award-number":["TTU-2015-5672"]}],"id":[{"id":"10.13039\/501100003062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s40618-019-1002-9","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:25:46Z","timestamp":1546997146000},"page":"923-930","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypothalamic\u2013pituitary\u2013adrenal axis function in traumatic spinal cord injury-related neuropathic pain: a case\u2013control study"],"prefix":"10.1007","volume":"42","author":[{"given":"E.","family":"Cuce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Cuce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,9]]},"reference":[{"issue":"Suppl 1","key":"1002_CR1","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.pain.2012.12.007","volume":"154","author":"NB Finnerup","year":"2013","unstructured":"Finnerup NB (2013) Pain in patients with spinal cord injury. Pain 154(Suppl 1):S71\u2013S76. \n                    https:\/\/doi.org\/10.1016\/j.pain.2012.12.007","journal-title":"Pain"},{"issue":"1","key":"1002_CR2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ejp.905","volume":"21","author":"D Burke","year":"2017","unstructured":"Burke D, Fullen BM, Stokes D, Lennon O (2017) Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis. Eur J Pain 21(1):29\u201344. \n                    https:\/\/doi.org\/10.1002\/ejp.905","journal-title":"Eur J Pain"},{"issue":"6","key":"1002_CR3","doi-asserted-by":"publisher","first-page":"489","DOI":"10.2340\/16501977-2241","volume":"49","author":"R Muller","year":"2017","unstructured":"Muller R, Landmann G, Bechir M, Hinrichs T, Arnet U, Jordan X, Brinkhof MWG (2017) Chronic pain, depression and quality of life in individuals with spinal cord injury: mediating role of participation. J Rehabil Med 49(6):489\u2013496. \n                    https:\/\/doi.org\/10.2340\/16501977-2241","journal-title":"J Rehabil Med"},{"issue":"1","key":"1002_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.expneurol.2007.05.019","volume":"207","author":"KM Lucin","year":"2007","unstructured":"Lucin KM, Sanders VM, Jones TB, Malarkey WB, Popovich PG (2007) Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation. Exp Neurol 207(1):75\u201384. \n                    https:\/\/doi.org\/10.1016\/j.expneurol.2007.05.019","journal-title":"Exp Neurol"},{"issue":"6","key":"1002_CR5","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1590\/0004-282x20170048","volume":"75","author":"C Rouanet","year":"2017","unstructured":"Rouanet C, Reges D, Rocha E, Gagliardi V, Silva GS (2017) Traumatic spinal cord injury: current concepts and treatment update. Arq Neuropsiquiatr 75(6):387\u2013393. \n                    https:\/\/doi.org\/10.1590\/0004-282x20170048","journal-title":"Arq Neuropsiquiatr"},{"issue":"21","key":"1002_CR6","doi-asserted-by":"publisher","first-page":"9355","DOI":"10.1523\/JNEUROSCI.19-21-09355.1999","volume":"19","author":"P Yan","year":"1999","unstructured":"Yan P, Xu J, Li Q, Chen S, Kim GM, Hsu CY, Xu XM (1999) Glucocorticoid receptor expression in the spinal cord after traumatic injury in adult rats. J Neurosci 19(21):9355\u20139363","journal-title":"J Neurosci"},{"issue":"1","key":"1002_CR7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.4103\/1673-5374.175039","volume":"11","author":"KM Madalena","year":"2016","unstructured":"Madalena KM, Lerch JK (2016) Glucocorticoids and nervous system plasticity. Neural Regen Res 11(1):37","journal-title":"Neural Regen Res"},{"issue":"39","key":"1002_CR8","doi-asserted-by":"publisher","first-page":"8595","DOI":"10.1523\/jneurosci.3058-04.2004","volume":"24","author":"S Wang","year":"2004","unstructured":"Wang S, Lim G, Zeng Q, Sung B, Ai Y, Guo G, Yang L, Mao J (2004) Expression of central glucocorticoid receptors after peripheral nerve injury contributes to neuropathic pain behaviors in rats. J Neurosci 24(39):8595\u20138605. \n                    https:\/\/doi.org\/10.1523\/jneurosci.3058-04.2004","journal-title":"J Neurosci"},{"issue":"3","key":"1002_CR9","doi-asserted-by":"publisher","first-page":"e91393","DOI":"10.1371\/journal.pone.0091393","volume":"9","author":"GM Coz Le","year":"2014","unstructured":"Le Coz GM, Anton F, Hanesch U (2014) Glucocorticoid-mediated enhancement of glutamatergic transmission may outweigh anti-inflammatory effects under conditions of neuropathic pain. PLoS One 9(3):e91393. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0091393","journal-title":"PLoS One"},{"issue":"2","key":"1002_CR10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.brainres.2005.03.005","volume":"1044","author":"SF Bomholt","year":"2005","unstructured":"Bomholt SF, Mikkelsen JD, Blackburn-Munro G (2005) Normal hypothalamo-pituitary-adrenal axis function in a rat model of peripheral neuropathic pain. Brain Res 1044(2):216\u2013226. \n                    https:\/\/doi.org\/10.1016\/j.brainres.2005.03.005","journal-title":"Brain Res"},{"issue":"1\u20132","key":"1002_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.physbeh.2006.03.012","volume":"88","author":"YM Ulrich-Lai","year":"2006","unstructured":"Ulrich-Lai YM, Xie W, Meij JT, Dolgas CM, Yu L, Herman JP (2006) Limbic and HPA axis function in an animal model of chronic neuropathic pain. Physiol Behav 88(1\u20132):67\u201376. \n                    https:\/\/doi.org\/10.1016\/j.physbeh.2006.03.012","journal-title":"Physiol Behav"},{"issue":"6","key":"1002_CR12","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/jnr.23881","volume":"95","author":"JL Kramer","year":"2017","unstructured":"Kramer JL, Minhas NK, Jutzeler CR, Erskine EL, Liu LJ, Ramer MS (2017) Neuropathic pain following traumatic spinal cord injury: models, measurement, and mechanisms. J Neurosci Res 95(6):1295\u20131306. \n                    https:\/\/doi.org\/10.1002\/jnr.23881","journal-title":"J Neurosci Res"},{"key":"1002_CR13","doi-asserted-by":"publisher","first-page":"2480689","DOI":"10.1155\/2017\/2480689","volume":"2017","author":"YS Gwak","year":"2017","unstructured":"Gwak YS, Hulsebosch CE (2017) Neuronal-glial interactions maintain chronic neuropathic pain after spinal cord injury. Neural Plast 2017:2480689. \n                    https:\/\/doi.org\/10.1155\/2017\/2480689","journal-title":"Neural Plast"},{"issue":"3","key":"1002_CR14","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.pmr.2014.04.001","volume":"25","author":"S Kirshblum","year":"2014","unstructured":"Kirshblum S, Waring W 3rd (2014) Updates for the international standards for neurological classification of spinal cord injury. Phys Med Rehabil Clin N Am 25(3):505\u2013517, vii. \n                    https:\/\/doi.org\/10.1016\/j.pmr.2014.04.001","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"6","key":"1002_CR15","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/sc.2011.156","volume":"50","author":"TN Bryce","year":"2012","unstructured":"Bryce TN, Biering-Sorensen F, Finnerup NB, Cardenas DD, Defrin R, Lundeberg T, Norrbrink C, Richards JS, Siddall P, Stripling T, Treede RD, Waxman SG, Widerstrom-Noga E, Yezierski RP, Dijkers M (2012) International spinal cord injury pain classification: part I. Background and description. March 6\u20137, 2009. Spinal Cord 50(6):413\u2013417. \n                    https:\/\/doi.org\/10.1038\/sc.2011.156","journal-title":"Spinal Cord"},{"issue":"1\u20132","key":"1002_CR16","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S0304-3959(00)00482-6","volume":"92","author":"M Bennett","year":"2001","unstructured":"Bennett M (2001) The LANSS Pain Scale: the Leeds assessment of neuropathic symptoms and signs. Pain 92(1\u20132):147\u2013157","journal-title":"Pain"},{"issue":"2","key":"1002_CR17","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s11102-010-0270-3","volume":"14","author":"Z Karaca","year":"2011","unstructured":"Karaca Z, Lale A, Tanriverdi F, Kula M, Unluhizarci K, Kelestimur F (2011) The comparison of low and standard dose ACTH and glucagon stimulation tests in the evaluation of hypothalamo\u2013pituitary\u2013adrenal axis in healthy adults. Pituitary 14(2):134\u2013140. \n                    https:\/\/doi.org\/10.1007\/s11102-010-0270-3","journal-title":"Pituitary"},{"issue":"7","key":"1002_CR18","first-page":"1374","volume":"25","author":"EN Griep","year":"1998","unstructured":"Griep EN, Boersma JW, Lentjes EG, Prins AP, van der Korst JK, de Kloet ER (1998) Function of the hypothalamic\u2013pituitary\u2013adrenal axis in patients with fibromyalgia and low back pain. J Rheumatol 25(7):1374\u20131381","journal-title":"J Rheumatol"},{"key":"1002_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/1471-2474-15-227","volume":"15","author":"E Generaal","year":"2014","unstructured":"Generaal E, Vogelzangs N, Macfarlane GJ, Geenen R, Smit JH, Penninx BW, Dekker J (2014) Reduced hypothalamic\u2013pituitary\u2013adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders. BMC Musculoskelet Disord 15:227. \n                    https:\/\/doi.org\/10.1186\/1471-2474-15-227","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"1002_CR20","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00006842-199805000-00017","volume":"60","author":"C Heim","year":"1998","unstructured":"Heim C, Ehlert U, Hanker JP, Hellhammer DH (1998) Abuse-related posttraumatic stress disorder and alterations of the hypothalamic\u2013pituitary\u2013adrenal axis in women with chronic pelvic pain. Psychosom Med 60(3):309\u2013318","journal-title":"Psychosom Med"},{"issue":"8","key":"1002_CR21","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/S0003-9993(99)90075-8","volume":"80","author":"YH Wang","year":"1999","unstructured":"Wang YH, Huang TS (1999) Impaired adrenal reserve in men with spinal cord injury: results of low- and high-dose adrenocorticotropin stimulation tests. Arch Phys Med Rehabil 80(8):863\u2013866","journal-title":"Arch Phys Med Rehabil"},{"issue":"2","key":"1002_CR22","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1097\/00002060-199803000-00004","volume":"77","author":"TS Huang","year":"1998","unstructured":"Huang TS, Wang YH, Lee SH, Lai JS (1998) Impaired hypothalamus\u2013pituitary\u2013adrenal axis in men with spinal cord injuries. Am J Phys Med Rehabil 77(2):108\u2013112","journal-title":"Am J Phys Med Rehabil"},{"issue":"9","key":"1002_CR23","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1016\/j.psyneuen.2012.02.016","volume":"37","author":"JY Park","year":"2012","unstructured":"Park JY, Ahn RS (2012) Hypothalamic-pituitary-adrenal axis function in patients with complex regional pain syndrome type 1. Psychoneuroendocrinology 37(9):1557\u20131568. \n                    https:\/\/doi.org\/10.1016\/j.psyneuen.2012.02.016","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"1002_CR24","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/sc.2014.184","volume":"53","author":"DJ Allison","year":"2015","unstructured":"Allison DJ, Ditor DS (2015) Immune dysfunction and chronic inflammation following spinal cord injury. Spinal Cord 53(1):14\u201318. \n                    https:\/\/doi.org\/10.1038\/sc.2014.184","journal-title":"Spinal Cord"},{"issue":"11","key":"1002_CR25","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/j.apmr.2007.08.004","volume":"88","author":"AL Davies","year":"2007","unstructured":"Davies AL, Hayes KC, Dekaban GA (2007) Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. Arch Phys Med Rehabil 88(11):1384\u20131393. \n                    https:\/\/doi.org\/10.1016\/j.apmr.2007.08.004","journal-title":"Arch Phys Med Rehabil"},{"issue":"3","key":"1002_CR26","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.semarthrit.2013.04.008","volume":"43","author":"RH Straub","year":"2013","unstructured":"Straub RH, Bijlsma JW, Masi A, Cutolo M (2013) Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases\u2014the 10-year update. Semin Arthritis Rheum 43(3):392\u2013404. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2013.04.008","journal-title":"Semin Arthritis Rheum"},{"issue":"11","key":"1002_CR27","doi-asserted-by":"publisher","first-page":"e0166842","DOI":"10.1371\/journal.pone.0166842","volume":"11","author":"J Tenk","year":"2016","unstructured":"Tenk J, Matrai P, Hegyi P, Rostas I, Garami A, Szabo I, Solymar M, Petervari E, Czimmer J, Marta K, Miko A, Furedi N, Parniczky A, Zsiboras C, Balasko M (2016) In obesity, HPA axis activity does not increase with BMI, but declines with aging: a meta-analysis of clinical studies. PLoS One 11(11):e0166842. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0166842","journal-title":"PLoS One"},{"issue":"7","key":"1002_CR28","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1046\/j.1468-2982.1996.1607476.x","volume":"16","author":"M Strittmatter","year":"1996","unstructured":"Strittmatter M, Grauer MT, Fischer C, Hamann G, Hoffmann KH, Blaes F, Schimrigk K (1996) Autonomic nervous system and neuroendocrine changes in patients with idiopathic trigeminal neuralgia. Cephalalgia 16(7):476\u2013480. \n                    https:\/\/doi.org\/10.1046\/j.1468-2982.1996.1607476.x","journal-title":"Cephalalgia"},{"issue":"1","key":"1002_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1037\/0033-2909.133.1.25","volume":"133","author":"GE Miller","year":"2007","unstructured":"Miller GE, Chen E, Zhou ES (2007) If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 133(1):25\u201345. \n                    https:\/\/doi.org\/10.1037\/0033-2909.133.1.25","journal-title":"Psychol Bull"},{"issue":"2","key":"1002_CR30","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/cphy.c150015","volume":"6","author":"JP Herman","year":"2016","unstructured":"Herman JP, McKlveen JM, Ghosal S, Kopp B, Wulsin A, Makinson R, Scheimann J, Myers B (2016) Regulation of the hypothalamic\u2013pituitary\u2013adrenocortical stress response. Compr Physiol 6(2):603\u2013621. \n                    https:\/\/doi.org\/10.1002\/cphy.c150015","journal-title":"Compr Physiol"},{"issue":"1\u20133","key":"1002_CR31","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.ejphar.2005.09.045","volume":"524","author":"I Takasaki","year":"2005","unstructured":"Takasaki I, Kurihara T, Saegusa H, Zong S, Tanabe T (2005) Effects of glucocorticoid receptor antagonists on allodynia and hyperalgesia in mouse model of neuropathic pain. Eur J Pharmacol 524(1\u20133):80\u201383. \n                    https:\/\/doi.org\/10.1016\/j.ejphar.2005.09.045","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"1002_CR32","doi-asserted-by":"publisher","first-page":"60","DOI":"10.5115\/acb.2011.44.1.60","volume":"44","author":"EH Kim","year":"2011","unstructured":"Kim EH, Ryu DH, Hwang S (2011) The expression of corticotropin-releasing factor and its receptors in the spinal cord and dorsal root ganglion in a rat model of neuropathic pain. Anat Cell Biol 44(1):60\u201368. \n                    https:\/\/doi.org\/10.5115\/acb.2011.44.1.60","journal-title":"Anat Cell Biol"},{"key":"1002_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2202-15-35","volume":"15","author":"GM Coz Le","year":"2014","unstructured":"Le Coz GM, Fiatte C, Anton F, Hanesch U (2014) Differential neuropathic pain sensitivity and expression of spinal mediators in Lewis and Fischer 344 rats. BMC Neurosci 15:35. \n                    https:\/\/doi.org\/10.1186\/1471-2202-15-35","journal-title":"BMC Neurosci"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-1002-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-019-1002-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-019-1002-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T19:14:18Z","timestamp":1578510858000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-019-1002-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,9]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1002"],"URL":"https:\/\/doi.org\/10.1007\/s40618-019-1002-9","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,9]]},"assertion":[{"value":"20 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consents were signed by all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}