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In this meta-analysis, the prevalence of associated autoimmune disorders was investigated in PAS II and III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive search in MEDLINE and Embase databases identified 479 studies with the keywords of PAS II and PAS III. 18 records containing a total of 1312 patients fulfilled our inclusion criteria (original studies reporting at least 10 cases and containing the combination of other autoimmune disorders) and were selected for further analysis. A meta-analysis of prevalence was performed using the random-effects model with the calculation of 95% confidence intervals (CI). Results of each meta-analysis were displayed graphically using forest plots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Distinction between PAS II and PAS III was made in 842 cases, of which 177 and 665 were PAS II and III (21.1 vs 78.9%), respectively. The prevalence of Hashimoto\u2019s thyroiditis was significantly higher than that of Graves\u2019s disease (39% [95% CI 17\u201365%] vs. 4% [95% CI 0\u201310%], respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). In PAS II, Addison\u2019s disease (AD) coexisted with AITDs, T1DM or the combination of these conditions in 65, 18 and 10% of cases, respectively. In addition, one other endocrine and five non-endocrine organ-specific autoimmune disorders were reported. In PAS III, two other autoimmune endocrinopathies, six non-endocrine organ-specific, and four systemic autoimmune disorders were found in combination with AITDs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AITDs, T1DM and AD are the most common combinations in PAS, thus screening for these conditions seems to be reasonable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40618-020-01229-1","type":"journal-article","created":{"date-parts":[[2020,3,29]],"date-time":"2020-03-29T11:02:30Z","timestamp":1585479750000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Prevalence of other autoimmune diseases in polyglandular autoimmune syndromes type II and III"],"prefix":"10.1007","volume":"43","author":[{"given":"G.","family":"Pham-Dobor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Han\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"M\u00e1rta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"P\u00e1rniczky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gergics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sarl\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Er\u0151ss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-3877","authenticated-orcid":false,"given":"E.","family":"Mez\u0151si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,17]]},"reference":[{"issue":"10","key":"1229_CR1","doi-asserted-by":"publisher","first-page":"4769","DOI":"10.1210\/jc.2019-00602","volume":"104","author":"L Frommer","year":"2019","unstructured":"Frommer L, Kahaly GJ (2019) Autoimmune polyendocrinopathy. 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