{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:56:14Z","timestamp":1793321774436,"version":"4.5.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T00:00:00Z","timestamp":1610150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s40618-020-01496-y","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T10:06:18Z","timestamp":1610186778000},"page":"1767-1773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessment of non-traumatic vertebral fractures in Cushing\u2019s syndrome patients"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-8669","authenticated-orcid":false,"given":"T.","family":"Apayd\u0131n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-6313","authenticated-orcid":false,"given":"D. G.","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,9]]},"reference":[{"key":"1496_CR1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000061073","volume":"30","author":"G Kaltsas","year":"2002","unstructured":"Kaltsas G, Manetti L, Grossman AB (2002) Osteoporosis in Cushing\u2019s syndrome. Front Horm Res 30:60\u201372. https:\/\/doi.org\/10.1159\/000061073","journal-title":"Front Horm Res"},{"issue":"6","key":"1496_CR2","doi-asserted-by":"publisher","first-page":"766","DOI":"10.4103\/ijem.IJEM_160_18","volume":"22","author":"SH Rahaman","year":"2018","unstructured":"Rahaman SH, Jyotsna VP, Kandasamy D, Shreenivas V, Gupta N, Tandon N (2018) Bone health in patients with Cushing\u2019s syndrome. Indian J Endocrinol Metab 22(6):766\u2013769. https:\/\/doi.org\/10.4103\/ijem.IJEM_160_18","journal-title":"Indian J Endocrinol Metab"},{"issue":"1","key":"1496_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1530\/eje.0.1460051","volume":"146","author":"P Vestergaard","year":"2002","unstructured":"Vestergaard P, Lindholm J, Jorgensen JO, Hagen C, Hoeck HC, Laurberg P, Rejnmark L, Brixen K, Kristensen LO, Feldt-Rasmussen U, Mosekilde L (2002) Increased risk of osteoporotic fractures in patients with Cushing\u2019s syndrome. Eur J Endocrinol 146(1):51\u201356. https:\/\/doi.org\/10.1530\/eje.0.1460051","journal-title":"Eur J Endocrinol"},{"issue":"7","key":"1496_CR4","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00198-007-0514-x","volume":"19","author":"L Futo","year":"2008","unstructured":"Futo L, Toke J, Patocs A, Szappanos A, Varga I, Glaz E, Tulassay Z, Racz K, Toth M (2008) Skeletal differences in bone mineral area and content before and after cure of endogenous Cushing\u2019s syndrome. Osteoporos Int 19(7):941\u2013949. https:\/\/doi.org\/10.1007\/s00198-007-0514-x","journal-title":"Osteoporos Int"},{"issue":"5","key":"1496_CR5","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1210\/jc.2005-0582","volume":"91","author":"L Tauchmanova","year":"2006","unstructured":"Tauchmanova L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A (2006) Bone demineralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status. J Clin Endocrinol Metab 91(5):1779\u20131784. https:\/\/doi.org\/10.1210\/jc.2005-0582","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1496_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/BF03345601","volume":"31","author":"I Chiodini","year":"2008","unstructured":"Chiodini I, Torlontano M, Carnevale V, Trischitta V, Scillitani A (2008) Skeletal involvement in adult patients with endogenous hypercortisolism. J Endocrinol Investig 31(3):267\u2013276. https:\/\/doi.org\/10.1007\/BF03345601","journal-title":"J Endocrinol Investig"},{"issue":"4","key":"1496_CR7","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1007\/BF03345431","volume":"35","author":"G Arnaldi","year":"2012","unstructured":"Arnaldi G, Mancini T, Tirabassi G, Trementino L, Boscaro M (2012) Advances in the epidemiology, pathogenesis, and management of Cushing\u2019s syndrome complications. J Endocrinol Investig 35(4):434\u2013448. https:\/\/doi.org\/10.1007\/BF03345431","journal-title":"J Endocrinol Investig"},{"issue":"5","key":"1496_CR8","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1365-2265.2009.03528.x","volume":"71","author":"A Szappanos","year":"2009","unstructured":"Szappanos A, Patocs A, Toke J, Boyle B, Sereg M, Majnik J, Borgulya G, Varga I, Liko I, Racz K, Toth M (2009) BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism. Clin Endocrinol 71(5):636\u2013643. https:\/\/doi.org\/10.1111\/j.1365-2265.2009.03528.x","journal-title":"Clin Endocrinol"},{"issue":"3","key":"1496_CR9","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1530\/EJE-07-0137","volume":"157","author":"L Tauchmanova","year":"2007","unstructured":"Tauchmanova L, Pivonello R, De Martino MC, Rusciano A, De Leo M, Ruosi C, Mainolfi C, Lombardi G, Salvatore M, Colao A (2007) Effects of sex steroids on bone in women with subclinical or overt endogenous hypercortisolism. Eur J Endocrinol 157(3):359\u2013366. https:\/\/doi.org\/10.1530\/EJE-07-0137","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1496_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1507\/endocrj.50.1","volume":"50","author":"N Ohmori","year":"2003","unstructured":"Ohmori N, Nomura K, Ohmori K, Kato Y, Itoh T, Takano K (2003) Osteoporosis is more prevalent in adrenal than in pituitary Cushing\u2019s syndrome. Endocr J 50(1):1\u20137. https:\/\/doi.org\/10.1507\/endocrj.50.1","journal-title":"Endocr J"},{"key":"1496_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1007\/s11657-015-0244-1","volume":"10","author":"ZE Belaya","year":"2015","unstructured":"Belaya ZE, Hans D, Rozhinskaya LY, Dragunova NV, Sasonova NI, Solodovnikov AG, Tsoriev TT, Dzeranova LK, Melnichenko GA, Dedov II (2015) The risk factors for fractures and trabecular bone-score value in patients with endogenous Cushing\u2019s syndrome. Arch Osteoporos 10:44. https:\/\/doi.org\/10.1007\/s11657-015-0244-1","journal-title":"Arch Osteoporos"},{"issue":"3","key":"1496_CR12","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00198-013-2520-5","volume":"25","author":"L Trementino","year":"2014","unstructured":"Trementino L, Appolloni G, Ceccoli L, Marcelli G, Concettoni C, Boscaro M, Arnaldi G (2014) Bone complications in patients with Cushing\u2019s syndrome: looking for clinical, biochemical, and genetic determinants. Osteoporos Int 25(3):913\u2013921. https:\/\/doi.org\/10.1007\/s00198-013-2520-5","journal-title":"Osteoporos Int"},{"issue":"5","key":"1496_CR13","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1210\/jc.2008-0125","volume":"93","author":"LK Nieman","year":"2008","unstructured":"Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM (2008) The diagnosis of Cushing\u2019s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93(5):1526\u20131540. https:\/\/doi.org\/10.1210\/jc.2008-0125","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1496_CR14","doi-asserted-by":"publisher","first-page":"3888","DOI":"10.1210\/jc.2016-2118","volume":"101","author":"M Fleseriu","year":"2016","unstructured":"Fleseriu M, Hashim IA, Karavitaki N, Melmed S, Murad MH, Salvatori R, Samuels MH (2016) Hormonal replacement in hypopituitarism in adults: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 101(11):3888\u20133921. https:\/\/doi.org\/10.1210\/jc.2016-2118","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"1496_CR15","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1210\/jc.2011-0179","volume":"96","author":"ME Molitch","year":"2011","unstructured":"Molitch ME, Clemmons DR, Malozowski S, Merriam GR, Vance ML, Endocrine S (2011) Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96(6):1587\u20131609. https:\/\/doi.org\/10.1210\/jc.2011-0179","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"1496_CR16","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8(9):1137\u20131148. https:\/\/doi.org\/10.1002\/jbmr.5650080915","journal-title":"J Bone Miner Res"},{"issue":"11","key":"1496_CR17","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1007\/s00198-004-1616-3","volume":"15","author":"M Minetto","year":"2004","unstructured":"Minetto M, Reimondo G, Osella G, Ventura M, Angeli A, Terzolo M (2004) Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing\u2019s syndrome. Osteoporos Int 15(11):855\u2013861. https:\/\/doi.org\/10.1007\/s00198-004-1616-3","journal-title":"Osteoporos Int"},{"issue":"4","key":"1496_CR18","first-page":"137","volume":"65","author":"AW van der Eerden","year":"2007","unstructured":"van der Eerden AW, den Heijer M, Oyen WJ, Hermus AR (2007) Cushing\u2019s syndrome and bone mineral density: lowest Z scores in young patients. Neth J Med 65(4):137\u2013141","journal-title":"Neth J Med"},{"issue":"3","key":"1496_CR19","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1530\/EJE-11-0272","volume":"165","author":"E Valassi","year":"2011","unstructured":"Valassi E, Santos A, Yaneva M, Toth M, Strasburger CJ, Chanson P, Wass JA, Chabre O, Pfeifer M, Feelders RA, Tsagarakis S, Trainer PJ, Franz H, Zopf K, Zacharieva S, Lamberts SW, Tabarin A, Webb SM, Group ES (2011) The European Registry on Cushing\u2019s syndrome: 2-year experience baseline demographic and clinical characteristics. Eur J Endocrinol 165(3):383\u2013392. https:\/\/doi.org\/10.1530\/EJE-11-0272","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"1496_CR20","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11102-011-0306-3","volume":"15","author":"ME Randazzo","year":"2012","unstructured":"Randazzo ME, Grossrubatscher E, Dalino Ciaramella P, Vanzulli A, Loli P (2012) Spontaneous recovery of bone mass after cure of endogenous hypercortisolism. Pituitary 15(2):193\u2013201. https:\/\/doi.org\/10.1007\/s11102-011-0306-3","journal-title":"Pituitary"},{"issue":"3","key":"1496_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1023\/a:1015362822901","volume":"4","author":"A Faggiano","year":"2001","unstructured":"Faggiano A, Pivonello R, Filippella M, Di Somma C, Orio F Jr, Lombard G, Colao A (2001) Spine abnormalities and damage in patients cured from Cushing\u2019s disease. Pituitary 4(3):153\u2013161. https:\/\/doi.org\/10.1023\/a:1015362822901","journal-title":"Pituitary"},{"issue":"1","key":"1496_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1530\/eje.1.02067","volume":"154","author":"C Kristo","year":"2006","unstructured":"Kristo C, Jemtland R, Ueland T, Godang K, Bollerslev J (2006) Restoration of the coupling process and normalization of bone mass following successful treatment of endogenous Cushing\u2019s syndrome: a prospective, long-term study. Eur J Endocrinol 154(1):109\u2013118. https:\/\/doi.org\/10.1530\/eje.1.02067","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1496_CR23","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1365-2265.1992.tb01437.x","volume":"36","author":"PJ Manning","year":"1992","unstructured":"Manning PJ, Evans MC, Reid IR (1992) Normal bone mineral density following cure of Cushing\u2019s syndrome. Clin Endocrinol 36(3):229\u2013234. https:\/\/doi.org\/10.1111\/j.1365-2265.1992.tb01437.x","journal-title":"Clin Endocrinol"},{"issue":"10","key":"1496_CR24","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1210\/jcem.80.10.7559865","volume":"80","author":"AR Hermus","year":"1995","unstructured":"Hermus AR, Smals AG, Swinkels LM, Huysmans DA, Pieters GF, Sweep CF, Corstens FH, Kloppenborg PW (1995) Bone mineral density and bone turnover before and after surgical cure of Cushing\u2019s syndrome. J Clin Endocrinol Metab 80(10):2859\u20132865. https:\/\/doi.org\/10.1210\/jcem.80.10.7559865","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"1496_CR25","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1007\/s001980170025","volume":"12","author":"G Luisetto","year":"2001","unstructured":"Luisetto G, Zangari M, Camozzi V, Boscaro M, Sonino N, Fallo F (2001) Recovery of bone mineral density after surgical cure, but not by ketoconazole treatment, in Cushing\u2019s syndrome. Osteoporos Int 12(11):956\u2013960. https:\/\/doi.org\/10.1007\/s001980170025","journal-title":"Osteoporos Int"},{"issue":"3","key":"1496_CR26","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1046\/j.1365-2265.2003.01713.x","volume":"58","author":"C Di Somma","year":"2003","unstructured":"Di Somma C, Pivonello R, Loche S, Faggiano A, Klain M, Salvatore M, Lombardi G, Colao A (2003) Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing\u2019s disease: a prospective study. Clin Endocrinol 58(3):302\u2013308. https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01713.x","journal-title":"Clin Endocrinol"},{"issue":"5","key":"1496_CR27","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1007\/s00268-007-9394-7","volume":"32","author":"A Kawamata","year":"2008","unstructured":"Kawamata A, Iihara M, Okamoto T, Obara T (2008) Bone mineral density before and after surgical cure of Cushing\u2019s syndrome due to adrenocortical adenoma: prospective study. World J Surg 32(5):890\u2013896. https:\/\/doi.org\/10.1007\/s00268-007-9394-7","journal-title":"World J Surg"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-020-01496-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-020-01496-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-020-01496-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T07:12:16Z","timestamp":1626419536000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-020-01496-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,9]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1496"],"URL":"https:\/\/doi.org\/10.1007\/s40618-020-01496-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,9]]},"assertion":[{"value":"20 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Tugce Apaydin and Dilek Gogas Yavuz declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients provided their consent for the use of their personal and medical information in the publication of this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}