{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T22:55:24Z","timestamp":1781045724142,"version":"3.54.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>The diagnosis of vitamin D deficiency is based on the determination of total plasma 25-hydroxyvitamin D (25-OHD) concentrations, but the regulation of vitamin D 25-hydroxylation is not a major consideration and very little information is available on this activity.<\/jats:p>\n                <jats:p>To check what factors could interfere with the activity of vitamin D-25-hydroxylase and thus alter the 25-OHD concentrations, we looked for potential correlations between 25-OHD and results of liver function tests in healthy adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This single-centre study was retrospective and consisted of evaluating the correlations between 25-OHD and the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and bone alkaline phosphatase (BALP) in 349 healthy subjects aged from 18 to 65\u00a0years. In particular, in Group 1 (<jats:italic>n<\/jats:italic>\u2009=\u2009119), we looked for correlations between 25OHD and all liver function tests and in Group 2 (<jats:italic>n<\/jats:italic>\u2009=\u2009230) the correlation between 25OHD and BALP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In Group 1, we found no correlation between 25OHD and AST (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.03; <jats:italic>p<\/jats:italic>\u2009=\u20090.8), ALT (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.02; <jats:italic>p<\/jats:italic>\u2009=\u20090.91), GGT (r\u2009=\u2009\u2009\u2212\u20090.08; p\u2009=\u20090.68), direct bilirubin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.02; <jats:italic>p<\/jats:italic>\u2009=\u20090.89), indirect bilirubin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.24; <jats:italic>p<\/jats:italic>\u2009=\u20090.21), and total bilirubin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.24; <jats:italic>p<\/jats:italic>\u2009=\u20090.21) but one between 25OHD and ALP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.007); in Group 2, we found a significant negative correlation between 25-OHD and BALP (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2009\u2212\u20090.2; <jats:italic>p<\/jats:italic>\u2009=\u20090.0008).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The correlations that we found suggest that ALP and BALP might be involved in the regulation of vitamin D-25-hydroxylase activity, but further studies are mandatory to confirm our assumptions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-021-01503-w","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T07:04:45Z","timestamp":1611558285000},"page":"1891-1896","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New insights into vitamin D regulation: is there a role for alkaline phosphatase?"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4748-321X","authenticated-orcid":false,"given":"G.","family":"Bellastella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Scappaticcio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Carotenuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. 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