{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:39:01Z","timestamp":1773974341573,"version":"3.50.1"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>COVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases are known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID pandemics imposed sudden changes in lifestyle and social isolation with consequent potential cardiometabolic sequelae. The present study aimed at investigating the impact of changes in lifestyle and social life on metabolic profile in hyperprolactinemic or osteoporotic patients without pre-existing cardiometabolic diseases at the time of COVID-19.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The primary study outcome measurement was the prevalence of obesity, arterial hypertension, impaired glucose tolerance (IGT) or diabetes mellitus (DM), dyslipidemia and metabolic syndrome after COVID-19 outbreak. Seventy-four patients (21 men and 53 women, aged 51.8\u2009\u00b1\u200917.8\u00a0years) were admitted to the outpatient clinic of the Neuroendocrine Disease Unit at University \u201cFederico II\u201d of Naples, Italy, as per their routine clinical practice because of tumoral and non-tumoral hyperprolactinemia in 52 patients (70.3%), and osteoporosis\/osteopenia in 22 (29.7%). Among female patients, 25 (47.2%) were at menopausal age.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At the end of lockdown, prevalence of obesity (from 37.8% to 51.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), dyslipidemia (from 28.4 to 48.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.003) and metabolic syndrome (from 14.9 to 27%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) significantly increased compared to pre-COVID evaluation. No significant change was found in the prevalence of arterial hypertension and IGT\/DM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>SARS-CoV-2 outbreak has led to a rapid increase in the prevalence of metabolic syndrome, potentially contributing to the increased COVID-19 related mortality.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-021-01563-y","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T09:02:51Z","timestamp":1622019771000},"page":"2845-2847","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Metabolic syndrome in the era of COVID-19 outbreak: impact of lockdown on cardiometabolic health"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-3419","authenticated-orcid":false,"given":"R. S.","family":"Auriemma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pirchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Liccardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Scairati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Del Vecchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-1348","authenticated-orcid":false,"given":"R.","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4049-2559","authenticated-orcid":false,"given":"A.","family":"Colao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"1563_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2020.05.027","author":"R Bracale","year":"2020","unstructured":"Bracale R, Vaccaro CM (2020) Changes in food choice following restrictive measures due to COVID-19. Nutr Metab Cardiovasc Dis. https:\/\/doi.org\/10.1016\/j.numecd.2020.05.027","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1563_CR2","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1056\/NEJMoa1200303","volume":"368","author":"R Estruch","year":"2013","unstructured":"Estruch R, Ros E, Salas-Salvad\u00f3 J, Covas MI, Corella D, Ar\u00f3s F, G\u00f3mez-Gracia E, Ruiz-Guti\u00e9rrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pint\u00f3 X, Basora J, Mu\u00f1oz MA, Sorl\u00ed JV, Mart\u00ednez JA, Mart\u00ednez-Gonz\u00e1lez MA (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368:1279\u20131290","journal-title":"N Engl J Med"},{"issue":"4","key":"1563_CR3","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1016\/S2213-2600(20)30116-8","volume":"8","author":"L Fang","year":"2020","unstructured":"Fang L, Karakiulakis G, Roth M (2020) Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med 8(4):e21","journal-title":"Lancet Respir Med"},{"issue":"7","key":"1563_CR4","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s40279-020-01295-8","volume":"50","author":"AJ King","year":"2020","unstructured":"King AJ, Burke LM, Halson SL, Hawley JA (2020) The challenge of maintaining metabolic health during a global pandemic. Sports Med 50(7):1233\u20131241","journal-title":"Sports Med"},{"key":"1563_CR5","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/S0140-6736(05)67402-8","volume":"366","author":"IDF The","year":"2005","unstructured":"The IDF, Alberti KG, Zimmet P, Shaw J (2005) IDF epidemiology task force consensus group. The metabolic syndromea new worldwide definition. Lancet 366:1059\u20131062","journal-title":"Lancet"},{"key":"1563_CR6","doi-asserted-by":"publisher","DOI":"10.2337\/dbi19-0023","author":"F Mauvais-Jarvis","year":"2020","unstructured":"Mauvais-Jarvis F (2020) Aging, male sex, obesity, and metabolic inflammation create the perfect storm for COVID-19. Diabetes. https:\/\/doi.org\/10.2337\/dbi19-0023","journal-title":"Diabetes"},{"issue":"6","key":"1563_CR7","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1037\/a0037618","volume":"140","author":"S Cacioppo","year":"2014","unstructured":"Cacioppo S, Capitanio JP, Cacioppo JT (2014) Toward a neurology of loneliness. Psychol Bull 140(6):1464\u20131504","journal-title":"Psychol Bull"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01563-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-021-01563-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01563-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T21:14:18Z","timestamp":1636233258000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-021-01563-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,26]]},"references-count":7,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1563"],"URL":"https:\/\/doi.org\/10.1007\/s40618-021-01563-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,26]]},"assertion":[{"value":"8 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}