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Data on CDU parameters at baseline and after 6 months with four different treatments were available and thus further longitudinally analyzed: local non-hormonal moisturizers (NH group), <jats:italic>n<\/jats:italic>\u2009=\u200937; transdermal 2% T gel 300 mcg\/day (T group), <jats:italic>n<\/jats:italic>\u2009=\u200923; local estrogens (E group), <jats:italic>n<\/jats:italic>\u2009=\u200912; combined therapy (T\u2009+\u2009E group), <jats:italic>n<\/jats:italic>\u2009=\u20099. Patients underwent physical, laboratory, and genital CDU examinations at both visits and completed different validated questionnaires, including the Female Sexual Function Index (FSFI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At 6-month visit, T therapy significantly increased clitoral artery peak systolic velocity (PSV) when compared to both NH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and E (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) groups. A similar increase was found in the T\u2009+\u2009E group (<jats:italic>p<\/jats:italic>\u2009=\u20090.039 vs. E). In addition, T treatment was associated with significantly higher FSFI desire, pain, arousal, lubrication, orgasm, and total scores at 6-month visit vs. baseline. Similar findings were observed in the T\u2009+\u2009E group. No significant differences in the variations of total and high-density lipoprotein-cholesterol, triglycerides, fasting glycemia, insulin and glycated hemoglobin levels were found among the four groups. No adverse events were observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In women complaining for FSD, systemic T administration, either alone or combined with local estrogens, was associated with a positive effect on clitoral blood flow and a clinical improvement in sexual function, showing a good safety profile.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration number<\/jats:title>\n                <jats:p>NCT04336891; date of registration: April 7, 2020.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-021-01598-1","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T05:02:39Z","timestamp":1623474159000},"page":"2765-2776","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Effects of testosterone treatment on clitoral haemodynamics in women with sexual dysfunction"],"prefix":"10.1007","volume":"44","author":[{"given":"S.","family":"Cipriani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Maseroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Di Stasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Scavello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Todisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Rastrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fambrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Petraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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