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The SPISE index correlated positively with the insulin sensitivity index (ISI) and the disposition index (DI), negatively with age, blood pressure, HOMA-IR, basal and 120\u00a0min blood glucose and insulin (all\n                      <jats:italic>p<\/jats:italic>\n                      values\u2009&lt;\u20090.001). A correlation between SPISE, HOMA-IR and ISI was also reported in normal-weight children. At the 6.5-year follow-up, lower basal SPISE\u2014but not ISI or HOMA-IR\u2014was an independent predictor of IGR development (OR\u2009=\u20093.89(1.65\u20139.13),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002; AUROC: 0.82(0.72\u20130.92),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children, low SPISE index is significantly associated with metabolic abnormalities and predicts the development of IGR in life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40618-021-01612-6","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T13:03:15Z","timestamp":1623934995000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The single-point insulin sensitivity estimator (SPISE) index is a strong predictor of abnormal glucose metabolism in overweight\/obese children: a long-term follow-up study"],"prefix":"10.1007","volume":"45","author":[{"given":"I.","family":"Barchetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bertoccini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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