{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:51:11Z","timestamp":1790776271501,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s40618-021-01711-4","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T21:04:44Z","timestamp":1638306284000},"page":"803-814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Screening for drugs potentially interfering with MCT8-mediated T3 transport in vitro identifies dexamethasone and some commonly used drugs as inhibitors of MCT8 activity"],"prefix":"10.1007","volume":"45","author":[{"given":"C.","family":"Di Cosmo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Agretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Dimida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Falcetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benvenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tonacchera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"issue":"1","key":"1711_CR1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1086\/380999","volume":"74","author":"AM Dumitrescu","year":"2004","unstructured":"Dumitrescu AM, Liao XH, Best TB, Brockmann K, Refetoff S (2004) A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. Am J Hum Genet 74(1):168\u2013175. https:\/\/doi.org\/10.1086\/380999","journal-title":"Am J Hum Genet"},{"key":"1711_CR2","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/S0140-6736(04)17226-7","volume":"364","author":"EC Friesema","year":"2004","unstructured":"Friesema EC, Grueters A, Biebermann H, Krude H, von Moers A, Reeser M, Barrett TG, Mancilla EE, Svensson J, Kester MH (2004) Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 364:1435\u20131437. https:\/\/doi.org\/10.1016\/S0140-6736(04)17226-7","journal-title":"Lancet"},{"issue":"7","key":"1711_CR3","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1016\/j.bbagen.2012.08.005","volume":"1830","author":"AM Dumitrescu","year":"2013","unstructured":"Dumitrescu AM, Refetoff S (2013) The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta 1830(7):3987\u20134003. https:\/\/doi.org\/10.1016\/j.bbagen.2012.08.005","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1711_CR4","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2133\/dmpk.23.22","volume":"23","author":"M Nishimura","year":"2008","unstructured":"Nishimura M, Naito S (2008) Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet 23(1):22\u201344. https:\/\/doi.org\/10.2133\/dmpk.23.22","journal-title":"Drug Metab Pharmacokinet"},{"issue":"3","key":"1711_CR5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/EJE-12-0177","volume":"167","author":"EC Friesema","year":"2012","unstructured":"Friesema EC, Visser TJ, Borgers AJ, Kalsbeek A, Swaab DF, Fliers E, Alkemade A (2012) Thyroid hormone transporters and deiodinases in the developing human hypothalamus. Eur J Endocrinol 167(3):379\u2013386. https:\/\/doi.org\/10.1530\/EJE-12-0177","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"1711_CR6","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1210\/en.2008-0378","volume":"149","author":"LM Roberts","year":"2008","unstructured":"Roberts LM, Woodford K, Zhou M, Black DS, Haggerty JE, Tate EH, Grindstaff KK, Mengesha W, Raman C, Zerangue N (2008) Expression of the thyroid hormone transporters monocarboxylate transporter-8 (SLC16A2) and organic ion transporter-14 (SLCO1C1) at the blood-brain barrier. Endocrinology 149(12):6251\u20136261. https:\/\/doi.org\/10.1210\/en.2008-0378","journal-title":"Endocrinology"},{"issue":"41","key":"1711_CR7","doi-asserted-by":"publisher","first-page":"40128","DOI":"10.1074\/jbc.m300909200","volume":"278","author":"EC Friesema","year":"2003","unstructured":"Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ (2003) Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem 278(41):40128\u201340135. https:\/\/doi.org\/10.1074\/jbc.m300909200","journal-title":"J Biol Chem"},{"issue":"11","key":"1711_CR8","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1210\/me.2005-0256","volume":"20","author":"EC Friesema","year":"2006","unstructured":"Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH (2006) Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol Endocrinol 20(11):2761\u20132772. https:\/\/doi.org\/10.1210\/me.2005-0256","journal-title":"Mol Endocrinol"},{"issue":"6","key":"1711_CR9","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1210\/me.2007-0112","volume":"22","author":"EC Friesema","year":"2008","unstructured":"Friesema EC, Jansen J, Jachtenberg J, Visser WE, Kester M, Visser T (2008) Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10. Mol Endocrinol 22(6):1357\u20131369. https:\/\/doi.org\/10.1210\/me.2007-0112","journal-title":"Mol Endocrinol"},{"issue":"12","key":"1711_CR10","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1007\/s00018-017-2461-9","volume":"74","author":"J Protz","year":"2017","unstructured":"Protz J, Braun D, Hinz KM, Bayer-Kusch D, Schweizer U, G. Krause G, (2017) Membrane-traversing mechanism of thyroid hormone transport by monocarboxylate transporter 8. Cell Mol Life Sci 74(12):2299\u20132318. https:\/\/doi.org\/10.1007\/s00018-017-2461-9","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"1711_CR11","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1210\/endrev\/bnz008","volume":"41","author":"S Groeneweg","year":"2020","unstructured":"Groeneweg S, van Geest FS, Peeters RP, Heuer H, Visser WE (2020) Thyroid HORMONE TRANSPORTERS. Endocr Rev 41(2):146\u2013201. https:\/\/doi.org\/10.1210\/endrev\/bnz008","journal-title":"Endocr Rev"},{"issue":"1","key":"1711_CR12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neulet.2010.04.055","volume":"478","author":"S Roth","year":"2010","unstructured":"Roth S, Kinne A, Schweizer U (2010) The tricyclic antidepressant desipramine inhibits T3 import into primary neurons. Neurosci Lett 478(1):5\u20138. https:\/\/doi.org\/10.1016\/j.neulet.2010.04.055","journal-title":"Neurosci Lett"},{"issue":"1","key":"1711_CR13","doi-asserted-by":"publisher","first-page":"E100","DOI":"10.1210\/jc.2011-1837","volume":"97","author":"D Braun","year":"2012","unstructured":"Braun D, Kim TD, le Coutre P, K\u00f6hrle J, Hershman JM, Schweizer U (2012) Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport. J Clin Endocrinol Metab 97(1):E100-105. https:\/\/doi.org\/10.1210\/jc.2011-1837","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"1711_CR14","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1089\/thy.2013.0660","volume":"24","author":"D Braun","year":"2014","unstructured":"Braun D, Schweizer U (2014) Authentic bosutinib inhibits triiodothyronine transport by monocarboxylate transporter 8. Thyroid 24(5):926\u2013927. https:\/\/doi.org\/10.1089\/thy.2013.0660","journal-title":"Thyroid"},{"key":"1711_CR15","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1210\/en.2015-1933","volume":"157","author":"J Johannes","year":"2016","unstructured":"Johannes J, Jayarama-Naidu R, Meyer F, Wirth EK, Schweizer U, Schomburg L, K\u00f6hrle J, Renko K (2016) A flavonolignan derived from the milk thistle, is a potent inhibitor of the thyroid hormone transporter MCT8. Endocrinology 157:1694\u20131701. https:\/\/doi.org\/10.1210\/en.2015-1933","journal-title":"Endocrinology"},{"issue":"1","key":"1711_CR16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2174\/1570163816666191125123142","volume":"18","author":"D Shaji","year":"2021","unstructured":"Shaji D (2021) Identification of inhibitors based on moleular docking: thyroid hormone transmembrane transporter MCT8 as a target. Curr Drug Discov Technol 18(1):105\u2013112. https:\/\/doi.org\/10.2174\/1570163816666191125123142","journal-title":"Curr Drug Discov Technol"},{"issue":"2","key":"1711_CR17","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1210\/en.2018-01034","volume":"160","author":"U Schweizer","year":"2019","unstructured":"Schweizer U, Braun D, Forrest D (2019) The ins and outs of steroid hormone transport across the plasma membrane: insight from an insect. Endocrinology 160(2):339\u2013340. https:\/\/doi.org\/10.1210\/en.2018-01034","journal-title":"Endocrinology"},{"issue":"6","key":"1711_CR18","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ejpn.2011.05.002","volume":"15","author":"SK Damsted","year":"2011","unstructured":"Damsted SK, Born AP, Paulson OB, Uldall P (2011) Exogenous glucocorticoids and adverse cerebral effects in children. Eur J Paediatr Neurol 15(6):465\u2013477. https:\/\/doi.org\/10.1016\/j.ejpn.2011.05.002","journal-title":"Eur J Paediatr Neurol"},{"issue":"5","key":"1711_CR19","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1210\/me.2015-1042","volume":"29","author":"ME Peffer","year":"2015","unstructured":"Peffer ME, Zhang JY, Umfrey L, Rudine AC, Monaghan AP, DeFranco DB (2015) Minireview: the impact of antenatal therapeutic synthetic glucocorticoids on the developing fetal brain. Mol Endocrinol 29(5):658\u2013666. https:\/\/doi.org\/10.1210\/me.2015-1042","journal-title":"Mol Endocrinol"},{"key":"1711_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.steroids.2016.05.012","volume":"114","author":"R Carson","year":"2016","unstructured":"Carson R, Monaghan-Nichols AP, DeFranco DB, Rudine AC (2016) Effects of antenatal glucocorticoids on the developing brain. Steroids 114:25\u201332. https:\/\/doi.org\/10.1016\/j.steroids.2016.05.012","journal-title":"Steroids"},{"issue":"2","key":"1711_CR21","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1210\/edrv.22.2.0427","volume":"22","author":"E Martino","year":"2001","unstructured":"Martino E, Bartalena L, Bogazzi F, Braverman LE (2001) The effects of amiodarone on the thyroid. Endoc Rev 22(2):240\u2013254. https:\/\/doi.org\/10.1210\/edrv.22.2.0427","journal-title":"Endoc Rev"},{"issue":"5","key":"1711_CR22","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1210\/endo-115-5-1710","volume":"115","author":"R Kannan","year":"1984","unstructured":"Kannan R, Ookhtens M, Chopra IJ, Singh BN (1984) Effects of chronic administration of amiodarone on kinetics of metabolism of iodothyronines. Endocrinology 115(5):1710\u20131716. https:\/\/doi.org\/10.1210\/endo-115-5-1710","journal-title":"Endocrinology"},{"issue":"4","key":"1711_CR23","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1476-5381.1970.tb09891.x","volume":"39","author":"BN Singh","year":"1970","unstructured":"Singh BN, Vaughan Williams EM (1970) The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol 39(4):657\u2013667. https:\/\/doi.org\/10.1111\/j.1476-5381.1970.tb09891.x","journal-title":"Br J Pharmacol"},{"issue":"1","key":"1711_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1530\/eje.0.1450059","volume":"145","author":"F Bogazzi","year":"2001","unstructured":"Bogazzi F, Bartalena L, Brogioni S, Burelli A, Raggi F, Ultimieri F, Cosci C, Vitale M, Fenzi G, Martino E (2001) Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level. Eur J Endocrinol 145(1):59\u201364. https:\/\/doi.org\/10.1530\/eje.0.1450059","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"1711_CR25","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1530\/eje-07-0017","volume":"156","author":"L Stoykov","year":"2007","unstructured":"Stoykov L, van Beeren HC, Moorman AFM, Christoffels VM, Wiersinga WM, Bakker O (2007) Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components. Eur J Endocrinol 156(6):695\u2013702. https:\/\/doi.org\/10.1530\/eje-07-0017","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1711_CR26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1677\/joe.0.1520413","volume":"152","author":"F Hudig","year":"1997","unstructured":"Hudig F, Bakker O, Wiersinga WM (1997) Tri-iodothyronine prevents the amiodarone-induced decrease in the expression of the liver low-density lipoprotein receptor gene. J Endocrinol 152(3):413\u2013421. https:\/\/doi.org\/10.1677\/joe.0.1520413","journal-title":"J Endocrinol"},{"issue":"1\u20132","key":"1711_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/s0014-5793(99)00453-6","volume":"450","author":"HC van Beeren","year":"1999","unstructured":"van Beeren HC, Bakker O, Chatterjee VK, Wiersinga WM (1999) Effect of mutations in the beta1-thyroid hormone receptor on the inhibition of T3 binding by desethylamiodarone. FEBS Lett 450(1\u20132):35\u201338. https:\/\/doi.org\/10.1016\/s0014-5793(99)00453-6","journal-title":"FEBS Lett"},{"issue":"2","key":"1711_CR28","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1210\/en.2002-220604","volume":"144","author":"HC van Beeren","year":"2003","unstructured":"van Beeren HC, Jong WMC, Kaptein E, Visser TJ, Bakker O, Wiersinga WM (2003) Dronerarone acts as a selective inhibitor of 3,5,3\u2032-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology 144(2):552\u2013558. https:\/\/doi.org\/10.1210\/en.2002-220604","journal-title":"Endocrinology"},{"key":"1711_CR29","doi-asserted-by":"publisher","unstructured":"Hall RC (1983) Psychiatric effects of thyroid hormone disturbance. Psychosomatics 24(1):7\u201311, 15\u201318. https:\/\/doi.org\/10.1016\/s0033-3182(83)73255-x","DOI":"10.1016\/s0033-3182(83)73255-x"},{"issue":"6","key":"1711_CR30","doi-asserted-by":"publisher","first-page":"448","DOI":"10.4088\/jcp.v62n0608","volume":"62","author":"BG Appelberg","year":"2001","unstructured":"Appelberg BG, Syvalahti EK, Koskinen TE, Mehtonen OP, Muhonen TT, Naukkarinen HH (2001) Patients with severe depression may benefit from buspirone augmentation of selective serotonin reuptake inhibitors: results from a placebo-controlled, randomized, double-blind, placebo wash-in study. J Clin Psychiatry 62(6):448\u2013452. https:\/\/doi.org\/10.4088\/jcp.v62n0608","journal-title":"J Clin Psychiatry"},{"issue":"1\u20133","key":"1711_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/s0165-0327(02)00090-3","volume":"76","author":"E Onder","year":"2003","unstructured":"Onder E, Tural U (2003) Faster response in depressive patients treated with fluoxetine alone than in combination with buspirone. J Affect Disord 76(1\u20133):223\u2013227. https:\/\/doi.org\/10.1016\/s0165-0327(02)00090-3","journal-title":"J Affect Disord"},{"issue":"1","key":"1711_CR32","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.eplepsyres.2009.09.008","volume":"89","author":"A Cansu","year":"2010","unstructured":"Cansu A (2010) Antiepileptic drugs and hormones in children. Epilepsy Res 89(1):89\u201395. https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.09.008","journal-title":"Epilepsy Res"},{"key":"1711_CR33","first-page":"228","volume":"38","author":"E Strack","year":"1959","unstructured":"Strack E, Woratz G, Rotzsch W (1959) Effects of carnitine in hyperfunction of the thyroid gland. Endokrinologie 38:228\u2013225","journal-title":"Endokrinologie"},{"key":"1711_CR34","first-page":"641","volume":"19","author":"G Hellthaler","year":"1967","unstructured":"Hellthaler G, Wenzel KW, Rotzsch W (1967) Aminotransferases influenced by thyroxine and carnitine. Acta Biol Med Ger 19:641\u2013652","journal-title":"Acta Biol Med Ger"},{"issue":"12","key":"1711_CR35","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1089\/thy.2000.10.1043","volume":"10","author":"S Benvenga","year":"2000","unstructured":"Benvenga S, Lakshmanan M, Trimarchi F (2000) Carnitine is a naturally occurring inhibitor of thyroid hormone nuclear uptake. Thyroid 10(12):1043\u20131050. https:\/\/doi.org\/10.1089\/thy.2000.10.1043","journal-title":"Thyroid"},{"issue":"36","key":"1711_CR36","doi-asserted-by":"publisher","first-page":"28054","DOI":"10.1074\/jbc.m110.129577","volume":"285","author":"A Kinne","year":"2010","unstructured":"Kinne A, Kleinau G, Hoefig CS, Gr\u00fcters A, K\u00f6hrle J, Krause G, Schweizer U (2010) Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem 285(36):28054\u201328063. https:\/\/doi.org\/10.1074\/jbc.m110.129577","journal-title":"J Biol Chem"},{"key":"1711_CR37","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/BF03347061","volume":"34","author":"P Agretti","year":"2011","unstructured":"Agretti P, Dimida A, De Marco G, Ferrarini E, Rodr\u00ecguez Gonz\u00e0lez JC, Santini F, Vitti P, Pinchera A, Tonacchera M (2011) Study of potential inhibitors of thyroid iodide uptake by using CHO cells stably expressing the human sodium\/iodide symporter (hNIS) protein. J Endocrinol Investig 34:170\u2013174. https:\/\/doi.org\/10.1007\/BF03347061","journal-title":"J Endocrinol Investig"},{"issue":"5","key":"1711_CR38","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/j.1552-4604.1991.tb01906.x","volume":"31","author":"H Derendorf","year":"1991","unstructured":"Derendorf H, M\u00f6llmann H, Barth J, M\u00f6llmann C, Tunn S, Krieg M (1991) Pharmacokinetics and oral bioavailability of hydrocortisone. J Clin Pharmacol 31(5):473\u2013476. https:\/\/doi.org\/10.1002\/j.1552-4604.1991.tb01906.x","journal-title":"J Clin Pharmacol"},{"issue":"7","key":"1711_CR39","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/s0026-0495(98)90113-5","volume":"47","author":"P Dandona","year":"1998","unstructured":"Dandona P, Thusu K, Hafeez R, Abdel-Rahman E, Chaudhuri A (1998) Effect of hydrocortisone on oxygen free radical generation by mononuclear cells. Metabolism 47(7):788\u2013791. https:\/\/doi.org\/10.1016\/s0026-0495(98)90113-5","journal-title":"Metabolism"},{"issue":"7","key":"1711_CR40","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nrendo.2014.73","volume":"10","author":"VG Moisiadis","year":"2014","unstructured":"Moisiadis VG, Matthews SG (2014) Glucocorticoids and fetal programming part 1: outcomes. Nat Rev Endocrinol 10(7):91\u2013402. https:\/\/doi.org\/10.1038\/nrendo.2014.73","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"1711_CR41","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/nrendo.2014.74","volume":"10","author":"VG Moisiadis","year":"2014","unstructured":"Moisiadis VG, Matthews SG (2014) Glucocorticoids and fetal programming part 2: mecchanism. Nat Rev Endocrinol 10(7):403\u2013411. https:\/\/doi.org\/10.1038\/nrendo.2014.74","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"1711_CR42","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3109\/00016349609047089","volume":"75","author":"CL Elliott","year":"1996","unstructured":"Elliott CL, Read GF, Wallace EM (1996) The pharmacokinetics of oral and intramuscular administration of dexamethasone in late pregnancy. Acta Obstet Gynecol Scand 75(3):213\u2013216. https:\/\/doi.org\/10.3109\/00016349609047089","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"1711_CR43","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/dneu.20583","volume":"68","author":"CW Noorlander","year":"2008","unstructured":"Noorlander CW, Visser GH, Ramakers GM, Nikkels PG, de Graan PN (2008) Prenatal corticosteroid exposure affects hippocampal plasticity and reduces lifespan. Dev Neurobiol 68(2):237\u2013246. https:\/\/doi.org\/10.1002\/dneu.20583","journal-title":"Dev Neurobiol"},{"issue":"1","key":"1711_CR44","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.ajog.2003.12.023","volume":"191","author":"A Spinillo","year":"2004","unstructured":"Spinillo A, Viazzo F, Colleonia R, Chiara A, Cerbo RM, Fazzic E (2004) Two-year infant neurodevelopmental outcome after single or multiple antenatal courses of corticosteroids to prevent complications of prematurity. Am J Obstet Gynecol 191(1):217\u2013224. https:\/\/doi.org\/10.1016\/j.ajog.2003.12.023","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"1711_CR45","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/nejmoa071152","volume":"357","author":"CA Crowther","year":"2004","unstructured":"Crowther CA, Doyle LW, Haslam RR, Hiller JE, Harding JE, Robinson JS (2004) Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. N Eng J Med 357(12):217\u2013224. https:\/\/doi.org\/10.1056\/nejmoa071152","journal-title":"N Eng J Med"},{"issue":"1","key":"1711_CR46","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1542\/peds.70.1.99","volume":"70","author":"BA MacArthur","year":"1982","unstructured":"MacArthur BA, Howie RN, Dezoete JA, Elkins J (1982) School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone. Pediatric 70(1):99\u2013105","journal-title":"Pediatric"},{"issue":"11","key":"1711_CR47","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1210\/jc.2018-01865","volume":"103","author":"PW Speiser","year":"2018","unstructured":"Speiser PW, Arlt W, Auchus RJ, Laurence SB, Conway GB, Merke DB, Meyer-Bahlburg PL, Miller WL, Murad MH, Sharon E (2018) Oberfield congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 103(11):4043\u20134088. https:\/\/doi.org\/10.1210\/jc.2018-01865","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1711_CR48","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jpeds.2006.10.051","volume":"150","author":"KJ Rademaker","year":"2007","unstructured":"Rademaker KJ, Uiterwaal CS, Groenendaal F, Venema MM, van Bel F, Beek FJ, van Haastert IJ, Grobbee DE, de Vries LS (2007) Neonatal hydrocortisone treatment: neurodevelopmental outcome and MRI at school age in preterm-born children. J Pediatr 150(4):351\u2013357. https:\/\/doi.org\/10.1016\/j.jpeds.2006.10.051","journal-title":"J Pediatr"},{"issue":"10","key":"1711_CR49","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1365-2826.2004.01243.x","volume":"16","author":"RT Zoeller","year":"2004","unstructured":"Zoeller RT, Rovet J (2004) Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings. J Neuroendocrinol 16(10):809\u2013818. https:\/\/doi.org\/10.1111\/j.1365-2826.2004.01243.x","journal-title":"J Neuroendocrinol"},{"issue":"6","key":"1711_CR50","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/j.1365-2826.2008.01733.x","volume":"20","author":"GR Williams","year":"2008","unstructured":"Williams GR (2008) Neurodevelopmental and neurophysiological actions of thyroid hormone. J Neuroendocrinol 20(6):784\u2013794. https:\/\/doi.org\/10.1111\/j.1365-2826.2008.01733.x","journal-title":"J Neuroendocrinol"},{"issue":"1PT1","key":"1711_CR51","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.1152\/ajpendo.1994.266.1.e44","volume":"266","author":"M de Jong","year":"1994","unstructured":"de Jong M, Docter R, Van der Hoek H, Krenning E, Van der Heide D, Quero C, Plaisier P, Vos R, Hennemann G (1994) Different effects of amiodarone on transport of T4 and T3 into the perfused rat liver. Am J Physiol 266(1PT1):E44-49. https:\/\/doi.org\/10.1152\/ajpendo.1994.266.1.e44","journal-title":"Am J Physiol"},{"issue":"1","key":"1711_CR52","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1172\/jci113874","volume":"83","author":"MF Norman","year":"1989","unstructured":"Norman MF, Lavin TN (1989) Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells. J Clin Investig 83(1):306\u2013313. https:\/\/doi.org\/10.1172\/jci113874","journal-title":"J Clin Investig"},{"issue":"4 Pt 2","key":"1711_CR53","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/0002-8703(83)90006-6","volume":"106","author":"DW Holt","year":"1983","unstructured":"Holt DW, Tucker GT, Jackson PR, Storey GC (1983) Amiodarone pharmacokinetics. Am Heart J 106(4 Pt 2):840\u2013847. https:\/\/doi.org\/10.1016\/0002-8703(83)90006-6","journal-title":"Am Heart J"},{"issue":"4","key":"1711_CR54","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/bf00542140","volume":"26","author":"JM Connell","year":"1984","unstructured":"Connell JM, Rapeport WG, Gordon S, Brodie MJ (1984) Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine. Eur J Clin Pharmacol 26(4):453\u2013456. https:\/\/doi.org\/10.1007\/bf00542140","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"1711_CR55","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1365-2265.1978.tb01493.x","volume":"8","author":"K Liewendahl","year":"1978","unstructured":"Liewendahl K, Majuri H, Helenius T (1978) Thyroid function tests in patients on long-term treatment with various anticonvulsant drugs. Clin Endocrinol (Oxf) 8(3):185\u2013191. https:\/\/doi.org\/10.1111\/j.1365-2265.1978.tb01493.x","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"8","key":"1711_CR56","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3109\/00365517809104880","volume":"38","author":"K Rootwelt","year":"1978","unstructured":"Rootwelt K, Ganes J, Johannessen SJ (1978) Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans. Scand J Clin Lab Investig 38(8):731\u2013736. https:\/\/doi.org\/10.3109\/00365517809104880","journal-title":"Scand J Clin Lab Investig"},{"issue":"3","key":"1711_CR57","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1055\/s-0032-1313913","volume":"43","author":"SH Kim","year":"2012","unstructured":"Kim SH, Chung HR, Kim SH, Kim H, Chan Lim B, Chae JH, Kim KJ, Hwang YS, Hwang H (2012) Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy. Neuropediatrics 43(3):135\u2013139. https:\/\/doi.org\/10.1055\/s-0032-1313913","journal-title":"Neuropediatrics"},{"issue":"2","key":"1711_CR58","first-page":"121","volume":"9","author":"AC Bach","year":"1983","unstructured":"Bach AC, Schirardin H, Sihr MO, Storck D (1983) Free and total carnitine in human serum after oral ingestion of l-carnitine. Diabete Metab 9(2):121\u2013124","journal-title":"Diabete Metab"},{"issue":"1","key":"1711_CR59","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/bf00555510","volume":"35","author":"P Harper","year":"1988","unstructured":"Harper P, Elwin CE, Cederblad G (1988) Pharmacokinetics of intravenous and oral bolus doses of l-carnitine in healthy subjects. Eur J Clin Pharmacol 35(1):69\u201375. https:\/\/doi.org\/10.1007\/bf00555510","journal-title":"Eur J Clin Pharmacol"},{"key":"1711_CR60","first-page":"1","volume-title":"Carnitine today","author":"J Bremer","year":"1997","unstructured":"Bremer J (1997) The role of carnitine in cell metabolism. In: De Simone C, Famularo G (eds) Carnitine today. RG Landes Company, Austin, pp 1\u201337"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01711-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-021-01711-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01711-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T10:26:56Z","timestamp":1647080816000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-021-01711-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,30]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1711"],"URL":"https:\/\/doi.org\/10.1007\/s40618-021-01711-4","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,30]]},"assertion":[{"value":"8 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"For this type of study formal consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}