{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:24:41Z","timestamp":1740173081754,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1007\/s40618-021-01731-0","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:03:41Z","timestamp":1643587421000},"page":"981-987","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal timing of blood samplings to detect GH inhibition during oral glucose tolerance test"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-7023","authenticated-orcid":false,"given":"F.","family":"Bioletto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Prencipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Berton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Varaldo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Gasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ghigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Grottoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"11","key":"1731_CR1","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER, Melmed S, Molitch ME, Murad MH, Utz A et al (2014) Acromegaly: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 99(11):3933\u20133951","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"1731_CR2","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41574-018-0058-5","volume":"14","author":"S Melmed","year":"2018","unstructured":"Melmed S, Bronstein MD, Chanson P, Klibanski A, Casanueva FF, Wass JAH et al (2018) A consensus statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol 14(9):552\u2013561","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"1731_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s40618-018-0928-7","volume":"42","author":"M Caputo","year":"2019","unstructured":"Caputo M, Ucciero A, Mele C, De Marchi L, Magnani C, Cena T et al (2019) Use of administrative health databases to estimate incidence and prevalence of acromegaly in Piedmont Region, Italy. J Endocrinol Invest 42(4):397\u2013402","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"1731_CR4","first-page":"168","volume":"85","author":"MR Drange","year":"2000","unstructured":"Drange MR, Fram NR, Herman-Bonert V, Melmed S (2000) Pituitary tumor registry: a novel clinical resource 1. J Clin Endocrinol Metab 85(1):168\u2013174","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"1731_CR5","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0889-8529(18)30204-4","volume":"21","author":"M Molitch","year":"1992","unstructured":"Molitch M (1992) Clinical manifestations of acromegaly. Endocrinol Metab Clin North Am 21(3):597\u2013614","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"1731_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s11102-017-0797-7","volume":"20","author":"R Pivonello","year":"2017","unstructured":"Pivonello R, Auriemma RS, Grasso LFS, Pivonello C, Simeoli C, Patalano R et al (2017) Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities. Pituitary 20(1):46\u201362","journal-title":"Pituitary"},{"issue":"22","key":"1731_CR7","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.3748\/wjg.14.3484","volume":"14","author":"T Rokkas","year":"2008","unstructured":"Rokkas T, Pistiolas D, Sechopoulos P, Margantinis G, Koukoulis G (2008) Risk of colorectal neoplasm in patients with acromegaly: a meta-analysis. World J Gastroenterol 14(22):3484\u20133489","journal-title":"World J Gastroenterol"},{"issue":"1","key":"1731_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1210\/jc.2007-1191","volume":"93","author":"OM Dekkers","year":"2008","unstructured":"Dekkers OM, Biermasz NR, Pereira AM, Romijn JA, Vandenbroucke JP (2008) Mortality in acromegaly: a metaanalysis. J Clin Endocrinol Metab 93(1):61\u201367","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1731_CR9","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1210\/er.2002-0022","volume":"25","author":"A Colao","year":"2004","unstructured":"Colao A, Ferone D, Marzullo P, Lombardi G (2004) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 25(1):102\u2013152","journal-title":"Endocr Rev"},{"issue":"5","key":"1731_CR10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1517\/17530059.2013.820181","volume":"7","author":"S Kannan","year":"2013","unstructured":"Kannan S, Kennedy L (2013) Diagnosis of acromegaly: State of the art. Expert Opin Med Diagn 7(5):443\u2013453","journal-title":"Expert Opin Med Diagn"},{"issue":"5","key":"1731_CR11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1046\/j.1365-2265.1997.1430983.x","volume":"46","author":"B Stoffel-Wagner","year":"1997","unstructured":"Stoffel-Wagner B, Springer W, Bidlingmaier F, Klingm\u00fcller D (1997) A comparison of different methods for diagnosing acromegaly. Clin Endocrinol (Oxf) 46(5):531\u2013537","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"1731_CR12","first-page":"3808","volume":"83","author":"PU Freda","year":"1998","unstructured":"Freda PU, Post KD, Powell JS, Wardlaw SL (1998) Evaluation of disease status with sensitive measures of growth hormone secretion in 60 postoperative patients with acromegaly 1. J Clin Endocrinol Metab 83(11):3808\u20133816","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1731_CR13","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1023\/B:PITU.0000023424.72021.e2","volume":"6","author":"PU Freda","year":"2003","unstructured":"Freda PU, Reyes CM, Nuruzzaman AT, Sundeen RE, Bruce JN (2003) Basal and glucose-suppressed GH levels less than 1 \u03bcg\/L in newly diagnosed acromegaly. Pituitary 6(4):175\u2013180","journal-title":"Pituitary"},{"issue":"5","key":"1731_CR14","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1227\/NEU.0b013e31823f5c16","volume":"70","author":"EH Kim","year":"2012","unstructured":"Kim EH, Oh MC, Lee EJ, Kim SH (2012) Predicting long-term remission by measuring immediate postoperative growth hormone levels and oral glucose tolerance test in acromegaly. Neurosurgery 70(5):1106\u20131112","journal-title":"Neurosurgery"},{"issue":"2","key":"1731_CR15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1053\/meta.2003.50036","volume":"52","author":"H Vierhapper","year":"2003","unstructured":"Vierhapper H, Heinze G, Gessl A, Exner M, Bieglmayr C (2003) Use of the oral glucose tolerance test to define remission in acromegaly. Metabolism 52(2):181\u2013185","journal-title":"Metabolism"},{"key":"1731_CR16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2670","author":"A Giustina","year":"2010","unstructured":"Giustina A, Chanson P, Bronstein MD, Klibanski A, Lamberts S, Casanueva FF et al (2010) A consensus on criteria for cure of acromegaly. J Clin Endocrinol Metabol Endocrine Soc. https:\/\/doi.org\/10.1210\/jc.2009-2670","journal-title":"J Clin Endocrinol Metabol Endocrine Soc"},{"key":"1731_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345139","author":"S Grottoli","year":"2003","unstructured":"Grottoli S, Razzore P, Gaia D, Gasperi M, Giusti M, Colao A et al (2003) Three-hour spontaneous GH secretion profile is as reliable as oral glucose tolerance test for the diagnosis of acromegaly. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/BF03345139","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"1731_CR18","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1053\/meta.2002.32017","volume":"51","author":"L De Marinis","year":"2002","unstructured":"De Marinis L, Mancini A, Bianchi A, Gentilella R, Valle D, Giampietro A et al (2002) Preoperative growth hormone response to thyrotropin-releasing hormone and oral glucose tolerance test in acromegaly: A retrospective evaluation of 50 patients. Metabolism 51(5):616\u2013621","journal-title":"Metabolism"},{"issue":"1","key":"1731_CR19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1365-2265.2004.02064.x","volume":"61","author":"F Minuto","year":"2004","unstructured":"Minuto F, Resmini E, Boschetti M, Arvigo M, Sormani MP, Giusti M et al (2004) Assessment of disease activity in acromegaly by means of a single blood sample: Comparison of the 120th minute postglucose value with spontaneous GH secretion and with the IGF system. Clin Endocrinol (Oxf) 61(1):138\u2013144","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"1731_CR20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/BF01584082","volume":"1","author":"J Edmonds","year":"1971","unstructured":"Edmonds J (1971) Matroids and the greedy algorithm. Mathem Programm. 1(1):127\u2013136","journal-title":"Mathem Programm."},{"issue":"2","key":"1731_CR21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/BF02604639","volume":"38","author":"A Bouchet","year":"1987","unstructured":"Bouchet A (1987) Greedy algorithm and symmetric matroids. Mathem Programm 38(2):147\u2013159","journal-title":"Mathem Programm"},{"key":"1731_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.matpr.2021.01.691","author":"K Rajesh Khanna","year":"2021","unstructured":"Rajesh Khanna K, Shirisha M, Kauda BP (2021) A review of approaches and associated dimensions with greedy method for research implementations. Mater Today Proc. https:\/\/doi.org\/10.1016\/j.matpr.2021.01.691","journal-title":"Mater Today Proc"},{"issue":"6","key":"1731_CR23","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1530\/EJE-11-0657","volume":"165","author":"S Yamada","year":"2011","unstructured":"Yamada S, Fukuhara N, Nishioka H, Takeshita A, Suzuki H, Miyakawa M et al (2011) GH deficiency in patients after cure of acromegaly by surgery alone. Eur J Endocrinol 165(6):873\u2013879","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1731_CR24","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.tem.2014.10.005","volume":"26","author":"G Mazziotti","year":"2015","unstructured":"Mazziotti G, Marzullo P, Doga M, Aimaretti G, Giustina A (2015) Growth hormone deficiency in treated acromegaly. Trends Endocrinol Metab 26(1):11\u201321","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"1731_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1530\/EJE-14-0304","volume":"171","author":"CR Ku","year":"2014","unstructured":"Ku CR, Hong JW, Kim EH, Kim SH, Lee EJ (2014) Clinical predictors of GH deficiency in surgically cured acromegalic patients. Eur J Endocrinol 171(3):379\u2013387","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1731_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1530\/EJE-09-0222","volume":"161","author":"CL Ronchi","year":"2009","unstructured":"Ronchi CL, Giavoli C, Ferrante E, Verrua E, Bergamaschi S, Ferrari DI et al (2009) Prevalence of GH deficiency in cured acromegalic patients: Impact of different previous treatments. Eur J Endocrinol 161(1):37\u201342","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"1731_CR27","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1210\/jc.2012-2477","volume":"97","author":"C Giavoli","year":"2012","unstructured":"Giavoli C, Profka E, Verrua E, Ronchi CL, Ferrante E, Bergamaschi S et al (2012) GH replacement improves quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency. J Clin Endocrinol Metab 97(11):3983\u20133988","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1731_CR28","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s11102-007-0030-1","volume":"10","author":"M Bidlingmaier","year":"2007","unstructured":"Bidlingmaier M, Strasburger CJ (2007) Growth hormone assays: Current methodologies and their limitations. Pituitary 10(2):115\u2013119","journal-title":"Pituitary"},{"key":"1731_CR29","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0284","author":"M Bidlingmaier","year":"2008","unstructured":"Bidlingmaier M (2008) Problems with GH assays and strategies toward standardization. Eur J Endocrinol. https:\/\/doi.org\/10.1530\/EJE-08-0284","journal-title":"Eur J Endocrinol"},{"key":"1731_CR30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/978-1-62703-616-0_7","volume":"1065","author":"N Guha","year":"2013","unstructured":"Guha N (2013) Assays for GH, IGF-I, and IGF binding protein-3. Methods Mol Biol 1065:117\u2013128","journal-title":"Methods Mol Biol"},{"issue":"6","key":"1731_CR31","doi-asserted-by":"publisher","first-page":"618","DOI":"10.20945\/2359-3997000000192","volume":"63","author":"K Schilbach","year":"2019","unstructured":"Schilbach K, Bidlingmaier M (2019) Laboratory investigations in the diagnosis and follow-up of GH-related disorders. Arch Endocrinol Metab 63(6):618\u2013629","journal-title":"Arch Endocrinol Metab"},{"issue":"4","key":"1731_CR32","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1373\/clinchem.2010.150631","volume":"57","author":"DR Clemmons","year":"2011","unstructured":"Clemmons DR (2011) Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays. Clin Chem 57(4):555\u2013559","journal-title":"Clin Chem"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01731-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-021-01731-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-021-01731-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T09:21:50Z","timestamp":1649582510000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-021-01731-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,31]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["1731"],"URL":"https:\/\/doi.org\/10.1007\/s40618-021-01731-0","relation":{},"ISSN":["1720-8386"],"issn-type":[{"type":"electronic","value":"1720-8386"}],"subject":[],"published":{"date-parts":[[2022,1,31]]},"assertion":[{"value":"25 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Nunzia Prencipe and Silvia Grottoli are members of the Editorial Board of the Journal of Endocrinological Investigation; the other\u00a0authors report no conflict of interest in this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local Ethics Committee (A.O.U. Citt\u00e0 della Salute e della Scienza, Turin, Italy) and was in accordance with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All subjects gave their informed consent to the collection of their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All subjects gave their informed consent to the analysis, processing and publication of their aggregated data.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}