{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:37:18Z","timestamp":1778924238841,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ERC starting grant","award":["759161 \u2018MRS in diabetes\u2019"],"award-info":[{"award-number":["759161 \u2018MRS in diabetes\u2019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>De novo lipogenesis has been inversely associated with serum sex hormone-binding globulin (SHBG) levels. However, the directionality of this association has remained uncertain. We, therefore, studied individuals with glycogen storage disease type 1a (GSD1a), who are characterized by a genetic defect in glucose-6-phosphatase resulting in increased rates of de novo lipogenesis, to assess the downstream effect on serum SHBG levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A case\u2013control study comparing serum SHBG levels in patients with GSD1a (<jats:italic>n<\/jats:italic>\u2009=\u200910) and controls matched for age, sex, and BMI (<jats:italic>n<\/jats:italic>\u2009=\u200910). Intrahepatic lipid content and saturated fatty acid fraction were quantified by proton magnetic resonance spectroscopy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Serum SHBG levels were statistically significantly lower in patients with GSD1a compared to the controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.041), while intrahepatic lipid content and intrahepatic saturated fatty acid fraction\u2014a marker of de novo lipogenesis\u2014were significantly higher in patients with GSD1a (<jats:italic>p<\/jats:italic>\u2009=\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.019, respectively). In addition, there was a statistically significant, inverse association of intrahepatic lipid content and saturated fatty acid fraction with serum SHBG levels in patients and controls combined (<jats:italic>\u03b2<\/jats:italic>: \u2212\u00a00.28, 95% CI: \u2212\u00a00.47;\u2212\u00a00.09 and <jats:italic>\u03b2<\/jats:italic>: \u2212\u00a00.02, 95% CI: \u2212\u00a00.04;\u2212\u00a00.01, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Patients with GSD1a, who are characterized by genetically determined higher rates of de novo lipogenesis, have lower serum SHBG levels than controls.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01753-2","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T17:18:48Z","timestamp":1644254328000},"page":"1227-1234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum sex hormone-binding globulin levels are reduced and inversely associated with intrahepatic lipid content and saturated fatty acid fraction in adult patients with glycogen storage disease type 1a"],"prefix":"10.1007","volume":"45","author":[{"given":"P. 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