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After 12\u00a0months of GHT, GHD children showed a significant increase in height (SDS) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), growth velocity (SDS) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), bone\/chronological age ratio (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) IGF-1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), fasting insulin (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), Homa-IR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and s\u03b1KL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with a concomitant decrease in BMI (SDS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and WC (SDS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.038) than baseline. At ROC curve analysis, we identified a s\u03b1KL cut-off to discriminate controls and GHD children of 1764.4\u00a0pg\/mL in females and 1339.4\u00a0pg\/mL in males.<\/jats:p>\n                <jats:p>At multivariate analysis, the independent variables significantly associated with s\u03b1KL levels after 12\u00a0months of GHT were the oral disposition index (<jats:italic>p<\/jats:italic>\u2009=\u20090.004, <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.327) and IGF-1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.019, <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.313).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Gender-related s\u03b1KL may be used as a marker of GHD combined to GH and IGF-1. Insulin and IGF-1 are independently associated with s\u03b1KL values after 12\u00a0months of GHT.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01757-y","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T03:02:20Z","timestamp":1647140540000},"page":"1247-1254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gender-specific soluble \u03b1-klotho levels as marker of GH deficiency in children: a case\u2013control study"],"prefix":"10.1007","volume":"45","author":[{"given":"V.","family":"Guarnotta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pizzolanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Petrancosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Radellini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Baiamonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1731-9395","authenticated-orcid":false,"given":"C.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"issue":"1","key":"1757_CR1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1530\/eje.1.02191","volume":"155","author":"K Stochholm","year":"2006","unstructured":"Stochholm K, Gravholt CH, Laursen T, J\u00f8rgensen JO, Laurberg P, Andersen M, Kristensen L\u00d8, Feldt-Rasmussen U, Christiansen JS, Frydenberg M, Green A (2006) Incidence of GH deficiency\u2014a nationwide study. 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