{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:22:51Z","timestamp":1777465371794,"version":"3.51.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s40618-022-01775-w","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T10:03:03Z","timestamp":1648202583000},"page":"1405-1412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low serm Fibroblast Growth Factor-21 levels is not associated with Carotid intima-media thickness in acromegaly patients"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-8142","authenticated-orcid":false,"given":"M. M.","family":"Uygur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dereli Yaz\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gogas Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"1775_CR1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz096","author":"A Giustina","year":"2020","unstructured":"Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C et al (2020) A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgz096 (Epub 2019\/10\/14)","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1775_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","volume":"5","author":"A Colao","year":"2019","unstructured":"Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM et al (2019) Acromegaly. Nat Rev Dis Primers 5(1):20. https:\/\/doi.org\/10.1038\/s41572-019-0071-6 (Epub 2019\/03\/23)","journal-title":"Nat Rev Dis Primers"},{"issue":"7","key":"1775_CR3","doi-asserted-by":"publisher","first-page":"3174","DOI":"10.1210\/jcem.87.7.8643","volume":"87","author":"G Brevetti","year":"2002","unstructured":"Brevetti G, Marzullo P, Silvestro A, Pivonello R, Oliva G, di Somma C et al (2002) Early vascular alterations in acromegaly. J Clin Endocrinol Metab 87(7):3174\u20133179. https:\/\/doi.org\/10.1210\/jcem.87.7.8643 (Epub 2002\/07\/11)","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"1775_CR4","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/0003319712436578.PubMedPMID:WOS:000308721000002","volume":"63","author":"M Rizzo","year":"2012","unstructured":"Rizzo M, Montalto G, Rizvi AA, Christ ER (2012) The role of elevated growth hormone on the increased atherosclerosis in patients with acromegaly. Angiology 63(7):492\u2013494. https:\/\/doi.org\/10.1177\/0003319712436578.PubMedPMID:WOS:000308721000002","journal-title":"Angiology"},{"issue":"1","key":"1775_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1742-1241.2008.01750.x.PubMedPMID:WOS:000272655800008","volume":"64","author":"I Kartal","year":"2010","unstructured":"Kartal I, Oflaz H, Pamukcu B, Meric M, Aral F, Ozbey N et al (2010) Investigation of early atherosclerotic changes in acromegalic patients. Int J Clin Pract 64(1):39\u201344. https:\/\/doi.org\/10.1111\/j.1742-1241.2008.01750.x.PubMedPMID:WOS:000272655800008","journal-title":"Int J Clin Pract"},{"key":"1775_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ghir.2017.10.002","volume":"37","author":"LR Braun","year":"2017","unstructured":"Braun LR, Feldpausch MN, Czerwonka N, Torriani M, Grinspoon SK, Stanley TL (2017) Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation. Growth Horm IGF Res 37:1\u20136. https:\/\/doi.org\/10.1016\/j.ghir.2017.10.002 (Epub 2017\/10\/17)","journal-title":"Growth Horm IGF Res"},{"issue":"10","key":"1775_CR7","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/ATVBAHA.113.301599","volume":"33","author":"WS Chow","year":"2013","unstructured":"Chow WS, Xu A, Woo YC, Tso AW, Cheung SC, Fong CH et al (2013) Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Arterioscler Thromb Vasc Biol 33(10):2454\u20132459. https:\/\/doi.org\/10.1161\/ATVBAHA.113.301599 (Epub 2013\/07\/28)","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"1775_CR8","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015226","volume":"9","author":"L Wu","year":"2020","unstructured":"Wu L, Qian L, Zhang L, Zhang J, Zhou J, Li Y et al (2020) Fibroblast growth factor 21 is related to atherosclerosis independent of nonalcoholic fatty liver disease and predicts atherosclerotic cardiovascular events. J Am Heart Assoc 9(11):e015226. https:\/\/doi.org\/10.1161\/JAHA.119.015226 (Epub 2020\/05\/21)","journal-title":"J Am Heart Assoc"},{"issue":"40","key":"1775_CR9","doi-asserted-by":"publisher","first-page":"34559","DOI":"10.1074\/jbc.M111.285965","volume":"286","author":"W Chen","year":"2011","unstructured":"Chen W, Hoo RL-C, Konishi M, Itoh N, Lee P-C, Ye H-Y et al (2011) Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J Biol Chem 286(40):34559\u201334566","journal-title":"J Biol Chem"},{"issue":"2","key":"1775_CR10","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1210\/en.2011-1591.PubMedPMID:WOS:000299928200024","volume":"153","author":"J Yu","year":"2012","unstructured":"Yu J, Zhao LD, Wang AH, Eleswarapu S, Ge XM, Chen DW et al (2012) Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5. Endocrinology 153(2):750\u2013758. https:\/\/doi.org\/10.1210\/en.2011-1591.PubMedPMID:WOS:000299928200024","journal-title":"Endocrinology"},{"issue":"3","key":"1775_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/joim.12112","volume":"274","author":"J Lundberg","year":"2013","unstructured":"Lundberg J, H\u00f6ybye C, Krusenstjerna-Hafstr\u00f8m T, Bina H, Kharitonenkov A, Angelin B et al (2013) Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans. J Intern Med 274(3):227\u2013232","journal-title":"J Intern Med"},{"issue":"1","key":"1775_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s40618-018-0885-1.PubMedPMID:WOS:000454270400007","volume":"42","author":"BS Yurekli","year":"2019","unstructured":"Yurekli BS, Kutbay NO, Aksit M, Suner A, Simsir IY, Seckiner S et al (2019) Acromegaly is associated with high fibroblast growth factor-21 levels. J Endocrinol Invest 42(1):53\u201360. https:\/\/doi.org\/10.1007\/s40618-018-0885-1.PubMedPMID:WOS:000454270400007","journal-title":"J Endocrinol Invest"},{"issue":"10","key":"1775_CR13","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1055\/s-0043-115647","volume":"125","author":"J Halupczok-Zyla","year":"2017","unstructured":"Halupczok-Zyla J, Jawiarczyk-Przybylowska A, Skrzypski M, Strowski MZ, Bolanowski M (2017) Fibroblast growth factor 21 in patients with acromegaly. Exp Clin Endocrinol Diabetes 125(10):649\u2013654. https:\/\/doi.org\/10.1055\/s-0043-115647 (Epub 2017\/09\/21)","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"10","key":"1775_CR14","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1210\/jc.2015-1797","volume":"100","author":"F Xiao","year":"2015","unstructured":"Xiao F, Lin M, Huang P, Zeng J, Zeng X, Zhang H et al (2015) Elevated serum fibroblast growth factor 21 levels in patients with hyperthyroidism. J Clin Endocrinol Metab 100(10):3800\u20133805. https:\/\/doi.org\/10.1210\/jc.2015-1797 (Epub 2015\/08\/05)","journal-title":"J Clin Endocrinol Metab"},{"key":"1775_CR15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12933-015-0229-9","volume":"14","author":"Y Xiao","year":"2015","unstructured":"Xiao Y, Liu L, Xu A, Zhou P, Long Z, Tu Y et al (2015) Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol 14:72. https:\/\/doi.org\/10.1186\/s12933-015-0229-9 (Epub 2015\/06\/07)","journal-title":"Cardiovasc Diabetol"},{"issue":"11","key":"1775_CR16","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A et al (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99(11):3933\u20133951. https:\/\/doi.org\/10.1210\/jc.2014-2700 (Epub 2014\/10\/31)","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"1775_CR17","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.2337\/dc14-S081","volume":"37","author":"DA American","year":"2014","unstructured":"American DA (2014) Diagnosis and classification of diabetes mellitus. Diabetes Care 37(Suppl 1):S81\u2013S90. https:\/\/doi.org\/10.2337\/dc14-S081 (Epub 2013\/12\/21)","journal-title":"Diabetes Care"},{"issue":"4","key":"1775_CR18","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/ehjcvp\/pvaa077","volume":"7","author":"M Zeitouni","year":"2021","unstructured":"Zeitouni M, Sabouret P, Kerneis M, Silvain J, Collet JP, Bruckert E et al (2021) 2019 ESC\/EAS guidelines for management of dyslipidaemia: strengths and limitations. Eur Heart J Cardiovasc Pharmacother 7(4):324\u2013333. https:\/\/doi.org\/10.1093\/ehjcvp\/pvaa077 (Epub 2020\/07\/12)","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"33","key":"1775_CR19","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","volume":"39","author":"B Williams","year":"2018","unstructured":"Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M et al (2018) 2018 ESC\/ESH Guidelines for the management of arterial hypertension. Eur Heart J 39(33):3021\u20133104. https:\/\/doi.org\/10.1093\/eurheartj\/ehy339 (Epub 2018\/08\/31)","journal-title":"Eur Heart J"},{"issue":"10","key":"1775_CR20","first-page":"1025","volume":"7","author":"TZ Naqvi","year":"2014","unstructured":"Naqvi TZ, Lee M-S (2014) Carotid intima-media thickness and plaque in cardiovascular risk assessment. JACC: Cardiovasc Imaging 7(10):1025\u20131038","journal-title":"JACC: Cardiovasc Imaging"},{"issue":"4","key":"1775_CR21","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000343145","volume":"34","author":"P-J Touboul","year":"2012","unstructured":"Touboul P-J, Hennerici M, Meairs S, Adams H, Amarenco P, Bornstein N et al (2012) Mannheim carotid intima-media thickness and plaque consensus (2004\u20132006\u20132011). Cerebrovasc Dis 34(4):290\u2013296","journal-title":"Cerebrovasc Dis"},{"issue":"4","key":"1775_CR22","first-page":"197","volume":"18","author":"GA Ferns","year":"1991","unstructured":"Ferns GA, Motani AS, Anggard EE (1991) The insulin-like growth factors: their putative role in atherogenesis. Artery 18(4):197\u2013225 (Epub 1991\/01\/01 PubMed PMID: 1714710)","journal-title":"Artery"},{"issue":"2","key":"1775_CR23","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1007\/BF00402540","volume":"35","author":"KE Bornfeldt","year":"1992","unstructured":"Bornfeldt KE, Arnqvist HJ, Capron L (1992) In vivo proliferation of rat vascular smooth muscle in relation to diabetes mellitus insulin-like growth factor I and insulin. Diabetologia 35(2):104\u2013108. https:\/\/doi.org\/10.1007\/BF00402540 (Epub 1992\/02\/01)","journal-title":"Diabetologia"},{"issue":"1","key":"1775_CR24","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/s0967-2109(98)00044-1","volume":"7","author":"SK Balaram","year":"1999","unstructured":"Balaram SK, Agrawal DK, Edwards JD (1999) Insulin like growth factor-1 activates nuclear factor-kappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells. Cardiovasc Surg 7(1):91\u201397. https:\/\/doi.org\/10.1016\/s0967-2109(98)00044-1 (Epub 1999\/03\/12)","journal-title":"Cardiovasc Surg"},{"key":"1775_CR25","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/j.1749-6632.1992.tb51633.x","volume":"667","author":"AJ Gearing","year":"1992","unstructured":"Gearing AJ, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ (1992) Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann NY Acad Sci 667:324\u2013331. https:\/\/doi.org\/10.1111\/j.1749-6632.1992.tb51633.x (Epub 1992\/12\/04)","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"1775_CR26","doi-asserted-by":"publisher","first-page":"250","DOI":"10.2337\/db08-0392","volume":"58","author":"J Xu","year":"2009","unstructured":"Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G et al (2009) Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58(1):250\u2013259. https:\/\/doi.org\/10.2337\/db08-0392 (Epub 2008\/10\/09)","journal-title":"Diabetes"},{"issue":"2","key":"1775_CR27","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1053\/j.gastro.2010.04.054","volume":"139","author":"J Dushay","year":"2010","unstructured":"Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM et al (2010) Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology 139(2):456\u2013463. https:\/\/doi.org\/10.1053\/j.gastro.2010.04.054 (Epub 2010\/05\/11)","journal-title":"Gastroenterology"},{"issue":"12","key":"1775_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015534","volume":"5","author":"Z Lin","year":"2010","unstructured":"Lin Z, Wu Z, Yin X, Liu Y, Yan X, Lin S et al (2010) Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile. PLoS ONE 5(12):e15534. https:\/\/doi.org\/10.1371\/journal.pone.0015534 (Epub 2011\/01\/06)","journal-title":"PLoS ONE"},{"issue":"1","key":"1775_CR29","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/cen.12134","volume":"80","author":"Y Lee","year":"2014","unstructured":"Lee Y, Lim S, Hong ES, Kim JH, Moon MK, Chun EJ et al (2014) Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status. Clin Endocrinol (Oxf) 80(1):57\u201364. https:\/\/doi.org\/10.1111\/cen.12134 (Epub 2013\/01\/03)","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1775_CR30","doi-asserted-by":"publisher","first-page":"110624","DOI":"10.1016\/j.exger.2019.05.013","volume":"124","author":"L Basurto","year":"2019","unstructured":"Basurto L, Gregory MA, Hernandez SB, Sanchez-Huerta L, Martinez AD, Manuel-Apolinar L et al (2019) Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women. Exp Gerontol 124:110624. https:\/\/doi.org\/10.1016\/j.exger.2019.05.013 (Epub 2019\/06\/04)","journal-title":"Exp Gerontol"},{"issue":"2","key":"1775_CR31","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.diabres.2012.01.004","volume":"96","author":"SY An","year":"2012","unstructured":"An SY, Lee MS, Yi SA, Ha ES, Han SJ, Kim HJ et al (2012) Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques. Diabetes Res Clin Pract 96(2):196\u2013203. https:\/\/doi.org\/10.1016\/j.diabres.2012.01.004 (Epub 2012\/02\/02)","journal-title":"Diabetes Res Clin Pract"}],"updated-by":[{"DOI":"10.1007\/s40618-022-01867-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000}}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01775-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-022-01775-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01775-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T17:07:00Z","timestamp":1658768820000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-022-01775-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,25]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["1775"],"URL":"https:\/\/doi.org\/10.1007\/s40618-022-01775-w","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s40618-022-01867-7","asserted-by":"object"}]},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,25]]},"assertion":[{"value":"3 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40618-022-01867-7","URL":"https:\/\/doi.org\/10.1007\/s40618-022-01867-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Local Ethics Committee approved the study protocol (protocol no: 09.2014.0043).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Patients signed informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}