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Adults with insulin-treated type 1 and type 2 diabetes, inadequate glycemic control, and no severe diabetes-related complications and\/or comorbidities were eligible for this study. Patients were randomized to either perform telemedicine-assisted (Group A) or standard (Group B) self-monitoring blood glucose (SMBG) for 6\u00a0months. In Group A, patients received prompt feedback about their blood glucose levels and therapy suggestions from the study staff via phone\/SMS, when appropriate. In Group B, patients had no remote assistance from the study staff between planned visits.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>123 patients were included in the final analysis. After 6\u00a0months, patients achieved a significant reduction in HbA1c in Group A (\u22120.38%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) but not in Group B (+\u20090.08%, <jats:italic>p<\/jats:italic>\u2009=\u20090.53). A significant difference in the percentage of patients with HbA1c\u2009&lt;\u20097% between Group A and Group B was found after 3\u00a0months (28.6% vs 11.1%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Also, fewer patients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) with HbA1c\u2009&gt;\u20098.5% were found in Group A vs Group B, respectively, after both 3\u00a0months (14.3% vs 35.2%) and 6\u00a0months (21.8% vs 42.9%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The use of the Glucoonline\u2122 system resulted in improved metabolic control. Telemedicine services have potential to support diabetes self-management and provide the patients with remote, prompt assistance using affordable technological equipment.<\/jats:p>\n                <jats:p><jats:bold>Trial registration<\/jats:bold> This study was registered at clinicaltrials.gov\u00a0(NCT01804803) on March 5, 2013.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01802-w","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T12:04:43Z","timestamp":1651061083000},"page":"1663-1671","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A telemedicine-based approach with real-time transmission of blood glucose data improves metabolic control in insulin-treated diabetes: the DIAMONDS randomized clinical trial"],"prefix":"10.1007","volume":"45","clinical-trial-number":[{"clinical-trial-number":"nct01804803","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"S.","family":"Di Molfetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Patruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cormio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cignarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Paleari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Lamacchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"De Cosmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Massa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Natalicchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Perrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Laviola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-2678","authenticated-orcid":false,"given":"F.","family":"Giorgino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"issue":"14","key":"1802_CR1","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"DM Nathan","year":"1993","unstructured":"Diabetes Control and Complications Trial Research Group, Nathan DM, Genuth S, Lachin J, Cleary P, Crofford O, Davis M, Rand L, Siebert C (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. 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AN: AstraZeneca, Novo Nordisk, Sanofi Aventis. FG: Abbott, Medtronic, Roche Diabetes Care Italy, Lifescan. LL: Abbott, Medtronic, Movi, Roche Diabetes Care Italy. OL: AstraZeneca, Eli Lilly, Novo Nordisk. SDM: Abbott, Roche Diabetes Care Italy. SP declares to be a member of the Editorial Board of the Journal of Endocrinological Investigation. AM, MM, PP, RP, SC, and SDC declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was carried out in adherence to Good Clinical Practice, ICH Harmonized Tripartite Guidelines for Good Clinical Practice and Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided informed consent for participation in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}