{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:48:50Z","timestamp":1768452530115,"version":"3.49.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Hypoparathyroidism (HypoPT) is a rare endocrine disease and conventional therapy is based on calcium and vitamin D analogues. Conventional therapy does not restore calcium homeostasis and patients complain with neuropsychological symptoms, which have been evaluated with nonspecific self-administered questionnaires. This study aims to evaluate cognitive functions of patients with chronic post-surgical (PS)-HypoPT compared to a control population, using a standardized neuropsychological approach and evaluating the relationship with serum calcium (Alb-Ca).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Observational, monocentric study on 33 patients with PS-HypoPT and 24 controls, in whom biochemical testing and a standardized neuropsychological assessment by a trained psychologist were performed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In patients with PS-HypoPT, low Alb-Ca correlated with a worse performance on semantic memory abilities and executive function, as suggested by a significant inverse correlation between Alb-Ca and Trail Making Test A (TMT-A) scores (<jats:italic>r<\/jats:italic>\u2009=\u2009\u2212\u00a00.423; <jats:italic>p<\/jats:italic>\u2009=\u20090.014) and by a positive correlation with Semantic Fluency Test scores (SF)(<jats:italic>r<\/jats:italic>\u2009=\u20090.510; <jats:italic>p<\/jats:italic>\u2009=\u20090.002). PS-HypoPT patients with Alb-Ca\u2009\u2264\u20098.9\u00a0mg\/dl had a significantly lower test performance compared with PS-HypoPT patients with Alb-Ca\u2009&gt;\u20098.9\u00a0mg\/dl, both at the TMT-A test (mean score: 34.53\u201318.55; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and at SF test (mean score: 41.94\u201348.68; <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and also a significantly lower test performance compared with control patients\u2019 group at TMT-A (mean score: 34.53\u201325.5; <jats:italic>p<\/jats:italic>\u2009=\u20090.0057).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Patients with chronic PS-HypoPT in conventional therapy do not show a severe cognitive impairment; however, cognitive functions namely visuo-spatial attention, executive function and semantic memory appear to be modulated by Alb-Ca and impaired by its low levels.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01822-6","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T15:02:54Z","timestamp":1656169374000},"page":"1909-1918","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0277-1648","authenticated-orcid":false,"given":"F.","family":"Saponaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Alfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cetani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Matrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mazoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Apicella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Borsari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Laurino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gemignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marcocci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"1822_CR1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1056\/NEJMcp0803050","volume":"359","author":"D Shoback","year":"2008","unstructured":"Shoback D (2008) Clinical practice. Hypoparathyroidism N Engl J Med 359:391\u2013403. https:\/\/doi.org\/10.1056\/NEJMcp0803050","journal-title":"Hypoparathyroidism N Engl J Med"},{"key":"1822_CR2","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1097\/BOR.0000000000000618","volume":"31","author":"NE Cusano","year":"2019","unstructured":"Cusano NE, Bilezikian JP (2019) Update on hypoparathyroidism. Curr Opin Rheumatol 31:381\u2013387. https:\/\/doi.org\/10.1097\/BOR.0000000000000618","journal-title":"Curr Opin Rheumatol"},{"key":"1822_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.483","author":"JP Bilezikian","year":"2011","unstructured":"Bilezikian JP, Khan A, Potts JT et al (2011) Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res. https:\/\/doi.org\/10.1002\/jbmr.483","journal-title":"J Bone Miner Res"},{"key":"1822_CR4","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1210\/jc.2015-3909","volume":"101","author":"DM Shoback","year":"2016","unstructured":"Shoback DM, Bilezikian JP, Costa AG et al (2016) Presentation of hypoparathyroidism: etiologies and clinical features. J Clin Endocrinol Metab 101:2300\u20132312. https:\/\/doi.org\/10.1210\/jc.2015-3909. (Epub 2016 Mar 4)","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1979","author":"L Underbjerg","year":"2013","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2013) Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res. https:\/\/doi.org\/10.1002\/jbmr.1979","journal-title":"J Bone Miner Res"},{"key":"1822_CR6","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/jbmr.2273","volume":"29","author":"L Underbjerg","year":"2014","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2014) Postsurgical hypoparathyroidism-risk of fractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res 29:2504\u20132510. https:\/\/doi.org\/10.1002\/jbmr.2273","journal-title":"J Bone Miner Res"},{"key":"1822_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2501","author":"L Underbjerg","year":"2015","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2015) The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res. https:\/\/doi.org\/10.1002\/jbmr.2501","journal-title":"J Bone Miner Res"},{"key":"1822_CR8","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22717.1","author":"MR Rubin","year":"2020","unstructured":"Rubin MR (2020) Recent advances in understanding and managing hypoparathyroidism. F1000Research. https:\/\/doi.org\/10.12688\/f1000research.22717.1","journal-title":"F1000Research"},{"key":"1822_CR9","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1002\/jbmr.2812","volume":"31","author":"T Sikjaer","year":"2016","unstructured":"Sikjaer T, Moser E, Rolighed L et al (2016) Concurrent hypoparathyroidism is associated with impaired physical function and quality of life in hypothyroidism. J Bone Miner Res 31:1440\u20131448. https:\/\/doi.org\/10.1002\/jbmr.2812","journal-title":"J Bone Miner Res"},{"key":"1822_CR10","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460215","author":"W Arlt","year":"2002","unstructured":"Arlt W, Fremerey C, Callies F et al (2002) Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol. https:\/\/doi.org\/10.1530\/eje.0.1460215","journal-title":"Eur J Endocrinol"},{"key":"1822_CR11","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01355-w","author":"G Zavatta","year":"2021","unstructured":"Zavatta G, Clarke BL (2021) Basal ganglia calcification in hypoparathyroidism and pseudohypoparathyroidism: local and systemic metabolic mechanisms. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-020-01355-w","journal-title":"J Endocrinol Invest"},{"key":"1822_CR12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.26.15455","author":"TB Usdin","year":"1995","unstructured":"Usdin TB, Gruber C, Bonner TI (1995) Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.270.26.15455","journal-title":"J Biol Chem"},{"key":"1822_CR13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211775","author":"G B\u00fchler","year":"1997","unstructured":"B\u00fchler G, Balabanova S, Milowski S et al (1997) Detection of immunoreactive parathyroid hormone-related protein in human cerebrospinal fluid. Exp Clin Endocrinol Diabetes. https:\/\/doi.org\/10.1055\/s-0029-1211775","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1822_CR14","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02430","author":"G Tabacco","year":"2019","unstructured":"Tabacco G, Tay YKD, Cusano NE et al (2019) Quality of life in hypoparathyroidism improves with rhPTH(1\u201384) throughout 8 years of therapy. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jc.2018-02430","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR15","doi-asserted-by":"publisher","first-page":"3694","DOI":"10.1210\/jc.2014-2267","volume":"99","author":"NE Cusano","year":"2014","unstructured":"Cusano NE, Rubin MR, McMahon DJ et al (2014) PTH(1\u201384) is associated with improved quality of life in hypoparathyroidism through 5 years of therapy. J Clin Endocrinol Metab 99:3694\u20133699. https:\/\/doi.org\/10.1210\/jc.2014-2267","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13593","author":"L Underbjerg","year":"2018","unstructured":"Underbjerg L, Sikjaer T, Rejnmark L (2018) Health-related quality of life in patients with nonsurgical hypoparathyroidism and pseudohypoparathyroidism. Clin Endocrinol (Oxf). https:\/\/doi.org\/10.1111\/cen.13593","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1822_CR17","doi-asserted-by":"publisher","first-page":"3045","DOI":"10.1210\/jc.2016-1477","volume":"101","author":"MC Astor","year":"2016","unstructured":"Astor MC, L\u00f8vas K, Debowska A et al (2016) Epidemiology and health-related quality of life in hypoparathyroidism in Norway. J Clin Endocrinol Metab 101:3045\u20133053. https:\/\/doi.org\/10.1210\/jc.2016-1477","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2018.07.010","author":"TJ Vokes","year":"2018","unstructured":"Vokes TJ (2018) Quality of life in hypoparathyroidism. Endocrinol Metab Clin North Am. https:\/\/doi.org\/10.1016\/j.ecl.2018.07.010","journal-title":"Endocrinol Metab Clin North Am"},{"key":"1822_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10368","author":"D Wilde","year":"2020","unstructured":"Wilde D, Wilken L, Stamm B et al (2020) Quantification of symptom load by a disease-specific questionnaire HPQ 28 and analysis of associated biochemical parameters in patients with postsurgical hypoparathyroidism. JBMR Plus. https:\/\/doi.org\/10.1002\/jbm4.10368","journal-title":"JBMR Plus"},{"key":"1822_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00123-7","author":"AE Bonomi","year":"2000","unstructured":"Bonomi AE, Patrick DL, Bushnell DM, Martin M (2000) Validation of the United States\u2019 version of the world health organization quality of life (WHOQOL) instrument. J Clin Epidemiol. https:\/\/doi.org\/10.1016\/S0895-4356(99)00123-7","journal-title":"J Clin Epidemiol"},{"key":"1822_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2005.00739.x","author":"MA Verdugo","year":"2005","unstructured":"Verdugo MA, Schalock RL, Keith KD, Stancliffe RJ (2005) Quality of life and its measurement: Important principles and guidelines. J Intellect Disabil Res. https:\/\/doi.org\/10.1111\/j.1365-2788.2005.00739.x","journal-title":"J Intellect Disabil Res"},{"key":"1822_CR22","doi-asserted-by":"publisher","DOI":"10.1080\/13825580601025932","author":"RL Heilbronner","year":"2007","unstructured":"Heilbronner RL (2007) American academy of clinical neuropsychology (AACN) practice guidelines for neuropsychological assessment and consultation. Clin Neuropsychol. https:\/\/doi.org\/10.1080\/13825580601025932","journal-title":"Clin Neuropsychol"},{"key":"1822_CR23","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2017-001743","author":"C Zucchella","year":"2018","unstructured":"Zucchella C, Federico A, Martini A et al (2018) Neuropsychological testing. Pract Neurol. https:\/\/doi.org\/10.1136\/practneurol-2017-001743","journal-title":"Pract Neurol"},{"key":"1822_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01423-1","author":"A Sardella","year":"2020","unstructured":"Sardella A, Bellone F, Morabito N et al (2020) The association between hypoparathyroidism and cognitive impairment: a systematic review. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-020-01423-1","journal-title":"J Endocrinol Invest"},{"key":"1822_CR25","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1046\/j.1365-2265.2003.01696.x","volume":"58","author":"F Cetani","year":"2003","unstructured":"Cetani F, Pardi E, Borsari S et al (2003) Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation. Clin Endocrinol (Oxf) 58:199\u2013206. https:\/\/doi.org\/10.1046\/j.1365-2265.2003.01696.x","journal-title":"Clin Endocrinol (Oxf)"},{"key":"1822_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0931-8","author":"G Viccica","year":"2016","unstructured":"Viccica G, Cetani F, Vignali E et al (2016) Impact of vitamin D deficiency on the clinical and biochemical phenotype in women with sporadic primary hyperparathyroidism. Endocrine. https:\/\/doi.org\/10.1007\/s12020-016-0931-8","journal-title":"Endocrine"},{"key":"1822_CR27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39582.589433.BE","author":"MS Cooper","year":"2008","unstructured":"Cooper MS, Gittoes NJL (2008) Diagnosis and management of hypocalcaemia. BMJ. https:\/\/doi.org\/10.1136\/bmj.39582.589433.BE","journal-title":"BMJ"},{"key":"1822_CR28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med. https:\/\/doi.org\/10.7326\/0003-4819-150-9-200905050-00006","journal-title":"Ann Intern Med"},{"key":"1822_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6177(03)00039-8","author":"TN Tombaugh","year":"2004","unstructured":"Tombaugh TN (2004) Trail making test A and B: normative data stratified by age and education. Arch Clin Neuropsychol. https:\/\/doi.org\/10.1016\/S0887-6177(03)00039-8","journal-title":"Arch Clin Neuropsychol"},{"key":"1822_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-012-1130-x","author":"M Monaco","year":"2013","unstructured":"Monaco M, Costa A, Caltagirone C, Carlesimo GA (2013) Forward and backward span for verbal and visuo-spatial data: standardization and normative data from an Italian adult population. Neurol Sci. https:\/\/doi.org\/10.1007\/s10072-012-1130-x","journal-title":"Neurol Sci"},{"key":"1822_CR31","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1729-1","author":"B Zarino","year":"2014","unstructured":"Zarino B, Crespi M, Launi M, Casarotti A (2014) A new standardization of semantic verbal fluency test. Neurol Sci. https:\/\/doi.org\/10.1007\/s10072-014-1729-1","journal-title":"Neurol Sci"},{"key":"1822_CR32","doi-asserted-by":"publisher","unstructured":"Reitan RM, Hom J, Van De Voorde J, Stanczak DE, Wolfson D (1998) The Houston Conference revisited. Arch Clin Neuropsychol 19(3):375\u201390. https:\/\/doi.org\/10.1016\/S0887-6177(03)00077-5. (PMID:15033223)","DOI":"10.1016\/S0887-6177(03)00077-5"},{"key":"1822_CR33","doi-asserted-by":"publisher","DOI":"10.1080\/01688639708403761","author":"E Capitani","year":"1997","unstructured":"Capitani E, Laiacona M (1997) Composite neuropsychological batteries and demographic correction: standardization based on equivalent scores, with a review of published data. J Clin Exp Neuropsychol. https:\/\/doi.org\/10.1080\/01688639708403761","journal-title":"J Clin Exp Neuropsychol"},{"key":"1822_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-008-0970-x","author":"A Bianchi","year":"2008","unstructured":"Bianchi A, Dai Pr\u00e0 M (2008) Twenty years after Spinnler and Tognoni: new instruments in the Italian neuropsychologist\u2019s toolbox. Neurol Sci. https:\/\/doi.org\/10.1007\/s10072-008-0970-x","journal-title":"Neurol Sci"},{"key":"1822_CR35","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1210\/jc.2015-3907","volume":"101","author":"ML Brandi","year":"2016","unstructured":"Brandi ML, Bilezikian JP, Shoback D et al (2016) Management of hypoparathyroidism: summary statement and guidelines. J Clin Endocrinol Metab 101:2273\u20132283. https:\/\/doi.org\/10.1210\/jc.2015-3907","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR36","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1002\/jbmr.483","volume":"26","author":"JP Bilezikian","year":"2011","unstructured":"Bilezikian JP, Khan A, Potts JT et al (2011) Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research. J Bone Miner Res 26:2317\u20132337. https:\/\/doi.org\/10.1002\/jbmr.483","journal-title":"J Bone Miner Res"},{"key":"1822_CR37","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1210\/jc.2015-3908","volume":"101","author":"BL Clarke","year":"2016","unstructured":"Clarke BL, Brown EM, Collins MT et al (2016) Epidemiology and diagnosis of hypoparathyroidism. J Clin Endocrinol Metab 101:2284\u20132299. https:\/\/doi.org\/10.1210\/jc.2015-3908","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR38","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2273","author":"L Underbjerg","year":"2014","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2014) Postsurgical hypoparathyroidism-risk of fractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res. https:\/\/doi.org\/10.1002\/jbmr.2273","journal-title":"J Bone Miner Res"},{"key":"1822_CR39","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080803","author":"MR Rubin","year":"2008","unstructured":"Rubin MR, Dempster DW, Zhou H et al (2008) Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res. https:\/\/doi.org\/10.1359\/jbmr.080803","journal-title":"J Bone Miner Res"},{"key":"1822_CR40","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/jbmr.1979","volume":"28","author":"L Underbjerg","year":"2013","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2013) Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res 28:2277\u20132285. https:\/\/doi.org\/10.1002\/jbmr.1979","journal-title":"J Bone Miner Res"},{"key":"1822_CR41","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-021-01686-2","author":"L Mazoni","year":"2021","unstructured":"Mazoni L, Matrone A, Apicella M et al (2021) Renal complications and quality of life in postsurgical hypoparathyroidism: a case\u2013control study. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-021-01686-2","journal-title":"J Endocrinol Invest"},{"key":"1822_CR42","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01442-y","author":"NAT Hamdy","year":"2021","unstructured":"Hamdy NAT, Decallonne B, Evenepoel P et al (2021) Burden of illness in patients with chronic hypoparathyroidism not adequately controlled with conventional therapy: a Belgium and the Netherlands survey. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-020-01442-y","journal-title":"J Endocrinol Invest"},{"key":"1822_CR43","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01471","author":"TJ Vokes","year":"2018","unstructured":"Vokes TJ, Mannstadt M, Levine MA et al (2018) Recombinant human parathyroid hormone effect on health-related quality of life in adults with chronic hypoparathyroidism. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jc.2017-01471","journal-title":"J Clin Endocrinol Metab"},{"key":"1822_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11657-020-00759-8","volume":"15","author":"S Hepsen","year":"2020","unstructured":"Hepsen S, Akhanli P, Sakiz D et al (2020) The effects of patient and disease-related factors on the quality of life in patients with hypoparathyroidism. Arch Osteoporos 15:1\u20138. https:\/\/doi.org\/10.1007\/s11657-020-00759-8","journal-title":"Arch Osteoporos"},{"key":"1822_CR45","doi-asserted-by":"publisher","DOI":"10.1177\/1073191115602552","author":"J Llin\u00e0s-Regl\u00e0","year":"2017","unstructured":"Llin\u00e0s-Regl\u00e0 J, Vilalta-Franch J, L\u00f3pez-Pousa S et al (2017) The trail making test: association with other neuropsychological measures and normative values for adults aged 55 years and older from a Spanish-speaking population-based sample. Assessment. https:\/\/doi.org\/10.1177\/1073191115602552","journal-title":"Assessment"},{"key":"1822_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2014.02.006","author":"C Reverberi","year":"2014","unstructured":"Reverberi C, Cherubini P, Baldinelli S, Luzzi S (2014) Semantic fluency: cognitive basis and diagnostic performance in focal dementias and Alzheimer\u2019s disease. Cortex. https:\/\/doi.org\/10.1016\/j.cortex.2014.02.006","journal-title":"Cortex"},{"key":"1822_CR47","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1530\/EJE-12-0946","volume":"168","author":"S Aggarwal","year":"2013","unstructured":"Aggarwal S, Kailash S, Sagar R et al (2013) Neuropsychological dysfunction in idiopathic hypoparathyroidism and its relationship with intracranial calcification and serum total calcium. Eur J Endocrinol 168:895\u2013903. https:\/\/doi.org\/10.1530\/EJE-12-0946","journal-title":"Eur J Endocrinol"},{"key":"1822_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00061","author":"EM Kawamoto","year":"2012","unstructured":"Kawamoto EM, Vivar C, Camandola S (2012) Physiology and pathology of calcium signaling in the brain. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2012.00061","journal-title":"Front Pharmacol"},{"key":"1822_CR49","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.26.041002.131412","author":"TC S\u00fcdhof","year":"2004","unstructured":"S\u00fcdhof TC (2004) The synaptic vesicle cycle. Annu Rev Neurosci. https:\/\/doi.org\/10.1146\/annurev.neuro.26.041002.131412","journal-title":"Annu Rev Neurosci"},{"key":"1822_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.022","author":"S Konur","year":"2005","unstructured":"Konur S, Ghosh A (2005) Calcium signaling and the control of dendritic development. Neuron. https:\/\/doi.org\/10.1016\/j.neuron.2005.04.022","journal-title":"Neuron"},{"key":"1822_CR51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07341.x","author":"K Michaelsen","year":"2010","unstructured":"Michaelsen K, Lohmann C (2010) Calcium dynamics at developing synapses: mechanisms and functions. Eur J Neurosci. https:\/\/doi.org\/10.1111\/j.1460-9568.2010.07341.x","journal-title":"Eur J Neurosci"},{"key":"1822_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218323","author":"S Patergnani","year":"2020","unstructured":"Patergnani S, Danese A, Bouhamida E et al (2020) Various aspects of calcium signaling in the regulation of apoptosis, autophagy, cell proliferation, and cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21218323","journal-title":"Int J Mol Sci"},{"key":"1822_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00379","author":"S Guerra-Gomes","year":"2018","unstructured":"Guerra-Gomes S, Viana JF, Nascimento DSM et al (2018) The role of astrocytic calcium signaling in the aged prefrontal cortex. Front Cell Neurosci. https:\/\/doi.org\/10.3389\/fncel.2018.00379","journal-title":"Front Cell Neurosci"},{"key":"1822_CR54","doi-asserted-by":"publisher","DOI":"10.1007\/s10867-009-9147-y","author":"A Pereira","year":"2009","unstructured":"Pereira A, Furlan FA (2009) On the role of synchrony for neuron-astrocyte interactions and perceptual conscious processing. J Biol Phys. https:\/\/doi.org\/10.1007\/s10867-009-9147-y","journal-title":"J Biol Phys"},{"key":"1822_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2012.00200","author":"V Nikoletopoulou","year":"2012","unstructured":"Nikoletopoulou V, Tavernarakis N (2012) Calcium homeostasis in aging neurons. Front Genet. https:\/\/doi.org\/10.3389\/fgene.2012.00200","journal-title":"Front Genet"},{"key":"1822_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094914","author":"R Cascella","year":"2021","unstructured":"Cascella R, Cecchi C (2021) Calcium dyshomeostasis in Alzheimer\u2019s disease pathogenesis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22094914","journal-title":"Int J Mol Sci"},{"key":"1822_CR57","doi-asserted-by":"publisher","DOI":"10.3109\/00365518809085762","author":"A Sorva","year":"1988","unstructured":"Sorva A, Elfving S, Pohja P, Tilvis RS (1988) Assessment of calcaemic status in geriatric hospital patients: serum ionized calcium versus albumin-adjusted total calcium. Scand J Clin Lab Invest. https:\/\/doi.org\/10.3109\/00365518809085762","journal-title":"Scand J Clin Lab Invest"},{"key":"1822_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)91068-1","author":"CY Tai","year":"1986","unstructured":"Tai CY, Smith QR, Rapoport SI (1986) Calcium influxes into brain and cerebrospinal fluid are linearly related to plasma ionized calcium concentration. Brain Res. https:\/\/doi.org\/10.1016\/0006-8993(86)91068-1","journal-title":"Brain Res"},{"key":"1822_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2017.00776","volume":"8","author":"P Suarez-Bregua","year":"2017","unstructured":"Suarez-Bregua P, Cal L, Ca\u00f1estro C, Rotllant J (2017) PTH reloaded: a new evolutionary perspective. Front Physiol 8:1\u20137. https:\/\/doi.org\/10.3389\/fphys.2017.00776","journal-title":"Front Physiol"},{"key":"1822_CR60","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00121","author":"A Dobolyi","year":"2012","unstructured":"Dobolyi A, Dimitrov E, Palkovits M, Usdin TB (2012) The neuroendocrine functions of the parathyroid hormone 2 receptor. Front Endocrinol (Lausanne). https:\/\/doi.org\/10.3389\/fendo.2012.00121","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1822_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.054","author":"AG Bag\u00f3","year":"2009","unstructured":"Bag\u00f3 AG, Dimitrov E, Saunders R et al (2009) Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. Neuroscience. https:\/\/doi.org\/10.1016\/j.neuroscience.2009.04.054","journal-title":"Neuroscience"},{"key":"1822_CR62","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21330","author":"CA Faber","year":"2007","unstructured":"Faber CA, Dobolyi A, Sleeman M, Usdin TB (2007) Distribution of tuberoinfundibular peptide of 39 residues and its receptor, parathyroid hormone 2 receptor, in the mouse brain. J Comp Neurol. https:\/\/doi.org\/10.1002\/cne.21330","journal-title":"J Comp Neurol"},{"key":"1822_CR63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00643.x","author":"L Coutellier","year":"2011","unstructured":"Coutellier L, Logemann A, Kuo J et al (2011) TIP39 modulates effects of novelty-induced arousal on memory. Genes, Brain Behav. https:\/\/doi.org\/10.1111\/j.1601-183X.2010.00643.x","journal-title":"Genes, Brain Behav"},{"key":"1822_CR64","doi-asserted-by":"publisher","DOI":"10.1038\/14724","author":"TB Usdin","year":"1999","unstructured":"Usdin TB, Hoare SRJ, Wang T et al (1999) TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus [2]. Nat Neurosci. https:\/\/doi.org\/10.1038\/14724","journal-title":"Nat Neurosci"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01822-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-022-01822-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01822-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T14:00:15Z","timestamp":1662732015000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-022-01822-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["1822"],"URL":"https:\/\/doi.org\/10.1007\/s40618-022-01822-6","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest. F. Cetani is member of JEI Editorial Board.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study has been approved by the appropriate institutional and\/or national research ethics committee and has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}