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The vitamin D and calcium sensing receptors (VDR and CaSR, respectively) are expressed in the stem cells of the hair follicle and epidermis where they play a critical role in enabling the stem cells to respond to wounding. Deletion of <jats:italic>Vdr<\/jats:italic> and\/or <jats:italic>Casr<\/jats:italic> from these cells delays wound healing. The VDR is regulated by co-regulators such as the Med 1 complex and other transcription factors such as Ctnnb (beta-catenin) and p63. The formation of the Cdh1\/Ctnn (E-cadherin\/catenin) complex jointly stimulated by vitamin D and calcium plays a critical role in the activation, migration, and re-epithelialization processes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Vitamin D and calcium signaling are critical for the ability of epidermal and hair follicle stem cells to respond to wounding. Vitamin D deficiency with the accompanying decrease in calcium signaling can result in delayed and\/or chronic wounds, a major cause of morbidity, loss of productivity, and medical expense.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01893-5","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T20:16:56Z","timestamp":1660421816000},"page":"205-212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Role of vitamin D and calcium signaling in epidermal wound healing"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-475X","authenticated-orcid":false,"given":"D. 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