{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:05:36Z","timestamp":1778295936877,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Sellar\/parasellar lesions have been studied in the adult and paediatric age range, but during the transition age their epidemiology, clinical manifestations, management and treatment outcomes have been poorly investigated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>An Italian multicentre cohort study, in which hospital records of patients with diagnosis of sellar\/parasellar lesions during the transition age and young adulthood (15\u201325\u00a0years), were reviewed in terms of prevalence, clinical and hormonal features at diagnosis, and outcomes where available. Both pituitary neuroendocrine tumours (pituitary tumours, Group A) and non-endocrine lesions (Group B) were included.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among Group A (<jats:italic>n<\/jats:italic>\u2009=\u2009170, 46.5% macroadenomas), the most frequent were prolactin and GH-secreting tumours, with a female predominance. Among Group B (<jats:italic>n<\/jats:italic>\u2009=\u200928), germinomas and Rathke cells cysts were the most common. In Group A, the most frequent hormonal deficiency was gonadal dysfunction. Galactorrhoea and amenorrhoea were relatively common in female patients with prolactinomas. Pre-surgical diabetes insipidus was only seen in Group B, in which also hormone deficiencies were more frequent and numerous. Larger lesions were more likely to be seen in Group B. Patients in Group B were more frequently male, younger, and leaner than those of Group A, whereas at last follow-up they showed more obesity and dyslipidaemia. In our cohort, the percentage of patients with at least one pituitary deficiency increased slightly after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The management of sellar\/parasellar lesions is challenging in the transition age, requiring an integrated and multidisciplinary approach. Hormone and metabolic disorders can occur many years after treatment, therefore long-term follow-up is mandatory.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-022-01900-9","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:04:25Z","timestamp":1661328265000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sellar and parasellar lesions in the transition age: a retrospective Italian multi-centre study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-0064","authenticated-orcid":false,"given":"T.","family":"Feola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-9328","authenticated-orcid":false,"given":"R.sa","family":"Pirchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-9146","authenticated-orcid":false,"given":"G.","family":"Puliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Pofi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-4767","authenticated-orcid":false,"given":"M.","family":"Crocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-4462","authenticated-orcid":false,"given":"V.","family":"Sada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-627X","authenticated-orcid":false,"given":"F.","family":"Sesti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Verdecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-8266","authenticated-orcid":false,"given":"D.","family":"Gianfrilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-1335","authenticated-orcid":false,"given":"M.","family":"Appetecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4492-4585","authenticated-orcid":false,"given":"N.","family":"Di Iorgi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Jaffrain-Rea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-1348","authenticated-orcid":false,"given":"R.","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5417","authenticated-orcid":false,"given":"A. M.","family":"Isidori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-9783","authenticated-orcid":false,"given":"E.","family":"Sbardella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"TALENT group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Foresta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Krausz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Durante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"De Martino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Paoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ferrigno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Caiulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Minnetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Hasenmajer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kanakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cangiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Tenuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Petrozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Carlomagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Di Nisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pallotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Tarsitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Spaziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cargnelutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Sabovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Grani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Virili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cozzolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Stramazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Filardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mazzotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"issue":"3","key":"1900_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s11102-020-01120-5","volume":"24","author":"LE Castellanos","year":"2021","unstructured":"Castellanos LE, Misra M, Smith TR, Laws ER, Iorgulescu JB (2021) The epidemiology and management patterns of pediatric pituitary tumors in the United States. Pituitary 24(3):412\u2013419. https:\/\/doi.org\/10.1007\/s11102-020-01120-5","journal-title":"Pituitary"},{"key":"1900_CR2","unstructured":"Colao A, Pirchio R. Pituitary Tumors in Childhood. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, et al., editors. Endotext. South Dartmouth (MA)2000."},{"issue":"6","key":"1900_CR3","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12995","volume":"33","author":"E Sbardella","year":"2021","unstructured":"Sbardella E, Puliani G, Feola T, Pofi R, Pirchio R, Sesti F et al (2021) A clinical approach to parasellar lesions in the transition age. J Neuroendocrinol 33(6):e12995. https:\/\/doi.org\/10.1111\/jne.12995","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"1900_CR4","doi-asserted-by":"publisher","first-page":"R155","DOI":"10.1530\/EJE-19-0298","volume":"181","author":"E Sbardella","year":"2019","unstructured":"Sbardella E, Pozza C, Isidori AM, Grossman AB (2019) Endocrinology and adolescence: dealing with transition in young patients with pituitary disorders. Eur J Endocrinol 181(4):R155\u2013R171. https:\/\/doi.org\/10.1530\/EJE-19-0298","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"1900_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2352-4642(18)30022-1","volume":"2","author":"SM Sawyer","year":"2018","unstructured":"Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC (2018) The age of adolescence. Lancet Child Adolesc Health 2(3):223\u2013228. https:\/\/doi.org\/10.1016\/S2352-4642(18)30022-1","journal-title":"Lancet Child Adolesc Health"},{"issue":"11","key":"1900_CR6","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S2352-4642(19)30266-4","volume":"3","author":"SM Sawyer","year":"2019","unstructured":"Sawyer SM, McNeil R, Francis KL, Matskarofski JZ, Patton GC, Bhutta ZA et al (2019) The age of paediatrics. Lancet Child Adolesc Health 3(11):822\u2013830. https:\/\/doi.org\/10.1016\/S2352-4642(19)30266-4","journal-title":"Lancet Child Adolesc Health"},{"issue":"4","key":"1900_CR7","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1586\/14737175.8.4.563","volume":"8","author":"MF Keil","year":"2008","unstructured":"Keil MF, Stratakis CA (2008) Pituitary tumors in childhood: update of diagnosis, treatment and molecular genetics. Expert Rev Neurother 8(4):563\u2013574. https:\/\/doi.org\/10.1586\/14737175.8.4.563","journal-title":"Expert Rev Neurother"},{"issue":"3","key":"1900_CR8","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.beem.2010.03.001","volume":"24","author":"S Vandeva","year":"2010","unstructured":"Vandeva S, Jaffrain-Rea ML, Daly AF, Tichomirowa M, Zacharieva S, Beckers A (2010) The genetics of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 24(3):461\u2013476. https:\/\/doi.org\/10.1016\/j.beem.2010.03.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"7","key":"1900_CR9","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1093\/jnen\/nlz040","volume":"78","author":"J Chen","year":"2019","unstructured":"Chen J, Schmidt RE, Dahiya S (2019) Pituitary adenoma in pediatric and adolescent populations. J Neuropathol Exp Neurol 78(7):626\u2013632. https:\/\/doi.org\/10.1093\/jnen\/nlz040","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"1900_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s11060-020-03512-w","volume":"148","author":"H Wang","year":"2020","unstructured":"Wang H, Wang R, Hu T, Wang Z, Duan Y, Han S et al (2020) Nonfunctioning pituitary adenomas in pediatric and adolescent patients: a clinical analysis of a series of 14 patients. J Neurooncol 148(1):179\u2013186. https:\/\/doi.org\/10.1007\/s11060-020-03512-w","journal-title":"J Neurooncol"},{"issue":"1","key":"1900_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11102-017-0836-4","volume":"21","author":"Y Nagata","year":"2018","unstructured":"Nagata Y, Inoshita N, Fukuhara N, Yamaguchi-Okada M, Nishioka H, Iwata T et al (2018) Growth hormone-producing pituitary adenomas in childhood and young adulthood: clinical features and outcomes. Pituitary 21(1):1\u20139. https:\/\/doi.org\/10.1007\/s11102-017-0836-4","journal-title":"Pituitary"},{"issue":"4","key":"1900_CR12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1530\/EJE-10-0519","volume":"163","author":"CA Steele","year":"2010","unstructured":"Steele CA, MacFarlane IA, Blair J, Cuthbertson DJ, Didi M, Mallucci C et al (2010) Pituitary adenomas in childhood, adolescence and young adulthood: presentation, management, endocrine and metabolic outcomes. Eur J Endocrinol 163(4):515\u2013522. https:\/\/doi.org\/10.1530\/EJE-10-0519","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"1900_CR13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1055\/s-0038-1625984","volume":"79","author":"A Perry","year":"2018","unstructured":"Perry A, Graffeo CS, Marcellino C, Pollock BE, Wetjen NM, Meyer FB (2018) Pediatric pituitary adenoma: case series, review of the literature, and a skull base treatment paradigm. J Neurol Surg B Skull Base 79(1):91\u2013114. https:\/\/doi.org\/10.1055\/s-0038-1625984","journal-title":"J Neurol Surg B Skull Base"},{"issue":"2","key":"1900_CR14","doi-asserted-by":"publisher","first-page":"214","DOI":"10.3171\/2018.9.PEDS18107","volume":"23","author":"N Prendergast","year":"2018","unstructured":"Prendergast N, Aldana PR, Rotondo RL, Torres-Santiago L, Beier AD (2018) Pediatric silent corticotroph pituitary adenoma and role for proton therapy: case report. J Neurosurg Pediatr 23(2):214\u2013218. https:\/\/doi.org\/10.3171\/2018.9.PEDS18107","journal-title":"J Neurosurg Pediatr"},{"issue":"2","key":"1900_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11060-019-03173-4","volume":"143","author":"H Gittleman","year":"2019","unstructured":"Gittleman H, Cioffi G, Vecchione-Koval T, Ostrom QT, Kruchko C, Osorio DS et al (2019) Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015. J Neurooncol 143(2):251\u2013260. https:\/\/doi.org\/10.1007\/s11060-019-03173-4","journal-title":"J Neurooncol"},{"issue":"5","key":"1900_CR16","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1530\/EJE-12-0236","volume":"167","author":"L Vroonen","year":"2012","unstructured":"Vroonen L, Jaffrain-Rea ML, Petrossians P, Tamagno G, Chanson P, Vilar L et al (2012) Prolactinomas resistant to standard doses of cabergoline: a multicenter study of 92 patients. Eur J Endocrinol 167(5):651\u2013662. https:\/\/doi.org\/10.1530\/EJE-12-0236","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1900_CR17","first-page":"450","volume":"10","author":"S Jackman","year":"2013","unstructured":"Jackman S, Diamond F (2013) Pituitary adenomas in childhood and adolescence. Pediatr Endocrinol Rev 10(4):450\u2013459","journal-title":"Pediatr Endocrinol Rev"},{"issue":"1","key":"1900_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/andr.12918","volume":"9","author":"M Tenuta","year":"2021","unstructured":"Tenuta M, Carlomagno F, Cangiano B, Kanakis G, Pozza C, Sbardella E et al (2021) Somatotropic-testicular axis: a crosstalk between GH\/IGF-I and gonadal hormones during development, transition, and adult age. Andrology 9(1):168\u2013184. https:\/\/doi.org\/10.1111\/andr.12918","journal-title":"Andrology"},{"issue":"1","key":"1900_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/neuros\/nyy204","volume":"85","author":"LR Barzaghi","year":"2019","unstructured":"Barzaghi LR, Losa M, Capitanio JF, Albano L, Weber G, Mortini P (2019) Pediatric pituitary adenomas: early and long-term surgical outcome in a series of 85 consecutive patients. Neurosurgery 85(1):65\u201374. https:\/\/doi.org\/10.1093\/neuros\/nyy204","journal-title":"Neurosurgery"},{"key":"1900_CR20","doi-asserted-by":"publisher","unstructured":"Abe T, Ludecke DK, Saeger W. Clinically nonsecreting pituitary adenomas in childhood and adolescence. Neurosurgery. 1998;42(4):744\u201350; discussion 50\u20131. https:\/\/doi.org\/10.1097\/00006123-199804000-00037.","DOI":"10.1097\/00006123-199804000-00037"},{"issue":"4","key":"1900_CR21","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s11102-020-01123-2","volume":"24","author":"S Giovinazzo","year":"2021","unstructured":"Giovinazzo S, Puglisi S, Cotta OR, Alibrandi A, Aversa T, Cannavo L et al (2021) Long-term cardiometabolic outcome in patients with pituitary adenoma diagnosed in childhood and adolescence. Pituitary 24(4):483\u2013491. https:\/\/doi.org\/10.1007\/s11102-020-01123-2","journal-title":"Pituitary"},{"key":"1900_CR22","first-page":"1","volume-title":"Polyendocrine Disorders and Endocrine Neoplastic Syndromes","author":"M-L Jaffrain-Rea","year":"2019","unstructured":"Jaffrain-Rea M-L, Filipponi S (2019) Hypophysitis and granulomatous pituitary lesions in systemic diseases. In: Colao A, Jaffrain-Rea M-L, Beckers A (eds) Polyendocrine Disorders and Endocrine Neoplastic Syndromes. Springer International Publishing, Cham, pp 1\u201327"},{"issue":"4","key":"1900_CR23","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1007\/s11102-020-01052-0","volume":"23","author":"E Sbardella","year":"2020","unstructured":"Sbardella E, Crocco M, Feola T, Papa F, Puliani G, Gianfrilli D et al (2020) GH deficiency in cancer survivors in the transition age: diagnosis and therapy. Pituitary 23(4):432\u2013456. https:\/\/doi.org\/10.1007\/s11102-020-01052-0","journal-title":"Pituitary"},{"key":"1900_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.634288","volume":"12","author":"M Spaziani","year":"2021","unstructured":"Spaziani M, Tarantino C, Tahani N, Gianfrilli D, Sbardella E, Isidori AM et al (2021) Clinical, diagnostic, and therapeutic aspects of growth hormone deficiency during the transition period: review of the literature. Front Endocrinol (Lausanne) 12:634288. https:\/\/doi.org\/10.3389\/fendo.2021.634288","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"1900_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11102-021-01184-x","volume":"25","author":"A Alikasifoglu","year":"2022","unstructured":"Alikasifoglu A, Celik NB, Ozon ZA, Gonc EN, Kandemir N (2022) Management of prolactinomas in children and adolescents; which factors define the response to treatment? Pituitary 25(1):167\u2013179. https:\/\/doi.org\/10.1007\/s11102-021-01184-x","journal-title":"Pituitary"},{"issue":"12","key":"1900_CR26","doi-asserted-by":"publisher","first-page":"4317","DOI":"10.1210\/jcem.84.12.6215","volume":"84","author":"AR Lafferty","year":"1999","unstructured":"Lafferty AR, Chrousos GP (1999) Pituitary tumors in children and adolescents. J Clin Endocrinol Metab 84(12):4317\u20134323. https:\/\/doi.org\/10.1210\/jcem.84.12.6215","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1900_CR27","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.beem.2011.12.005","volume":"26","author":"E Giannetta","year":"2012","unstructured":"Giannetta E, Gianfrilli D, Barbagallo F, Isidori AM, Lenzi A (2012) Subclinical male hypogonadism. Best Pract Res Clin Endocrinol Metab 26(4):539\u2013550. https:\/\/doi.org\/10.1016\/j.beem.2011.12.005","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"1900_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111094","volume":"520","author":"M Spaziani","year":"2021","unstructured":"Spaziani M, Tarantino C, Tahani N, Gianfrilli D, Sbardella E, Lenzi A et al (2021) Hypothalamo-pituitary axis and puberty. Mol Cell Endocrinol 520:111094. https:\/\/doi.org\/10.1016\/j.mce.2020.111094","journal-title":"Mol Cell Endocrinol"},{"issue":"9\u201310","key":"1900_CR29","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1159\/000508107","volume":"110","author":"E Sbardella","year":"2020","unstructured":"Sbardella E, Minnetti M, Pofi R, Cozzolino A, Greco E, Gianfrilli D et al (2020) Late effects of parasellar lesion treatment: hypogonadism and infertility. Neuroendocrinology 110(9\u201310):868\u2013881. https:\/\/doi.org\/10.1159\/000508107","journal-title":"Neuroendocrinology"},{"key":"1900_CR30","doi-asserted-by":"publisher","unstructured":"Colao A, Loche S, Cappa M, Di Sarno A, Landi ML, Sarnacchiaro F, et al. Prolactinomas in children and adolescents. Clinical presentation and long-term follow-up. J Clin Endocrinol Metab. 1998;83(8):2777\u201380. https:\/\/doi.org\/10.1210\/jcem.83.8.5001.","DOI":"10.1210\/jcem.83.8.5001"},{"issue":"3","key":"1900_CR31","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1210\/jc.2014-3670","volume":"100","author":"S Salenave","year":"2015","unstructured":"Salenave S, Ancelle D, Bahougne T, Raverot G, Kamenicky P, Bouligand J et al (2015) Macroprolactinomas in children and adolescents: factors associated with the response to treatment in 77 patients. J Clin Endocrinol Metab 100(3):1177\u20131186. https:\/\/doi.org\/10.1210\/jc.2014-3670","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"1900_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00006123-199907000-00001","volume":"45","author":"T Abe","year":"1999","unstructured":"Abe T, Tara LA, Ludecke DK (1999) Growth hormone-secreting pituitary adenomas in childhood and adolescence: features and results of transnasal surgery. Neurosurgery 45(1):1\u201310. https:\/\/doi.org\/10.1097\/00006123-199907000-00001","journal-title":"Neurosurgery"},{"key":"1900_CR33","doi-asserted-by":"publisher","unstructured":"Aranda G, Ensenat J, Mora M, Puig-Domingo M, Martinez de Osaba MJ, Casals G, et al. Long-term remission and recurrence rate in a cohort of Cushing's disease: the need for long-term follow-up. Pituitary. 2015;18(1):142\u20139. https:\/\/doi.org\/10.1007\/s11102-014-0567-8.","DOI":"10.1007\/s11102-014-0567-8"},{"issue":"2","key":"1900_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/cen.13232","volume":"86","author":"E Sbardella","year":"2017","unstructured":"Sbardella E, Isidori AM, Woods CP, Argese N, Tomlinson JW, Shine B et al (2017) Baseline morning cortisol level as a predictor of pituitary-adrenal reserve: a comparison across three assays. Clin Endocrinol (Oxf) 86(2):177\u2013184. https:\/\/doi.org\/10.1111\/cen.13232","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"8","key":"1900_CR35","doi-asserted-by":"publisher","first-page":"3050","DOI":"10.1210\/jc.2018-00529","volume":"103","author":"R Pofi","year":"2018","unstructured":"Pofi R, Feliciano C, Sbardella E, Argese N, Woods CP, Grossman AB et al (2018) The short synacthen (Corticotropin) test can be used to predict recovery of hypothalamo-pituitary-adrenal axis function. J Clin Endocrinol Metab 103(8):3050\u20133059. https:\/\/doi.org\/10.1210\/jc.2018-00529","journal-title":"J Clin Endocrinol Metab"},{"key":"1900_CR36","doi-asserted-by":"publisher","unstructured":"Gerges MM, Rumalla K, Godil SS, Younus I, Elshamy W, Dobri GA, et al. Long-term outcomes after endoscopic endonasal surgery for nonfunctioning pituitary macroadenomas. J Neurosurg. 2020:1\u201312. https:\/\/doi.org\/10.3171\/2019.11.JNS192457.","DOI":"10.3171\/2019.11.JNS192457"},{"issue":"5","key":"1900_CR37","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s40618-019-01146-y","volume":"43","author":"AM Isidori","year":"2020","unstructured":"Isidori AM, Arnaldi G, Boscaro M, Falorni A, Giordano C, Giordano R et al (2020) Towards the tailoring of glucocorticoid replacement in adrenal insufficiency: the Italian society of endocrinology expert opinion. J Endocrinol Invest 43(5):683\u2013696. https:\/\/doi.org\/10.1007\/s40618-019-01146-y","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"1900_CR38","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12954","volume":"33","author":"A Angelousi","year":"2021","unstructured":"Angelousi A, Mytareli C, Xekouki P, Kassi E, Barkas K, Grossman A et al (2021) Diabetes insipidus secondary to sellar\/parasellar lesions. J Neuroendocrinol 33(3):e12954. https:\/\/doi.org\/10.1111\/jne.12954","journal-title":"J Neuroendocrinol"},{"issue":"1","key":"1900_CR39","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1210\/er.2018-00017","volume":"40","author":"L van Iersel","year":"2019","unstructured":"van Iersel L, Brokke KE, Adan RAH, Bulthuis LCM, van den Akker ELT, van Santen HM (2019) Pathophysiology and individualized treatment of hypothalamic obesity following craniopharyngioma and other suprasellar tumors: a systematic review. Endocr Rev 40(1):193\u2013235. https:\/\/doi.org\/10.1210\/er.2018-00017","journal-title":"Endocr Rev"},{"key":"1900_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.817257","volume":"12","author":"A Romigi","year":"2021","unstructured":"Romigi A, Feola T, Cappellano S, De Angelis M, Pio G, Caccamo M et al (2021) Sleep disorders in patients with craniopharyngioma: a physiopathological and practical update. Front Neurol 12:817257. https:\/\/doi.org\/10.3389\/fneur.2021.817257","journal-title":"Front Neurol"},{"key":"1900_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.coemr.2018.04.002","volume":"1","author":"F Hannah-Shmouni","year":"2018","unstructured":"Hannah-Shmouni F, Stratakis CA (2018) An update on the genetics of benign pituitary adenomas in children and adolescents. Curr Opin Endocr Metab Res 1:19\u201324. https:\/\/doi.org\/10.1016\/j.coemr.2018.04.002","journal-title":"Curr Opin Endocr Metab Res"},{"issue":"4","key":"1900_CR42","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1530\/EJE-11-0304","volume":"165","author":"MA Tichomirowa","year":"2011","unstructured":"Tichomirowa MA, Barlier A, Daly AF, Jaffrain-Rea ML, Ronchi C, Yaneva M et al (2011) High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas. Eur J Endocrinol 165(4):509\u2013515. https:\/\/doi.org\/10.1530\/EJE-11-0304","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"1900_CR43","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1530\/EJE-12-0763","volume":"168","author":"T Cuny","year":"2013","unstructured":"Cuny T, Pertuit M, Sahnoun-Fathallah M, Daly A, Occhi G, Odou MF et al (2013) Genetic analysis in young patients with sporadic pituitary macroadenomas: besides AIP don\u2019t forget MEN1 genetic analysis. Eur J Endocrinol 168(4):533\u2013541. https:\/\/doi.org\/10.1530\/EJE-12-0763","journal-title":"Eur J Endocrinol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01900-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-022-01900-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-022-01900-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T15:48:53Z","timestamp":1673624933000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-022-01900-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["1900"],"URL":"https:\/\/doi.org\/10.1007\/s40618-022-01900-9","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]},"assertion":[{"value":"21 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest relevant to this article to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Medical Ethics Committee of the Policlinico Umberto I, Rome (protocol code 6525).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"All procedures performed were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants"}},{"value":"Informed consent was obtained from all individual participants involved in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}