{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:51:19Z","timestamp":1769039479571,"version":"3.49.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To evaluate the association among andrological diseases at the first outpatient visit and the medications taken by patients for other comorbidities, as well as the differential impact between specific medication and relative comorbidities.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is a single-center retrospective study based on subjects who referred to the Andrology Unit with a well-defined andrological diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 3752 subjects were studied (mean age\u2009\u00b1\u2009DS 46.2\u2009\u00b1\u200916.5\u00a0years). A total of 19 categories of andrological diseases and 110 type of medications for other comorbidities were identified. ED was the most frequent andrological pathology at the first andrological examination (28.7%), followed by infertility (12.4%). The couple of variables that were statistically significant in the univariate association analysis (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were: ED and (a) antihypertensives; (b) antihyperglycemics; (c) lipids-lowering; (d) psychotropics. The univariate and multivariate regression analyses confirmed the association. All the related comorbidities were also significantly associated with the univariate analysis, and all remained significantly associated with multivariate analysis. A multivariate analysis was also conducted to analyze the association between ED and the following pairs of variables \u201cDM-antihyperglycemics\u201d, \u201cdyslipidemia-lipids-lowering\u201d, and \u201chypertension-antihypertensives\u201d. In all cases, the pathology, but not the specific treatment, was significantly associated with ED.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ED is significantly associated with antihypertensive, antihyperglycemic, lipid-lowering, psychotropic drugs\u2019 intake. Anyway, ED appears to be more related to the diseases than to the specific therapies. The definitive cause\/effect relationship should be established based on future prospective studies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-023-02011-9","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T11:19:05Z","timestamp":1674127145000},"page":"1465-1473","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6707-3413","authenticated-orcid":false,"given":"R.","family":"Mazzilli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mangini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Olana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Defeudis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gianfrilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"issue":"2","key":"2011_CR1","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.juro.2007.03.127","volume":"178","author":"ME Francis","year":"2007","unstructured":"Francis ME, Kusek JW, Nyberg LM, Eggers PW (2007) The contribution of common medical conditions and drug exposures to erectile dysfunction in adult males. J Urol 178(2):591\u2013596. https:\/\/doi.org\/10.1016\/j.juro.2007.03.127. (discussion 596; Epub 2007 Jun 13)","journal-title":"J Urol"},{"key":"2011_CR2","doi-asserted-by":"publisher","first-page":"16003","DOI":"10.1038\/nrdp.2016.3","volume":"2","author":"FA Yafi","year":"2016","unstructured":"Yafi FA, Jenkins L, Albersen M, Corona G, Isidori AM, Goldfarb S, Maggi M, Nelson CJ, Parish S, Salonia A, Tan R, Mulhall JP, Hellstrom WJ (2016) Erectile dysfunction. Nat Rev Dis Primers 2:16003. https:\/\/doi.org\/10.1038\/nrdp.2016.3","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"2011_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/s0094-0143(02)00079-4","volume":"29","author":"DM Nudell","year":"2002","unstructured":"Nudell DM, Monoski MM, Lipshultz LI (2002) Common medications and drugs: how they affect male fertility. Urol Clin North Am 29(4):965\u2013973. https:\/\/doi.org\/10.1016\/s0094-0143(02)00079-4","journal-title":"Urol Clin North Am"},{"key":"2011_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejim.2020.07.009","volume":"81","author":"A Manolis","year":"2020","unstructured":"Manolis A, Doumas M, Ferri C, Mancia G (2020) Erectile dysfunction and adherence to antihypertensive therapy: focus on \u03b2-blockers. Eur J Intern Med 81:1\u20136. https:\/\/doi.org\/10.1016\/j.ejim.2020.07.009. (Epub 2020 Jul 19)","journal-title":"Eur J Intern Med"},{"issue":"3","key":"2011_CR5","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.esxm.2019.04.001","volume":"7","author":"AM Isidori","year":"2019","unstructured":"Isidori AM, Giammusso B, Corona G, Verze P (2019) Diagnostic and therapeutic workup of erectile dysfunction: results from a delphi consensus of andrology experts. Sex Med 7(3):292\u2013302. https:\/\/doi.org\/10.1016\/j.esxm.2019.04.001. (Epub 2019 Jun 10)","journal-title":"Sex Med"},{"issue":"1","key":"2011_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4081\/aiua.2013.1.20","volume":"85","author":"J Elia","year":"2013","unstructured":"Elia J, Imbrogno N, Delfino M, Mazzilli R, Spinosa V, Mazzilli F (2013) Impact of long-term and short-term therapies on seminal parameters. Arch Ital Urol Androl 85(1):20\u201323. https:\/\/doi.org\/10.4081\/aiua.2013.1.20","journal-title":"Arch Ital Urol Androl"},{"issue":"1","key":"2011_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/humrep\/deaa266","volume":"36","author":"F Pallotti","year":"2021","unstructured":"Pallotti F, Pelloni M, Faja F, Di Chiano S, Di Rocco A, Lenzi A, Lombardo F, Paoli D (2021) Semen quality in non-Hodgkin lymphoma survivors: a monocentric retrospective study. Hum Reprod 36(1):16\u201325. https:\/\/doi.org\/10.1093\/humrep\/deaa266","journal-title":"Hum Reprod"},{"issue":"3","key":"2011_CR8","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.fertnstert.2021.07.1202","volume":"116","author":"D Velez","year":"2021","unstructured":"Velez D, Ohlander S (2021) Medical therapies causing iatrogenic male infertility. Fertil Steril 116(3):618\u2013624. https:\/\/doi.org\/10.1016\/j.fertnstert.2021.07.1202","journal-title":"Fertil Steril"},{"key":"2011_CR9","doi-asserted-by":"publisher","first-page":"620936","DOI":"10.3389\/fendo.2021.620936","volume":"12","author":"R Mazzilli","year":"2021","unstructured":"Mazzilli R, Curto M, De Bernardini D, Olana S, Capi M, Salerno G, Cipolla F, Zamponi V, Santi D, Mazzilli F, Simmaco M, Lionetto L (2021) Psychotropic drugs levels in seminal fluid: a new therapeutic drug monitoring analysis? Front Endocrinol (Lausanne) 12:620936. https:\/\/doi.org\/10.3389\/fendo.2021.620936. (PMID: 33776918)","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"2011_CR10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.5694\/mja2.50167","volume":"210","author":"CG McMahon","year":"2019","unstructured":"McMahon CG (2019) Current diagnosis and management of erectile dysfunction. Med J Aust 210(10):469\u2013476. https:\/\/doi.org\/10.5694\/mja2.50167. (Epub 2019 May 17)","journal-title":"Med J Aust"},{"issue":"1","key":"2011_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5534\/wjmh.180015","volume":"37","author":"JB Kostis","year":"2019","unstructured":"Kostis JB, Dobrzynski JM (2019) Statins and erectile dysfunction. World J Mens Health 37(1):1\u20133. https:\/\/doi.org\/10.5534\/wjmh.180015. (Epub 2018 May 11)","journal-title":"World J Mens Health"},{"issue":"1","key":"2011_CR12","doi-asserted-by":"publisher","first-page":"44","DOI":"10.4081\/aiua.2018.1.44","volume":"90","author":"R Mazzilli","year":"2018","unstructured":"Mazzilli R, Angeletti G, Olana S, Delfino M, Zamponi V, Rapinesi C, Del Casale A, Kotzalidis GD, Elia J, Callovini G, Girardi P, Mazzilli F (2018) Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors. Arch Ital Urol Androl 90(1):44\u201348. https:\/\/doi.org\/10.4081\/aiua.2018.1.44","journal-title":"Arch Ital Urol Androl"},{"issue":"8","key":"2011_CR13","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.jsxm.2021.05.016","volume":"18","author":"M Trinchieri","year":"2021","unstructured":"Trinchieri M, Trinchieri M, Perletti G, Magri V, Stamatiou K, Cai T, Montanari E, Trinchieri A (2021) Erectile and ejaculatory dysfunction associated with use of psychotropic drugs: a systematic review. J Sex Med 18(8):1354\u20131363. https:\/\/doi.org\/10.1016\/j.jsxm.2021.05.016. (Epub 2021 Jul 8)","journal-title":"J Sex Med"},{"key":"2011_CR14","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2147\/VHRM.S223331","volume":"16","author":"J Hern\u00e1ndez-Cerda","year":"2020","unstructured":"Hern\u00e1ndez-Cerda J, Bertomeu-Gonz\u00e1lez V, Zuazola P, Cordero A (2020) Understanding erectile dysfunction in hypertensive patients: the need for good patient management. Vasc Health Risk Manag 16:231\u2013239. https:\/\/doi.org\/10.2147\/VHRM.S223331","journal-title":"Vasc Health Risk Manag"},{"issue":"1","key":"2011_CR15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11154-019-09535-7","volume":"21","author":"G Corona","year":"2020","unstructured":"Corona G, Isidori AM, Aversa A, Bonomi M, Ferlin A, Foresta C, La Vignera S, Maggi M, Pivonello R, Vignozzi L, Lombardo F (2020) Male and female sexual dysfunction in diabetic subjects: focus on new antihyperglycemic drugs. Rev Endocr Metab Disord 21(1):57\u201365. https:\/\/doi.org\/10.1007\/s11154-019-09535-7","journal-title":"Rev Endocr Metab Disord"},{"key":"2011_CR16","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13192","author":"G Defeudis","year":"2022","unstructured":"Defeudis G, Mazzilli R, Di Tommaso AM, Zamponi V, Carlomagno F, Tuccinardi D, Watanabe M, Faggiano A, Gianfrilli D (2022) Effects of diet and antihyperglycemic drugs on erectile dysfunction: a systematic review. Andrology. https:\/\/doi.org\/10.1111\/andr.13192. (Epub ahead of print)","journal-title":"Andrology"},{"issue":"6","key":"2011_CR17","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1111\/andr.12099","volume":"3","author":"VA Giagulli","year":"2015","unstructured":"Giagulli VA, Carbone MD, Ramunni MI, Licchelli B, De Pergola G, Sabb\u00e0 C, Guastamacchia E, Triggiani V (2015) Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism. Andrology 3(6):1094\u20131103. https:\/\/doi.org\/10.1111\/andr.12099. (Epub 2015 Oct 7)","journal-title":"Andrology"},{"issue":"12","key":"2011_CR18","doi-asserted-by":"publisher","first-page":"3382","DOI":"10.3390\/jcm11123382","volume":"11","author":"G Defeudis","year":"2022","unstructured":"Defeudis G, Di Tommaso AM, Di Rosa C, Cimadomo D, Khazrai YM, Faggiano A, Cincione RI, Napoli N, Mazzilli R (2022) The role of antihyperglycemic drugs and diet on erectile function: results from a perspective study on a population with prediabetes and diabetes. J Clin Med 11(12):3382. https:\/\/doi.org\/10.3390\/jcm11123382","journal-title":"J Clin Med"},{"issue":"649","key":"2011_CR19","doi-asserted-by":"publisher","first-page":"eabl8503","DOI":"10.1126\/scitranslmed.abl8503","volume":"14","author":"R Pofi","year":"2022","unstructured":"Pofi R, Giannetta E, Feola T, Galea N, Barbagallo F, Campolo F, Badagliacca R, Barbano B, Ciolina F, Defeudis G, Filardi T, Sesti F, Minnetti M, Vizza CD, Pasqualetti P, Caboni P, Carbone I, Francone M, Catalano C, Pozzilli P, Lenzi A, Venneri MA, Gianfrilli D, Isidori AM (2022) Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial. Sci Transl Med. 14(649):eabl8503. https:\/\/doi.org\/10.1126\/scitranslmed.abl8503","journal-title":"Sci Transl Med."},{"issue":"9","key":"2011_CR20","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1080\/14656566.2022.2071124","volume":"23","author":"TB Jannini","year":"2022","unstructured":"Jannini TB, Sansone A, Rossi R, Di Lorenzo G, Toscano M, Siracusano A, Jannini EA (2022) Pharmacological strategies for sexual recovery in men undergoing antipsychotic treatment. Expert Opin Pharmacother 23(9):1065\u20131080. https:\/\/doi.org\/10.1080\/14656566.2022.2071124","journal-title":"Expert Opin Pharmacother"},{"issue":"1105","key":"2011_CR21","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1136\/postgradmedj-2016-134073","volume":"93","author":"DF Mobley","year":"2017","unstructured":"Mobley DF, Khera M, Baum N (2017) Recent advances in the treatment of erectile dysfunction. Postgrad Med J 93(1105):679\u2013685. https:\/\/doi.org\/10.1136\/postgradmedj-2016-134073. (Epub 2017 Jul 27)","journal-title":"Postgrad Med J"},{"issue":"2","key":"2011_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s40618-020-01350-1","volume":"44","author":"A Sansone","year":"2021","unstructured":"Sansone A, Mollaioli D, Ciocca G, Limoncin E, Colonnello E, Vena W, Jannini EA (2021) Addressing male sexual and reproductive health in the wake of COVID-19 outbreak. J Endocrinol Invest 44(2):223\u2013231","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"2011_CR23","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s40618-021-01717-y","volume":"45","author":"J Katz","year":"2022","unstructured":"Katz J, Yue S, Xue W, Xue W, Gao H (2022) Increased odds ratio for erectile dysfunction in COVID-19 patients. J Endocrinol Invest 45(4):859\u2013864. https:\/\/doi.org\/10.1007\/s40618-021-01717-y","journal-title":"J Endocrinol Invest"},{"issue":"3","key":"2011_CR24","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s40618-021-01679-1","volume":"45","author":"D Pizzol","year":"2022","unstructured":"Pizzol D, Shin JI, Trott M, Ilie PC, Ippoliti S, Carrie AM, Ghayda RA, Lozano JMO, Muyor JM, Butler L, McDermott DT, Barnett Y, Markovic L, Grabovac I, Koyanagi A, Soysal P, Tully MA, Veronese N, Smith L (2022) Social environmental impact of COVID-19 and erectile dysfunction: an explorative review. J Endocrinol Invest 45(3):483\u2013487","journal-title":"J Endocrinol Invest"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02011-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02011-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02011-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T09:22:20Z","timestamp":1686561740000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02011-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["2011"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02011-9","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"assertion":[{"value":"16 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study adhered to the Hospital\u2019s Ethics Committee guidelines and to the Ethical Principles for Medical Research Involving Human Subjects as adopted at the 18th WMA General Assembly, Helsinki, Finland, June 1964, and amended by the 55th WMA General Assembly, Tokyo, Japan, October 2004 and subsequent modifications when enforced (last, Fortaleza, Brazil, October 2013).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"For this type of study, no informed consent is required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}