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GHD was defined by the presence of at least 3 other pituitary deficits (n\u2009=\u2009223), while a preserved somatotropic function was defined by the lack of other pituitary deficits and an IGF-I SDS\u2009\u2265\u20090 (n\u2009=\u2009135). The cut-off with the best sensitivity (SE)\u00a0and specificity\u00a0(SP), was identified for each BMI category using the ROC curve analysis. To avoid over-diagnosis of GHD we subsequently searched for the cut-offs with a SP\u2009\u2265\u200995%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The best GH cut-off was 8.0\u00a0\u03bcg\/l (SE 95%, SP 100%) in lean, 7.0\u00a0\u03bcg\/l (SE 97.3%, SP 82.8%) in overweight, and 2.8\u00a0\u03bcg\/l (SE 84.3%, SP 91.7%) in obese subjects. The cut-off with a SP\u2009\u2265\u200995% was 2.6\u00a0\u03bcg\/l (SE 68.5%, SP 96.6%) in overweight and 1.75\u00a0\u03bcg\/l (SE 70.0%, SP 97.2%) in obese subjects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This is the first study that evaluates the diagnostic cut-offs of GH response to GHRH\u2009+\u2009ARG related to BMI using a clinical definition of GHD as gold standard. Our results suggest that with this new approach, the GHRH\u2009+\u2009ARG cut-offs should be revised to avoid GHD over-diagnosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-023-02081-9","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T10:01:57Z","timestamp":1681639317000},"page":"2175-2183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["GHRH\u2009+\u2009arginine test and body mass index: do we need to review diagnostic criteria for GH deficiency?"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6491-5731","authenticated-orcid":false,"given":"V.","family":"Gasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cuboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Varaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bioletto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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