{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:27:57Z","timestamp":1781047677786,"version":"3.54.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>We aimed to study the relationship between aging and increased parathyroid hormone (PTH) values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a retrospective cross-sectional study with data from patients who underwent outpatient PTH measurements performed by a second-generation electrochemiluminescence immunoassay. We included patients over 18\u00a0years of age with simultaneous PTH, calcium, and creatinine measurements and 25-OHD measured within 30\u00a0days. Patients with glomerular filtration rate\u2009&lt;\u200960\u00a0mL\/min\/1.73 m<jats:sup>2<\/jats:sup>, altered calcemia, 25-OHD level\u2009&lt;\u200920\u00a0ng\/mL, PTH values\u2009&gt;\u2009100\u00a0pg\/mL or using lithium, furosemide or antiresorptive therapy were excluded. Statistical analyses were performed using the RefineR method.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Our sample comprised 263,242 patients for the group with 25-OHD\u2009\u2265\u200920\u00a0ng\/mL, that included 160,660 with 25-OHD\u2009\u2265\u200930\u00a0ng\/mL. The difference in PTH values among age groups divided by decades was statistically significant (p\u2009&lt;\u20090.0001), regardless of 25-OHD values,\u2009\u2265\u200920 or\u2009\u2265\u200930\u00a0ng\/mL. In the group with 25-OHD\u2009\u2265\u200920\u00a0ng\/mL and more than 60\u00a0years, the PTH values were 22.1\u201384.0\u00a0pg\/mL, a different upper reference limit from the reference value recommended by the kit manufacturer.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We observed a correlation between aging and PTH increase, when measured by a second-generation immunoassay, regardless of vitamin D levels, if greater than 20\u00a0ng\/mL, in normocalcemic individuals without renal dysfunction.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-023-02107-2","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:01:42Z","timestamp":1686189702000},"page":"2525-2533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Big data-based parathyroid hormone (PTH) values emphasize need for age correction"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-3172","authenticated-orcid":false,"given":"L. 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Jose Gilberto Henriques Vieira owns stocks of Fleury Group.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Fleury Ethics Committee approved this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"There was no need to use a consent form, as the survey was retrospective and only used anonymized data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}