{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:17:52Z","timestamp":1794071872705,"version":"4.8.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-023-02111-6","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T12:02:36Z","timestamp":1684497756000},"page":"2555-2562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk"],"prefix":"10.1007","volume":"46","author":[{"given":"L.","family":"Rav\u00e0","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Fintini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Deodati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Inzaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pedicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bizzarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cianfarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6581-975X","authenticated-orcid":false,"given":"M.","family":"Manco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"2111_CR1","unstructured":"International Diabetes Federation facts and figures (2021) The IDF Diabetes Atlas Tenth edition. https:\/\/www.idf.org\/aboutdiabetes\/what-is-diabetes\/facts-figures.html. Accessed 20 Jan 2023"},{"issue":"2","key":"2111_CR2","doi-asserted-by":"publisher","first-page":"e194498","DOI":"10.1001\/jamapediatrics.2019.4498","volume":"174","author":"LJ Andes","year":"2020","unstructured":"Andes LJ, Cheng YJ, Rolka DB, Gregg EW, Imperatore G (2020) Prevalence of prediabetes among adolescents and young adults in the United States, 2005\u20132016. JAMA Pediatr 174(2):e194498","journal-title":"JAMA Pediatr"},{"issue":"7","key":"2111_CR3","doi-asserted-by":"publisher","first-page":"e12900","DOI":"10.1111\/ijpo.12900","volume":"17","author":"S Pedicelli","year":"2022","unstructured":"Pedicelli S, Fintini D, Rav\u00e0 L et al (2022) Prevalence of prediabetes in children and adolescents by class of obesity. Pediatr Obes 17(7):e12900. https:\/\/doi.org\/10.1111\/ijpo.12900","journal-title":"Pediatr Obes"},{"issue":"9","key":"2111_CR4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1046\/j.1464-5491.2002.00835.x","volume":"19","author":"N Unwin","year":"2002","unstructured":"Unwin N, Shaw J, Zimmet P, Alberti KG (2002) Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabetic Med 19(9):708\u2013723","journal-title":"Diabetic Med"},{"key":"2111_CR5","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.2337\/diab.28.12.1039","volume":"28","author":"National Diabetes Data Group","year":"1979","unstructured":"National Diabetes Data Group (1979) Classification and diagnosis of diabetes and other categories of glucose intolerance. Diabetes 28:1039\u20131057","journal-title":"Diabetes"},{"key":"2111_CR6","doi-asserted-by":"publisher","first-page":"108233","DOI":"10.1016\/j.diabres.2020.108233","volume":"165","author":"M Bergman","year":"2020","unstructured":"Bergman M, Abdul-Ghani M, DeFronzo RA et al (2020) Review of methods for detecting glycemic disorders. Diabetes Res Clin Pract 165:108233. https:\/\/doi.org\/10.1016\/j.diabres.2020.108233. (Epub Jun 1)","journal-title":"Diabetes Res Clin Pract"},{"key":"2111_CR7","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.diabres.2018.09.017","volume":"146","author":"M Bergman","year":"2018","unstructured":"Bergman M, Manco M, Sesti G et al (2018) Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose \u2265 155 mg\/dl (8.6 mmol\/L). Diabetes Res Clin Pract 146:18\u201333. https:\/\/doi.org\/10.1016\/j.diabres.2018.09.017","journal-title":"Diabetes Res Clin Pract"},{"key":"2111_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-022-01963-3","author":"M Andellini","year":"2022","unstructured":"Andellini M, Manco M, Esposito MT, Tozzi AE, Bergman M, Ritrovato M (2022) A simulation model estimates lifetime health and economic outcomes of screening prediabetes using the 1-h plasma glucose. Acta Diabetol. https:\/\/doi.org\/10.1007\/s00592-022-01963-3","journal-title":"Acta Diabetol"},{"issue":"6","key":"2111_CR9","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.2337\/dc17-1900","volume":"41","author":"E Paddock","year":"2018","unstructured":"Paddock E, Looker HC, Piaggi P, Knowler WC, Krakoff J, Chang DC (2018) One-hour plasma glucose compared with two-hour plasma glucose in relation to diabetic retinopathy in American Indians. Diabetes Care 41(6):1212\u20131217. https:\/\/doi.org\/10.2337\/dc17-1900","journal-title":"Diabetes Care"},{"key":"2111_CR10","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.diabres.2016.04.045","volume":"116","author":"D Fintini","year":"2016","unstructured":"Fintini D, Cappa M, Brufani C, Bernardini S, Barbetti F (2016) Prevalence of elevated 1-h plasma glucose and its associations in obese youth. Diabetes Res Clin Pract 116:202\u2013204. https:\/\/doi.org\/10.1016\/j.diabres.2016.04.045","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"2111_CR11","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00592-012-0384-3","volume":"49","author":"M Manco","year":"2012","unstructured":"Manco M, Miraglia Del Giudice E, Spreghini MR et al (2012) 1-Hour plasma glucose in obese youth. Acta Diabetol 49(6):435\u2013443","journal-title":"Acta Diabetol"},{"issue":"6","key":"2111_CR12","first-page":"572","volume":"12","author":"H Tfayli","year":"2011","unstructured":"Tfayli H, Lee SJ, Bacha F, Arslanian S (2011) One-hour plasma glucose concentration during the OGTT: what does it tell about \u03b2-cell function relative to insulin sensitivity in overweight\/obese children? Pediatr Diabetes 12(6):572\u2013579","journal-title":"Pediatr Diabetes"},{"issue":"5","key":"2111_CR13","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1111\/dom.13640","volume":"21","author":"D Tric\u00f2","year":"2019","unstructured":"Tric\u00f2 D, Galderisi A, Mari A, Santoro N, Caprio S (2019) One-hour post-load plasma glucose predicts progression to prediabetes in a multi-ethnic cohort of obese youths. Diabetes Obes Metab 21(5):1191\u20131198","journal-title":"Diabetes Obes Metab"},{"issue":"8","key":"2111_CR14","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.2337\/dc18-0243","volume":"41","author":"RISE Consortium","year":"2018","unstructured":"RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: II. Observations using the oral glucose tolerance test. Diabetes Care 41(8):1707\u20131716. https:\/\/doi.org\/10.2337\/dc18-0243","journal-title":"Diabetes Care"},{"issue":"8","key":"2111_CR15","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.2337\/dc18-0244","volume":"41","author":"RISE Consortium","year":"2018","unstructured":"RISE Consortium (2018) Metabolic contrasts between youth and adults with impaired glucose tolerance or recently diagnosed type 2 diabetes: I Observations using the hyperglycemic clamp. Diabetes Care 41(8):1696\u20131706. https:\/\/doi.org\/10.2337\/dc18-0244","journal-title":"Diabetes Care"},{"issue":"5","key":"2111_CR16","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1159\/000464144","volume":"87","author":"C Brufani","year":"2017","unstructured":"Brufani C, Tura A, Bedogni G et al (2017) Inside out the ragbag of glucose intolerance in obese adolescents. Horm Res Paediatr 87(5):287\u2013294. https:\/\/doi.org\/10.1159\/000464144","journal-title":"Horm Res Paediatr"},{"issue":"1","key":"2111_CR17","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1399-5448.2009.00527.x","volume":"11","author":"C Brufani","year":"2010","unstructured":"Brufani C, Ciampalini P, Grossi A et al (2010) Glucose tolerance status in 510 children and adolescents attending an obesity clinic in Central Italy. Pediatr Diabetes 11(1):47\u201354","journal-title":"Pediatr Diabetes"},{"issue":"2","key":"2111_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00592-015-0782-4","volume":"53","author":"B Shashaj","year":"2016","unstructured":"Shashaj B, Luciano R, Contoli B et al (2016) Reference ranges of HOMA-IR in normal-weight and obese young Caucasians. Acta Diabetol 53(2):251\u2013260","journal-title":"Acta Diabetol"},{"issue":"10","key":"2111_CR19","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1001\/jamapediatrics.2014.900","volume":"168","author":"B Shashaj","year":"2014","unstructured":"Shashaj B, Bedogni G, Graziani MP et al (2014) Origin of cardiovascular risk in overweight preschool children: a cohort study of cardiometabolic risk factors at the onset of obesity. JAMA Pediatr 168(10):917\u2013924","journal-title":"JAMA Pediatr"},{"issue":"8","key":"2111_CR20","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s00592-020-01669-4","volume":"58","author":"F Del Chierico","year":"2021","unstructured":"Del Chierico F, Manco M, Gardini S et al (2021) Fecal microbiota signatures of insulin resistance, inflammation, and metabolic syndrome in youth with obesity: a pilot study. Acta Diabetol 58(8):1009\u20131022","journal-title":"Acta Diabetol"},{"issue":"2","key":"2111_CR21","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/sj.ijo.0803711","volume":"32","author":"M Manco","year":"2008","unstructured":"Manco M, Marcellini M, Devito R, Comparcola D, Sartorelli MR, Nobili V (2008) Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis. Int J Obes 32(2):381\u2013387","journal-title":"Int J Obes"},{"issue":"9","key":"2111_CR22","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1136\/gut.2007.142919","volume":"57","author":"M Manco","year":"2008","unstructured":"Manco M, Bedogni G, Marcellini M et al (2008) Waist circumference correlates with liver fibrosis in children with non-alcoholic steatohepatitis. Gut 57(9):1283\u20131287","journal-title":"Gut"},{"issue":"5","key":"2111_CR23","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1093\/hmg\/ddab287","volume":"31","author":"Z Balkhiyarova","year":"2022","unstructured":"Balkhiyarova Z, Luciano R, Kaakinen M et al (2022) Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents. Hum Mol Genet 31(5):816\u2013826","journal-title":"Hum Mol Genet"},{"key":"2111_CR24","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1753-4887.1981.tb06734.x","volume":"39","author":"JM Tanner","year":"1981","unstructured":"Tanner JM (1981) Growth and maturation during adolescence. Nutr Rev 39:43\u201355","journal-title":"Nutr Rev"},{"issue":"7","key":"2111_CR25","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28(7):412\u2013419","journal-title":"Diabetologia"},{"issue":"9","key":"2111_CR26","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","volume":"22","author":"M Matsuda","year":"1999","unstructured":"Matsuda M, DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22(9):1462\u20131470","journal-title":"Diabetes Care"},{"issue":"3","key":"2111_CR27","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1464-5491.1994.tb00273.x","volume":"11","author":"DI Phillips","year":"1994","unstructured":"Phillips DI, Clark PM, Hales CN, Osmond C (1994) Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 11(3):286\u2013292","journal-title":"Diabet Med"},{"issue":"9","key":"2111_CR28","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.2337\/dc09-2261","volume":"33","author":"M Manco","year":"2010","unstructured":"Manco M, Panunzi S, Macfarlane DP, Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) Consortium et al (2010) One-hour plasma glucose identifies insulin resistance and beta-cell dysfunction in individuals with normal glucose tolerance: cross-sectional data from the relationship between Insulin sensitivity and cardiovascular risk (RISC) study. Diabetes Care 33(9):2090\u20132097","journal-title":"Diabetes Care"},{"issue":"1","key":"2111_CR29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2337\/dc17-1351","volume":"41","author":"M Pareek","year":"2018","unstructured":"Pareek M, Bhatt DL, Nielsen ML et al (2018) Enhanced predictive capability of a 1-hour oral glucose tolerance test: a prospective population-based cohort study. Diabetes Care 41(1):171\u2013177","journal-title":"Diabetes Care"},{"key":"2111_CR30","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1136\/bmj.301.6749.397","volume":"301","author":"JS Yudkin","year":"1990","unstructured":"Yudkin JS, Alberti KG, McLarty DG, Swai AB (1990) Impaired glucose tolerance. BMJ 301:397\u2013402","journal-title":"BMJ"},{"issue":"8","key":"2111_CR31","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.2337\/dc08-0225","volume":"31","author":"MA Abdul-Ghani","year":"2008","unstructured":"Abdul-Ghani MA, Abdul-Ghani T, Ali N, Defronzo RA (2008) One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes. Diabetes Care 31(8):1650\u20131655","journal-title":"Diabetes Care"},{"issue":"2","key":"2111_CR32","doi-asserted-by":"publisher","first-page":"e3096","DOI":"10.1002\/dmrr.3096","volume":"35","author":"TV Fiorentino","year":"2019","unstructured":"Fiorentino TV, Succurro E, Andreozzi F, Sciacqua A, Perticone F, Sesti G (2019) One-hour post-load hyperglycemia combined with HbA1c identifies individuals with higher risk of cardiovascular diseases: cross-sectional data from the CATAMERI study. Diabetes Metab Res Rev 35(2):e3096","journal-title":"Diabetes Metab Res Rev"},{"issue":"9","key":"2111_CR33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.numecd.2011.02.002","volume":"21","author":"E Succurro","year":"2011","unstructured":"Succurro E, Arturi F, Grembiale A et al (2011) One-hour post-load plasma glucose levels are associated with elevated liver enzymes. Nutr Metab Cardiovasc Dis 21(9):713\u2013718","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"10","key":"2111_CR34","doi-asserted-by":"publisher","first-page":"3744","DOI":"10.1210\/jc.2015-2573","volume":"100","author":"TV Fiorentino","year":"2015","unstructured":"Fiorentino TV, Marini MA, Andreozzi F et al (2015) One-hour postload hyperglycemia is a stronger predictor of type 2 diabetes than impaired fasting glucose. J Clin Endocrinol Metab 100(10):3744\u20133751","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2111_CR35","doi-asserted-by":"publisher","first-page":"753","DOI":"10.2337\/dc07-9920","volume":"30","author":"DM Nathan","year":"2007","unstructured":"Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, Zinman B, American Diabetes Association (2007) Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care 30(3):753\u2013759","journal-title":"Diabetes Care"},{"issue":"2","key":"2111_CR36","doi-asserted-by":"publisher","first-page":"159S","DOI":"10.3945\/an.111.000307","volume":"2","author":"KM Flegal","year":"2011","unstructured":"Flegal KM, Ogden CL (2011) Childhood obesity: are we all speaking the same language? Adv Nutr 2(2):159S-S166","journal-title":"Adv Nutr"},{"issue":"1","key":"2111_CR37","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s13052-018-0525-6","volume":"44","author":"G Valerio","year":"2018","unstructured":"Valerio G, Maffeis C, Saggese G et al (2018) Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian society for pediatric endocrinology and diabetology and the Italian society of pediatrics. Ital J Pediatr 44(1):88","journal-title":"Ital J Pediatr"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02111-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02111-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02111-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T17:22:45Z","timestamp":1699464165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02111-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["2111"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02111-6","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,19]]},"assertion":[{"value":"30 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No disclosures were reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the OPBG Ethics Committee (#2050\/2020).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent in accordance with the Helsinki declaration was obtained from the child\u2019s parents or legal guardians. Children over age 6 and adolescents provided written absent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}