{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:29:03Z","timestamp":1778502543082,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-023-02177-2","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T09:29:09Z","timestamp":1692782949000},"page":"593-601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Features of patients and fracture risk in hypoparathyroidism; a single center study"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3647-0680","authenticated-orcid":false,"given":"I.","family":"Slutzky-Shraga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4354-7212","authenticated-orcid":false,"given":"D.","family":"Hirsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gorshtein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Masri-Iraqi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shochat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-4212","authenticated-orcid":false,"given":"E.","family":"Robenshtok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-3894","authenticated-orcid":false,"given":"I.","family":"Shimon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-7300","authenticated-orcid":false,"given":"G.","family":"Tsvetov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"2177_CR1","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1056\/NEJMcp1800213","volume":"18","author":"RI Gafni","year":"2019","unstructured":"Gafni RI, Collins MT (2019) Hypoparathyroidism. N Engl J Med 18:1738\u20131747. https:\/\/doi.org\/10.1056\/NEJMcp1800213","journal-title":"N Engl J Med"},{"key":"2177_CR2","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1210\/clinem\/dgaa113","volume":"6","author":"JP Bilezikian","year":"2020","unstructured":"Bilezikian JP (2020) Hypoparathyroidism. J Clin Endocrinol Metab 6:1722\u20131736. https:\/\/doi.org\/10.1210\/clinem\/dgaa113","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR3","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1002\/jbmr.2273","volume":"11","author":"L Underbjerg","year":"2014","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2014) Postsurgical hypoparathyroidism-risk of fractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res 11:2504\u20132510. https:\/\/doi.org\/10.1002\/jbmr.2273","journal-title":"J Bone Miner Res"},{"key":"2177_CR4","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1002\/jbmr.1979","volume":"11","author":"L Underbjerg","year":"2013","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2013) Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. J Bone Miner Res 11:2277\u20132285. https:\/\/doi.org\/10.1002\/jbmr.1979","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2177_CR5","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1002\/jbmr.4691","volume":"37","author":"AA Khan","year":"2022","unstructured":"Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, Mannstadt M (2022) Evaluation and management of hypoparathyroidism summary statement and guidelines from the second international workshop. J Bone Miner Res 37(12):2568\u20132585. https:\/\/doi.org\/10.1002\/jbmr.4691","journal-title":"J Bone Miner Res"},{"key":"2177_CR6","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s40618-022-01822-6","volume":"45","author":"F Saponaro","year":"2022","unstructured":"Saponaro F, Alfi G, Cetani F et al (2022) Serum calcium levels are associated with cognitive function in hypoparathyroidism: a neuropsychological and biochemical study in an Italian cohort of patients with chronic post-surgical hypoparathyroidism. J Endocrinol Invest 45:1909\u20131918. https:\/\/doi.org\/10.1007\/s40618-022-01822-6","journal-title":"J Endocrinol Invest"},{"key":"2177_CR7","first-page":"1661","volume-title":"Principles of bone biology","author":"DA Hanley","year":"2008","unstructured":"Hanley DA, Watson PH, Hodsman AB, Dempster DW (2008) Pharmacological mechanisms of therapeutics: parathyroid hormone. In: Bilezikian JP, Raisz LG, Martin TJ (eds) Principles of bone biology, 3rd edn. Academic Press, Amsterdam, pp 1661\u20131695","edition":"3"},{"issue":"3","key":"2177_CR8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.23736\/S2724-6507.21.03527-2","volume":"46","author":"YD Tay","year":"2021","unstructured":"Tay YD, Tabacco G, Bilezikian JP (2021) Bone quality in hypoparathyroidism. Minerva Endocrinol 46(3):325\u2013334. https:\/\/doi.org\/10.23736\/S2724-6507.21.03527-2","journal-title":"Minerva Endocrinol"},{"key":"2177_CR9","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1210\/jcem.76.6.8501170","volume":"6","author":"S Abugassa","year":"1993","unstructured":"Abugassa S, Nordenstr\u00f6m J, Eriksson S, Sj\u00f6d\u00e9n G (1993) Bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 6:1617\u20131621. https:\/\/doi.org\/10.1210\/jcem.76.6.8501170","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR10","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1210\/jcem.80.7.7608266","volume":"7","author":"K Fujiyama","year":"1995","unstructured":"Fujiyama K, Kiriyama T, Ito M, Nakata K, Yamashita S, Yokoyama N, Nagataki S (1995) Attenuation of postmenopausal high turnover bone loss in patients with hypoparathyroidism. J Clin Endocrinol Metab 7:2135\u20132138. https:\/\/doi.org\/10.1210\/jcem.80.7.7608266","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR11","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1359\/jbmr.080803","volume":"12","author":"MR Rubin","year":"2008","unstructured":"Rubin MR, Dempster DW, Zhou H, Shane E, Nickolas T, Sliney J Jr, Silverberg SJ, Bilezikian JP (2008) Dynamic and structural properties of the skeleton in hypoparathyroidism. J Bone Miner Res 12:2018\u20132024. https:\/\/doi.org\/10.1359\/jbmr.080803","journal-title":"J Bone Miner Res"},{"key":"2177_CR12","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1111\/cen.13895","volume":"2","author":"T Vadiveloo","year":"2019","unstructured":"Vadiveloo T, Donnan PT, Leese CJ, Abraham KJ, Leese GP (2019) Increased mortality and morbidity in patients with chronic hypoparathyroidism: a population-based study. Clin Endocrinol (Oxf) 2:285\u2013292. https:\/\/doi.org\/10.1111\/cen.13895","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2177_CR13","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s11154-019-09507-x","volume":"3","author":"AM Formenti","year":"2019","unstructured":"Formenti AM, Tecilazich F, Giubbini R, Giustina A (2019) Risk of vertebral fractures in hypoparathyroidism. Rev Endocr Metab Disord 3:295\u2013302. https:\/\/doi.org\/10.1007\/s11154-019-09507-x","journal-title":"Rev Endocr Metab Disord"},{"issue":"13","key":"2177_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1472-6823-13-1","volume":"13","author":"ML Mendon\u00e7a","year":"2013","unstructured":"Mendon\u00e7a ML, Pereira FA, Nogueira-Barbosa MH, Monsignore LM, Teixeira SR, Watanabe PC, Maciel LM, de Paula FJ (2013) Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density. BMC Endocr Disord 13(13):1\u20138. https:\/\/doi.org\/10.1186\/1472-6823-13-1","journal-title":"BMC Endocr Disord"},{"key":"2177_CR15","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1210\/clinem\/dgab076","volume":"5","author":"C Cipriani","year":"2021","unstructured":"Cipriani C, Minisola S, Bilezikian JP, Diacinti D, Colangelo L, Piazzolla V, Angelozzi M, Nieddu L, Pepe J, Diacinti D (2021) Vertebral fracture assessment in postmenopausal women with postsurgical hypoparathyroidism. J Clin Endocrinol Metab 5:1303\u20131311. https:\/\/doi.org\/10.1210\/clinem\/dgab076","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR16","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1210\/jc.2016-3292","volume":"1","author":"H Chawla","year":"2017","unstructured":"Chawla H, Saha S, Kandasamy D, Sharma R, Sreenivas V, Goswami R (2017) Vertebral fractures and bone mineral density in patients with idiopathic hypoparathyroidism on long-term follow-up. J Clin Endocrinol Metab 1:251\u2013258. https:\/\/doi.org\/10.1210\/jc.2016-3292","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232842","volume":"5","author":"SH Kim","year":"2020","unstructured":"Kim SH, Rhee Y, Kim YM, Won YJ, Noh J, Moon H, Lee J, Kim SG (2020) Prevalence and complications of nonsurgical hypoparathyroidism in Korea: a nationwide cohort study. PLoS ONE 5:e0232842. https:\/\/doi.org\/10.1371\/journal.pone.0232842","journal-title":"PLoS ONE"},{"key":"2177_CR18","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"9","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kujik C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 9:1137\u20131148. https:\/\/doi.org\/10.1002\/jbmr.5650080915","journal-title":"J Bone Miner Res"},{"key":"2177_CR19","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1002\/jbmr.2501","volume":"9","author":"L Underbjerg","year":"2015","unstructured":"Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L (2015) The epidemiology of nonsurgical hypoparathyroidism in Denmark: a nationwide case finding study. J Bone Miner Res 9:1738\u20131744. https:\/\/doi.org\/10.1002\/jbmr.2501","journal-title":"J Bone Miner Res"},{"key":"2177_CR20","doi-asserted-by":"publisher","first-page":"9485","DOI":"10.3389\/fendo.2022.948435","volume":"13","author":"CB d'Alva","year":"2022","unstructured":"d\u2019Alva CB, Barreto ARF, Nogueira-Barbosa MH, Arruda CCC, Albuquerque \u00c1M, Praciano DMC, Viana RP, Gadelha DD, Viana AB Jr, Moreira IM, de Moura Filho FJR, Junqueira AFTA, Montenegro RM (2022) Morphometric vertebral fracture risk in women with postsurgical hypoparathyroidism. Front Endocrinol (Lausanne). 13:9485. https:\/\/doi.org\/10.3389\/fendo.2022.948435. (eCollection 2022. PMID: 36619538)","journal-title":"Front Endocrinol (Lausanne)."},{"key":"2177_CR21","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1007\/s00198-021-05966-8","volume":"11","author":"R Pal","year":"2021","unstructured":"Pal R, Bhadada SK, Mukherjee S, Banerjee M, Kumar A (2021) Fracture risk in hypoparathyroidism: a systematic review and meta-analysis. Osteoporos Int 11:2145\u20132153. https:\/\/doi.org\/10.1007\/s00198-021-05966-8","journal-title":"Osteoporos Int"},{"key":"2177_CR22","doi-asserted-by":"publisher","first-page":"4507","DOI":"10.1210\/jc.2012-1808","volume":"12","author":"DM Mitchell","year":"2012","unstructured":"Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, Burnett-Bowie SA, Mannstadt M (2012) Long-term follow-up of patients with hypoparathyroidism. J Clin Endocrinol Metab 12:4507\u20134514. https:\/\/doi.org\/10.1210\/jc.2012-1808. (Epub 2012 Oct 5)","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1210\/jc.2002-021388","volume":"7","author":"FK Chan","year":"2003","unstructured":"Chan FK, Tiu SC, Choi KL, Choi CH, Kong AP, Shek CC (2003) Increased bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 7:155\u20133159. https:\/\/doi.org\/10.1210\/jc.2002-021388","journal-title":"J Clin Endocrinol Metab"},{"key":"2177_CR24","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1002\/jbmr.4108","volume":"10","author":"L Johansson","year":"2020","unstructured":"Johansson L, Sundh D, Magnusson P, Rukmangatharajan K, Mellstr\u00f6m D, Nilsson A, Lorentzon M (2020) Grade 1 vertebral fractures identified by densitometric lateral spine imaging predict incident major osteoporotic fracture independently of clinical risk factors and bone mineral density in older women. JBMR 10:1942\u20131951. https:\/\/doi.org\/10.1002\/jbmr.4108","journal-title":"JBMR"},{"key":"2177_CR25","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1159\/000489672","volume":"6","author":"SM Ott","year":"2018","unstructured":"Ott SM (2018) Cortical or trabecular bone: what\u2019s the difference? Am J Nephrol 6:373\u2013375. https:\/\/doi.org\/10.1159\/000489672","journal-title":"Am J Nephrol"},{"key":"2177_CR26","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/jbmr.3094","volume":"32","author":"N Campos-Obando","year":"2017","unstructured":"Campos-Obando N, Koek WNH, Hooker ER, van der Eerden BC, Pols HA, Hofman A, van Leeuwen JP, Uitterlinden AG, Nielson CM, Zillikens MC (2017) Serum phosphate is associated with fracture risk: the Rotterdam study and MrOS. J Bone Miner Res 32:1182\u20131193. https:\/\/doi.org\/10.1002\/jbmr.3094","journal-title":"J Bone Miner Res"},{"key":"2177_CR27","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/jbmr.294","volume":"26","author":"R Zhang","year":"2011","unstructured":"Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, BonewaldL F, Feng JQ (2011) Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res 26:1047\u20131056. https:\/\/doi.org\/10.1002\/jbmr.294","journal-title":"J Bone Miner Res"},{"issue":"2016","key":"2177_CR28","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1210\/en.2005-0671","volume":"147","author":"Y Koyama","year":"2016","unstructured":"Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano T, Taketani Y, Nifuji A, Denhardt D, Noda M (2016) Osteopontin deficiency suppresses high phosphate load- induced bone loss via specific modulation of osteoclasts. Endocrinology 147(2016):3040\u20133047. https:\/\/doi.org\/10.1210\/en.2005-0671","journal-title":"Endocrinology"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02177-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02177-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02177-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T17:27:55Z","timestamp":1709227675000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02177-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["2177"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02177-2","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"9 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the ethical standards of the responsible committee on human experimentation\u00a0at the Rabin Medical Center and Israel, and with the Helsinki declaration of 1964 and later versions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and \/ or animals"}},{"value":"For this type of study formal consent was not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}