{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:32:53Z","timestamp":1770744773338,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["21790"],"award-info":[{"award-number":["21790"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003197","name":"Agenzia Italiana del Farmaco, Ministero della Salute","doi-asserted-by":"publisher","award":["AIFA-2016- 02365049"],"award-info":[{"award-number":["AIFA-2016- 02365049"]}],"id":[{"id":"10.13039\/501100003197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Surgery plays a key role in the treatment of thyroid cancer (TC) patients. Locally advanced cases, however, can require an extensive surgical approach with technical issues and a high risk of complications. In these cases, a multidisciplinary evaluation should be carried out to evaluate pros and cons. The aim of this study was to share our experience, as a multidisciplinary team, in the management of patients with locally advanced TC with a particularly extensive local disease, whose surgical approach could be challenging and part of a multimodal treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively evaluated clinical, surgical, and oncologic features of all patients with locally advanced TC who had undergone multidisciplinary surgery from January 2019 to June 2020.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Six patients (two cases each of poorly differentiated, papillary, and medullary TC) were included. Four out of six were suffering from symptoms related to the advanced disease. At pre-surgical evaluation, a multidisciplinary team proposed extended surgery with radical intent via cervicotomy and sternotomy, considering other therapies not feasible or probably ineffective without it. No one passed away in intra- or perioperative time. At the end of follow-up (median 2.6\u00a0years), all patients presented a remission of symptoms due to the advanced disease, four patients were submitted to adjuvant therapies and only one patient died for a cause unrelated to the disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This series of very advanced TCs shows the effectiveness of a surgery performed by a multidisciplinary team in controlling symptoms, allowing adjuvant therapies, and improving the survival of patients whose cases would otherwise be very difficult to manage.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40618-023-02234-w","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:01:41Z","timestamp":1701327701000},"page":"1165-1173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Management of patients with extensive locally advanced thyroid cancer: results of multimodal treatments"],"prefix":"10.1007","volume":"47","author":[{"given":"A.","family":"Prete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pieroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Marrama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bruschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Scioti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Aprile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guarracino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Ambrosini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Molinaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-9257","authenticated-orcid":false,"given":"R.","family":"Elisei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Materazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"2234_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/nrendo.2016.110","volume":"12","author":"CM Kitahara","year":"2016","unstructured":"Kitahara CM, Sosa JA (2016) The changing incidence of thyroid cancer. Nat Rev Endocrinol 12:646\u2013653. https:\/\/doi.org\/10.1038\/nrendo.2016.110","journal-title":"Nat Rev Endocrinol"},{"key":"2234_CR2","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1056\/NEJMra1501993","volume":"375","author":"JA Fagin","year":"2016","unstructured":"Fagin JA, Wells SA (2016) Biologic and clinical perspectives on thyroid cancer. N Engl J Med 375:1054\u20131067. https:\/\/doi.org\/10.1056\/NEJMra1501993","journal-title":"N Engl J Med"},{"key":"2234_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fendo.2020.00102","volume":"11","author":"A Prete","year":"2020","unstructured":"Prete A, Borges de Souza P, Censi S et al (2020) Update on fundamental mechanisms of thyroid cancer. Front Endocrinol 11:102. https:\/\/doi.org\/10.3389\/fendo.2020.00102","journal-title":"Front Endocrinol"},{"key":"2234_CR4","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1016\/S0140-6736(16)30172-6","volume":"388","author":"ME Cabanillas","year":"2016","unstructured":"Cabanillas ME, McFadden DG, Durante C (2016) Thyroid cancer. Lancet 388:2783\u20132795. https:\/\/doi.org\/10.1016\/S0140-6736(16)30172-6","journal-title":"Lancet"},{"key":"2234_CR5","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.3390\/cancers13133200","volume":"13","author":"A Prete","year":"2021","unstructured":"Prete A, Matrone A, Gambale C et al (2021) Poorly differentiated and anaplastic thyroid cancer: insights into genomics. Microenviron New Drugs Cancers 13:3200. https:\/\/doi.org\/10.3390\/cancers13133200","journal-title":"Microenviron New Drugs Cancers"},{"key":"2234_CR6","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/jc.2005-2838","volume":"91","author":"C Durante","year":"2006","unstructured":"Durante C, Haddy N, Baudin E et al (2006) Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 91:2892\u20132899. https:\/\/doi.org\/10.1210\/jc.2005-2838","journal-title":"J Clin Endocrinol Metab"},{"key":"2234_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.canep.2018.05.009","volume":"55","author":"C Mirian","year":"2018","unstructured":"Mirian C, Gr\u00f8nh\u00f8j C, Jensen DH et al (2018) Trends in thyroid cancer: retrospective analysis of incidence and survival in Denmark 1980\u20132014. Cancer Epidemiol 55:81\u201387. https:\/\/doi.org\/10.1016\/j.canep.2018.05.009","journal-title":"Cancer Epidemiol"},{"key":"2234_CR8","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejca.2017.12.027","volume":"92","author":"C de la Fouchardi\u00e8re","year":"2018","unstructured":"de la Fouchardi\u00e8re C, Decaussin-Petrucci M, Berthiller J et al (2018) Predictive factors of outcome in poorly differentiated thyroid carcinomas. Eur J Cancer 92:40\u201347. https:\/\/doi.org\/10.1016\/j.ejca.2017.12.027","journal-title":"Eur J Cancer"},{"key":"2234_CR9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/cancers13010094","volume":"13","author":"A Matrone","year":"2020","unstructured":"Matrone A, Gambale C, Prete A et al (2020) Impact of advanced age on the clinical presentation and outcome of sporadic medullary thyroid carcinoma. Cancers 13:94. https:\/\/doi.org\/10.3390\/cancers13010094","journal-title":"Cancers"},{"key":"2234_CR10","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s40618-018-0884-2","volume":"41","author":"F Pacini","year":"2018","unstructured":"Pacini F, Basolo F, Bellantone R et al (2018) Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies. J Endocrinol Invest 41:849\u2013876. https:\/\/doi.org\/10.1007\/s40618-018-0884-2","journal-title":"J Endocrinol Invest"},{"key":"2234_CR11","doi-asserted-by":"publisher","first-page":"S105","DOI":"10.2103\/gs.2019.12.16","volume":"9","author":"MD Russell","year":"2020","unstructured":"Russell MD, Kamani D, Randolph GW (2020) Modern surgery for advanced thyroid cancer: a tailored approach. Gland Surg 9:S105\u2013S119. https:\/\/doi.org\/10.2103\/gs.2019.12.16","journal-title":"Gland Surg"},{"key":"2234_CR12","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ejcts.2008.12.055","volume":"36","author":"JR Porterfield","year":"2009","unstructured":"Porterfield JR, Cassivi SD, Wigle DA et al (2009) Thoracic metastasectomy for thyroid malignancies. Eur J Cardiothorac Surg 36:155\u2013158. https:\/\/doi.org\/10.1016\/j.ejcts.2008.12.055","journal-title":"Eur J Cardiothorac Surg"},{"key":"2234_CR13","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.1158\/1078-0432.CCR-16-0484","volume":"22","author":"F Raue","year":"2016","unstructured":"Raue F, Frank-Raue K (2016) Thyroid cancer: risk-stratified management and individualized therapy. Clin Cancer Res 22:5012\u20135021. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-0484","journal-title":"Clin Cancer Res"},{"key":"2234_CR14","doi-asserted-by":"publisher","first-page":"854755","DOI":"10.3389\/fonc.2022.854755","volume":"12","author":"A Matrone","year":"2022","unstructured":"Matrone A, De Napoli L, Torregrossa L et al (2022) Core needle biopsy can early and precisely identify large thyroid masses. Front Oncol 12:854755. https:\/\/doi.org\/10.3389\/fonc.2022.854755","journal-title":"Front Oncol"},{"key":"2234_CR15","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.amjsurg.2009.11.008","volume":"200","author":"LGT Morris","year":"2010","unstructured":"Morris LGT, Myssiorek D (2010) Improved detection does not fully explain the rising incidence of well-differentiated thyroid cancer: a population-based analysis. Am J Surg 200:454\u2013461. https:\/\/doi.org\/10.1016\/j.amjsurg.2009.11.008","journal-title":"Am J Surg"},{"key":"2234_CR16","doi-asserted-by":"publisher","first-page":"099","DOI":"10.1093\/bjsopen\/zrab099","volume":"5","author":"J Dahlberg","year":"2021","unstructured":"Dahlberg J, Adok C, B\u00fcmming P et al (2021) Incidence, detection and outcome of differentiated thyroid cancer in Western Sweden. BJS Open 5:099. https:\/\/doi.org\/10.1093\/bjsopen\/zrab099","journal-title":"BJS Open"},{"key":"2234_CR17","doi-asserted-by":"publisher","first-page":"e172","DOI":"10.1210\/clinem\/dgz113","volume":"105","author":"E Molinaro","year":"2020","unstructured":"Molinaro E, Campopiano MC, Pieruzzi L et al (2020) Active surveillance in papillary thyroid microcarcinomas is feasible and safe: experience at a single Italian center. J Clin Endocrinol Metab 105:e172-180. https:\/\/doi.org\/10.1210\/clinem\/dgz113","journal-title":"J Clin Endocrinol Metab"},{"key":"2234_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1\u2013133. https:\/\/doi.org\/10.1089\/thy.2015.0020","journal-title":"Thyroid"},{"key":"2234_CR19","doi-asserted-by":"publisher","first-page":"644605","DOI":"10.3389\/fsurg.2021.644605","volume":"8","author":"W Chen","year":"2021","unstructured":"Chen W, Lei J, Wang Y et al (2021) Case report: superior vena cava resection and reconstruction for invasive thyroid cancer: report of three cases and literature review. Front Surg 8:644605. https:\/\/doi.org\/10.3389\/fsurg.2021.644605","journal-title":"Front Surg"},{"key":"2234_CR20","doi-asserted-by":"publisher","first-page":"368.e9","DOI":"10.1016\/j.avsg.2017.08.025","volume":"46","author":"BH Shirah","year":"2018","unstructured":"Shirah BH, Shirah HA, Al Hassan AK, Elnour AE (2018) Retrosternal metastatic papillary thyroid cancer causing superior vena cava syndrome: a very rare presentation. Ann Vasc Surg 46:368.e9-368.e12. https:\/\/doi.org\/10.1016\/j.avsg.2017.08.025","journal-title":"Ann Vasc Surg"},{"key":"2234_CR21","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/14737140.2019.1559059","volume":"19","author":"MS Xu","year":"2019","unstructured":"Xu MS, Li J, Wiseman SM (2019) Major vessel invasion by thyroid cancer: a comprehensive review. Expert Rev Anticancer Ther 19:191\u2013203. https:\/\/doi.org\/10.1080\/14737140.2019.1559059","journal-title":"Expert Rev Anticancer Ther"},{"key":"2234_CR22","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1089\/thy.2015.0166","volume":"25","author":"R Dadu","year":"2015","unstructured":"Dadu R, Hu MI, Cleeland C et al (2015) Efficacy of the natural clay, calcium aluminosilicate anti-diarrheal, in reducing medullary thyroid cancer-related diarrhea and its effects on quality of life: a pilot study. Thyroid 25:1085\u20131090. https:\/\/doi.org\/10.1089\/thy.2015.0166","journal-title":"Thyroid"},{"key":"2234_CR23","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1056\/NEJMoa2005651","volume":"383","author":"LJ Wirth","year":"2020","unstructured":"Wirth LJ, Sherman E, Robinson B et al (2020) Efficacy of selpercatinib in RET-altered thyroid cancers. N Engl J Med 383:825\u2013835. https:\/\/doi.org\/10.1056\/NEJMoa2005651","journal-title":"N Engl J Med"},{"key":"2234_CR24","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.surg.2016.04.027","volume":"160","author":"LY Wang","year":"2016","unstructured":"Wang LY, Nixon IJ, Patel SG et al (2016) Operative management of locally advanced, differentiated thyroid cancer. Surgery 160:738\u2013746. https:\/\/doi.org\/10.1016\/j.surg.2016.04.027","journal-title":"Surgery"},{"key":"2234_CR25","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.beem.2017.06.001","volume":"31","author":"A Matrone","year":"2017","unstructured":"Matrone A, Valerio L, Pieruzzi L et al (2017) Protein kinase inhibitors for the treatment of advanced and progressive radiorefractory thyroid tumors: from the clinical trials to the real life. Best Pract Res Clin Endocrinol Metab 31:319\u2013334. https:\/\/doi.org\/10.1016\/j.beem.2017.06.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2234_CR26","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1007\/s40618-020-01491-3","volume":"44","author":"A Matrone","year":"2021","unstructured":"Matrone A, Prete A, Nervo A et al (2021) Lenvatinib as a salvage therapy for advanced metastatic medullary thyroid cancer. J Endocrinol Invest 44:2139\u20132151. https:\/\/doi.org\/10.1007\/s40618-020-01491-3","journal-title":"J Endocrinol Invest"},{"key":"2234_CR27","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jash.2018.03.008","volume":"12","author":"RM Touyz","year":"2018","unstructured":"Touyz RM, Herrmann SMS, Herrmann J (2018) Vascular toxicities with VEGF inhibitor therapies-focus on hypertension and arterial thrombotic events. J Am Soc Hypertens 12:409\u2013425. https:\/\/doi.org\/10.1016\/j.jash.2018.03.008","journal-title":"J Am Soc Hypertens"},{"key":"2234_CR28","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1136\/heartjnl-2018-313726","volume":"104","author":"SJH Dobbin","year":"2018","unstructured":"Dobbin SJH, Cameron AC, Petrie MC et al (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart 104:1995\u20132002. https:\/\/doi.org\/10.1136\/heartjnl-2018-313726","journal-title":"Heart"},{"key":"2234_CR29","doi-asserted-by":"publisher","first-page":"4205","DOI":"10.1863\/oncotarget.24599","volume":"10","author":"Y Bai","year":"2019","unstructured":"Bai Y, Li J-Y, Li J et al (2019) Risk of venous and arterial thromboembolic events associated with tyrosine kinase inhibitors in advanced thyroid cancer: a meta-analysis and systematic review. Oncotarget 10:4205\u20134212. https:\/\/doi.org\/10.1863\/oncotarget.24599","journal-title":"Oncotarget"},{"key":"2234_CR30","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1056\/NEJMoa1406470","volume":"372","author":"M Schlumberger","year":"2015","unstructured":"Schlumberger M, Tahara M, Wirth LJ et al (2015) Lenvatinib versus placebo in radioiodine-refractory thyroid cancer. N Engl J Med 372:621\u2013630. https:\/\/doi.org\/10.1056\/NEJMoa1406470","journal-title":"N Engl J Med"},{"key":"2234_CR31","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1200\/JCO.2012.48.4659","volume":"31","author":"R Elisei","year":"2013","unstructured":"Elisei R, Schlumberger MJ, M\u00fcller SP et al (2013) Cabozantinib in progressive medullary thyroid cancer. J Clin Oncol 31:3639\u20133646. https:\/\/doi.org\/10.1200\/JCO.2012.48.4659","journal-title":"J Clin Oncol"},{"key":"2234_CR32","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1530\/ERC-18-0049","volume":"25","author":"AG Gianoukakis","year":"2018","unstructured":"Gianoukakis AG, Dutcus CE, Batty N et al (2018) Prolonged duration of response in lenvatinib responders with thyroid cancer. Endocr Relat Cancer 25:699\u2013704. https:\/\/doi.org\/10.1530\/ERC-18-0049","journal-title":"Endocr Relat Cancer"},{"key":"2234_CR33","doi-asserted-by":"publisher","first-page":"e6809","DOI":"10.1097\/MD.0000000000006809","volume":"96","author":"R Wang","year":"2017","unstructured":"Wang R, Zhang Y, Tan J et al (2017) Analysis of radioiodine therapy and prognostic factors of differentiated thyroid cancer patients with pulmonary metastasis: an 8-year retrospective study. Medicine 96:e6809. https:\/\/doi.org\/10.1097\/MD.0000000000006809","journal-title":"Medicine"},{"key":"2234_CR34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1530\/EJE-15-0296","volume":"173","author":"H-J Song","year":"2015","unstructured":"Song H-J, Qiu Z-L, Shen C-T et al (2015) Pulmonary metastases in differentiated thyroid cancer: efficacy of radioiodine therapy and prognostic factors. Eur J Endocrinol 173:399\u2013408. https:\/\/doi.org\/10.1530\/EJE-15-0296","journal-title":"Eur J Endocrinol"},{"key":"2234_CR35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1477-7819-7-40","volume":"7","author":"P-YR Marcy","year":"2009","unstructured":"Marcy P-YR, Thariat J, Bozec A et al (2009) Venous obstruction of thyroid malignancy origin: the Antoine Lacassagne institute experience. World J Surg Oncol 7:40. https:\/\/doi.org\/10.1186\/1477-7819-7-40","journal-title":"World J Surg Oncol"},{"key":"2234_CR36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/1477-7819-6-36","volume":"6","author":"SL Hyer","year":"2008","unstructured":"Hyer SL, Dandekar P, Newbold K et al (2008) Thyroid cancer causing obstruction of the great veins in the neck. World J Surg Oncol 6:36. https:\/\/doi.org\/10.1186\/1477-7819-6-36","journal-title":"World J Surg Oncol"},{"key":"2234_CR37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/MOO.0000000000000346","volume":"25","author":"RA Dedivitis","year":"2017","unstructured":"Dedivitis RA, Aires FT, Cernea CR (2017) Hypoparathyroidism after thyroidectomy: prevention, assessment and management. Curr Opin Otolaryngol Head Neck Surg 25:142\u2013146. https:\/\/doi.org\/10.1097\/MOO.0000000000000346","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2234_CR38","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s40618-018-0857-5","volume":"41","author":"A Meola","year":"2018","unstructured":"Meola A, Vignali E, Matrone A et al (2018) Efficacy and safety of long-term management of patients with chronic post-surgical hypoparathyroidism. J Endocrinol Invest 41:1221\u20131226. https:\/\/doi.org\/10.1007\/s40618-018-0857-5","journal-title":"J Endocrinol Invest"},{"key":"2234_CR39","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.surg.2010.09.013","volume":"148","author":"M Roy","year":"2010","unstructured":"Roy M, Rajamanickam V, Chen H, Sippel R (2010) Is DVT prophylaxis necessary for thyroidectomy and parathyroidectomy? Surgery 148:1163\u20131168. https:\/\/doi.org\/10.1016\/j.surg.2010.09.013","journal-title":"Surgery"},{"key":"2234_CR40","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1442-2042.2004.00743.x","volume":"11","author":"T Kobayashi","year":"2004","unstructured":"Kobayashi T, Ogura K, Nishizawa K et al (2004) Successful recovery from a massive pulmonary artery tumor embolism occurring during surgery for renal cell carcinoma. Int J Urol 11:114\u2013116. https:\/\/doi.org\/10.1111\/j.1442-2042.2004.00743.x","journal-title":"Int J Urol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02234-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02234-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02234-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T07:22:34Z","timestamp":1713770554000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02234-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["2234"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02234-w","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]},"assertion":[{"value":"21 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study has been approved by the local ethical committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All patients signed an informed consent for the use of their clinical and biochemical data for research purposes. They also signed an informed consent to proceed with the suggested interventional treatments.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}