{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:30:52Z","timestamp":1773916252938,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173444"],"award-info":[{"award-number":["82173444"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803154"],"award-info":[{"award-number":["81803154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research Plan of Shanghai Hospital Development Center","award":["SHDC22022302"],"award-info":[{"award-number":["SHDC22022302"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-023-02254-6","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T09:02:35Z","timestamp":1702976555000},"page":"1467-1476","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acromegaly presented with acne vulgaris: a retrospective study with 123 cases"],"prefix":"10.1007","volume":"47","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. F.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. Y.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. F.","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Y.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. Y.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. F.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3688-8972","authenticated-orcid":false,"given":"Y.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"issue":"1","key":"2254_CR1","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jaad.2007.06.045","volume":"58","author":"CN Collier","year":"2008","unstructured":"Collier CN, Harper JC, Cafardi JA, Cantrell WC, Wang W, Foster KW et al (2008) The prevalence of acne in adults 20 years and older. J Am Acad Dermatol 58(1):56\u201359","journal-title":"J Am Acad Dermatol"},{"issue":"05","key":"2254_CR2","first-page":"177","volume":"30","author":"Y Yu","year":"2021","unstructured":"Yu Y, Weng W, Li J, Zhang M, Gao Y (2021) Progress in the post-adolescent acne. Chin J Aesthetic Med. 30(05):177\u2013180","journal-title":"Chin J Aesthetic Med."},{"issue":"5","key":"2254_CR3","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1046\/j.1365-2133.2000.03467.x","volume":"142","author":"AE Till","year":"2000","unstructured":"Till AE, Goulden V, Cunliffe WJ, Holland KT (2000) The cutaneous microflora of adolescent, persistent and late-onset acne patients does not differ. Br J Dermatol 142(5):885\u2013892","journal-title":"Br J Dermatol"},{"issue":"1","key":"2254_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1365-2133.1997.tb08748.x","volume":"136","author":"V Goulden","year":"1997","unstructured":"Goulden V, Clark SM, Cunliffe WJ (1997) Post-adolescent acne: a review of clinical features. Br J Dermatol 136(1):66\u201370","journal-title":"Br J Dermatol"},{"issue":"2","key":"2254_CR5","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3892\/etm.2021.11074","volume":"23","author":"DE Branisteanu","year":"2022","unstructured":"Branisteanu DE, Toader MP, Porumb EA, Serban IL, Pinzariu AC, Branisteanu CI et al (2022) Adult female acne: clinical and therapeutic particularities (Review). Exp Ther Med 23(2):151","journal-title":"Exp Ther Med"},{"issue":"9","key":"2254_CR6","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/exd.14168","volume":"29","author":"S Briganti","year":"2020","unstructured":"Briganti S, Flori E, Mastrofrancesco A, Ottaviani M (2020) Acne as an altered dermato-endocrine response problem. Exp Dermatol 29(9):833\u2013839","journal-title":"Exp Dermatol"},{"issue":"6","key":"2254_CR7","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.mcna.2009.08.008","volume":"93","author":"MS Lolis","year":"2009","unstructured":"Lolis MS, Bowe WP, Shalita AR (2009) Acne and systemic disease. Med Clin North Am 93(6):1161\u20131181","journal-title":"Med Clin North Am"},{"issue":"11","key":"2254_CR8","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","volume":"10","author":"M Fleseriu","year":"2022","unstructured":"Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S (2022) Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol 10(11):804\u2013826","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"2254_CR9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0889-8529(18)30204-4","volume":"21","author":"ME Molitch","year":"1992","unstructured":"Molitch ME (1992) Clinical manifestations of acromegaly. Endocrinol Metab Clin North Am 21(3):597\u2013614","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"2254_CR10","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.mayocp.2021.11.007","volume":"97","author":"N Ershadinia","year":"2022","unstructured":"Ershadinia N, Tritos NA (2022) Diagnosis and treatment of acromegaly: an update. Mayo Clin Proc 97(2):333\u2013346","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"2254_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000525069","volume":"14","author":"FA Khamdan","year":"2022","unstructured":"Khamdan FA, Shah MA, Khamdan MA, Albasri E (2022) Acromegaly presenting with resistant acne vulgaris. Case Rep Dermatol 14(2):151\u2013156","journal-title":"Case Rep Dermatol"},{"issue":"2","key":"2254_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4103\/0378-6323.39699","volume":"74","author":"K Jain","year":"2008","unstructured":"Jain K, Jain VK, Aggarwal K, Bansal A (2008) Late onset isotretinoin resistant acne conglobata in a patient with acromegaly. Indian J Dermatol Venereol Leprol 74(2):139\u2013141","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"4","key":"2254_CR13","doi-asserted-by":"publisher","first-page":"348","DOI":"10.4158\/ep.10.4.348","volume":"10","author":"AA Rizvi","year":"2004","unstructured":"Rizvi AA (2004) Some clues and pitfalls in the diagnosis of acromegaly. Endocr Pract 10(4):348\u2013352","journal-title":"Endocr Pract"},{"key":"2254_CR14","doi-asserted-by":"publisher","first-page":"1093942","DOI":"10.3389\/fendo.2022.1093942","volume":"13","author":"X Guo","year":"2022","unstructured":"Guo X, Wang Y, Yao Y, Bao X, Duan L, Zhu H et al (2022) Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: a study using dermatoscopy and ultra-high-frequency ultrasound. Front Endocrinol (Lausanne) 13:1093942","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"13","key":"2254_CR15","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.clinbiochem.2011.06.984","volume":"44","author":"MK Arora","year":"2011","unstructured":"Arora MK, Yadav A, Saini V (2011) Role of hormones in acne vulgaris. Clin Biochem 44(13):1035\u20131040","journal-title":"Clin Biochem"},{"issue":"2","key":"2254_CR16","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/ced.12588","volume":"40","author":"RS Raghunath","year":"2015","unstructured":"Raghunath RS, Venables ZC, Millington GW (2015) The menstrual cycle and the skin. Clin Exp Dermatol 40(2):111\u2013115","journal-title":"Clin Exp Dermatol"},{"issue":"5","key":"2254_CR17","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.jaad.2015.12.037","volume":"74","author":"AL Zaenglein","year":"2016","unstructured":"Zaenglein AL, Pathy AL, Schlosser BJ, Alikhan A, Baldwin HE, Berson DS et al (2016) Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 74(5):945\u201373.e33","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2254_CR18","first-page":"577","volume":"41","author":"V Goulden","year":"1999","unstructured":"Goulden V, Stables GI, Cunliffe WJ (1999) Prevalence of facial acne in adults. J Am Acad Dermatol 41(4):577\u2013580","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"2254_CR19","doi-asserted-by":"publisher","first-page":"40","DOI":"10.2340\/00015555-1164","volume":"92","author":"Y Shen","year":"2012","unstructured":"Shen Y, Wang T, Zhou C, Wang X, Ding X, Tian S et al (2012) Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17,345 subjects in six cities. Acta Derm Venereol 92(1):40\u201344","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"2254_CR20","first-page":"562","volume":"141","author":"JF Cara","year":"1987","unstructured":"Cara JF, Rosenfield RL, Furlanetto RW (1987) A longitudinal study of the relationship of plasma somatomedin-C concentration to the pubertal growth spurt. Arch Dis Child 141(5):562\u2013564","journal-title":"Arch Dis Child"},{"issue":"4","key":"2254_CR21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1346-8138.1995.tb03381.x","volume":"22","author":"H Aizawa","year":"1995","unstructured":"Aizawa H, Niimura M (1995) Elevated serum insulin-like growth factor-1 (IGF-1) levels in women with postadolescent acne. J Dermatol 22(4):249\u2013252","journal-title":"J Dermatol"},{"issue":"3","key":"2254_CR22","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1001\/archderm.141.3.333","volume":"141","author":"M Cappel","year":"2005","unstructured":"Cappel M, Mauger D, Thiboutot D (2005) Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and acne lesion counts in adult women. Arch Dermatol 141(3):333\u2013338","journal-title":"Arch Dermatol"},{"issue":"10","key":"2254_CR23","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/j.1600-0625.2009.00924.x","volume":"18","author":"BC Melnik","year":"2009","unstructured":"Melnik BC, Schmitz G (2009) Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris. Exp Dermatol 18(10):833\u2013841","journal-title":"Exp Dermatol"},{"issue":"2","key":"2254_CR24","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1210\/en.2011-1635","volume":"153","author":"HJ Kim","year":"2012","unstructured":"Kim HJ, Kobayashi M, Sasaki T, Kikuchi O, Amano K, Kitazumi T et al (2012) Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology 153(2):659\u2013671","journal-title":"Endocrinology"},{"issue":"6","key":"2254_CR25","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/sj.jid.5700278","volume":"126","author":"TM Smith","year":"2006","unstructured":"Smith TM, Cong Z, Gilliland KL, Clawson GA, Thiboutot DM (2006) Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol 126(6):1226\u20131232","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2254_CR26","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/sj.jid.5701155","volume":"128","author":"TM Smith","year":"2008","unstructured":"Smith TM, Gilliland K, Clawson GA, Thiboutot D (2008) IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase\/Akt pathway. J Invest Dermatol 128(5):1286\u20131293","journal-title":"J Invest Dermatol"},{"key":"2254_CR27","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mce.2015.08.001","volume":"415","author":"Y Mirdamadi","year":"2015","unstructured":"Mirdamadi Y, Thielitz A, Wiede A, Goihl A, Papakonstantinou E, Hartig R et al (2015) Insulin and insulin-like growth factor-1 can modulate the phosphoinositide-3-kinase\/Akt\/FoxO1 pathway in SZ95 sebocytes in vitro. Mol Cell Endocrinol 415:32\u201344","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"2254_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4103\/0378-6323.110753","volume":"79","author":"R Kumari","year":"2013","unstructured":"Kumari R, Thappa DM (2013) Role of insulin resistance and diet in acne. Indian J Dermatol Venereol Leprol 79(3):291\u2013299","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"2 Pt 1","key":"2254_CR29","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0190-9622(95)90243-0","volume":"33","author":"GF Webster","year":"1995","unstructured":"Webster GF (1995) Inflammation in acne vulgaris. J Am Acad Dermatol 33(2 Pt 1):247\u2013253","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"2254_CR30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.5021\/ad.2017.29.1.20","volume":"29","author":"H Kim","year":"2017","unstructured":"Kim H, Moon SY, Sohn MY, Lee WJ (2017) Insulin-like growth factor-1 increases the expression of inflammatory biomarkers and sebum production in cultured sebocytes. Ann Dermatol 29(1):20\u201325","journal-title":"Ann Dermatol"},{"issue":"9","key":"2254_CR31","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1111\/j.1610-0387.2008.06822.x","volume":"6","author":"B Melnik","year":"2008","unstructured":"Melnik B, Schmitz G (2008) FGFR2 signaling and the pathogenesis of acne. J Dtsch Dermatol Ges 6(9):721\u2013728","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6","key":"2254_CR32","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1111\/j.1365-2133.2008.08559.x","volume":"158","author":"BC Melnik","year":"2008","unstructured":"Melnik BC, Vakilzadeh F, Aslanidis C, Schmitz G (2008) Unilateral segmental acneiform naevus: a model disorder towards understanding fibroblast growth factor receptor 2 function in acne? Br J Dermatol 158(6):1397\u20131399","journal-title":"Br J Dermatol"},{"issue":"3","key":"2254_CR33","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s10038-007-0241-3","volume":"53","author":"X Chen","year":"2008","unstructured":"Chen X, Guan J, Song Y, Chen P, Zheng H, Tang C et al (2008) IGF-I (CA) repeat polymorphisms and risk of cancer: a meta-analysis. J Hum Genet 53(3):227\u2013238","journal-title":"J Hum Genet"},{"issue":"2","key":"2254_CR34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/j.1468-3083.2011.04299.x","volume":"27","author":"L Tasli","year":"2013","unstructured":"Tasli L, Turgut S, Kacar N, Ayada C, Coban M, Akcilar R et al (2013) Insulin-like growth factor-I gene polymorphism in acne vulgaris. J Eur Acad Dermatol Venereol 27(2):254\u2013257","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"8","key":"2254_CR35","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1038\/jid.2009.8","volume":"129","author":"BC Melnik","year":"2009","unstructured":"Melnik BC, Schmitz G, Zouboulis CC (2009) Anti-acne agents attenuate FGFR2 signal transduction in acne. J Invest Dermatol 129(8):1868\u20131877","journal-title":"J Invest Dermatol"},{"issue":"12","key":"2254_CR36","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1038\/jid.2012.202","volume":"132","author":"M Im","year":"2012","unstructured":"Im M, Kim SY, Sohn KC, Choi DK, Lee Y, Seo YJ et al (2012) Epigallocatechin-3-gallate suppresses IGF-I-induced lipogenesis and cytokine expression in sz95 sebocytes. J Invest Dermatol 132(12):2700\u20132708","journal-title":"J Invest Dermatol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02254-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02254-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02254-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:25:11Z","timestamp":1717172711000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02254-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["2254"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02254-6","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"12 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None declared.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The studies involving human participants were reviewed and approved by the Huashan Hospital Ethics Committee, Fudan University, Shanghai, China.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study. Patients signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}