{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:50:48Z","timestamp":1790970648861,"version":"4.1.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-023-02260-8","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:02:03Z","timestamp":1703181723000},"page":"1505-1511","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Calcium\/phosphate ratio: an additional tool for the clinical management of asymptomatic primary hyperparathyroidism?"],"prefix":"10.1007","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-4267","authenticated-orcid":false,"given":"E.","family":"Castellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Attanasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gianotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Borretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"2260_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/nrendo.2017.104","volume":"14","author":"MD Walker","year":"2018","unstructured":"Walker MD, Silverberg SJ (2018) Primary hyperparathyroidism. Nat Rev Endocrinol 14:115\u2013125. https:\/\/doi.org\/10.1038\/nrendo.2017.104","journal-title":"Nat Rev Endocrinol"},{"key":"2260_CR2","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.beem.2018.09.001","volume":"32","author":"S Minisola","year":"2018","unstructured":"Minisola S, Gianotti L, Bhadada S, Silverberg SJ (2018) Classical complications of primary hyperparathyroidism. Best Pract Res Clin Endocrinol Metab 32:791\u2013803. https:\/\/doi.org\/10.1016\/j.beem.2018.09.001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2260_CR3","doi-asserted-by":"publisher","first-page":"e612","DOI":"10.1210\/clinem\/dgab676","volume":"107","author":"E Castellano","year":"2022","unstructured":"Castellano E, Attanasio R, Boriano A, Pellegrino M, Borretta G (2022) Serum phosphate: a neglected test in the clinical management of primary hyperparathyroidism. J Clin Endocrinol Metab 107:e612\u2013e618. https:\/\/doi.org\/10.1210\/clinem\/dgab676","journal-title":"J Clin Endocrinol Metab"},{"key":"2260_CR4","doi-asserted-by":"publisher","first-page":"e1756","DOI":"10.1210\/clinem\/dgab768","volume":"107","author":"BL Clarke","year":"2022","unstructured":"Clarke BL (2022) Is moderate hypophosphatemia a new indication for surgery in asymptomatic primary hyperparathyroidism? J Clin Endocrinol Metab 107:e1756\u2013e1757. https:\/\/doi.org\/10.1210\/clinem\/dgab768","journal-title":"J Clin Endocrinol Metab"},{"key":"2260_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02064-w","author":"H D\u00fc\u011fer","year":"2023","unstructured":"D\u00fc\u011fer H, Bostan H, G\u00fcl \u00dc, U\u00e7an B, Hep\u015fen S, Sak\u0131z D, Akhanl\u0131 P, \u00c7akal E, K\u0131z\u0131lg\u00fcl M (2023) The importance of hypophosphatemia in the clinical management of primary hyperparathyroidism. J Endocrinol Investig. https:\/\/doi.org\/10.1007\/s40618-023-02064-w","journal-title":"J Endocrinol Investig"},{"key":"2260_CR6","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00423-021-02173-1","volume":"406","author":"T Weber","year":"2021","unstructured":"Weber T, Dotzenrath C, Dralle H et al (2021) Management of primary and renal hyperparathyroidism: guidelines from the German Association of Endocrine Surgeons (CAEK). Langenbecks Arch Surg 406:571\u2013585. https:\/\/doi.org\/10.1007\/s00423-021-02173-1","journal-title":"Langenbecks Arch Surg"},{"issue":"11","key":"2260_CR7","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1002\/jbmr.4677","volume":"37","author":"JP Bilezikian","year":"2022","unstructured":"Bilezikian JP, Khan AA, Silverberg SJ, Fuleihan GE, Marcocci C, Minisola S, Perrier N, Sitges-Serra A, Thakker RV, Guyatt G, Mannstadt M, Potts JT, Clarke BL, Brandi ML, International Workshop on Primary Hyperparathyroidism (2022) Evaluation and management of primary hyperparathyroidism: summary statement and guidelines from the fifth international workshop. J Bone Miner Res 37(11):2293\u20132314. https:\/\/doi.org\/10.1002\/jbmr.4677","journal-title":"J Bone Miner Res"},{"key":"2260_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00198-016-3716-2","volume":"28","author":"AA Khan","year":"2017","unstructured":"Khan AA, Hanley DA, Rizzoli R, Bollerslev J, Young JE, Rejnmark L, Thakker R, D\u2019Amour P, Paul T, Van Uum S, Shrayyef MZ, Goltzman D, Kaiser S, Cusano NE, Bouillon R, Mosekilde L, Kung AW, Rao SD, Bhadada SK, Clarke BL, Liu J, Duh Q, Lewiecki EM, Bandeira F, Eastell R, Marcocci C, Silverberg SJ, Udelsman R, Davison KS, Potts JT Jr, Brandi ML, Bilezikian JP (2017) Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus. Osteoporos Int 28:1\u201319. https:\/\/doi.org\/10.1007\/s00198-016-3716-2","journal-title":"Osteoporos Int"},{"key":"2260_CR9","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s40618-019-01025-6","volume":"42","author":"B Madeo","year":"2019","unstructured":"Madeo B, De Vincentis S, Kara E, Vescini F, Trenti T, Guaraldi G, Rochira V (2019) Reliability of calcium-phosphorus (Ca\/P) ratio as a new, accurate and inexpensive tool in the diagnosis of some Ca-P disorders. J Endocrinol Investig 42:1041\u20131049. https:\/\/doi.org\/10.1007\/s40618-019-01025-6","journal-title":"J Endocrinol Investig"},{"issue":"3","key":"2260_CR10","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s12020-020-02276-7","volume":"68","author":"B Madeo","year":"2020","unstructured":"Madeo B, De Vincentis S, Repaci A, Altieri P, Vicennati V, Kara E, Vescini F, Amadori P, Balestrieri A, Pagotto U, Simoni M, Rochira V (2020) The calcium-to-phosphorous (Ca\/P) ratio in the diagnosis of primary hyperparathyroidism and hypoparathyroidism: a multicentric study. Endocrine 68(3):679\u2013687. https:\/\/doi.org\/10.1007\/s12020-020-02276-7","journal-title":"Endocrine"},{"key":"2260_CR11","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s40618-015-0261-3","volume":"38","author":"C Marcocci","year":"2015","unstructured":"Marcocci C, Brandi ML, Scillitani A, Corbetta S, Faggiano A, Gianotti L, Migliaccio S, Minisola S (2015) Italian Society of Endocrinology Consensus Statement: definition, evaluation and management of patients with mild primary hyperparathyroidism. J Endocrinol Investig 38:577\u2013593. https:\/\/doi.org\/10.1007\/s40618-015-0261-3","journal-title":"J Endocrinol Investig"},{"issue":"2 Suppl 1","key":"2260_CR12","first-page":"S1","volume":"39","author":"National Kidney Foundation","year":"2002","unstructured":"National Kidney Foundation (2002) K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2 Suppl 1):S1\u2013S266","journal-title":"Am J Kidney Dis"},{"issue":"19","key":"2260_CR13","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.3390\/nu14194148","volume":"14","author":"F Bertoldo","year":"2022","unstructured":"Bertoldo F, Cianferotti L, Di Monaco M, Falchetti A, Fassio A, Gatti D, Gennari L, Giannini S, Girasole G, Gonnelli S, Malavolta N, Minisola S, Pedrazzoni M, Rendina D, Rossini M, Chiodini I (2022) Definition, assessment, and management of vitamin D inadequacy: suggestions, recommendations, and warnings from the Italian Society for Osteoporosis, mineral metabolism and bone diseases (SIOMMMS). Nutrients 14(19):4148. https:\/\/doi.org\/10.3390\/nu14194148","journal-title":"Nutrients"},{"key":"2260_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/jbm4.10019","volume":"2","author":"B Madeo","year":"2017","unstructured":"Madeo B, Kara E, Cioni K, Vezzani S, Trenti T, Santi D, Simoni M, Rochira V (2017) Serum calcium to phosphorous (Ca\/P) ratio is a simple, inexpensive, and accurate tool in the diagnosis of primary hyperparathyroidism. JBMR Plus 2:109\u2013117. https:\/\/doi.org\/10.1002\/jbm4.10019","journal-title":"JBMR Plus"},{"key":"2260_CR15","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s42000-018-0069-6","volume":"18","author":"DA Anastasilakis","year":"2019","unstructured":"Anastasilakis DA, Makras P, Polyzos SA, Anastasilakis AD, Part of the COMBO ENDO TEAM 2017 (2019) Asymptomatic and normocalcemic hyperparathyroidism, the silent attack: a combo-endocrinology overview. Hormones (Athens) 18:65\u201370. https:\/\/doi.org\/10.1007\/s42000-018-0069-6","journal-title":"Hormones (Athens)"},{"key":"2260_CR16","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1007\/s12020-016-0931-8","volume":"55","author":"G Viccica","year":"2017","unstructured":"Viccica G, Cetani F, Vignali E, Miccoli M, Marcocci C (2017) Impact of vitamin D deficiency on the clinical and biochemical phenotype in women with sporadic primary hyperparathyroidism. Endocrine 55:256\u2013265. https:\/\/doi.org\/10.1007\/s12020-016-0931-8","journal-title":"Endocrine"},{"key":"2260_CR17","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1210\/jcem.85.3.6440","volume":"85","author":"DS Rao","year":"2000","unstructured":"Rao DS, Honasoge M, Divine GW, Phillips ER, Lee MW, Ansari MR, Talpos GB, Parfitt AM (2000) Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. J Clin Endocrinol Metab 85:1054\u20131058. https:\/\/doi.org\/10.1210\/jcem.85.3.6440","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2260_CR18","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.3390\/jcm10143089","volume":"13","author":"M Syka\u0142a","year":"2021","unstructured":"Syka\u0142a M, Szumowski P, Mojsak M, Abdelrazek S, \u017bukowski \u0141, Lipi\u0144ska D, Juchnicka I, Koz\u0142owska G, Szelachowska M, Kr\u0119towski A, My\u015bliwiec J (2021) Assessment of clinical utility of assaying FGF-23, klotho protein, osteocalcin, NTX, and sclerostin in patients with primary hyperparathyroidism. J Clin Med 13(10):3089. https:\/\/doi.org\/10.3390\/jcm10143089","journal-title":"J Clin Med"},{"key":"2260_CR19","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.1210\/jc.2017-01080","volume":"102","author":"E Castellano","year":"2017","unstructured":"Castellano E, Attanasio R, Boriano A, Pellegrino M, Garino F, Gianotti L, Borretta G (2017) Sex difference in the clinical presentation of primary hyperparathyroidism: influence of menopausal status. J Clin Endocrinol Metab 102:4148\u20134152. https:\/\/doi.org\/10.1210\/jc.2017-01080","journal-title":"J Clin Endocrinol Metab"},{"key":"2260_CR20","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1002\/jbmr.1846","volume":"28","author":"Z Cheng","year":"2013","unstructured":"Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W (2013) Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res 28:1087\u20131100. https:\/\/doi.org\/10.1002\/jbmr.1846","journal-title":"J Bone Miner Res"},{"key":"2260_CR21","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1053\/j.ajkd.2013.07.012","volume":"63","author":"D Zhang","year":"2014","unstructured":"Zhang D, Maalouf NM, Adams-Huet B, Moe OW, Sakhaee K (2014) Effects of sex and postmenopausal estrogen use on serum phosphorus levels: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) 2003\u20132006. Am J Kidney Dis 63:198\u2013205. https:\/\/doi.org\/10.1053\/j.ajkd.2013.07.012","journal-title":"Am J Kidney Dis"},{"key":"2260_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/292953","author":"KP Aggarwal","year":"2013","unstructured":"Aggarwal KP, Narula S, Kakkar M, Tandon C (2013) Nephrolithiasis: molecular mechanism of renal stone formation and the critical role played by modulators. Biomed Res Int. https:\/\/doi.org\/10.1155\/2013\/292953","journal-title":"Biomed Res Int"},{"issue":"8","key":"2260_CR23","doi-asserted-by":"publisher","first-page":"dgaa233","DOI":"10.1210\/clinem\/dgaa233","volume":"105","author":"F Saponaro","year":"2020","unstructured":"Saponaro F, Marcocci C, Apicella M, Mazoni L, Borsari S, Pardi E, Di Giulio M, Carlucci F, Scalese M, Bilezikian JP, Cetani F (2020) Hypomagnesuria is associated with nephrolithiasis in patients with asymptomatic primary hyperparathyroidism. J Clin Endocrinol Metab 105(8):dgaa233. https:\/\/doi.org\/10.1210\/clinem\/dgaa233","journal-title":"J Clin Endocrinol Metab"},{"key":"2260_CR24","doi-asserted-by":"publisher","first-page":"6","DOI":"10.14797\/mdcj-12-4s1-6","volume":"12","author":"WN Suki","year":"2016","unstructured":"Suki WN, Moore LW (2016) Phosphorus regulation in chronic kidney disease. Methodist Debakey Cardiovasc J 12:6\u20139. https:\/\/doi.org\/10.14797\/mdcj-12-4s1-6","journal-title":"Methodist Debakey Cardiovasc J"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02260-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-023-02260-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-023-02260-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:25:27Z","timestamp":1717172727000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-023-02260-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["2260"],"URL":"https:\/\/doi.org\/10.1007\/s40618-023-02260-8","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"assertion":[{"value":"27 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki. Patients gave informed consent to these investigations (as part of their normal medical care both at diagnosis and follow-up). The study was approved by the institutional review board and the ethics committee of our institution (ID ENDO38).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}]}}