{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:46:42Z","timestamp":1791521202066,"version":"4.3.4"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007343","name":"Universit\u00e0 degli Studi di Brescia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007343","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of the study was to analyze the modification of total and regional body composition in early breast cancer patients treated with aromatase inhibitors (AIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a prospective, single-center, observational, longitudinal study. Four-hundred and twenty-eight patients treated with adjuvant aromatase inhibitors were enrolled at the Medical Oncology and Breast Unit of Spedali Civili Hospital in Brescia from September 2014 to June 2022. Several body composition parameters including total and regional fat and lean body mass were investigated with dual-energy X-ray absorptiometry (DXA) scan at baseline and after 18\u00a0months of treatment with aromatase inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A significant increase in fat body mass (mean\u2009+\u20097.2%, 95% confidence interval [CI]: 5.5;8.9%) and a reduction in lean body mass (mean \u22123.1%, 95% CI \u22123.9; \u22122.4) were documented in this population. The changes in fat and lean body mass varied considerably according to different body districts ranging between\u2009+\u20093.2% to\u2009+\u200910.9% and from\u22121.3% to \u22123.9%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aromatase inhibitor adjuvant therapy in early breast cancer is associated with changes in body composition, with a wide variability among different body districts, leading to a risk of sarcopenic obesity. Supervised physical exercise that focuses on single body parts that may display detrimental variations may be beneficial for AIs treated patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40618-024-02401-7","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:02:15Z","timestamp":1718013735000},"page":"3119-3128","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in body composition in early breast cancer patients treated with aromatase inhibitors"],"prefix":"10.1007","volume":"47","author":[{"given":"R.","family":"Pedersini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9514-283X","authenticated-orcid":false,"given":"G.","family":"Schivardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Laini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zamparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bonalumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"di Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Amoroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Di Meo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gonano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Zanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lagan\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rinaudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. L.","family":"Simoncini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Cosentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berruti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"3","key":"2401_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"key":"2401_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju289","author":"D Munoz","year":"2014","unstructured":"Munoz D, Near AM, van Ravesteyn NT et al (2014) Effects of screening and systemic adjuvant therapy on ER-specific US breast cancer mortality. J Natl Cancer Inst. https:\/\/doi.org\/10.1093\/jnci\/dju289","journal-title":"J Natl Cancer Inst"},{"key":"2401_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2015.02.002","author":"RE Reinbolt","year":"2015","unstructured":"Reinbolt RE, Mangini N, Hill JL et al (2015) Endocrine therapy in breast cancer: the neoadjuvant, adjuvant, and metastatic approach. Semin Oncol Nurs. https:\/\/doi.org\/10.1016\/j.soncn.2015.02.002. (Published online 2015)","journal-title":"Semin Oncol Nurs"},{"key":"2401_CR4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21319","author":"CD Runowicz","year":"2016","unstructured":"Runowicz CD, Leach CR, Henry NL et al (2016) American cancer society\/American society of clinical oncology breast cancer survivorship care guideline. CA Cancer J Clin. https:\/\/doi.org\/10.3322\/caac.21319. (Published online 2016)","journal-title":"CA Cancer J Clin"},{"key":"2401_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00805.x","author":"V Vance","year":"2011","unstructured":"Vance V, Mourtzakis M, Mccargar L, Hanning R (2011) Weight gain in breast cancer survivors: prevalence, pattern and health consequences. Obes Rev. https:\/\/doi.org\/10.1111\/j.1467-789X.2010.00805.x. (Published online 2011)","journal-title":"Obes Rev"},{"key":"2401_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3242-4","author":"MMGA Berg","year":"2017","unstructured":"Berg MMGA, Winkels RM, Kruif JTCM et al (2017) Weight change during chemotherapy in breast cancer patients: a meta-analysis. BMC Cancer. https:\/\/doi.org\/10.1186\/s12885-017-3242-4","journal-title":"BMC Cancer"},{"issue":"1","key":"2401_CR7","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1200\/JCO.1999.17.1.120","volume":"17","author":"PJ Goodwin","year":"1999","unstructured":"Goodwin PJ, Ennis M, Pritchard KI et al (1999) Adjuvant treatment and onset of menopause predict weight gain after breast cancer diagnosis. J Clin Oncol 17(1):120\u2013129. https:\/\/doi.org\/10.1200\/JCO.1999.17.1.120","journal-title":"J Clin Oncol"},{"key":"2401_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3874-0","author":"KA Nyrop","year":"2016","unstructured":"Nyrop KA, Williams GR, Muss HB, Shachar SS (2016) Weight gain during adjuvant endocrine treatment for early-stage breast cancer: What is the evidence? Breast Cancer Res Treat. https:\/\/doi.org\/10.1007\/s10549-016-3874-0. (Published online 2016)","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"2401_CR9","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10549-023-07095-8","volume":"202","author":"R Pedersini","year":"2023","unstructured":"Pedersini R, Lagan\u00e0 M, Bosio S et al (2023) Is weight gain preventable in women with early breast cancer undergoing chemotherapy? a real-world study on dietary pattern, physical activity, and body weight before and after chemotherapy. Breast Cancer Res Treat 202(3):461\u2013471. https:\/\/doi.org\/10.1007\/s10549-023-07095-8","journal-title":"Breast Cancer Res Treat"},{"key":"2401_CR10","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2011.n.009","author":"MJ Nissen","year":"2011","unstructured":"Nissen MJ, Shapiro A, Swenson K (2011) Changes in weight and body composition in women receiving chemotherapy for breast cancer. Clin Breast Cancer. https:\/\/doi.org\/10.3816\/CBC.2011.n.009. (Published online 2011)","journal-title":"Clin Breast Cancer"},{"key":"2401_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71035-6","author":"I Sestak","year":"2014","unstructured":"Sestak I, Singh S, Cuzick J et al (2014) Changes in bone mineral density at 3 years in postmenopausal women receiving anastrozole and risedronate in the IBIS-II bone substudy: an international, double-blind, randomised, placebo-controlled trial. Lancet Oncol. https:\/\/doi.org\/10.1016\/S1470-2045(14)71035-6. (Published online 2014)","journal-title":"Lancet Oncol"},{"key":"2401_CR12","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2001.00031.x","author":"AM Prentice","year":"2001","unstructured":"Prentice AM, Jebb SA (2001) Beyond body mass index. Obes Rev. https:\/\/doi.org\/10.1046\/j.1467-789x.2001.00031.x. (Published online 2001)","journal-title":"Obes Rev"},{"key":"2401_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21659","author":"G Zong","year":"2016","unstructured":"Zong G, Zhang Z, Yang Q, Wu H, Hu FB, Sun Q (2016) Total and regional adiposity measured by dual-energy X-ray absorptiometry and mortality in NHANES 1999\u20132006. Obesity. https:\/\/doi.org\/10.1002\/oby.21659. (Published online 2016)","journal-title":"Obesity"},{"key":"2401_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.5","author":"DO Okorodudu","year":"2010","unstructured":"Okorodudu DO, Jumean MF, Montori VM et al (2010) Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obes. https:\/\/doi.org\/10.1038\/ijo.2010.5. (Published online 2010)","journal-title":"Int J Obes"},{"key":"2401_CR15","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008733","author":"D Gallagher","year":"1996","unstructured":"Gallagher D, Visser M, Sep\u00falveda D, Pierson RN, Harris T, Heymsfieid SB (1996) How useful is body mass index for comparison of body fatness across age, sex, and ethnic groups? Am J Epidemiol. https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a008733. (Published online 1996)","journal-title":"Am J Epidemiol"},{"key":"2401_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf024","author":"TB Harris","year":"2002","unstructured":"Harris TB (2002) Invited commentary: Body composition in studies of aging: new opportunities to better understand health risks associated with weight. Am J Epidemiol. https:\/\/doi.org\/10.1093\/aje\/kwf024. (Published online 2002)","journal-title":"Am J Epidemiol"},{"key":"2401_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-018-0097-6","author":"EK Oikonomou","year":"2019","unstructured":"Oikonomou EK, Antoniades C (2019) The role of adipose tissue in cardiovascular health and disease. Nat Rev Cardiol. https:\/\/doi.org\/10.1038\/s41569-018-0097-6. (Published online 2019)","journal-title":"Nat Rev Cardiol"},{"key":"2401_CR18","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.94","author":"J Park","year":"2014","unstructured":"Park J, Morley TS, Kim M, Clegg DJ, Scherer PE (2014) Obesity and cancer - Mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol. https:\/\/doi.org\/10.1038\/nrendo.2014.94. (Published online 2014)","journal-title":"Nat Rev Endocrinol"},{"key":"2401_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. https:\/\/doi.org\/10.1093\/ageing\/afy169. (Published online 2019)","journal-title":"Age Ageing"},{"key":"2401_CR20","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0137","author":"BJ Caan","year":"2018","unstructured":"Caan BJ, Cespedes Feliciano EM, Prado CM et al (2018) Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer. JAMA Oncol. https:\/\/doi.org\/10.1001\/jamaoncol.2018.0137. (Published online 2018)","journal-title":"JAMA Oncol"},{"key":"2401_CR21","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3902-6","author":"E Deluche","year":"2018","unstructured":"Deluche E, Leobon S, Desport JC, Venat-Bouvet L, Usseglio J, Tubiana-Mathieu N (2018) Impact of body composition on outcome in patients with early breast cancer. Support Care Cancer. https:\/\/doi.org\/10.1007\/s00520-017-3902-6. (Published online 2018)","journal-title":"Support Care Cancer"},{"key":"2401_CR22","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-022-01355-z","author":"Y Pang","year":"2022","unstructured":"Pang Y, Wei Y, Kartsonaki C (2022) Associations of adiposity and weight change with recurrence and survival in breast cancer patients: a systematic review and meta-analysis. Breast Cancer. https:\/\/doi.org\/10.1007\/s12282-022-01355-z. (Published online 2022)","journal-title":"Breast Cancer"},{"issue":"15_suppl","key":"2401_CR23","doi-asserted-by":"publisher","first-page":"9528","DOI":"10.1200\/jco.2009.27.15_suppl.9528","volume":"27","author":"GJ Van Londen","year":"2009","unstructured":"Van Londen GJ, Perera S, Vujevich K, Rastogi P, Lembersky B, Brufsky A, Vogel V, Greenspan S (2009) Changes in body composition in women with breast cancer on aromatase inhibitors: A two-year trial. J Clin Oncol 27(15_suppl):9528\u20139528","journal-title":"J Clin Oncol"},{"key":"2401_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603258","author":"G Francini","year":"2006","unstructured":"Francini G, Petrioli R, Montagnani A et al (2006) Exemestane after tamoxifen as adjuvant hormonal therapy in postmenopausal women with breast cancer: effects on body composition and lipids. Br J Cancer. https:\/\/doi.org\/10.1038\/sj.bjc.6603258. (Published online 2006)","journal-title":"Br J Cancer"},{"key":"2401_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013","author":"E von Elm","year":"2014","unstructured":"von Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP (2014) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg. https:\/\/doi.org\/10.1016\/j.ijsu.2014.07.013. (Published online 2014)","journal-title":"Int J Surg"},{"key":"2401_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2013.08.020","author":"DL Kendler","year":"2013","unstructured":"Kendler DL, Borges JLC, Fielding RA et al (2013) The official positions of the international society for clinical densitometry: indications of use and reporting of DXA for body composition. J Clin Densitom. https:\/\/doi.org\/10.1016\/j.jocd.2013.08.020. (Published online 2013)","journal-title":"J Clin Densitom"},{"key":"2401_CR27","doi-asserted-by":"publisher","DOI":"10.21037\/qims.2018.01.05","author":"S Guerri","year":"2018","unstructured":"Guerri S, Mercatelli D, G\u00f3mez MPA et al (2018) Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia. Quant Imaging Med Surg. https:\/\/doi.org\/10.21037\/qims.2018.01.05. (Published online 2018)","journal-title":"Quant Imaging Med Surg"},{"key":"2401_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2016.04.004","author":"A Bazzocchi","year":"2016","unstructured":"Bazzocchi A, Ponti F, Albisinni U, Battista G, Guglielmi G (2016) DXA: technical aspects and application. Eur J Radiol. https:\/\/doi.org\/10.1016\/j.ejrad.2016.04.004. (Published online 2016)","journal-title":"Eur J Radiol"},{"key":"2401_CR29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175110","author":"MT Imboden","year":"2017","unstructured":"Imboden MT, Welch WA, Swartz AM et al (2017) Reference standards for body fat measures using GE dual energy x-ray absorptiometry in Caucasian adults. PLoS One. https:\/\/doi.org\/10.1371\/journal.pone.0175110. (Published online 2017)","journal-title":"PLoS One"},{"issue":"1","key":"2401_CR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.21037\/qims.2018.01.01","volume":"8","author":"C Messina","year":"2018","unstructured":"Messina C, Maffi G, Vitale JA, Ulivieri FM, Guglielmi G, Sconfenza LM (2018) Diagnostic imaging of osteoporosis and sarcopenia: a narrative review. Quant Imaging Med Surg 8(1):86\u201399. https:\/\/doi.org\/10.21037\/qims.2018.01.01","journal-title":"Quant Imaging Med Surg"},{"issue":"1","key":"2401_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40170-023-00322-2","volume":"11","author":"T Van Soom","year":"2023","unstructured":"Van Soom T, Tjalma W, Papadimitriou K, Gebruers N, van Breda E (2023) The effects of chemotherapy on resting energy expenditure, body composition, and cancer-related fatigue in women with breast cancer: a prospective cohort study. Cancer Metab 11(1):1\u201311. https:\/\/doi.org\/10.1186\/s40170-023-00322-2","journal-title":"Cancer Metab"},{"key":"2401_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2014.02.003","author":"S Battisti","year":"2014","unstructured":"Battisti S, Guida FM, Coppa F et al (2014) Modification of abdominal fat distribution after aromatase inhibitor therapy in breast cancer patients visualized using 3-D computed tomography volumetry. Clin Breast Cancer. https:\/\/doi.org\/10.1016\/j.clbc.2014.02.003. (Published online 2014)","journal-title":"Clin Breast Cancer"},{"key":"2401_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(97)00082-1","author":"PA Ali","year":"1998","unstructured":"Ali PA, Al-Ghorabie FH, Evans CJ, El-Sharkawi AM, Hancock DA (1998) Body composition measurements using DXA and other techniques in tamoxifen-treated patients. Appl Radiat Isot. https:\/\/doi.org\/10.1016\/S0969-8043(97)00082-1","journal-title":"Appl Radiat Isot"},{"key":"2401_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801488","author":"MC Nguyen","year":"2001","unstructured":"Nguyen MC, Stewart RB, Banerji MA, Gordon DH, Kral JG (2001) Relationships between tamoxifen use, liver fat and body fat distribution in women with breast cancer. Int J Obes. https:\/\/doi.org\/10.1038\/sj.ijo.0801488. (Published online 2001)","journal-title":"Int J Obes"},{"issue":"2","key":"2401_CR35","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s10549-010-1223-2","volume":"125","author":"GJ Van Londen","year":"2011","unstructured":"Van Londen GJ, Perera S, Vujevich K et al (2011) The impact of an aromatase inhibitor on body composition and gonadal hormone levels in women with breast cancer. Breast Cancer Res Treat 125(2):441\u2013446. https:\/\/doi.org\/10.1007\/s10549-010-1223-2","journal-title":"Breast Cancer Res Treat"},{"key":"2401_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01447-9","author":"A Dalla Volta","year":"2023","unstructured":"Dalla Volta A, Caramella I, Di Mauro P et al (2023) Role of body composition in the prediction of skeletal fragility induced by hormone deprivation therapies in cancer patients. Curr Oncol Rep. https:\/\/doi.org\/10.1007\/s11912-023-01447-9. (Published online 2023)","journal-title":"Curr Oncol Rep"},{"key":"2401_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10440","author":"S Monteverdi","year":"2020","unstructured":"Monteverdi S, Pedersini R, Gallo F et al (2020) The interaction of lean body mass with fat body mass is associated with vertebral fracture prevalence in women with early breast cancer undergoing aromatase inhibitor therapy. JBMR Plus. https:\/\/doi.org\/10.1002\/jbm4.10440. (Published online 2020)","journal-title":"JBMR Plus"},{"issue":"1","key":"2401_CR38","doi-asserted-by":"publisher","first-page":"E2350950","DOI":"10.1001\/jamanetworkopen.2023.50950","volume":"7","author":"D Cosentini","year":"2024","unstructured":"Cosentini D, Pedersini R, Di Mauro P et al (2024) Fat body mass and vertebral fracture progression in women with breast cancer. JAMA Netw Open 7(1):E2350950. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.50950","journal-title":"JAMA Netw Open"},{"key":"2401_CR39","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac489","author":"C Palumbo","year":"2022","unstructured":"Palumbo C, Dalla Volta A, Zamboni S et al (2022) Effect of degarelix administration on bone health in prostate cancer patients without bone metastases the blade study. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/clinem\/dgac489. (Published online 2022)","journal-title":"J Clin Endocrinol Metab"},{"key":"2401_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64985-3","author":"A Berruti","year":"2002","unstructured":"Berruti A, Dogliotti L, Terrone C et al (2002) Changes in bone mineral density, lean body mass and fat content as measured by dual energy x-ray absorptiometry in patients with prostate cancer without apparent bone metastases given androgen deprivation therapy. J Urol. https:\/\/doi.org\/10.1016\/S0022-5347(05)64985-3. (Published online 2002)","journal-title":"J Urol"},{"key":"2401_CR41","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8299","author":"MR Smith","year":"2002","unstructured":"Smith MR, Finkelstein JS, McGovern FJ et al (2002) Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. https:\/\/doi.org\/10.1210\/jcem.87.2.8299. (Published online 2002)","journal-title":"J Clin Endocrinol Metab"},{"key":"2401_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11030690","author":"A Kury\u0142owicz","year":"2023","unstructured":"Kury\u0142owicz A (2023) Estrogens in adipose tissue physiology and obesity-related dysfunction. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines11030690. (Published online 2023)","journal-title":"Biomedicines"},{"key":"2401_CR43","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124865","author":"GA Greendale","year":"2019","unstructured":"Greendale GA, Sternfeld B, Huang MH et al (2019) Changes in body composition and weight during the menopause transition. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.124865. (Published online 2019)","journal-title":"JCI Insight"},{"key":"2401_CR44","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1849","author":"PS Karia","year":"2021","unstructured":"Karia PS, Joshu CE, Visvanathan K (2021) Association of oophorectomy and fat and lean body mass: evidence from a population-based sample of US women. Cancer Epidemiol Biomarkers Prev. https:\/\/doi.org\/10.1158\/1055-9965.EPI-20-1849. (Published online 2021)","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2401_CR45","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/53.6.1378","author":"JF Aloia","year":"1991","unstructured":"Aloia JF, McGowan DM, Vaswani AN, Ross P, Cohn SH (1991) Relationship of menopause to skeletal and muscle mass. Am J Clin Nutr. https:\/\/doi.org\/10.1093\/ajcn\/53.6.1378. (Published online 1991)","journal-title":"Am J Clin Nutr"},{"key":"2401_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-023-02150-z","author":"A Dalla Volta","year":"2023","unstructured":"Dalla Volta A, Palumbo C, Zamboni S et al (2023) Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health\u2014the BLADE study. J Endocrinol Invest. https:\/\/doi.org\/10.1007\/s40618-023-02150-z. (Published online 2023)","journal-title":"J Endocrinol Invest"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02401-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-024-02401-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02401-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:16:26Z","timestamp":1731028586000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-024-02401-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,10]]},"references-count":46,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2401"],"URL":"https:\/\/doi.org\/10.1007\/s40618-024-02401-7","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,10]]},"assertion":[{"value":"16 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was performed in accordance with the Declaration of Helsinki. Ethical Committee of ASST Spedali Civili of Brescia approved the study (internal protocol n\u00b0 3270, registered in August 2014).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}