{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:34:33Z","timestamp":1782218073694,"version":"3.54.5"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-024-02478-0","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T12:01:53Z","timestamp":1729080113000},"page":"721-730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Osteocalcin: may be a useful biomarker for early identification of rapidly progressive central precocious puberty in girls"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5615-3151","authenticated-orcid":false,"given":"W.","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-0883","authenticated-orcid":false,"given":"D.","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"issue":"3","key":"2478_CR1","first-page":"e202202840","volume":"121","author":"N Geniuk","year":"2023","unstructured":"Geniuk N, de Jes\u00fas Su\u00e1rez Mozo M, Pose MN, Vidaurreta S (2023) Rapidly progressive precocious puberty during the COVID-19 lockdown. Arch Argentinos De Pediatria 121(3):e202202840","journal-title":"Arch Argentinos De Pediatria"},{"key":"2478_CR2","doi-asserted-by":"publisher","first-page":"1107911","DOI":"10.3389\/fendo.2022.1107911","volume":"13","author":"S Prosperi","year":"2022","unstructured":"Prosperi S, Chiarelli F (2022) Early and precocious puberty during the COVID-19 pandemic. Front Endocrinol 13:1107911","journal-title":"Front Endocrinol"},{"issue":"9","key":"2478_CR3","doi-asserted-by":"publisher","first-page":"bvad094","DOI":"10.1210\/jendso\/bvad094","volume":"7","author":"D Fava","year":"2023","unstructured":"Fava D, Pepino C, Tosto V, Gastaldi R, Pepe A, Paoloni D et al (2023) Precocious puberty diagnoses Spike, COVID-19 pandemic, and body Mass Index: findings from a 4-year study. J Endocr Soc 7(9):bvad094","journal-title":"J Endocr Soc"},{"issue":"11","key":"2478_CR4","doi-asserted-by":"publisher","first-page":"5007","DOI":"10.1007\/s00431-023-05174-y","volume":"182","author":"Y Liu","year":"2023","unstructured":"Liu Y, Cheng Y, Sun M, Hao X, Li M (2023) Analysis of serum insulin-like growth factor-1, fibroblast growth factor 23, and Klotho levels in girls with rapidly progressive central precocious puberty. Eur J Pediatrics 182(11):5007\u20135013","journal-title":"Eur J Pediatrics"},{"issue":"3","key":"2478_CR5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1515\/jpem-2017-0247","volume":"31","author":"D \u00c7i\u00e7ek","year":"2018","unstructured":"\u00c7i\u00e7ek D, Savas-Erdeve S, Cetinkaya S, Aycan Z (2018) Clinical follow-up data and the rate of development of precocious and rapidly progressive puberty in patients with premature thelarche. J Pediatr Endocrinol Metabolism: JPEM 31(3):305\u2013312","journal-title":"J Pediatr Endocrinol Metabolism: JPEM"},{"issue":"1","key":"2478_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/uog.6271","volume":"33","author":"V Calcaterra","year":"2009","unstructured":"Calcaterra V, Sampaolo P, Klersy C, Larizza D, Alfei A, Brizzi V et al (2009) Utility of breast ultrasonography in the diagnostic work-up of precocious puberty and proposal of a prognostic index for identifying girls with rapidly progressive central precocious puberty. Ultrasound Obstet Gynecology: Official J Int Soc Ultrasound Obstet Gynecol 33(1):85\u201391","journal-title":"Ultrasound Obstet Gynecology: Official J Int Soc Ultrasound Obstet Gynecol"},{"issue":"5","key":"2478_CR7","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1530\/EJE-14-0010","volume":"170","author":"A Zung","year":"2014","unstructured":"Zung A, Burundukov E, Ulman M, Glaser T, Rosenberg M, Chen M et al (2014) The diagnostic value of first-voided urinary LH compared with GNRH-stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls. Eur J Endocrinol 170(5):749\u2013758","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2478_CR8","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jpag.2020.11.020","volume":"34","author":"Y Chen","year":"2021","unstructured":"Chen Y, Liu J (2021) Do most 7- to 8-Year-old girls with early puberty require extensive investigation and treatment? J Pediatr Adolesc Gynecol 34(2):124\u2013129","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"6","key":"2478_CR9","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jped.2014.04.008","volume":"90","author":"CM Fortes","year":"2014","unstructured":"Fortes CM, Goldberg TB, Kurokawa CS, Silva CC, Moretto MR, Biason TP et al (2014) Relationship between chronological and bone ages and pubertal stage of breasts with bone biomarkers and bone mineral density in adolescents. Jornal De Pediatria 90(6):624\u2013631","journal-title":"Jornal De Pediatria"},{"key":"2478_CR10","doi-asserted-by":"publisher","first-page":"610227","DOI":"10.3389\/fped.2021.610227","volume":"9","author":"PM Pald\u00e1nius","year":"2021","unstructured":"Pald\u00e1nius PM, Ivaska KK, M\u00e4kitie O, Viljakainen H (2021) Serum and urinary osteocalcin in healthy 7- to 19-Year-old Finnish children and adolescents. Front Pead 9:610227","journal-title":"Front Pead"},{"issue":"1","key":"2478_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40510-017-0184-y","volume":"18","author":"T Tripathi","year":"2017","unstructured":"Tripathi T, Gupta P, Rai P, Sharma J, Gupta VK, Singh N (2017) Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators. Prog Orthodont 18(1):30","journal-title":"Prog Orthodont"},{"issue":"2","key":"2478_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/s00198-013-2485-4","volume":"25","author":"M Bayer","year":"2014","unstructured":"Bayer M (2014) Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy central European population aged 0\u201318 years. Osteoporos Int 25(2):729\u2013736","journal-title":"Osteoporos Int"},{"key":"2478_CR13","doi-asserted-by":"publisher","first-page":"100752","DOI":"10.1016\/j.jbior.2020.100752","volume":"78","author":"T Otani","year":"2020","unstructured":"Otani T, Mizokami A, Kawakubo-Yasukochi T, Takeuchi H, Inai T, Hirata M (2020) The roles of osteocalcin in lipid metabolism in adipose tissue and liver. Adv Biol Regul 78:100752","journal-title":"Adv Biol Regul"},{"issue":"11","key":"2478_CR14","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1507\/endocrj.EJ17-0323","volume":"64","author":"I Kanazawa","year":"2017","unstructured":"Kanazawa I (2017) Interaction between bone and glucose metabolism. Endocr J 64(11):1043\u20131053","journal-title":"Endocr J"},{"issue":"10","key":"2478_CR15","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1515\/cclm-2015-0953","volume":"54","author":"P Magni","year":"2016","unstructured":"Magni P, Macchi C, Sirtori CR, Corsi Romanelli MM (2016) Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases. Clin Chem Lab Med 54(10):1579\u20131587","journal-title":"Clin Chem Lab Med"},{"key":"2478_CR16","doi-asserted-by":"publisher","unstructured":"Yadav VK, Berger JM, Singh P, Nagarajan P, Karsenty G (2022) Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Investig. 132(4):e153752. https:\/\/doi.org\/10.1172\/JCI153752.","DOI":"10.1172\/JCI153752"},{"issue":"5","key":"2478_CR17","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.cmet.2019.08.012","volume":"30","author":"JM Berger","year":"2019","unstructured":"Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E et al (2019) Mediation of the Acute stress response by the Skeleton. Cell Metabol 30(5):890\u2013902e898","journal-title":"Cell Metabol"},{"issue":"10","key":"2478_CR18","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1084\/jem.20171320","volume":"214","author":"L Khrimian","year":"2017","unstructured":"Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS et al (2017) Gpr158 mediates osteocalcin\u2019s regulation of cognition. J Exp Med 214(10):2859\u20132873","journal-title":"J Exp Med"},{"issue":"4","key":"2478_CR19","doi-asserted-by":"publisher","first-page":"4924","DOI":"10.1002\/jcb.27767","volume":"120","author":"S Solhjoo","year":"2019","unstructured":"Solhjoo S, Akbari M, Toolee H, Mortezaee K, Mohammadipour M, Nematollahi-Mahani SN et al (2019) Roles for osteocalcin in proliferation and differentiation of spermatogonial cells cocultured with somatic cells. J Cell Biochem 120(4):4924\u20134934","journal-title":"J Cell Biochem"},{"issue":"4","key":"2478_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1620\/tjem.245.239","volume":"245","author":"WY Lee","year":"2018","unstructured":"Lee WY, Jung G, Kim HR, Nam HK, Rhie YJ, Lee KH (2018) Serum osteocalcin levels in girls with central precocious puberty: relation to the Onset of Puberty. Tohoku J Exp Med 245(4):239\u2013243","journal-title":"Tohoku J Exp Med"},{"issue":"6","key":"2478_CR21","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1172\/JCI65952","volume":"123","author":"F Oury","year":"2013","unstructured":"Oury F, Ferron M, Huizhen W, Confavreux C, Xu L, Lacombe J et al (2013) Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis. J Clin Investig 123(6):2421\u20132433","journal-title":"J Clin Investig"},{"issue":"5","key":"2478_CR22","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1177\/0009922814541807","volume":"54","author":"GB Kletter","year":"2015","unstructured":"Kletter GB, Klein KO, Wong YY (2015) A pediatrician\u2019s guide to central precocious puberty. Clin Pediatr 54(5):414\u2013424","journal-title":"Clin Pediatr"},{"key":"2478_CR23","unstructured":"[Consensus statement For the diagnosis and treatment of central precocious puberty (2015) ]. Zhonghua er ke za zhi\u2009=\u2009Chinese journal of pediatrics. 2015;53(6):412\u2013418"},{"issue":"22","key":"2478_CR24","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1056\/NEJMcp0800459","volume":"358","author":"JC Carel","year":"2008","unstructured":"Carel JC, L\u00e9ger J (2008) Clinical practice. Precocious puberty. N Engl J Med 358(22):2366\u20132377","journal-title":"N Engl J Med"},{"key":"2478_CR25","doi-asserted-by":"publisher","first-page":"3126309","DOI":"10.1155\/2020\/3126309","volume":"2020","author":"J Xue","year":"2020","unstructured":"Xue J, Song W, Si M, Sun C, Li K, Wang W et al (2020) Serum Kisspeptin and AMH levels are good references for precocious puberty progression. Int J Endocrinol 2020:3126309","journal-title":"Int J Endocrinol"},{"issue":"3","key":"2478_CR26","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jpag.2017.01.010","volume":"30","author":"T Chen","year":"2017","unstructured":"Chen T, Wu H, Xie R, Wang F, Chen X, Sun H et al (2017) Serum Anti-M\u00fcllerian hormone and inhibin B as potential markers for progressive central precocious puberty in girls. J Pediatr Adolesc Gynecol 30(3):362\u2013366","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"6","key":"2478_CR27","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1515\/jpem-2019-0577","volume":"33","author":"V Calcaterra","year":"2020","unstructured":"Calcaterra V, Klersy C, Vinci F, Regalbuto C, Dobbiani G, Montalbano C et al (2020) Rapid progressive central precocious puberty: diagnostic and predictive value of basal sex hormone levels and pelvic ultrasound. J Pediatr Endocrinol Metabolism: JPEM 33(6):785\u2013791","journal-title":"J Pediatr Endocrinol Metabolism: JPEM"},{"issue":"2","key":"2478_CR28","doi-asserted-by":"publisher","first-page":"R43","DOI":"10.1530\/JOE-20-0203","volume":"249","author":"C Shan","year":"2021","unstructured":"Shan C, Yue J, Liu W (2021) Broadening the role of osteocalcin in the hypothalamic-pituitary-gonadal axis. J Endocrinol 249(2):R43\u2013r51","journal-title":"J Endocrinol"},{"issue":"2","key":"2478_CR29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1515\/jpem-2016-0243","volume":"30","author":"MM Sch\u00fcndeln","year":"2017","unstructured":"Sch\u00fcndeln MM, B\u00e4der L, Kiewert C, Herrmann R, F\u00fchrer D, Hauffa BP et al (2017) Plasma concentrations of osteocalcin are associated with the timing of pubertal progress in boys. J Pediatr Endocrinol Metab 30(2):141\u2013147","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"7","key":"2478_CR30","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1080\/09513590.2017.1423467","volume":"34","author":"MJ Kang","year":"2018","unstructured":"Kang MJ, Oh YJ, Shim YS, Baek JW, Yang S, Hwang IT (2018) The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty. Gynecol Endocrinol 34(7):627\u2013630","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"2478_CR31","first-page":"311","volume":"60","author":"XQ Xu","year":"2022","unstructured":"Xu XQ, Zhang JW, Chen RM, Luo JS, Chen SK, Zheng RX et al (2022) Relationship between body mass index and sexual development in Chinese children. Chin J Pediatr 60(4):311\u2013316","journal-title":"Chin J Pediatr"},{"issue":"4","key":"2478_CR32","doi-asserted-by":"publisher","first-page":"e014004","DOI":"10.1136\/bmjopen-2016-014004","volume":"7","author":"C Chen","year":"2017","unstructured":"Chen C, Zhang Y, Sun W, Chen Y, Jiang Y, Song Y et al (2017) Investigating the relationship between precocious puberty and obesity: a cross-sectional study in Shanghai, China. BMJ open 7(4):e014004","journal-title":"BMJ open"},{"issue":"2","key":"2478_CR33","doi-asserted-by":"publisher","first-page":"104","DOI":"10.6065\/apem.2019.24.2.104","volume":"24","author":"SB Oh","year":"2019","unstructured":"Oh SB, Lee WY, Nam HK, Rhie YJ, Lee KH (2019) Serum osteocalcin levels in overweight children. Annals Pediatr Endocrinol Metabolism 24(2):104\u2013107","journal-title":"Annals Pediatr Endocrinol Metabolism"},{"key":"2478_CR34","doi-asserted-by":"publisher","first-page":"1273170","DOI":"10.3389\/fendo.2023.1273170","volume":"14","author":"M Zhang","year":"2023","unstructured":"Zhang M, Sun J, Wang Y, Wu Y, Li X, Li R et al (2023) The value of luteinizing hormone basal values and sex hormone-binding globulin for early diagnosis of rapidly progressive central precocious puberty. Front Endocrinol 14:1273170","journal-title":"Front Endocrinol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02478-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-024-02478-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02478-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T10:27:45Z","timestamp":1740997665000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-024-02478-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,3]]}},"alternative-id":["2478"],"URL":"https:\/\/doi.org\/10.1007\/s40618-024-02478-0","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,16]]},"assertion":[{"value":"22 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Consent for publication was obtained from all participants included in the study","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}