{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:08:01Z","timestamp":1784268481320,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-024-02515-y","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T07:48:31Z","timestamp":1733989711000},"page":"941-950","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deciphering 18F-DOPA uptake in SDH-related head and neck paragangliomas: a radiomics approach"],"prefix":"10.1007","volume":"48","author":[{"given":"Valentina","family":"Berti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Fasciglione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Charpiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Montanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Pepponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Hubele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Taieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Pacak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Goichot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-5146","authenticated-orcid":false,"given":"Alessio","family":"Imperiale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"2515_CR1","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1177\/0003489420931540","volume":"129","author":"ND Cass","year":"2020","unstructured":"Cass ND, Schopper MA, Lubin JA, Fishbein L, Gubbels SP (2020) The changing paradigm of head and neck paragangliomas: what every otolaryngologist needs to know. Annals Otology Rhinology Laryngology 129:1135\u20131143","journal-title":"Annals Otology Rhinology Laryngology"},{"key":"2515_CR2","doi-asserted-by":"publisher","first-page":"e210088","DOI":"10.1148\/rycan.210088","volume":"4","author":"EP Lin","year":"2022","unstructured":"Lin EP, Chin BB, Fishbein L, Moritani T, Montoya SP, Ellika S et al (2022) Head and Neck paragangliomas: an update on the molecular classification, state-of-the-art imaging, and Management recommendations. Radiol Imaging Cancer 4:e210088","journal-title":"Radiol Imaging Cancer"},{"key":"2515_CR3","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1530\/ERC-21-0359","volume":"29","author":"S Richter","year":"2022","unstructured":"Richter S, Qiu B, Ghering M, Kunath C, Constantinescu G, Luths C et al (2022) Given the potential hereditary component, genetic counseling and testing are necessary Head\/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine. Endocr Relat Cancer 29:213\u2013224","journal-title":"Endocr Relat Cancer"},{"key":"2515_CR4","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s00259-016-3354-0","volume":"43","author":"D Ta\u00efeb","year":"2016","unstructured":"Ta\u00efeb D, Imperiale A, Pacak K (2016) (18)F-DOPA: the versatile radiopharmaceutical. Eur J Nucl Med Mol Imaging 43:1187\u20131189","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2515_CR5","doi-asserted-by":"publisher","first-page":"T135","DOI":"10.1530\/ERC-15-0175","volume":"22","author":"F Castinetti","year":"2015","unstructured":"Castinetti F, Kroiss A, Kumar R, Pacak K, Taieb D (2015) 15 YEARS OF PARAGANGLIOMA: imaging and imaging-based treatment of pheochromocytoma and paraganglioma. Endocr Relat Cancer 22:T135\u2013T145","journal-title":"Endocr Relat Cancer"},{"key":"2515_CR6","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s00259-017-3833-y","volume":"45","author":"V Amodru","year":"2018","unstructured":"Amodru V, Guerin C, Delcourt S, Romanet P, Loundou A, Viana B et al (2018) Quantitative (18)F-DOPA PET\/CT in pheochromocytoma: the relationship between tumor secretion and its biochemical phenotype. Eur J Nucl Med Mol Imaging 45:278\u2013282","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2515_CR7","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000491578","volume":"107","author":"S Moog","year":"2018","unstructured":"Moog S, Houy S, Chevalier E, Ory S, Weryha G, Rame M et al (2018) 18F-FDOPA PET\/CT uptake parameters correlate with catecholamine secretion in human pheochromocytomas. Neuroendocrinology 107:228\u2013236","journal-title":"Neuroendocrinology"},{"key":"2515_CR8","doi-asserted-by":"publisher","first-page":"R627","DOI":"10.1530\/ERC-19-0165","volume":"26","author":"D Ta\u00efeb","year":"2019","unstructured":"Ta\u00efeb D, Jha A, Treglia G, Pacak K (2019) Molecular imaging and radionuclide therapy of pheochromocytoma and paraganglioma in the era of genomic characterization of disease subgroups. Endocr Relat Cancer 26:R627\u2013R652","journal-title":"Endocr Relat Cancer"},{"key":"2515_CR9","doi-asserted-by":"publisher","first-page":"4757","DOI":"10.1210\/jc.2009-1248","volume":"94","author":"HJ Timmers","year":"2009","unstructured":"Timmers HJ, Chen CC, Carrasquillo JA, Whatley M, Ling A, Havekes B et al (2009) Comparison of 18F-Fluoro-L-DOPA, 18F-Fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma. J Clin Endocrinol Metab 94:4757\u20134767","journal-title":"J Clin Endocrinol Metab"},{"key":"2515_CR10","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1111\/cen.12126","volume":"79","author":"S Gabriel","year":"2013","unstructured":"Gabriel S, Blanchet EM, Sebag F, Chen CC, Fakhry N, Deveze A et al (2013) Functional characterization of no metastatic paraganglioma and pheochromocytoma by (18)F-FDOPA PET: focus on missed lesions. Clin Endocrinol 79:170\u2013177","journal-title":"Clin Endocrinol"},{"key":"2515_CR11","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/cen.14086","volume":"91","author":"T Reichert","year":"2019","unstructured":"Reichert T, Fakhry N, Lavieille JP, Amodru V, Sebag F, Romanet P et al (2019) Exploring the link between tumour metabolism and succinate dehydrogenase deficiency: a 18 F-FDOPA PET\/CT study in head and neck paragangliomas. Clin Endocrinol (Oxf) 91:879\u2013884","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2515_CR12","doi-asserted-by":"publisher","first-page":"38S","DOI":"10.2967\/jnumed.118.220582","volume":"60","author":"M Hatt","year":"2019","unstructured":"Hatt M, Le Rest CC, Tixier F, Badic B, Schick U, Visvikis D (2019) Radiomics: Data are also images. J Nucl Med 60:38S\u201344S","journal-title":"J Nucl Med"},{"key":"2515_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41571-021-00560-7","volume":"19","author":"K Bera","year":"2022","unstructured":"Bera K, Braman N, Gupta A, Velcheti V, Madabhushi A (2022) Predicting cancer outcomes with radiomics and artificial intelligence in radiology. Nat Rev Clin Oncol 19:132\u2013146","journal-title":"Nat Rev Clin Oncol"},{"key":"2515_CR14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s13014-022-02192-2","volume":"17","author":"S Li","year":"2022","unstructured":"Li S, Zhou B (2022) A review of radiomics and genomics applications in cancers: the way towards precision medicine. Radiat Oncol 17:217","journal-title":"Radiat Oncol"},{"key":"2515_CR15","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.ejca.2011.11.036","volume":"48","author":"P Lambin","year":"2022","unstructured":"Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout RG, Granton P et al (2022) Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer 48:441\u2013446","journal-title":"Eur J Cancer"},{"key":"2515_CR16","doi-asserted-by":"publisher","unstructured":"Ansquer C, Drui D, Miralli\u00e9 E, Renaudin-Autain K, Denis A, Gimenez-Roqueplo AP et al (2020) A usefulness of FDG-PET\/CT-Based Radiomics for the characterization and genetic orientation of Pheochromocytomas before surgery. Cancers (Basel) 12(9):2424. https:\/\/doi.org\/10.3390\/cancers12092424","DOI":"10.3390\/cancers12092424"},{"key":"2515_CR17","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1007\/s00330-022-09034-5","volume":"32","author":"WA Noortman","year":"2022","unstructured":"Noortman WA, Vriens D, de Geus-Oei LF, Slump CH, Aarntzen EH, van Berkel A et al (2022) [18F]FDG-PET\/CT radiomics for the identification of genetic clusters in pheochromocytomas and paragangliomas. Eur Radiol 32:7227\u20137236","journal-title":"Eur Radiol"},{"key":"2515_CR18","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.1007\/s00259-019-04398-1","volume":"46","author":"D Ta\u00efeb","year":"2019","unstructured":"Ta\u00efeb D, Hicks RJ, Hindi\u00e9 E, Guillet BA, Avram A, Ghedini P et al (2019) European Association of Nuclear Medicine Practice Guideline\/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma. Eur J Nucl Med Mol Imaging 46:2112\u20132137","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"2515_CR19","doi-asserted-by":"publisher","first-page":"4786","DOI":"10.1158\/0008-5472.CAN-18-0125","volume":"78","author":"C Nioche","year":"2018","unstructured":"Nioche C, Orlhac F, Boughdad S, Reuz\u00e9 S, Goya-Outi J, Robert C et al (2018) LIFEx: a freeware for radiomic feature calculation in multimodality imaging to accelerate advances in the characterization of tumor heterogeneity. Cancer Res 78:4786\u20134789","journal-title":"Cancer Res"},{"key":"2515_CR20","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.2967\/jnumed.117.199935","volume":"59","author":"F Orlhac","year":"2018","unstructured":"Orlhac F, Boughdad S, Philippe C, Stalla-Bourdillon H, Nioche C, Champion L et al (2018) Postreconstruction Harmonization Method for Multicenter Radiomic studies in PET. J Nucl Med 59:1321\u20131328","journal-title":"J Nucl Med"},{"key":"2515_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrendo.2016.185","volume":"13","author":"RA Toledo","year":"2017","unstructured":"Toledo RA, Burnichon N, Cascon A, Benn DE, Bayley JP, Welander J et al (2017) Consensus Statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas. Nat Rev Endocrinol 13:233\u2013247","journal-title":"Nat Rev Endocrinol"},{"key":"2515_CR22","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1097\/RLU.0000000000004870","volume":"433","author":"Y Zhi","year":"2023","unstructured":"Zhi Y, Gerhard-Hartmann E, Hartrampf PE, Weich A, Higuchi T, Bley TA et al (2023) Somatostatin receptor-Directed PET\/CT can differentiate between different subtypes of Head and Neck Paragangliomas. Clin Nucl Med 433:48:923\u2013927","journal-title":"Clin Nucl Med"},{"key":"2515_CR23","doi-asserted-by":"publisher","unstructured":"Pepponi M, Berti V, Fasciglione E, Montanini F, Canu L, Hubele F et al (2024) [68Ga]DOTATOC PET-derived radiomics to predict genetic background of head and neck paragangliomas: a pilot investigation. Eur J Nucl Med Mol Imaging. 51(9):2684\u20132694. https:\/\/doi.org\/10.1007\/s00259-024-06735-5","DOI":"10.1007\/s00259-024-06735-5"},{"key":"2515_CR24","doi-asserted-by":"publisher","first-page":"745","DOI":"10.2967\/jnumed.118.216796","volume":"60","author":"A van Berkel","year":"2019","unstructured":"van Berkel A, Vriens D, Visser EP, Janssen MJR, Gotthardt M, Hermus ARMM et al (2019) Metabolic subtyping of Pheochromocytoma and Paraganglioma by (18)F-FDG pharmacokinetics using dynamic PET\/CT scanning. J Nucl Med 60:745\u2013751","journal-title":"J Nucl Med"},{"key":"2515_CR25","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.2967\/jnumed.123.265584","volume":"64","author":"O De Rycke","year":"2023","unstructured":"De Rycke O, Perrier M, Ouvrard \u00c9, Mennetrey C, Lachachi C, Bando-Delaunay A et al (2023) High Tumor Uptake on 18F-FDOPA PET\/CT indicates poor prognosis in patients with metastatic midgut neuroendocrine tumors: a study from the Groupe d\u2019\u00e9tude Des Tumeurs endocrines and ENDOCAN-RENATEN Network. J Nucl Med 64:1699\u20131705","journal-title":"J Nucl Med"}],"updated-by":[{"DOI":"10.1007\/s40618-026-02985-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000}}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02515-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-024-02515-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-024-02515-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:42:02Z","timestamp":1784266922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-024-02515-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["2515"],"URL":"https:\/\/doi.org\/10.1007\/s40618-024-02515-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"18 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: due to due to competing statement was incorrectly published in the article. The original article has been corrected.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2026","order":8,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":9,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":10,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40618-026-02985-2","URL":"https:\/\/doi.org\/10.1007\/s40618-026-02985-2","order":11,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D. Taieb is a cofounder, stakeholder, and the chief medical officer (CMO) of SILON Therapeutics (\n                      \n                      ) and reports receiving advisory board honoraria from Novartis. The other authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Local institutional review board approved this retrospective study (IRB-2024-04), and all patients included gave a free and written informed consent for the use of the anonymous personal medical data extracted from their file for scientific or epidemiological purposes.","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients included gave a free and written informed consent for the use of the anonymous personal medical data extracted from their file for scientific or epidemiological purposes.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}