{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:21:57Z","timestamp":1789050117761,"version":"build-2803163510"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02544-1","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T16:30:28Z","timestamp":1739291428000},"page":"1371-1382","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Morphometric vertebral fractures at hospitalization associate with Long COVID occurrence"],"prefix":"10.1007","volume":"48","author":[{"given":"Luigi","family":"di Filippo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Doga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mangini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Gifuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seynt Jiro","family":"Sahagun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Rovere Querini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6783-3398","authenticated-orcid":false,"given":"Andrea","family":"Giustina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"issue":"5","key":"2544_CR1","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.3390\/ijerph18052621","volume":"18","author":"C Fern\u00e1ndez-de-Las-Pe\u00f1as","year":"2021","unstructured":"Fern\u00e1ndez-de-Las-Pe\u00f1as C, Palacios-Ce\u00f1a D, G\u00f3mez-Mayordomo V, Cuadrado ML, Florencio LL (2021) Defining Post-COVID, symptoms (Post-acute COVID, Long COVID, Persistent Post-COVID): an integrative classification. Int J Environ Res Public Health 18(5):2621. https:\/\/doi.org\/10.3390\/ijerph18052621. Published 2021 Mar 5","journal-title":"Int J Environ Res Public Health"},{"issue":"23","key":"2544_CR2","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1056\/NEJMp2304550","volume":"388","author":"J\u017d Nikolich","year":"2023","unstructured":"Nikolich J\u017d, Rosen CJ (2023) Toward Comprehensive Care for Long Covid. N Engl J Med 388(23):2113\u20132115. https:\/\/doi.org\/10.1056\/NEJMp2304550","journal-title":"N Engl J Med"},{"issue":"20","key":"2544_CR3","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.3390\/nu15204474","volume":"15","author":"R De Lorenzo","year":"2023","unstructured":"De Lorenzo R, Di Filippo L, Scelfo S et al (2023) Longitudinal changes in physical function and their impact on Health outcomes in COVID-19 patients. Nutrients 15(20):4474. https:\/\/doi.org\/10.3390\/nu15204474. Published 2023 Oct 22","journal-title":"Nutrients"},{"issue":"24","key":"2544_CR4","doi-asserted-by":"publisher","first-page":"7314","DOI":"10.3390\/jcm11247314","volume":"11","author":"KI Notarte","year":"2022","unstructured":"Notarte KI, de Oliveira MHS, Peligro PJ et al (2022) Age, sex and previous comorbidities as risk factors not Associated with SARS-CoV-2 infection for long COVID-19: a systematic review and Meta-analysis. J Clin Med 11(24):7314 Published 2022 Dec 9. https:\/\/doi.org\/10.3390\/jcm11247314","journal-title":"J Clin Med"},{"issue":"6","key":"2544_CR5","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.3390\/jcm11061541","volume":"11","author":"G Maglietta","year":"2022","unstructured":"Maglietta G, Diodati F, Puntoni M et al (2022) Prognostic factors for Post-COVID-19 syndrome: a systematic review and Meta-analysis. J Clin Med 11(6):1541. https:\/\/doi.org\/10.3390\/jcm11061541. Published 2022 Mar 11","journal-title":"J Clin Med"},{"key":"2544_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-024-01442-8","author":"L di Filippo","year":"2024","unstructured":"di Filippo L, Franzese V, Santoro S, Doga M, Giustina A (2024) Long COVID and pituitary dysfunctions: an unsuspected bidirectional relationship? Pituitary. https:\/\/doi.org\/10.1007\/s11102-024-01442-8. In press","journal-title":"Pituitary"},{"issue":"10","key":"2544_CR7","doi-asserted-by":"publisher","first-page":"e1106","DOI":"10.1210\/clinem\/dgad207","volume":"108","author":"L di Filippo","year":"2023","unstructured":"di Filippo L, Frara S, Nannipieri F et al (2023) Low vitamin D levels are Associated with Long COVID Syndrome in COVID-19 survivors. J Clin Endocrinol Metab 108(10):e1106\u2013e1116. https:\/\/doi.org\/10.1210\/clinem\/dgad207","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2544_CR8","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s12020-011-9570-2","volume":"41","author":"G Mazziotti","year":"2012","unstructured":"Mazziotti G, Bilezikian J, Canalis E, Cocchi D, Giustina A (2012) New understanding and treatments for osteoporosis. Endocrine 41(1):58\u201369. https:\/\/doi.org\/10.1007\/s12020-011-9570-2","journal-title":"Endocrine"},{"issue":"3","key":"2544_CR9","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s12020-024-03784-6","volume":"85","author":"L di Filippo","year":"2024","unstructured":"di Filippo L, Bilezikian JP, Canalis E, Terenzi U, Giustina A (2024) New insights into the vitamin D\/PTH axis in endocrine-driven metabolic bone diseases. Endocrine 85(3):1007\u20131019. https:\/\/doi.org\/10.1007\/s12020-024-03784-6","journal-title":"Endocrine"},{"issue":"2","key":"2544_CR10","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/jbmr.5650070214","volume":"7","author":"C Cooper","year":"1992","unstructured":"Cooper C, Atkinson EJ, O\u2019Fallon WM, Melton LJ 3 (1992) Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985\u20131989. J Bone Min Res 7(2):221\u2013227. https:\/\/doi.org\/10.1002\/jbmr.5650070214","journal-title":"J Bone Min Res"},{"issue":"7","key":"2544_CR11","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1359\/jbmr.2003.18.7.1254","volume":"18","author":"T Jalava","year":"2003","unstructured":"Jalava T, Sarna S, Pylkk\u00e4nen L et al (2003) Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Min Res 18(7):1254\u20131260. https:\/\/doi.org\/10.1359\/jbmr.2003.18.7.1254","journal-title":"J Bone Min Res"},{"issue":"3","key":"2544_CR12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00198-017-4337-0","volume":"29","author":"R Watanabe","year":"2018","unstructured":"Watanabe R, Shiraki M, Saito M, Okazaki R, Inoue D (2018) Restrictive pulmonary dysfunction is associated with vertebral fractures and bone loss in elderly postmenopausal women. Osteoporos Int 29(3):625\u2013633. https:\/\/doi.org\/10.1007\/s00198-017-4337-0","journal-title":"Osteoporos Int"},{"issue":"4","key":"2544_CR13","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jocd.2015.02.004","volume":"18","author":"JH Krege","year":"2015","unstructured":"Krege JH, Kendler D, Krohn K et al (2015) Relationship between vertebral fracture burden, height loss, and pulmonary function in Postmenopausal Women with osteoporosis. J Clin Densitom 18(4):506\u2013511. https:\/\/doi.org\/10.1016\/j.jocd.2015.02.004","journal-title":"J Clin Densitom"},{"issue":"14","key":"2544_CR14","doi-asserted-by":"publisher","first-page":"E830","DOI":"10.1097\/BRS.0000000000002536","volume":"43","author":"B Kim","year":"2018","unstructured":"Kim B, Kim J, Jo YH et al (2018) Risk of Pneumonia after Vertebral Compression fracture in women with low bone density: a Population-based study. Spine (Phila Pa 1976) 43(14):E830\u2013E835. https:\/\/doi.org\/10.1097\/BRS.0000000000002536","journal-title":"Spine (Phila Pa 1976)"},{"issue":"2","key":"2544_CR15","doi-asserted-by":"publisher","first-page":"e602","DOI":"10.1210\/clinem\/dgaa738","volume":"106","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Formenti AM, Doga M, Pedone E, Rovere-Querini P, Giustina A (2021) Radiological thoracic vertebral fractures are highly prevalent in COVID-19 and predict Disease outcomes. J Clin Endocrinol Metab 106(2):e602\u2013e614. https:\/\/doi.org\/10.1210\/clinem\/dgaa738","journal-title":"J Clin Endocrinol Metab"},{"key":"2544_CR16","doi-asserted-by":"publisher","first-page":"115790","DOI":"10.1016\/j.bone.2020.115790","volume":"144","author":"J Kottlors","year":"2021","unstructured":"Kottlors J, Gro\u00dfe Hokamp N, Fervers P et al (2021) Early extrapulmonary prognostic features in chest computed tomography in COVID-19 pneumonia: bone mineral density is a relevant predictor for the clinical outcome - A multicenter feasibility study. Bone 144:115790. https:\/\/doi.org\/10.1016\/j.bone.2020.115790","journal-title":"Bone"},{"issue":"4","key":"2544_CR17","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.jocd.2021.07.007","volume":"24","author":"M Tahtabasi","year":"2021","unstructured":"Tahtabasi M, Kilicaslan N, Akin Y et al (2021) The Prognostic Value of vertebral bone density on chest CT in hospitalized COVID-19 patients. J Clin Densitom 24(4):506\u2013515. https:\/\/doi.org\/10.1016\/j.jocd.2021.07.007","journal-title":"J Clin Densitom"},{"key":"2544_CR18","doi-asserted-by":"publisher","unstructured":"Ahn SH, Seo SH, Jung CY et al (2024) Clinical outcomes of COVID-19 infection in patients with osteoporosis: a nationwide cohort study in Korea using the common data model. Sci Rep.;14(1):17738. Published 2024 Jul 31. https:\/\/doi.org\/10.1038\/s41598-024-68356-0","DOI":"10.1038\/s41598-024-68356-0"},{"key":"2544_CR19","doi-asserted-by":"publisher","first-page":"117095","DOI":"10.1016\/j.bone.2024.117095","volume":"184","author":"S Azekawa","year":"2024","unstructured":"Azekawa S, Maetani T, Chubachi S et al (2024) CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome. Bone 184:117095. https:\/\/doi.org\/10.1016\/j.bone.2024.117095","journal-title":"Bone"},{"issue":"1","key":"2544_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s12020-020-02541-9","volume":"71","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Formenti AM, Doga M et al (2021) Hypocalcemia is a distinctive biochemical feature of hospitalized COVID-19 patients. Endocrine 71(1):9\u201313. https:\/\/doi.org\/10.1007\/s12020-020-02541-9","journal-title":"Endocrine"},{"issue":"2","key":"2544_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12020-021-02882-z","volume":"74","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Allora A, Locatelli M et al (2021) Hypocalcemia in COVID-19 is associated with low vitamin D levels and impaired compensatory PTH response. Endocrine 74(2):219\u2013225. https:\/\/doi.org\/10.1007\/s12020-021-02882-z","journal-title":"Endocrine"},{"issue":"1","key":"2544_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12020-021-02671-8","volume":"72","author":"A Giustina","year":"2021","unstructured":"Giustina A (2021) Hypovitaminosis D and the endocrine phenotype of COVID-19. Endocrine 72(1):1\u201311. https:\/\/doi.org\/10.1007\/s12020-021-02671-8","journal-title":"Endocrine"},{"issue":"8","key":"2544_CR23","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41574-021-00516-y","volume":"17","author":"L di Filippo","year":"2021","unstructured":"di Filippo L, Frara S, Giustina A (2021) The emerging osteo-metabolic phenotype of COVID-19: clinical and pathophysiological aspects. Nat Rev Endocrinol 17(8):445\u2013446. https:\/\/doi.org\/10.1038\/s41574-021-00516-y","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"2544_CR24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12020-022-03135-3","volume":"78","author":"L di Filippo","year":"2022","unstructured":"di Filippo L, Frara S, Doga M, Giustina A (2022) The osteo-metabolic phenotype of COVID-19: an update. Endocrine 78(2):247\u2013254. https:\/\/doi.org\/10.1007\/s12020-022-03135-3","journal-title":"Endocrine"},{"issue":"2","key":"2544_CR25","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s12020-022-03096-7","volume":"77","author":"L di Filippo","year":"2022","unstructured":"di Filippo L, Compagnone N, Frara S et al (2022) Vertebral fractures at hospitalization predict impaired respiratory function during follow-up of COVID-19 survivors. Endocrine 77(2):392\u2013400. https:\/\/doi.org\/10.1007\/s12020-022-03096-7","journal-title":"Endocrine"},{"key":"2544_CR26","doi-asserted-by":"publisher","unstructured":"Rovere-Querini P, Tresoldi C, Conte C et al (2020) Biobanking for COVID-19 research. Panminerva Med. https:\/\/doi.org\/10.23736\/S0031-0808.20.04168-3 [published online ahead of print, 2020 Oct 19]","DOI":"10.23736\/S0031-0808.20.04168-3"},{"issue":"9\u2013S","key":"2544_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.23750\/abm.v91i9-S.10146","volume":"91","author":"P Rovere Querini","year":"2020","unstructured":"Rovere Querini P, De Lorenzo R, Conte C et al (2020) Post-COVID-19 follow-up clinic: depicting chronicity of a new disease. Acta Biomed 91(9\u2013S):22\u201328 Published 2020 Jul 20. https:\/\/doi.org\/10.23750\/abm.v91i9-S.10146","journal-title":"Acta Biomed"},{"issue":"8","key":"2544_CR28","doi-asserted-by":"publisher","first-page":"110406","DOI":"10.1016\/j.isci.2024.110406","volume":"27","author":"P Ghosh","year":"2024","unstructured":"Ghosh P, Niesen MJM, Pawlowski C et al (2024) Case-control study on post-COVID-19 conditions reveals severe acute infection and chronic pulmonary disease as potential risk factors. iScience 27(8):110406. https:\/\/doi.org\/10.1016\/j.isci.2024.110406. Published 2024 Jun 28","journal-title":"iScience"},{"key":"2544_CR29","unstructured":"Overview| COVID-19 rapid guideline: managing the long-term effects of COVID-19| Guidance| NICE. Accessed: Jul. 09, 2024. [Online]. Available: https:\/\/www.nice.org.uk\/guidance\/ng188"},{"key":"2544_CR30","doi-asserted-by":"publisher","first-page":"m4938","DOI":"10.1136\/bmj.m4938","volume":"371","author":"M Sivan","year":"2020","unstructured":"Sivan M, Taylor S (2020) NICE guideline on long covid. BMJ 371:m4938 Published 2020 Dec 23. https:\/\/doi.org\/10.1136\/bmj.m4938","journal-title":"BMJ"},{"issue":"9","key":"2544_CR31","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Min Res 8(9):1137\u20131148. https:\/\/doi.org\/10.1002\/jbmr.5650080915","journal-title":"J Bone Min Res"},{"key":"2544_CR32","doi-asserted-by":"publisher","first-page":"105114","DOI":"10.1016\/j.phrs.2020.105114","volume":"161","author":"N Farina","year":"2020","unstructured":"Farina N, Ramirez GA, De Lorenzo R et al (2020) COVID-19: pharmacology and kinetics of viral clearance. Pharmacol Res 161:105114. https:\/\/doi.org\/10.1016\/j.phrs.2020.105114","journal-title":"Pharmacol Res"},{"key":"2544_CR33","doi-asserted-by":"publisher","first-page":"108509","DOI":"10.1016\/j.clim.2020.108509","volume":"217","author":"F Ciceri","year":"2020","unstructured":"Ciceri F, Castagna A, Rovere-Querini P et al (2020) Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy. Clin Immunol 217:108509. https:\/\/doi.org\/10.1016\/j.clim.2020.108509","journal-title":"Clin Immunol"},{"key":"2544_CR34","unstructured":"EMA endorses use of dexamethasone in COVID-19 patients on oxygen or mechanical ventilation. Reference Number: EMA\/483739\/2020. 18 September 2020"},{"key":"2544_CR35","unstructured":"WHO \/2019-nCoV\/Corticosteroids\/2020.1"},{"issue":"3","key":"2544_CR36","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s12020-021-02872-1","volume":"74","author":"S Battisti","year":"2021","unstructured":"Battisti S, Napoli N, Pedone C et al (2021) Vertebral fractures and mortality risk in hospitalised patients during the COVID-19 pandemic emergency. Endocrine 74(3):461\u2013469. https:\/\/doi.org\/10.1007\/s12020-021-02872-1","journal-title":"Endocrine"},{"issue":"5","key":"2544_CR37","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1007\/s00198-017-3909-3","volume":"28","author":"G Ballane","year":"2017","unstructured":"Ballane G, Cauley JA, Luckey MM, El-Hajj Fuleihan G (2017) Worldwide prevalence and incidence of osteoporotic vertebral fractures. Osteoporos Int 28(5):1531\u20131542. https:\/\/doi.org\/10.1007\/s00198-017-3909-3","journal-title":"Osteoporos Int"},{"issue":"4","key":"2544_CR38","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.bone.2009.06.006","volume":"45","author":"T Mancini","year":"2009","unstructured":"Mancini T, Mazziotti G, Doga M et al (2009) Vertebral fractures in males with type 2 diabetes treated with rosiglitazone. Bone 45(4):784\u2013788. https:\/\/doi.org\/10.1016\/j.bone.2009.06.006","journal-title":"Bone"},{"issue":"7","key":"2544_CR39","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/jbmr.5650110719","volume":"11","author":"TW O\u2019Neill","year":"1996","unstructured":"O\u2019Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ (1996) The prevalence of vertebral deformity in European men and women: the European vertebral osteoporosis study. J Bone Min Res 11(7):1010\u20131018. https:\/\/doi.org\/10.1002\/jbmr.5650110719","journal-title":"J Bone Min Res"},{"issue":"5","key":"2544_CR40","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s00198-015-3035-z","volume":"26","author":"AD Manthripragada","year":"2015","unstructured":"Manthripragada AD, O\u2019Malley CD, Gruntmanis U, Hall JW, Wagman RB, Miller PD (2015) Fracture incidence in a large cohort of men age 30 years and older with osteoporosis. Osteoporos Int 26(5):1619\u20131627. https:\/\/doi.org\/10.1007\/s00198-015-3035-z","journal-title":"Osteoporos Int"},{"key":"2544_CR41","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.2147\/CIA.S190440","volume":"13","author":"AD Ciubean","year":"2018","unstructured":"Ciubean AD, Ungur RA, Irsay L et al (2018) Health-related quality of life in Romanian postmenopausal women with osteoporosis and fragility fractures. Clin Interv Aging 13:2465\u20132472 Published 2018 Dec 3. https:\/\/doi.org\/10.2147\/CIA.S190440","journal-title":"Clin Interv Aging"},{"issue":"10","key":"2544_CR42","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.1007\/s00198-016-3648-x","volume":"27","author":"UA Al-Sari","year":"2016","unstructured":"Al-Sari UA, Tobias J, Clark E (2016) Health-related quality of life in older people with osteoporotic vertebral fractures: a systematic review and meta-analysis. Osteoporos Int 27(10):2891\u20132900. https:\/\/doi.org\/10.1007\/s00198-016-3648-x","journal-title":"Osteoporos Int"},{"issue":"2","key":"2544_CR43","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/s12020-021-02792-0","volume":"74","author":"J Hu","year":"2021","unstructured":"Hu J, Zheng W, Zhao D et al (2021) Health-related quality of life in men with osteoporosis: a systematic review and meta-analysis. Endocrine 74(2):270\u2013280. https:\/\/doi.org\/10.1007\/s12020-021-02792-0","journal-title":"Endocrine"},{"issue":"1","key":"2544_CR44","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/s12877-019-1268-y","volume":"19","author":"B Stanghelle","year":"2019","unstructured":"Stanghelle B, Bentzen H, Giangregorio L, Pripp AH, Bergland A (2019) Associations between health-related quality of life, physical function and pain in older women with osteoporosis and vertebral fracture. BMC Geriatr 19(1):298 Published 2019 Nov 4. https:\/\/doi.org\/10.1186\/s12877-019-1268-y","journal-title":"BMC Geriatr"},{"issue":"1","key":"2544_CR45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00198-013-2457-8","volume":"25","author":"S Yang","year":"2014","unstructured":"Yang S, Nguyen ND, Center JR, Eisman JA, Nguyen TV (2014) Association between hypertension and fragility fracture: a longitudinal study. Osteoporos Int 25(1):97\u2013103. https:\/\/doi.org\/10.1007\/s00198-013-2457-8","journal-title":"Osteoporos Int"},{"issue":"1","key":"2544_CR46","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bone.2012.09.025","volume":"52","author":"J Makovey","year":"2013","unstructured":"Makovey J, Macara M, Chen JS, Hayward CS, March L, Sambrook PN (2013) High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women. Bone 52(1):120\u2013125. https:\/\/doi.org\/10.1016\/j.bone.2012.09.025","journal-title":"Bone"},{"issue":"10","key":"2544_CR47","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrrheum.2012.120","volume":"8","author":"CE Lampropoulos","year":"2012","unstructured":"Lampropoulos CE, Papaioannou I, D\u2019Cruz DP (2012) Osteoporosis\u2013a risk factor for cardiovascular disease? Nat Rev Rheumatol 8(10):587\u2013598. https:\/\/doi.org\/10.1038\/nrrheum.2012.120","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"2544_CR48","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1182\/blood-2007-01-068395","volume":"110","author":"G Zauli","year":"2007","unstructured":"Zauli G, Corallini F, Bossi F et al (2007) Osteoprotegerin increases leukocyte adhesion to endothelial cells both in vitro and in vivo. Blood 110(2):536\u2013543. https:\/\/doi.org\/10.1182\/blood-2007-01-068395","journal-title":"Blood"},{"issue":"1","key":"2544_CR49","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10456-008-9127-z","volume":"12","author":"JS McGonigle","year":"2009","unstructured":"McGonigle JS, Giachelli CM, Scatena M (2009) Osteoprotegerin and RANKL differentially regulate angiogenesis and endothelial cell function. Angiogenesis 12(1):35\u201346. https:\/\/doi.org\/10.1007\/s10456-008-9127-z","journal-title":"Angiogenesis"},{"issue":"3","key":"2544_CR50","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3390\/ijms20030705","volume":"20","author":"L Rochette","year":"2019","unstructured":"Rochette L, Meloux A, Rigal E, Zeller M, Cottin Y, Vergely C (2019) The role of Osteoprotegerin and its ligands in vascular function. Int J Mol Sci 20(3):705 Published 2019 Feb 6. https:\/\/doi.org\/10.3390\/ijms20030705","journal-title":"Int J Mol Sci"},{"issue":"13","key":"2544_CR51","doi-asserted-by":"publisher","first-page":"4779","DOI":"10.3390\/ijms21134779","volume":"21","author":"A Catalano","year":"2020","unstructured":"Catalano A, Bellone F, Morabito N, Corica F (2020) Sclerostin and Vascular Pathophysiology. Int J Mol Sci 21(13):4779 Published 2020 Jul 6. https:\/\/doi.org\/10.3390\/ijms21134779","journal-title":"Int J Mol Sci"},{"issue":"5","key":"2544_CR52","doi-asserted-by":"publisher","first-page":"519","DOI":"10.17219\/acem\/169567","volume":"33","author":"P Koce\u0142ak","year":"2024","unstructured":"Koce\u0142ak P, Puzianowska-Ku\u017anicka M, Olszanecka-Glinianowicz M, Chudek J (2024) Wnt signaling pathway and sclerostin in the development of atherosclerosis and vascular calcification. Adv Clin Exp Med 33(5):519\u2013532. https:\/\/doi.org\/10.17219\/acem\/169567","journal-title":"Adv Clin Exp Med"},{"issue":"9","key":"2544_CR53","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.3390\/ijms21093199","volume":"21","author":"A Mar\u00e9","year":"2020","unstructured":"Mar\u00e9 A, D\u2019Haese PC, Verhulst A (2020) The role of Sclerostin in Bone and ectopic calcification. Int J Mol Sci 21(9):3199 Published 2020 Apr 30. https:\/\/doi.org\/10.3390\/ijms21093199","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2544_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1590\/s0004-27302010000200007","volume":"54","author":"PG Lacativa","year":"2010","unstructured":"Lacativa PG, Farias ML (2010) Osteoporosis and inflammation. Arq Bras Endocrinol Metabol 54(2):123\u2013132. https:\/\/doi.org\/10.1590\/s0004-27302010000200007","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"2544_CR55","doi-asserted-by":"publisher","first-page":"114834","DOI":"10.1016\/j.biopha.2023.114834","volume":"163","author":"C Zhang","year":"2023","unstructured":"Zhang C, Li H, Li J, Hu J, Yang K, Tao L (2023) Oxidative stress: a common pathological state in a high-risk population for osteoporosis. Biomed Pharmacother 163:114834. https:\/\/doi.org\/10.1016\/j.biopha.2023.114834","journal-title":"Biomed Pharmacother"},{"key":"2544_CR56","doi-asserted-by":"publisher","first-page":"e78200","DOI":"10.7554\/eLife.78200","volume":"11","author":"PE Scherer","year":"2022","unstructured":"Scherer PE, Kirwan JP, Rosen CJ (2022) Post-acute sequelae of COVID-19: a metabolic perspective. Elife 11:e78200 Published 2022 Mar 23. https:\/\/doi.org\/10.7554\/eLife.78200","journal-title":"Elife"},{"key":"2544_CR57","unstructured":"Sahagun S, Stevens K, Emery I, Kirwan J, Li J, Costa S, Rosen CJ Lower spinal and femoral bone density and chronic adipose tissue inflammation in Long COVID. American Society of Bone and Mineral Research (ASBMR) Annual Meeting, Toronto, Canada, September 2024"},{"issue":"4","key":"2544_CR58","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.tem.2023.01.006","volume":"34","author":"MM Uygur","year":"2023","unstructured":"Uygur MM, Frara S, di Filippo L, Giustina A (2023) New tools for bone health assessment in secreting pituitary adenomas. Trends Endocrinol Metab 34(4):231\u2013242. https:\/\/doi.org\/10.1016\/j.tem.2023.01.006","journal-title":"Trends Endocrinol Metab"},{"issue":"8","key":"2544_CR59","doi-asserted-by":"publisher","first-page":"3046","DOI":"10.26355\/eurrev_202204_28636","volume":"26","author":"BM Berkta\u015f","year":"2022","unstructured":"Berkta\u015f BM, G\u00f6k\u00e7ek A, Hoca NT, Koyuncu A (2022) COVID-19 illness and treatment decrease bone mineral density of surviving hospitalized patients. Eur Rev Med Pharmacol Sci 26(8):3046\u20133056. https:\/\/doi.org\/10.26355\/eurrev_202204_28636","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"2544_CR60","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s43166-022-00165-7","volume":"49","author":"SH Elmedany","year":"2022","unstructured":"Elmedany SH, Badr OI, Abu-Zaid MH, Tabra SAA (2022) Bone mineral density changes in osteoporotic and osteopenic patients after COVID-19 infection. Egypt Rheumatol Rehabilitation 49(1):64. https:\/\/doi.org\/10.1186\/s43166-022-00165-7","journal-title":"Egypt Rheumatol Rehabilitation"},{"key":"2544_CR61","unstructured":"Creecy A, di Filippo L, Kacena M, Giustina A (2025) The effect of COVID-19 on bone. In: John P. Bilezikian (ed) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 10th edn. Wolters Kluwer Health. Chapter n.73"},{"issue":"1","key":"2544_CR62","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s11914-023-00843-1","volume":"22","author":"A Harris","year":"2024","unstructured":"Harris A, Creecy A, Awosanya OD et al (2024) SARS-CoV-2 and its multifaceted impact on Bone Health: mechanisms and clinical evidence. Curr Osteoporos Rep 22(1):135\u2013145. https:\/\/doi.org\/10.1007\/s11914-023-00843-1","journal-title":"Curr Osteoporos Rep"},{"key":"2544_CR63","doi-asserted-by":"publisher","unstructured":"Guazzoni E, di Filippo L, Castelli A, Giustina A, Grassi F (2024) Chapter 44 - Tissue location of SARS-CoV-2 RNA: A focus on bone and implications for skeletal health. Management, Body Systems, and Case Studies in COVID-19, Academic Press, Pages 485\u2013492, ISBN 9780443187032. https:\/\/doi.org\/10.1016\/B978-0-443-18703-2.00016-5","DOI":"10.1016\/B978-0-443-18703-2.00016-5"},{"issue":"5","key":"2544_CR64","doi-asserted-by":"publisher","first-page":"R231","DOI":"10.1530\/EJE-17-0154","volume":"177","author":"G Mazziotti","year":"2017","unstructured":"Mazziotti G, Formenti AM, Frara S, MANAGEMENT OF ENDOCRINE DISEASE et al (2017) Risk of overtreatment in patients with adrenal insufficiency: current and emerging aspects. Eur J Endocrinol 177(5):R231\u2013R248. https:\/\/doi.org\/10.1530\/EJE-17-0154","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2544_CR65","doi-asserted-by":"publisher","first-page":"101515","DOI":"10.1016\/j.beem.2021.101515","volume":"35","author":"S Frara","year":"2021","unstructured":"Frara S, Allora A, di Filippo L et al (2021) Osteopathy in mild adrenal Cushing\u2019s syndrome and Cushing disease. Best Pract Res Clin Endocrinol Metab 35(2):101515. https:\/\/doi.org\/10.1016\/j.beem.2021.101515","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"1","key":"2544_CR66","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12020-022-03208-3","volume":"79","author":"A Giustina","year":"2023","unstructured":"Giustina A, Bouillon R, Dawson-Hughes B et al (2023) Vitamin D in the older population: a consensus statement. Endocrine 79(1):31\u201344. https:\/\/doi.org\/10.1007\/s12020-022-03208-3","journal-title":"Endocrine"},{"issue":"5","key":"2544_CR67","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1210\/endrev\/bnae009","volume":"45","author":"A Giustina","year":"2024","unstructured":"Giustina A, Bilezikian JP, Adler RA et al (2024) Consensus Statement on vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows. Endocr Rev 45(5):625\u2013654. https:\/\/doi.org\/10.1210\/endrev\/bnae009","journal-title":"Endocr Rev"},{"key":"2544_CR68","doi-asserted-by":"publisher","unstructured":"di Filippo L, Giustina A (2024) Vitamin D deficiency and type 2 diabetes: the dangerous link between two modern pandemics. J Clin Endocrinol Metab Published Online June 13. https:\/\/doi.org\/10.1210\/clinem\/dgae390","DOI":"10.1210\/clinem\/dgae390"},{"issue":"1","key":"2544_CR69","doi-asserted-by":"publisher","first-page":"e348","DOI":"10.1210\/clinem\/dgab599","volume":"107","author":"L di Filippo","year":"2022","unstructured":"di Filippo L, Allora A, Doga M et al (2022) Vitamin D levels are Associated with blood glucose and BMI in COVID-19 patients, Predicting Disease Severity. J Clin Endocrinol Metab 107(1):e348\u2013e360. https:\/\/doi.org\/10.1210\/clinem\/dgab599","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2544_CR70","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/s41574-023-00942-0","volume":"20","author":"A Giustina","year":"2024","unstructured":"Giustina A, Lazaretti-Castro M, Martineau AR, Mason RS, Rosen CJ, Schoenmakers I (2024) A view on vitamin D: a pleiotropic factor? Nat Rev Endocrinol 20(4):202\u2013208. https:\/\/doi.org\/10.1038\/s41574-023-00942-0","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"2544_CR71","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s12020-023-03331-9","volume":"80","author":"L di Filippo","year":"2023","unstructured":"di Filippo L, Uygur M, Locatelli M, Nannipieri F, Frara S, Giustina A (2023) Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization. Endocrine 80(3):669\u2013683. https:\/\/doi.org\/10.1007\/s12020-023-03331-9","journal-title":"Endocrine"},{"issue":"3","key":"2544_CR72","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s12020-023-03481-w","volume":"82","author":"L di Filippo","year":"2023","unstructured":"di Filippo L, Frara S, Terenzi U et al (2023) Lack of vitamin D predicts impaired long-term immune response to COVID-19 vaccination. Endocrine 82(3):536\u2013541. https:\/\/doi.org\/10.1007\/s12020-023-03481-w","journal-title":"Endocrine"},{"issue":"1","key":"2544_CR73","doi-asserted-by":"publisher","first-page":"e438","DOI":"10.1210\/clinem\/dgad327","volume":"109","author":"L di Filippo","year":"2023","unstructured":"di Filippo L, Frara S, Giustina A (2023) Response to the letter to the editor from Min et al: low vitamin D levels are Associated with Long COVID Syndrome in COVID-19 survivors. J Clin Endocrinol Metab 109(1):e438\u2013e439. https:\/\/doi.org\/10.1210\/clinem\/dgad327","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02544-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02544-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02544-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:50:35Z","timestamp":1751536235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02544-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,11]]},"references-count":73,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2544"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02544-1","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,11]]},"assertion":[{"value":"4 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Andrea Giustina is consultant for Abiogen and received research grant to Institution from Takeda. All other authors have no conflict of interest to declare. The Work submitted for publication is original and has not been published in any language or format and has not been submitted elsewhere for print or electronic publication consideration.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}