{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:59:51Z","timestamp":1792007991067,"version":"4.4.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02547-y","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T07:48:26Z","timestamp":1739605706000},"page":"1457-1471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Stratified analysis of health and gender-affirming care among Italian transgender and gender diverse adults"],"prefix":"10.1007","volume":"48","author":[{"given":"Matteo","family":"Marconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ruocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiska","family":"Ristori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Bonadonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Pivonello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Meriggiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Mosconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Oppo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Federici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia","family":"Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Lami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Michela","family":"Crespi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Manoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Matarrese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Santangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Barbati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"D\u2019Arienzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Daphne","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-3754","authenticated-orcid":false,"given":"Marina","family":"Pierdominici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"issue":"Suppl 1","key":"2547_CR1","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1080\/26895269.2022.2100644","volume":"23","author":"E Coleman","year":"2022","unstructured":"Coleman E, Radix AE, Bouman WP et al (2022) Standards of Care for the health of transgender and gender diverse people, Version 8. Int J Transgend Health 23(Suppl 1):S1\u2013S259. https:\/\/doi.org\/10.1080\/26895269.2022.2100644","journal-title":"Int J Transgend Health"},{"key":"2547_CR2","unstructured":"Gender R, Diversity E-, Equity and Inclusion (GRE) (2024) Frequently asked questions on sexual and gender diversity, health and human rights: an introduction to key concepts, second edition. World Health Organization [Available from: chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/cdn.who.int\/media\/docs\/default-source\/documents\/gender\/sogie---faq-final-08.10.2024.pdf?sfvrsn=ef076e29_3&download=true ] Accessed October 2024"},{"issue":"2","key":"2547_CR3","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1080\/26895269.2020.1753136","volume":"21","author":"Q Zhang","year":"2020","unstructured":"Zhang Q, Goodman M, Adams N et al (2020) Epidemiological considerations in transgender health: a systematic review with focus on higher quality data. Int J Transgend Health 21(2):125\u2013137. https:\/\/doi.org\/10.1080\/26895269.2020.1753136","journal-title":"Int J Transgend Health"},{"issue":"6","key":"2547_CR4","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1007\/s40618-023-02251-9","volume":"47","author":"AD Fisher","year":"2024","unstructured":"Fisher AD, Marconi M, Castellini G et al (2024) Estimate and needs of the transgender adult population: the SPoT study. J Endocrinol Invest 47(6):1373\u20131383. https:\/\/doi.org\/10.1007\/s40618-023-02251-9","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"2547_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1089\/trgh.2019.0070","volume":"5","author":"MC Leinung","year":"2020","unstructured":"Leinung MC, Joseph J (2020) Changing demographics in Transgender individuals seeking hormonal therapy: are Trans Women more common Than Trans men? Transgend Health 5(4):241\u2013245. https:\/\/doi.org\/10.1089\/trgh.2019.0070","journal-title":"Transgend Health"},{"key":"2547_CR6","unstructured":"European Commision (2024) LGBTIQ Equality Strategy 2020\u20132025.[Available from: https:\/\/commission.europa.eu\/strategy-and-policy\/policies\/justice-and-fundamental-rights\/combatting-discrimination\/lesbian-gay-bi-trans-and-intersex-equality\/lgbtiq-equality-strategy-2020-2025_en] Accessed September 2024"},{"key":"2547_CR7","unstructured":"National Academies of Sciences Egineering and Medicine (2020) Understanding the Well-Being of LGBTQI\u2009+\u2009Populations. National Academies Press [Availabe from: https:\/\/nap.nationalacademies.org\/read\/25877\/chapter\/1] Accessed June 2024"},{"key":"2547_CR8","doi-asserted-by":"publisher","first-page":"102277","DOI":"10.1016\/j.eclinm.2023.102277","volume":"65","author":"AG Leone","year":"2023","unstructured":"Leone AG, Casolino R, Trapani D et al (2023) Position paper of the Italian association of medical oncology on health disparities among transgender and gender-diverse people: the Assisi recommendations. EClinicalMedicine 65:102277. https:\/\/doi.org\/10.1016\/j.eclinm.2023.102277","journal-title":"EClinicalMedicine"},{"key":"2547_CR9","unstructured":"European Union Agency for Fundamental Rights (2024) LGBTIQ equality at a crossroads - Progress and challenges. Luxembourg: Publications Office of the European Union. [Available from: https:\/\/fra.europa.eu\/sites\/default\/files\/fra_uploads\/fra-2024-lgbtiq-equality_en.pdf] Accessed September 2024"},{"issue":"2","key":"2547_CR10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/MED.0000000000000227","volume":"23","author":"JD Safer","year":"2016","unstructured":"Safer JD, Coleman E, Feldman J et al (2016) Barriers to healthcare for transgender individuals. Curr Opin Endocrinol Diabetes Obes 23(2):168\u2013171. https:\/\/doi.org\/10.1097\/MED.0000000000000227","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"6","key":"2547_CR11","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1111\/andr.13052","volume":"9","author":"JL Feldman","year":"2021","unstructured":"Feldman JL, Luhur WE, Herman JL, Poteat T, Meyer IH (2021) Health and health care access in the US transgender population health (TransPop) survey. Andrology 9(6):1707\u20131718. https:\/\/doi.org\/10.1111\/andr.13052","journal-title":"Andrology"},{"issue":"1","key":"2547_CR12","doi-asserted-by":"publisher","first-page":"2296571","DOI":"10.1080\/13814788.2023.2296571","volume":"30","author":"D Holland","year":"2024","unstructured":"Holland D, White LCJ, Pantelic M, Llewellyn C (2024) The experiences of transgender and nonbinary adults in primary care: a systematic review. Eur J Gen Pract 30(1):2296571. https:\/\/doi.org\/10.1080\/13814788.2023.2296571","journal-title":"Eur J Gen Pract"},{"issue":"8","key":"2547_CR13","doi-asserted-by":"publisher","first-page":"e369","DOI":"10.1016\/S2468-2667(19)30129-X","volume":"4","author":"RM Thomson","year":"2019","unstructured":"Thomson RM, Katikireddi SV (2019) Improving the health of trans people: the need for good data. Lancet Public Health 4(8):e369\u2013e370. https:\/\/doi.org\/10.1016\/S2468-2667(19)30129-X","journal-title":"Lancet Public Health"},{"key":"2547_CR14","doi-asserted-by":"publisher","unstructured":"Safer JD (2021) Research gaps in medical treatment of transgender\/nonbinary people. J Clin Invest 131(4). https:\/\/doi.org\/10.1172\/JCI142029","DOI":"10.1172\/JCI142029"},{"key":"2547_CR15","doi-asserted-by":"publisher","unstructured":"Scheim AI, Rich AJ, Zubizarreta D et al (2024) Health status of transgender people globally: a systematic review of research on disease burden and correlates. PLoS ONE 19(3):e0299373. https:\/\/doi.org\/10.1371\/journal.pone.0299373","DOI":"10.1371\/journal.pone.0299373"},{"issue":"709","key":"2547_CR16","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3399\/bjgp21X716753","volume":"71","author":"D Crowley","year":"2021","unstructured":"Crowley D, Cullen W, Van Hout MC (2021) Transgender health care in primary care. Br J Gen Pract 71(709):377\u2013378. https:\/\/doi.org\/10.3399\/bjgp21X716753","journal-title":"Br J Gen Pract"},{"issue":"11","key":"2547_CR17","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1007\/s40618-024-02362-x","volume":"47","author":"M Marconi","year":"2024","unstructured":"Marconi M, Pagano MT, Ristori J et al (2024) Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population. J Endocrinol Invest 47(11):2851\u20132864. https:\/\/doi.org\/10.1007\/s40618-024-02362-x","journal-title":"J Endocrinol Invest"},{"key":"2547_CR18","doi-asserted-by":"publisher","unstructured":"Santangelo C, Marconi M, Ruocco A et al (2024) Dietary habits, physical activity and body Mass Index in transgender and gender diverse adults in Italy: a Voluntary Sampling Observational Study. Nutrients 16(18). https:\/\/doi.org\/10.3390\/nu16183139","DOI":"10.3390\/nu16183139"},{"issue":"3","key":"2547_CR19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s11154-018-9461-4","volume":"19","author":"J Gerth","year":"2018","unstructured":"Gerth J, Becerra-Culqui T, Bradlyn A et al (2018) Agreement between medical records and self-reports: implications for transgender health research. Rev Endocr Metab Disord 19(3):263\u2013269. https:\/\/doi.org\/10.1007\/s11154-018-9461-4","journal-title":"Rev Endocr Metab Disord"},{"issue":"12","key":"2547_CR20","doi-asserted-by":"publisher","first-page":"e018121","DOI":"10.1136\/bmjopen-2017-018121","volume":"7","author":"VP Quinn","year":"2017","unstructured":"Quinn VP, Nash R, Hunkeler E et al (2017) Cohort profile: study of transition, outcomes and gender (STRONG) to assess health status of transgender people. BMJ Open 7(12):e018121. https:\/\/doi.org\/10.1136\/bmjopen-2017-018121","journal-title":"BMJ Open"},{"key":"2547_CR21","doi-asserted-by":"publisher","unstructured":"He Y, Wang Y, Yuan L, Fan L et al (2023) Exploring the gap between self-reported transgender and gender dysphoria in Chinese Youth. J Psychiatry Brain Sci 8:e230009. https:\/\/doi.org\/10.20900\/jpbs.20230009","DOI":"10.20900\/jpbs.20230009"},{"key":"2547_CR22","unstructured":"Sorveglianza PASSI (2020\u20132021) Depression [Available from: https:\/\/www.epicentro.iss.it\/passi\/dati\/depressione] Accessed January 2025"},{"issue":"10042","key":"2547_CR23","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/S0140-6736(16)00684-X","volume":"388","author":"SL Reisner","year":"2016","unstructured":"Reisner SL, Poteat T, Keatley J et al (2016) Global health burden and needs of transgender populations: a review. Lancet 388(10042):412\u2013436. https:\/\/doi.org\/10.1016\/S0140-6736(16)00684-X","journal-title":"Lancet"},{"key":"2547_CR24","doi-asserted-by":"crossref","unstructured":"Cicero EC, Reisner SL, Merwin EI, Humphreys JC, Silva SG (2020) The health status of transgender and gender nonbinary adults in the United States. PLoS ONE 15(2):e0228765. https:\/\/doi.org\/10.1371\/journal.pone.0228765","DOI":"10.1371\/journal.pone.0228765"},{"key":"2547_CR25","doi-asserted-by":"publisher","unstructured":"James HA, Chang AY, Imhof RL et al (2020) A community-based study of demographics, medical and psychiatric conditions, and gender dysphoria\/incongruence treatment in transgender\/gender diverse individuals. Biol Sex Differ 11(1):55. https:\/\/doi.org\/10.1186\/s13293-020-00332-5","DOI":"10.1186\/s13293-020-00332-5"},{"key":"2547_CR26","unstructured":"Herman JL, Wilson BD, Becker T (2017) Demographic and health characteristics of Transgender adults in California: findings from the 2015\u20132016 California health interview survey. Policy Brief UCLA Cent Health Policy Res 8:1-10"},{"issue":"3","key":"2547_CR27","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.amepre.2018.04.045","volume":"55","author":"JM Downing","year":"2018","unstructured":"Downing JM, Przedworski JM (2018) Health of Transgender adults in the U.S., 2014\u20132016. Am J Prev Med 55(3):336\u2013344. https:\/\/doi.org\/10.1016\/j.amepre.2018.04.045","journal-title":"Am J Prev Med"},{"issue":"7","key":"2547_CR28","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1089\/lgbt.2017.0275","volume":"5","author":"CG Streed","year":"2018","unstructured":"Streed CG, McCarthy EP, Haas JS (2018) Self-reported physical and Mental Health of Gender Nonconforming Transgender Adults in the United States. LGBT Health 5(7):443\u2013448. https:\/\/doi.org\/10.1089\/lgbt.2017.0275","journal-title":"LGBT Health"},{"key":"2547_CR29","doi-asserted-by":"publisher","unstructured":"Lauretta R, Sansone M, Sansone A, Romanelli F, Appetecchia M (2018) Gender in Endocrine Diseases: Role of Sex Gonadal Hormones. Int J Endocrinol 2018:4847376. https:\/\/doi.org\/10.1155\/2018\/4847376","DOI":"10.1155\/2018\/4847376"},{"issue":"6","key":"2547_CR30","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00774-020-01127-9","volume":"38","author":"G Motta","year":"2020","unstructured":"Motta G, Marinelli L, Barale M et al (2020) Fracture risk assessment in an Italian group of transgender women after gender-confirming surgery. J Bone Min Metab 38(6):885\u2013893. https:\/\/doi.org\/10.1007\/s00774-020-01127-9","journal-title":"J Bone Min Metab"},{"issue":"5","key":"2547_CR31","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s00223-022-00972-2","volume":"110","author":"C Verroken","year":"2022","unstructured":"Verroken C, Collet S, Lapauw B, T\u2019Sjoen G (2022) Osteoporosis and bone health in Transgender individuals. Calcif Tissue Int 110(5):615\u2013623. https:\/\/doi.org\/10.1007\/s00223-022-00972-2","journal-title":"Calcif Tissue Int"},{"key":"2547_CR32","doi-asserted-by":"publisher","first-page":"204201882210993","DOI":"10.1177\/20420188221099346","volume":"13","author":"G Giacomelli","year":"2022","unstructured":"Giacomelli G, Meriggiola MC (2022) Bone health in transgender people: a narrative review. Ther Adv Endocrinol Metab 13:20420188221099346. https:\/\/doi.org\/10.1177\/20420188221099346","journal-title":"Ther Adv Endocrinol Metab"},{"key":"2547_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02155-8_4","volume-title":"Sex hormones and immunity to infection","author":"SL Klein","year":"2010","unstructured":"Klein SL, Huber S (2010) Sex differences in susceptibility to viral infection. In: Klein S, Roberts C (eds) Sex hormones and immunity to infection. Springer, Berlin, Heidelberg. https:\/\/doi.org\/10.1007\/978-3-642-02155-8_4."},{"issue":"2","key":"2547_CR34","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1089\/trgh.2019.0053","volume":"5","author":"OT Van Gerwen","year":"2020","unstructured":"Van Gerwen OT, Jani A, Long DM, Austin EL, Musgrove K, Muzny CA (2020) Prevalence of sexually transmitted infections and human immunodeficiency virus in Transgender persons: a systematic review. Transgend Health 5(2):90\u2013103. https:\/\/doi.org\/10.1089\/trgh.2019.0053","journal-title":"Transgend Health"},{"issue":"8","key":"2547_CR35","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3109\/10826084.2013.855787","volume":"49","author":"BR Hoffman","year":"2014","unstructured":"Hoffman BR (2014) The interaction of drug use, sex work, and HIV among transgender women. Subst Use Misuse 49(8):1049\u20131053. https:\/\/doi.org\/10.3109\/10826084.2013.855787","journal-title":"Subst Use Misuse"},{"issue":"1","key":"2547_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10461-007-9299-3","volume":"12","author":"JH Herbst","year":"2008","unstructured":"Herbst JH, Jacobs ED, Finlayson TJ et al (2008) Estimating HIV prevalence and risk behaviors of transgender persons in the United States: a systematic review. AIDS Behav 12(1):1\u201317. https:\/\/doi.org\/10.1007\/s10461-007-9299-3","journal-title":"AIDS Behav"},{"issue":"10042","key":"2547_CR37","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/S0140-6736(16)00683-8","volume":"388","author":"S Winter","year":"2016","unstructured":"Winter S, Diamond M, Green J et al (2016) Transgender people: health at the margins of society. Lancet 388(10042):390\u2013400. https:\/\/doi.org\/10.1016\/S0140-6736(16)00683-8","journal-title":"Lancet"},{"issue":"5","key":"2547_CR38","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1007\/s12325-020-01295-0","volume":"37","author":"KH Mayer","year":"2020","unstructured":"Mayer KH, Agwu A, Malebranche D (2020) Barriers to the wider use of pre-exposure Prophylaxis in the United States: a narrative review. Adv Ther 37(5):1778\u20131811. https:\/\/doi.org\/10.1007\/s12325-020-01295-0","journal-title":"Adv Ther"},{"key":"2547_CR39","doi-asserted-by":"publisher","unstructured":"Cocchetti C, Romani A, Mazzoli F et al (2022) Prevalence and correlates of sexually transmitted infections in Transgender people: an Italian multicentric cross-sectional study. J Clin Med 11(10). https:\/\/doi.org\/10.3390\/jcm11102774","DOI":"10.3390\/jcm11102774"},{"issue":"1","key":"2547_CR40","doi-asserted-by":"publisher","first-page":"6317","DOI":"10.1038\/s41467-020-19741-6","volume":"11","author":"H Peckham","year":"2020","unstructured":"Peckham H, de Gruijter NM, Raine C et al (2020) Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission. Nat Commun 11(1):6317. https:\/\/doi.org\/10.1038\/s41467-020-19741-6","journal-title":"Nat Commun"},{"issue":"5","key":"2547_CR41","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1007\/s40618-023-02220-2","volume":"47","author":"D Santi","year":"2024","unstructured":"Santi D, Spaggiari G, Marinelli L et al (2024) Gender-affirming hormone treatment: friend or foe? Long-term follow-up of 755 transgender people. J Endocrinol Invest 47(5):1091\u20131100. https:\/\/doi.org\/10.1007\/s40618-023-02220-2","journal-title":"J Endocrinol Invest"},{"key":"2547_CR42","doi-asserted-by":"publisher","unstructured":"Aksoy C, Wellenbrock S, Reimold P et al (2022) Genital gender-affirming surgery trends in Germany: total population data with 19,600 cases from 2006 to 2022. https:\/\/doi.org\/10.1111\/andr.13762. Advance online publication","DOI":"10.1111\/andr.13762"},{"key":"2547_CR43","doi-asserted-by":"crossref","unstructured":"Wright JD, Chen L, Suzuki Y, Matsuo K, Hershman DL (2023) National estimates of gender-affirming surgery in the US. JAMA Netw Open 6(8):e2330348. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.30348","DOI":"10.1001\/jamanetworkopen.2023.30348"},{"issue":"1","key":"2547_CR44","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1055\/s-0042-1758383","volume":"50","author":"AC Hu","year":"2023","unstructured":"Hu AC, Liu MT, Chan CH et al (2023) Gender affirming surgery in Nonbinary patients: a single institutional experience. Arch Plast Surg 50(1):63\u201369. https:\/\/doi.org\/10.1055\/s-0042-1758383","journal-title":"Arch Plast Surg"},{"key":"2547_CR45","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3389\/fpsyg.2019.01453","volume":"10","author":"C Scandurra","year":"2019","unstructured":"Scandurra C, Mezza F, Maldonato NM et al (2019) Health of non-binary and Genderqueer people: a systematic review. Front Psychol 10:1453. https:\/\/doi.org\/10.3389\/fpsyg.2019.01453","journal-title":"Front Psychol"},{"issue":"8","key":"2547_CR46","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/s41562-023-01605-w","volume":"7","author":"DM Doyle","year":"2023","unstructured":"Doyle DM, Lewis TOG, Barreto M (2023) A systematic review of psychosocial functioning changes after gender-affirming hormone therapy among transgender people. Nat Hum Behav 7(8):1320\u20131331. https:\/\/doi.org\/10.1038\/s41562-023-01605-w","journal-title":"Nat Hum Behav"},{"issue":"11","key":"2547_CR47","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.1210\/jc.2016-1276","volume":"101","author":"AD Fisher","year":"2016","unstructured":"Fisher AD, Castellini G, Ristori J et al (2016) Cross-sex hormone treatment and psychobiological changes in Transsexual persons: two-year Follow-Up data. J Clin Endocrinol Metab 101(11):4260\u20134269. https:\/\/doi.org\/10.1210\/jc.2016-1276","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2547_CR48","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/jsm.12363","volume":"11","author":"G Heylens","year":"2014","unstructured":"Heylens G, Verroken C, De Cock S, T\u2019Sjoen G, De Cuypere G (2014) Effects of different steps in gender reassignment therapy on psychopathology: a prospective study of persons with a gender identity disorder. J Sex Med 11(1):119\u2013126 https\/\/:. https:\/\/doi.org\/10.1111\/jsm.12363","journal-title":"J Sex Med"},{"issue":"6","key":"2547_CR49","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1111\/andr.12884","volume":"9","author":"Z Aldridge","year":"2021","unstructured":"Aldridge Z, Patel S, Guo B et al (2021) Long-term effect of gender-affirming hormone treatment on depression and anxiety symptoms in transgender people: a prospective cohort study. Andrology 9(6):1808\u20131816. https:\/\/doi.org\/10.1111\/andr.12884","journal-title":"Andrology"},{"issue":"12","key":"2547_CR50","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/s44159-022-00109-0","volume":"1","author":"EA Tebbe","year":"2022","unstructured":"Tebbe EA, Budge SL (2022) Factors that drive mental health disparities and promote well-being in transgender and nonbinary people. Nat Rev Psychol 1(12):694\u2013707. https:\/\/doi.org\/10.1038\/s44159-022-00109-0","journal-title":"Nat Rev Psychol"},{"key":"2547_CR51","doi-asserted-by":"crossref","unstructured":"Barocas DA, Chen V, Cooperberg M et al (2013) Using a population-based observational cohort study to address difficult comparative effectiveness research questions: the CEASAR study. J Comp Eff Res 2(4):445\u2013460. https:\/\/doi.org\/10.2217\/cer.13.34","DOI":"10.2217\/cer.13.34"},{"issue":"2","key":"2547_CR52","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/MED.0000000000000229","volume":"23","author":"SL Reisner","year":"2016","unstructured":"Reisner SL, Deutsch MB, Bhasin S et al (2016) Advancing methods for US transgender health research. Curr Opin Endocrinol Diabetes Obes 23(2):198\u2013207. https:\/\/doi.org\/10.1097\/MED.0000000000000229","journal-title":"Curr Opin Endocrinol Diabetes Obes"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02547-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02547-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02547-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T09:50:33Z","timestamp":1751536233000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02547-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["2547"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02547-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study received approval from the Ethics Committee of the ISS and the Ethics Committees of each participating clinical center, as follows: ISS, AOO-ISS 01\/07\/2019 0020061; Florence University Hospital (Florence), 29\/10\/2019 15521_oss; University of Turin (Turin), 17\/10\/2019 0101526; University Federico II (Naples), 27\/09\/2019 251\/19; University of Bologna (Bologna), 17\/10\/2019 3696\/2019; University of Cagliari (Cagliari), 27\/11\/2019 PG\/2019\/16576; Hospital S. Camillo-Forlanini (Rome), 09\/10\/2019 1887\/CE Lazio 1; Istituto Auxologico Italiano (Milan), 29\/01\/2020 2020_01_28_05; Sapienza University of Rome (Rome) 23\/07\/2020 0555\/2020 Rif. 5939.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"For Module 1, signed informed consent was not required from participants as the survey was conducted anonymously. For Module 2 a signed informed consent was provided by participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}