{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:01:25Z","timestamp":1781766085908,"version":"3.54.5"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31870974"],"award-info":[{"award-number":["31870974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51873101"],"award-info":[{"award-number":["51873101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02568-7","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T02:00:11Z","timestamp":1742695211000},"page":"1549-1562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is orbital adipose tissue obesity-privileged? The relationship between small adipocyte size and metabolically healthy state from the view of orbital fat"],"prefix":"10.1007","volume":"48","author":[{"given":"Y.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-1677","authenticated-orcid":false,"given":"G.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,22]]},"reference":[{"key":"2568_CR1","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1038\/nature05482","volume":"444","author":"SE Kahn","year":"2006","unstructured":"Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nat 444:840\u2013846. https:\/\/doi.org\/10.1038\/nature05482","journal-title":"Nat"},{"key":"2568_CR2","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/s41580-018-0093-z","volume":"20","author":"AL Ghaben","year":"2019","unstructured":"Ghaben AL, Scherer PE (2019) Adipogenesis and metabolic health. Nat Rev Mol Cell Biol 20:242\u2013258. https:\/\/doi.org\/10.1038\/s41580-018-0093-z","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2568_CR3","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1152\/physrev.00034.2017","volume":"98","author":"A Hammarstedt","year":"2018","unstructured":"Hammarstedt A, Gogg S, Hedjazifar S et al (2018) Impaired Adipogenesis and Dysfunctional Adipose Tissue in Human Hypertrophic Obesity. Physiol Rev 98:1911\u20131941. https:\/\/doi.org\/10.1152\/physrev.00034.2017","journal-title":"Physiol Rev"},{"key":"2568_CR4","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1172\/JCI129191","volume":"129","author":"L Vishvanath","year":"2019","unstructured":"Vishvanath L, Gupta RK (2019) Contribution of adipogenesis to healthy adipose tissue expansion in obesity. J Clin Investig 129:4022\u20134031. https:\/\/doi.org\/10.1172\/JCI129191","journal-title":"J Clin Investig"},{"key":"2568_CR5","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11154-014-9301-0","volume":"15","author":"N Kl\u00f6ting","year":"2014","unstructured":"Kl\u00f6ting N, Bl\u00fcher M (2014) Adipocyte dysfunction, inflammation and metabolic syndrome. Rev Endocr Metab Disord 15:277\u2013287. https:\/\/doi.org\/10.1007\/s11154-014-9301-0","journal-title":"Rev Endocr Metab Disord"},{"key":"2568_CR6","doi-asserted-by":"publisher","first-page":"R284","DOI":"10.1152\/ajpregu.00257.2017","volume":"315","author":"KG Stenkula","year":"2018","unstructured":"Stenkula KG, Erlanson-Albertsson C (2018) Adipose cell size: importance in health and disease. Am J Physiol Regul Integr Comp Physiol 315:R284\u2013R295. https:\/\/doi.org\/10.1152\/ajpregu.00257.2017","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2568_CR7","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1007\/s001250051560","volume":"43","author":"C Weyer","year":"2000","unstructured":"Weyer C, Foley JE, Bogardus C et al (2000) Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43:1498\u20131506. https:\/\/doi.org\/10.1007\/s001250051560","journal-title":"Diabetologia"},{"key":"2568_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2337\/db09-0942","volume":"59","author":"E Arner","year":"2010","unstructured":"Arner E, Westermark PO, Spalding KL et al (2010) Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59:105\u2013109. https:\/\/doi.org\/10.2337\/db09-0942","journal-title":"Diabetes"},{"key":"2568_CR9","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1002\/stem.190","volume":"27","author":"AWB Joe","year":"2009","unstructured":"Joe AWB, Yi L, Even Y et al (2009) Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells 27:2563\u20132570. https:\/\/doi.org\/10.1002\/stem.190","journal-title":"Stem Cells"},{"key":"2568_CR10","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1007\/s00125-015-3594-8","volume":"58","author":"L van Beek","year":"2015","unstructured":"van Beek L, van Klinken JB, Pronk ACM et al (2015) The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl\/6J mice. Diabetologia 58:1601\u20131609. https:\/\/doi.org\/10.1007\/s00125-015-3594-8","journal-title":"Diabetologia"},{"key":"2568_CR11","doi-asserted-by":"publisher","first-page":"18226","DOI":"10.1073\/pnas.1005259107","volume":"107","author":"YD Tchoukalova","year":"2010","unstructured":"Tchoukalova YD, Votruba SB, Tchkonia T et al (2010) Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci USA 107:18226\u201318231. https:\/\/doi.org\/10.1073\/pnas.1005259107","journal-title":"Proc Natl Acad Sci USA"},{"key":"2568_CR12","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1038\/oby.2010.86","volume":"18","author":"A Koster","year":"2010","unstructured":"Koster A, Stenholm S, Alley DE et al (2010) Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring) 18:2354\u20132361. https:\/\/doi.org\/10.1038\/oby.2010.86","journal-title":"Obesity (Silver Spring)"},{"key":"2568_CR13","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s10517-018-3997-x","volume":"164","author":"DS Afanas\u2019eva","year":"2018","unstructured":"Afanas\u2019eva DS, Gushchina MB, Borzenok SA (2018) Comparison of morphology of adipose body of the orbit and subcutaneous fat in humans. Bull Exp Biol Med 164:394\u2013396. https:\/\/doi.org\/10.1007\/s10517-018-3997-x","journal-title":"Bull Exp Biol Med"},{"key":"2568_CR14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1677\/JOE-06-0042","volume":"192","author":"IJ Bujalska","year":"2007","unstructured":"Bujalska IJ, Durrani OM, Abbott J et al (2007) Characterisation of 11\u03b2-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparison with subcutaneous and omental fat. J Endocrinol 192:279\u2013288. https:\/\/doi.org\/10.1677\/JOE-06-0042","journal-title":"J Endocrinol"},{"key":"2568_CR15","doi-asserted-by":"publisher","first-page":"28052","DOI":"10.1021\/acsomega.2c08013","volume":"8","author":"K Zhang","year":"2023","unstructured":"Zhang K, Zhou Y, Xie Z, Liu G (2023) Subcutaneous and orbital adipose tissues: intrinsic differences in carotenoid contents and lipidomic compositions. ACS Omega 8:28052\u201328059. https:\/\/doi.org\/10.1021\/acsomega.2c08013","journal-title":"ACS Omega"},{"key":"2568_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/0266-4356(95)90085-3","volume":"33","author":"V Ilankovan","year":"1995","unstructured":"Ilankovan V, Soames JV (1995) Morphometric analysis of orbital, buccal and subcutaneous fats: their potential in the treatment of enophthalmos. Br J Oral Maxillofac Surg 33:40\u201342. https:\/\/doi.org\/10.1016\/0266-4356(95)90085-3","journal-title":"Br J Oral Maxillofac Surg"},{"key":"2568_CR17","doi-asserted-by":"publisher","first-page":"17010","DOI":"10.1073\/pnas.1105404108","volume":"108","author":"L Landsman","year":"2011","unstructured":"Landsman L, Parent A, Hebrok M (2011) Elevated Hedgehog\/Gli signaling causes \u03b2-cell dedifferentiation in mice. Proc Natl Acad Sci USA 108:17010\u201317015. https:\/\/doi.org\/10.1073\/pnas.1105404108","journal-title":"Proc Natl Acad Sci USA"},{"key":"2568_CR18","first-page":"237","volume":"14","author":"J Goldner","year":"1938","unstructured":"Goldner J (1938) A modification of the masson trichrome technique for routine laboratory purposes. Am J Pathol 14:237\u2013243","journal-title":"Am J Pathol"},{"key":"2568_CR19","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0022-2275(20)38388-7","volume":"30","author":"P Julien","year":"1989","unstructured":"Julien P, Despres JP, Angel A (1989) Scanning electron microscopy of very small fat cells and mature fat cells in human obesity. J Lipid Res 30:293\u2013299","journal-title":"J Lipid Res"},{"key":"2568_CR20","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100493RR","volume":"35","author":"Y Wang","year":"2021","unstructured":"Wang Y, Chen X, Fan W et al (2021) Integrated application of metabolomics and RNA-seq reveals thermogenic regulation in goat brown adipose tissues. FASEB J 35. https:\/\/doi.org\/10.1096\/fj.202100493RR","journal-title":"FASEB J"},{"key":"2568_CR21","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"2568_CR22","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2023.0154","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Liu G (2024) Evaluation of the treatment effects of conditioned medium from human orbital adipose-derived stem cells in a corneal alkali burn rabbit model. J Ocul Pharmacol Ther. https:\/\/doi.org\/10.1089\/jop.2023.0154","journal-title":"J Ocul Pharmacol Ther"},{"key":"2568_CR23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0022-1759(91)90198-O","volume":"139","author":"I Nicoletti","year":"1991","unstructured":"Nicoletti I, Migliorati G, Pagliacci MC et al (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 139:271\u2013279. https:\/\/doi.org\/10.1016\/0022-1759(91)90198-O","journal-title":"J Immunol Methods"},{"key":"2568_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166590","volume":"11","author":"X Ye","year":"2016","unstructured":"Ye X, Liao C, Liu G et al (2016) Age-related changes in the regenerative potential of adipose-derived stem cells isolated from the prominent fat pads in human lower eyelids. PLoS ONE 11. https:\/\/doi.org\/10.1371\/journal.pone.0166590","journal-title":"PLoS ONE"},{"key":"2568_CR25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000324","volume":"5","author":"J Jo","year":"2009","unstructured":"Jo J, Gavrilova O, Pack S et al (2009) Hypertrophy and\/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol 5. https:\/\/doi.org\/10.1371\/journal.pcbi.1000324","journal-title":"PLoS Comput Biol"},{"key":"2568_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1575-0922(13)70026-3","volume":"60","author":"A Vidal-Puig","year":"2013","unstructured":"Vidal-Puig A (2013) Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr 60:39\u201343. https:\/\/doi.org\/10.1016\/S1575-0922(13)70026-3","journal-title":"Endocrinol Nutr"},{"key":"2568_CR27","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3390\/ijms23010520","volume":"23","author":"M Sot\u00e1k","year":"2022","unstructured":"Sot\u00e1k M, Rajan MR, Clark M et al (2022) Healthy subcutaneous and omental adipose tissue is associated with high expression of extracellular matrix components. IJMS 23:520. https:\/\/doi.org\/10.3390\/ijms23010520","journal-title":"IJMS"},{"key":"2568_CR28","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.016","volume":"18","author":"K Sun","year":"2013","unstructured":"Sun K, Tordjman J, Cl\u00e9ment K, Scherer PE (2013) Fibrosis and adipose tissue dysfunction. Cell Metab 18:470\u2013477. https:\/\/doi.org\/10.1016\/j.cmet.2013.06.016","journal-title":"Cell Metab"},{"key":"2568_CR29","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1186\/gb-2008-9-1-r14","volume":"9","author":"C Henegar","year":"2008","unstructured":"Henegar C, Tordjman J, Achard V et al (2008) Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 9:R14. https:\/\/doi.org\/10.1186\/gb-2008-9-1-r14","journal-title":"Genome Biol"},{"key":"2568_CR30","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bcp.2016.05.005","volume":"119","author":"D Lin","year":"2016","unstructured":"Lin D, Chun T-H, Kang L (2016) Adipose extracellular matrix remodelling in obesity and insulin resistance. Biochem Pharmacol 119:8\u201316. https:\/\/doi.org\/10.1016\/j.bcp.2016.05.005","journal-title":"Biochem Pharmacol"},{"key":"2568_CR31","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2337\/diabetes.51.4.1093","volume":"51","author":"E Maquoi","year":"2002","unstructured":"Maquoi E, Munaut C, Colige A et al (2002) Modulation of adipose tissue expression of murine matrix metalloproteinases and their tissue inhibitors with obesity. Diabetes 51:1093\u20131101. https:\/\/doi.org\/10.2337\/diabetes.51.4.1093","journal-title":"Diabetes"},{"key":"2568_CR32","doi-asserted-by":"publisher","first-page":"11888","DOI":"10.1074\/jbc.M209196200","volume":"278","author":"C Chavey","year":"2003","unstructured":"Chavey C, Mari B, Monthouel M-N et al (2003) Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278:11888\u201311896. https:\/\/doi.org\/10.1074\/jbc.M209196200","journal-title":"J Biol Chem"},{"key":"2568_CR33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922654","volume":"13","author":"HL Fisk","year":"2022","unstructured":"Fisk HL, Childs CE, Miles EA et al (2022) Dysregulation of subcutaneous white adipose tissue inflammatory environment modelling in non-insulin resistant obesity and responses to omega-3 fatty acids \u2013 a double blind. Randomised Clinical Trial Front Immunol 13. https:\/\/doi.org\/10.3389\/fimmu.2022.922654","journal-title":"Randomised Clinical Trial Front Immunol"},{"key":"2568_CR34","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1172\/JCI19246","volume":"112","author":"SP Weisberg","year":"2003","unstructured":"Weisberg SP, McCann D, Desai M et al (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796\u20131808. https:\/\/doi.org\/10.1172\/JCI19246","journal-title":"J Clin Invest"},{"key":"2568_CR35","doi-asserted-by":"publisher","first-page":"E506","DOI":"10.1152\/ajpendo.00586.2009","volume":"299","author":"N Kl\u00f6ting","year":"2010","unstructured":"Kl\u00f6ting N, Fasshauer M, Dietrich A et al (2010) Insulin-sensitive obesity. American Journal of Physiology-Endocrinology and Metabolism 299:E506\u2013E515. https:\/\/doi.org\/10.1152\/ajpendo.00586.2009","journal-title":"American Journal of Physiology-Endocrinology and Metabolism"},{"key":"2568_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/3932615","volume":"2018","author":"S Nepali","year":"2018","unstructured":"Nepali S, Park M, Lew H, Kim O (2018) Comparative analysis of human adipose-derived mesenchymal stem cells from orbital and abdominal fat. Stem Cells International 2018:1\u20139. https:\/\/doi.org\/10.1155\/2018\/3932615","journal-title":"Stem Cells International"},{"key":"2568_CR37","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.metabol.2013.11.007","volume":"63","author":"A Michaud","year":"2014","unstructured":"Michaud A, Boulet MM, Veilleux A et al (2014) Abdominal subcutaneous and omental adipocyte morphology and its relation to gene expression, lipolysis and adipocytokine levels in women. Metabolism 63:372\u2013381. https:\/\/doi.org\/10.1016\/j.metabol.2013.11.007","journal-title":"Metabolism"},{"key":"2568_CR38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12902-023-01347-w","volume":"23","author":"N Jannat Ali Pour","year":"2023","unstructured":"Jannat Ali Pour N, Zabihi-Mahmoudabadi H, Ebrahimi R et al (2023) Principal component analysis of adipose tissue gene expression of lipogenic and adipogenic factors in obesity. BMC Endocr Disord 23:94. https:\/\/doi.org\/10.1186\/s12902-023-01347-w","journal-title":"BMC Endocr Disord"},{"key":"2568_CR39","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.molmet.2014.01.005","volume":"3","author":"M Bl\u00fcher","year":"2014","unstructured":"Bl\u00fcher M (2014) Adipokines \u2013 removing road blocks to obesity and diabetes therapy. Molecular Metabolism 3:230\u2013240. https:\/\/doi.org\/10.1016\/j.molmet.2014.01.005","journal-title":"Molecular Metabolism"},{"key":"2568_CR40","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00125-016-3933-4","volume":"59","author":"V Pellegrinelli","year":"2016","unstructured":"Pellegrinelli V, Carobbio S, Vidal-Puig A (2016) Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Diabetologia 59:1075\u20131088. https:\/\/doi.org\/10.1007\/s00125-016-3933-4","journal-title":"Diabetologia"},{"key":"2568_CR41","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1471-2156-15-18","volume":"15","author":"J Kim","year":"2014","unstructured":"Kim J, Lee T, Lee H-J, Kim H (2014) Genotype-environment interactions for quantitative traits in Korea Associated Resource (KARE) cohorts. BMC Genet 15:18. https:\/\/doi.org\/10.1186\/1471-2156-15-18","journal-title":"BMC Genet"},{"key":"2568_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2023\/8282961","volume":"2023","author":"S Gu","year":"2023","unstructured":"Gu S, Gong Z, Liu S et al (2023) Global single-cell sequencing landscape of adipose tissue of different anatomical site origin in humans. Stem Cells International 2023:1\u201316. https:\/\/doi.org\/10.1155\/2023\/8282961","journal-title":"Stem Cells International"},{"key":"2568_CR43","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.cmet.2005.11.012","volume":"3","author":"JM Suh","year":"2006","unstructured":"Suh JM, Gao X, McKay J et al (2006) Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab 3:25\u201334. https:\/\/doi.org\/10.1016\/j.cmet.2005.11.012","journal-title":"Cell Metab"},{"key":"2568_CR44","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31649","author":"Y Shi","year":"2017","unstructured":"Shi Y, Long F (2017) Hedgehog signaling via Gli2 prevents obesity induced by high-fat diet in adult mice. Elife. https:\/\/doi.org\/10.7554\/eLife.31649","journal-title":"Elife"},{"key":"2568_CR45","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.734810","volume":"9","author":"Z Ji","year":"2021","unstructured":"Ji Z, Cai Z, Gu S et al (2021) Exosomes derived from human adipose-derived stem cells inhibit lipogenesis involving hedgehog signaling pathway. Front Bioeng Biotechnol 9. https:\/\/doi.org\/10.3389\/fbioe.2021.734810","journal-title":"Front Bioeng Biotechnol"},{"key":"2568_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106194","volume":"179","author":"C Garg","year":"2022","unstructured":"Garg C, Khan H, Kaur A et al (2022) Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment. Pharmacol Res 179. https:\/\/doi.org\/10.1016\/j.phrs.2022.106194","journal-title":"Pharmacol Res"},{"key":"2568_CR47","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/s41392-022-01149-x","volume":"7","author":"X Wen","year":"2022","unstructured":"Wen X, Zhang B, Wu B et al (2022) Signaling pathways in obesity: mechanisms and therapeutic interventions. Sig Transduct Target Ther 7:298. https:\/\/doi.org\/10.1038\/s41392-022-01149-x","journal-title":"Sig Transduct Target Ther"},{"key":"2568_CR48","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1038\/s41467-022-33800-0","volume":"13","author":"H Shen","year":"2022","unstructured":"Shen H, Huang X, Zhao Y et al (2022) The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis. Nat Commun 13:6030. https:\/\/doi.org\/10.1038\/s41467-022-33800-0","journal-title":"Nat Commun"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02568-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02568-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02568-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:36:53Z","timestamp":1757151413000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02568-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,22]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["2568"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02568-7","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,22]]},"assertion":[{"value":"16 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No competing interests to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All patients provided their written informed consent. Procedures involving humans were conducted under the Declaration of Helsinki and approved by the ethics committee of Shanghai Tenth People's Hospital (approval number: SHSY-LYZX-223).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}