{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:08:24Z","timestamp":1757617704880,"version":"3.44.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2018M641870"],"award-info":[{"award-number":["2018M641870"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02576-7","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T02:08:12Z","timestamp":1743818892000},"page":"1563-1573","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coronary morphological and functional features in subclinical hypothyroidism with ST-Elevation myocardial infarction"],"prefix":"10.1007","volume":"48","author":[{"given":"Donghui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglong","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-229X","authenticated-orcid":false,"given":"Ruoxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-463X","authenticated-orcid":false,"given":"Huimin","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"issue":"4","key":"2576_CR1","first-page":"e29","volume":"131","author":"D Mozaffarian","year":"2015","unstructured":"Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M et al (2015) Heart disease and stroke statistics\u20132015 update: a report from the American heart association. Circulation 131(4):e29\u2013322","journal-title":"Circulation"},{"issue":"7","key":"2576_CR2","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1056\/NEJM200102153440707","volume":"344","author":"I Klein","year":"2001","unstructured":"Klein I, Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344(7):501\u2013509","journal-title":"N Engl J Med"},{"issue":"1","key":"2576_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nrcardio.2016.174","volume":"14","author":"A Jabbar","year":"2017","unstructured":"Jabbar A, Pingitore A, Pearce SH, Zaman A, Iervasi G, Razvi S (2017) Thyroid hormones and cardiovascular disease. Nat Rev Cardiol 14(1):39\u201355","journal-title":"Nat Rev Cardiol"},{"issue":"1","key":"2576_CR4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/cen.14613","volume":"96","author":"C Han","year":"2022","unstructured":"Han C, Xu K, Wang L, Zhang Y, Zhang R, Wei A et al (2022) Impact of persistent subclinical hypothyroidism on clinical outcomes in non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. Clin Endocrinol (Oxf) 96(1):70\u201381","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2576_CR5","first-page":"428","volume":"46","author":"Y Treister-Goltzman","year":"2021","unstructured":"Treister-Goltzman Y, Yarza S, Peleg R (2021) Lipid profile in mild subclinical hypothyroidism: systematic review and meta-analysis. Minerva Endocrinol (Torino) 46(4):428\u2013440","journal-title":"Minerva Endocrinol (Torino)"},{"issue":"4","key":"2576_CR6","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1001\/archinte.160.4.526","volume":"160","author":"GJ Canaris","year":"2000","unstructured":"Canaris GJ, Manowitz NR, Mayor G, Ridgway EC (2000) The Colorado thyroid disease prevalence study. Arch Intern Med 160(4):526\u2013534","journal-title":"Arch Intern Med"},{"issue":"1","key":"2576_CR7","first-page":"13","volume":"34","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Zhang R, Hou J, Yu B (2018) Relationship between fragmented QRS and NT-proBNP in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention. Acta Cardiol Sin 34(1):13\u201322","journal-title":"Acta Cardiol Sin"},{"issue":"12","key":"2576_CR8","first-page":"1606","volume":"34","author":"Z Jiang","year":"2018","unstructured":"Jiang Z, Zhang R, Sun M, Liu Q, Wang S, Wang W et al (2018) Effect of clopidogrel vs Ticagrelor on platelet aggregation and inflammation markers after percutaneous coronary intervention for ST-Elevation myocardial infarction. Can J Cardiol 34(12):1606\u20131612","journal-title":"Can J Cardiol"},{"key":"2576_CR9","doi-asserted-by":"publisher","first-page":"726307","DOI":"10.3389\/fcvm.2021.726307","volume":"8","author":"H Hou","year":"2021","unstructured":"Hou H, Zhao Q, Qu C, Sun M, Liu Q, Huang X et al (2021) Sex differences in the Non-infarct-Related Artery-Based quantitative flow ratio in patients with ST-Elevation myocardial infarction: A retrospective study. Front Cardiovasc Med 8:726307","journal-title":"Front Cardiovasc Med"},{"issue":"19","key":"2576_CR10","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/j.jcin.2016.07.013","volume":"9","author":"S Tu","year":"2016","unstructured":"Tu S, Westra J, Yang J, von Birgelen C, Ferrara A, Pellicano M et al (2016) Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography: the international multicenter FAVOR pilot study. JACC Cardiovasc Interv 9(19):2024\u20132035","journal-title":"JACC Cardiovasc Interv"},{"issue":"25","key":"2576_CR11","doi-asserted-by":"publisher","first-page":"3077","DOI":"10.1016\/j.jacc.2017.10.035","volume":"70","author":"B Xu","year":"2017","unstructured":"Xu B, Tu S, Qiao S, Qu X, Chen Y, Yang J et al (2017) Diagnostic accuracy of Angiography-Based quantitative flow ratio measurements for online assessment of coronary stenosis. J Am Coll Cardiol 70(25):3077\u20133087","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"2576_CR12","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1042\/CS20180879","volume":"133","author":"X Liu","year":"2019","unstructured":"Liu X, Zhang R, Hou J, Wu J, Zhang M, Fang S et al (2019) Interleukin-35 promotes early endothelialization after stent implantation by regulating macrophage activation. Clin Sci (Lond) 133(7):869\u2013884","journal-title":"Clin Sci (Lond)"},{"key":"2576_CR13","doi-asserted-by":"publisher","first-page":"33657","DOI":"10.1038\/srep33657","volume":"6","author":"R Zhang","year":"2016","unstructured":"Zhang R, Chen S, Zhang H, Liu Q, Xing J, Zhao Q et al (2016) Effects of methotrexate in a rabbit model of In-Stent neoatherosclerosis: an optical coherence tomography study. Sci Rep 6:33657","journal-title":"Sci Rep"},{"issue":"4","key":"2576_CR14","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/eurheartj\/ehp433","volume":"31","author":"F Prati","year":"2010","unstructured":"Prati F, Regar E, Mintz GS, Arbustini E, Di Mario C, Jang IK et al (2010) Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis. Eur Heart J 31(4):401\u2013415","journal-title":"Eur Heart J"},{"issue":"12","key":"2576_CR15","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1161\/01.CIR.0000159354.43778.69","volume":"111","author":"IK Jang","year":"2005","unstructured":"Jang IK, Tearney GJ, MacNeill B, Takano M, Moselewski F, Iftima N et al (2005) In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography. Circulation 111(12):1551\u20131555","journal-title":"Circulation"},{"issue":"4","key":"2576_CR16","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1161\/CIRCIMAGING.112.973701","volume":"5","author":"K Kato","year":"2012","unstructured":"Kato K, Yonetsu T, Kim SJ, Xing L, Lee H, McNulty I et al (2012) Nonculprit plaques in patients with acute coronary syndromes have more vulnerable features compared with those with non-acute coronary syndromes: a 3-vessel optical coherence tomography study. Circ Cardiovasc Imaging 5(4):433\u2013440","journal-title":"Circ Cardiovasc Imaging"},{"issue":"4","key":"2576_CR17","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.jcmg.2016.02.007","volume":"9","author":"AS Bharadwaj","year":"2016","unstructured":"Bharadwaj AS, Vengrenyuk Y, Yoshimura T, Baber U, Hasan C, Narula J et al (2016) Multimodality intravascular imaging to evaluate sex differences in plaque morphology in stable CAD. JACC Cardiovasc Imaging 9(4):400\u2013407","journal-title":"JACC Cardiovasc Imaging"},{"issue":"12","key":"2576_CR18","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.jacc.2011.09.079","volume":"59","author":"GJ Tearney","year":"2012","unstructured":"Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG et al (2012) Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the international working group for intravascular optical coherence tomography standardization and validation. J Am Coll Cardiol 59(12):1058\u20131072","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2576_CR19","doi-asserted-by":"publisher","first-page":"3231","DOI":"10.3892\/etm.2017.4380","volume":"13","author":"R Zhang","year":"2017","unstructured":"Zhang R, Chen S, Zhao Q, Sun M, Yu B, Hou J (2017) Fragmented QRS complex is a prognostic marker of microvascular reperfusion and changes in LV function occur in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention. Exp Ther Med 13(6):3231\u20133238","journal-title":"Exp Ther Med"},{"key":"2576_CR20","doi-asserted-by":"publisher","first-page":"103086","DOI":"10.1016\/j.ajp.2022.103086","volume":"71","author":"X Wang","year":"2022","unstructured":"Wang X, Luo J, Yuan XF, Chen X, Yu HY, Zhu XQ et al (2022) Relationship of free thyroxine and Triiodothyronine on recurrence in maintenance therapy for bipolar depression. Asian J Psychiatr 71:103086","journal-title":"Asian J Psychiatr"},{"issue":"2","key":"2576_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.2019.9052","volume":"322","author":"B Biondi","year":"2019","unstructured":"Biondi B, Cappola AR, Cooper DS (2019) Subclinical hypothyroidism: A review. JAMA 322(2):153\u2013160","journal-title":"JAMA"},{"issue":"5","key":"2576_CR22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1507\/endocrj.K10E-333","volume":"58","author":"EE T\u00fcremen","year":"2011","unstructured":"T\u00fcremen EE, \u00c7etinarslan B, \u015eahin T, Cant\u00fcrk Z, Tarkun \u0130 (2011) Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis. Endocr J 58(5):349\u2013354","journal-title":"Endocr J"},{"issue":"15","key":"2576_CR23","doi-asserted-by":"publisher","first-page":"e927","DOI":"10.4244\/EIJ-D-23-01043","volume":"20","author":"Y Osumi","year":"2024","unstructured":"Osumi Y, Kawamori H, Toba T, Hiromasa T, Fujimoto D, Kakizaki S et al (2024) Impact of morphofunctional assessment with quantitative flow ratio and optical coherence tomography in patients with acute coronary syndromes. EuroIntervention 20(15):e927\u2013e936","journal-title":"EuroIntervention"},{"issue":"8","key":"2576_CR24","first-page":"534","volume":"15","author":"XQ Cai","year":"2018","unstructured":"Cai XQ, Tian F, Han TW, Shan DK, Liu Y, Yin WJ et al (2018) Subclinical hypothyroidism is associated with lipid-rich plaques in patients with coronary artery disease as assessed by optical coherence tomography. J Geriatr Cardiol 15(8):534\u2013539","journal-title":"J Geriatr Cardiol"},{"issue":"19","key":"2576_CR25","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.jacc.2013.05.071","volume":"62","author":"H Jia","year":"2013","unstructured":"Jia H, Abtahian F, Aguirre AD, Lee S, Chia S, Lowe H et al (2013) In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography. J Am Coll Cardiol 62(19):1748\u20131758","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"2576_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1001\/jamacardio.2017.5234","volume":"3","author":"T Sugiyama","year":"2018","unstructured":"Sugiyama T, Yamamoto E, Bryniarski K, Xing L, Lee H, Isobe M et al (2018) Nonculprit plaque characteristics in patients with acute coronary syndrome caused by plaque erosion vs plaque rupture: A 3-Vessel optical coherence tomography study. JAMA Cardiol 3(3):207\u2013214","journal-title":"JAMA Cardiol"},{"issue":"8 Suppl","key":"2576_CR27","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","volume":"47","author":"E Falk","year":"2006","unstructured":"Falk E (2006) Pathogenesis of atherosclerosis. J Am Coll Cardiol 47(8 Suppl):C7\u201312","journal-title":"J Am Coll Cardiol"},{"key":"2576_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.atherosclerosis.2016.02.010","volume":"247","author":"J Dai","year":"2016","unstructured":"Dai J, Tian J, Hou J, Xing L, Liu S, Ma L et al (2016) Association between cholesterol crystals and culprit lesion vulnerability in patients with acute coronary syndrome: an optical coherence tomography study. Atherosclerosis 247:111\u2013117","journal-title":"Atherosclerosis"},{"key":"2576_CR29","doi-asserted-by":"publisher","first-page":"117118","DOI":"10.1016\/j.atherosclerosis.2023.03.023","volume":"378","author":"C Wang","year":"2023","unstructured":"Wang C, Tian X, Feng X, Demuyakor A, Hu S, Wang Y et al (2023) Pancoronary plaque characteristics and clinical outcomes in acute coronary syndrome patients with cancer history. Atherosclerosis 378:117118","journal-title":"Atherosclerosis"},{"key":"2576_CR30","doi-asserted-by":"crossref","unstructured":"Deng C, Liu Z, Li C, Xu G, Zhang R, Bai Z et al (2025) Predictive models for cholesterol crystals and plaque vulnerability in acute myocardial infarction: insights from an optical coherence tomography study. Int J Cardiol 2:132610","DOI":"10.1016\/j.ijcard.2024.132610"},{"issue":"6","key":"2576_CR31","first-page":"659","volume":"52","author":"JW Zhao","year":"2024","unstructured":"Zhao JW, Zhao R, Fang C, Chen YZ, Xu XM, Cui LN et al (2024) The association of cholesterol crystals and non-culprit plaque characteristics in AMI patients: an OCT study. Zhonghua Xin Xue Guan Bing Za Zhi 52(6):659\u2013666","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"issue":"15","key":"2576_CR32","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.jacc.2011.11.003","volume":"59","author":"S Sen","year":"2012","unstructured":"Sen S, Escaned J, Malik IS, Mikhail GW, Foale RA, Mila R et al (2012) Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine vasodilator independent stenosis Evaluation) study. J Am Coll Cardiol 59(15):1392\u20131402","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2576_CR33","doi-asserted-by":"publisher","first-page":"e0228292","DOI":"10.1371\/journal.pone.0228292","volume":"15","author":"LC Engel","year":"2020","unstructured":"Engel LC, Landmesser U, Abdelwahed YS, Jaguszewski M, Gigengack K, Wurster TH et al (2020) Comprehensive multimodality characterization of hemodynamically significant and non-significant coronary lesions using invasive and noninvasive measures. PLoS ONE 15(1):e0228292","journal-title":"PLoS ONE"},{"issue":"6","key":"2576_CR34","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jcin.2013.02.016","volume":"6","author":"SJ Kang","year":"2013","unstructured":"Kang SJ, Ahn JM, Han S, Lee JY, Kim WJ, Park DW et al (2013) Sex differences in the visual-functional mismatch between coronary angiography or intravascular ultrasound versus fractional flow reserve. JACC Cardiovasc Interv 6(6):562\u2013568","journal-title":"JACC Cardiovasc Interv"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02576-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02576-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02576-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T09:12:37Z","timestamp":1757149957000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02576-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["2576"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02576-7","relation":{},"ISSN":["1720-8386"],"issn-type":[{"type":"electronic","value":"1720-8386"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"20 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol, approved by the ethics committees of the Second Affiliated Hospital of Harbin Medical University (SYDWGZR-2020-128) and Heilongjiang Provincial People\u2019s Hospital, adhered to the principles outlined in the Declaration of Helsinki and its subsequent amendments. Prior to participation, all patients were provided with detailed information regarding the study objectives, following which their consent was obtained.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors have declared that they have no conflicts of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest\u00a0"}}]}}