{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:37:23Z","timestamp":1790285843892,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02624-2","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T01:46:20Z","timestamp":1749519980000},"page":"2027-2039","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sarcopenic obesity and physical function in acromegaly: impact of disease control and evaluation using dual X-ray absorptiometry and multifrequency bioelectrical impedance analysis"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7158-1530","authenticated-orcid":false,"given":"Arthur Costa","family":"Inojosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-990X","authenticated-orcid":false,"given":"Ana Vit\u00f3ria","family":"Hirt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5765-1099","authenticated-orcid":false,"given":"Tha\u00eds","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5087-6282","authenticated-orcid":false,"given":"Maria Eduarda","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2369-3719","authenticated-orcid":false,"given":"Luma","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0563-4008","authenticated-orcid":false,"given":"Vin\u00edcius","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-7643","authenticated-orcid":false,"given":"Daniella","family":"Rego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1889-8109","authenticated-orcid":false,"given":"Aline","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-0742","authenticated-orcid":false,"given":"Francisco","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"2624_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruy\u00e8re O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afz046","journal-title":"Age Ageing"},{"key":"2624_CR2","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1002\/jbmr.2492","volume":"30","author":"RR McLean","year":"2015","unstructured":"McLean RR, Kiel DP (2015) Developing consensus criteria for sarcopenia: an update. J Bone Min Res 30:588\u2013592. https:\/\/doi.org\/10.1002\/jbmr.2492","journal-title":"J Bone Min Res"},{"key":"2624_CR3","doi-asserted-by":"publisher","first-page":"472S","DOI":"10.1093\/ajcn\/64.3.472s","volume":"64","author":"D Heber","year":"1996","unstructured":"Heber D, Ingles S, Ashley J, Maxwell M, Lyons R, Elashoff R (1996) Clinical detection of sarcopenic obesity by bioelectrical impedance analysis. Am J Clin Nutr 64:472S\u2013477S. https:\/\/doi.org\/10.1093\/ajcn\/64.3.472s","journal-title":"Am J Clin Nutr"},{"key":"2624_CR4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1159\/000521241","volume":"15","author":"LM Donini","year":"2022","unstructured":"Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, Bauer JM, Boirie Y, Cruz-Jentoft AJ, Dicker D, Frara S, Fr\u00fchbeck G, Genton L, Gepner Y, Giustina A, Gonzalez MC, Han H-S, Heymsfield SB, Higashiguchi T, Laviano A, Lenzi A, Nyulasi I, Parrinello E, Poggiogalle E, Prado CM, Salvador J, Rolland Y, Santini F, Serlie MJ, Shi H, Sieber CC, Siervo M, Vettor R, Villareal DT, Volkert D, Yu J, Zamboni M, Barazzoni R (2022) Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement. Obes Facts 15:321\u2013335. https:\/\/doi.org\/10.1159\/000521241","journal-title":"Obes Facts"},{"key":"2624_CR5","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S0899-9007(03)00061-3","volume":"19","author":"UG Kyle","year":"2003","unstructured":"Kyle UG, Schutz Y, Dupertuis YM, Pichard C (2003) Body composition interpretation: contributions of the fat-free mass index and the body fat mass index. Nutrition 19:597\u2013604","journal-title":"Nutrition"},{"key":"2624_CR6","doi-asserted-by":"publisher","first-page":"155639","DOI":"10.1016\/j.metabol.2023.155639","volume":"146","author":"CL Axelrod","year":"2022","unstructured":"Axelrod CL, Dantas WS, Kirwan JP (2022) Sarcopenic obesity: emerging mechanisms and therapeutic potential. Metabolism 146:155639. https:\/\/doi.org\/10.1016\/j.metabol.2023.155639","journal-title":"Metabolism"},{"key":"2624_CR7","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1559-4564.2007.06673.x","volume":"2","author":"LJ Dominguez","year":"2007","unstructured":"Dominguez LJ, Barbagallo M (2007) The cardiometabolic syndrome and sarcopenic obesity in older persons. J Cardiometabolic Syndr 2:183\u2013189. https:\/\/doi.org\/10.1111\/j.1559-4564.2007.06673.x","journal-title":"J Cardiometabolic Syndr"},{"key":"2624_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.11005\/jbm.2024.31.3.182","volume":"31","author":"AC Inojosa","year":"2024","unstructured":"Inojosa AC, Ribeiro AVH, Ara\u00fajo TF, Xavier ME, R\u00eago D, Bandeira F (2024) Body composition, sarcopenia, and serum myokines in acromegaly: a narrative review. J Bone Metab 31:182\u2013195. https:\/\/doi.org\/10.11005\/jbm.2024.31.3.182","journal-title":"J Bone Metab"},{"key":"2624_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jendso\/bvae032","volume":"8","author":"A Milioto","year":"2024","unstructured":"Milioto A, Corica G, Nista F, Wildemberg LEA, Rossi F, Bignotti B, Gadelha MR, Ferone D, Tagliafico AS, Gatto F (2024) Skeletal muscle evaluation in patients with acromegaly. J Endocr Soc [Internet] 8:1\u20139. https:\/\/doi.org\/10.1210\/jendso\/bvae032","journal-title":"J Endocr Soc [Internet]"},{"key":"2624_CR10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.ecl.2020.04.002","volume":"49","author":"AF Daly","year":"2020","unstructured":"Daly AF, Beckers A (2020) The epidemiology of pituitary adenomas. Endocr Metab Clin 49:347\u2013355. https:\/\/doi.org\/10.1016\/j.ecl.2020.04.002","journal-title":"Endocr Metab Clin"},{"key":"2624_CR11","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1056\/nejmra1810772","volume":"382","author":"S Melmed","year":"2020","unstructured":"Melmed S (2020) Pituitary-tumor endocrinopathies. N Engl J Med 382:937\u2013950. https:\/\/doi.org\/10.1056\/nejmra1810772","journal-title":"N Engl J Med"},{"key":"2624_CR12","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s11102-023-01373-w","volume":"27","author":"A Giustina","year":"2024","unstructured":"Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S (2024) Correction: Consensus on criteria for acromegaly diagnosis and remission. Pituitary 27:88\u201388. https:\/\/doi.org\/10.1007\/s11102-023-01373-w","journal-title":"Pituitary"},{"key":"2624_CR13","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1007\/s11102-015-0657-2","volume":"18","author":"TJ Reid","year":"2015","unstructured":"Reid TJ, Jin Z, Shen W, Reyes-Vidal CM, Fernandez JC, Bruce JN, Kostadinov J, Post KD, Freda PU (2015) IGF-1 levels across the spectrum of normal to elevated in acromegaly: relationship to insulin sensitivity, markers of cardiovascular risk and body composition. Pituitary 18:808\u2013819. https:\/\/doi.org\/10.1007\/s11102-015-0657-2","journal-title":"Pituitary"},{"key":"2624_CR14","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s11102-023-01352-1","volume":"26","author":"M Coskun","year":"2023","unstructured":"Coskun M, Sendur HN, Cerit MN, Babayeva A, Cerit ET, Yalcin MM, Altinova AE, Akturk M, Karakoc MA, Toruner FB (2023) Assessment of forearm muscles with ultrasound shear wave elastography in patients with acromegaly. Pituitary 26:716\u2013724. https:\/\/doi.org\/10.1007\/s11102-023-01352-1","journal-title":"Pituitary"},{"key":"2624_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2022.867921","volume":"13","author":"JA Young","year":"2022","unstructured":"Young JA, Zhu S, List EO, Duran-Ortiz S, Slama Y, Berryman DE (2022) Musculoskeletal effects of altered GH action. Front Physiol 13:1\u201312. https:\/\/doi.org\/10.3389\/fphys.2022.867921","journal-title":"Front Physiol"},{"key":"2624_CR16","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/s2213-8587(18)30110-4","volume":"6","author":"A Clegg","year":"2018","unstructured":"Clegg A, Hassan-Smith Z (2018) Frailty and the endocrine system. Lancet Diabetes Endocrinol 6:743\u2013752. https:\/\/doi.org\/10.1016\/s2213-8587(18)30110-4","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2624_CR17","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s11102-024-01422-y","volume":"27","author":"F Gatto","year":"2024","unstructured":"Gatto F, Milioto A, Corica G, Nista F, Campana C, Arecco A, Mattioli L, Belluscio L, Bignotti B, Ferone D, Tagliafico AS (2024) Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients. Pituitary 27:507\u2013517. https:\/\/doi.org\/10.1007\/s11102-024-01422-y","journal-title":"Pituitary"},{"key":"2624_CR18","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-2362.1993.tb00762.x","volume":"23","author":"R-JM Brummer","year":"1993","unstructured":"Brummer R-JM, L\u00f6nns L, Kvist H, Grang\u00e5rd U, Bengtsson B, \u2010A, Sj\u00f6str\u00f6m L (1993) Adipose tissue and muscle volume determination by computed tomography in acromegaly, before and I year after adenomectomy. Eur J Clin Invest 23:199\u2013205. https:\/\/doi.org\/10.1111\/j.1365-2362.1993.tb00762.x","journal-title":"Eur J Clin Invest"},{"key":"2624_CR19","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1507\/endocrj.45.335","volume":"45","author":"A Tominaga","year":"1998","unstructured":"Tominaga A, Arita K, Kurisu K, Uozumi T, Migita K, Eguchi K, Iida K, Kawamoto H, Mizoue T (1998) Effects of successful adenomectomy on body composition in acromegaly. Endocr J 45:335\u2013342","journal-title":"Endocr J"},{"key":"2624_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4125013","volume":"2018","author":"X Guo","year":"2018","unstructured":"Guo X, Gao L, Shi X, Li H, Wang Q, Wang Z, Chen W, Xing B (2018) Pre- and postoperative body composition and metabolic characteristics in patients with acromegaly: a prospective study. Int J Endocrinol 2018:1\u201310. https:\/\/doi.org\/10.1155\/2018\/4125013","journal-title":"Int J Endocrinol"},{"key":"2624_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/j.1365-2265.1994.tb02552.x","volume":"41","author":"TB Hansen","year":"1994","unstructured":"Hansen TB, Gram J, Bjerre P, Hagen C, Bollerslev J (1994) Body composition in active acromegaly during treatment with octreotide: a double-blind, placebo\u2010controlled cross\u2010over study. Clin Endocrinol 41:323\u2013329. https:\/\/doi.org\/10.1111\/j.1365-2265.1994.tb02552.x","journal-title":"Clin Endocrinol"},{"key":"2624_CR22","doi-asserted-by":"publisher","unstructured":"O'Sullivan AJ, Kelly JJ, Hoffman DM, Freund J, Ho KK (1994) Body composition and energy expenditure in acromegaly. J Clin Endocrinol Metab 78(2):381\u2013386. https:\/\/doi.org\/10.1210\/jcem.78.2.8106626.","DOI":"10.1210\/jcem.78.2.8106626"},{"key":"2624_CR23","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1589\/jpts.27.719","volume":"27","author":"AJ Lopes","year":"2015","unstructured":"Lopes AJ, Guedes da Silva DP, Ferreira A, de Kasuki S, Gadelha L, Guimar\u00e3es MR FS (2015) What is the effect of peripheral muscle fatigue, pulmonary function, and body composition on functional exercise capacity in acromegalic patients? J Phys Ther Sci 27:719\u2013724. https:\/\/doi.org\/10.1589\/jpts.27.719","journal-title":"J Phys Ther Sci"},{"key":"2624_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12877-021-02549-4","volume":"21","author":"I Gagliardi","year":"2021","unstructured":"Gagliardi I, Chiloiro S, Vallillo M, Bondanelli M, Volpato S, Giampietro A, Bianchi A, De Marinis L, Zatelli MC, Ambrosio MR (2021) Multidimensional geriatric evaluation in acromegaly: a comparative cross-sectional study. BMC Geriatr 21:1\u20139. https:\/\/doi.org\/10.1186\/s12877-021-02549-4","journal-title":"BMC Geriatr"},{"key":"2624_CR25","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ghir.2014.12.003","volume":"25","author":"E Hatipoglu","year":"2015","unstructured":"Hatipoglu E, Yuruyen M, Keskin E, Yavuzer H, Niyazoglu M, Doventas A, Erdincler DS, Beger T, Kadioglu P, Gundogdu S (2015) Acromegaly and aging: a comparative cross-sectional study. Growth Horm Igf Res 25:47\u201352. https:\/\/doi.org\/10.1016\/j.ghir.2014.12.003","journal-title":"Growth Horm Igf Res"},{"key":"2624_CR26","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1007\/s40618-023-02114-3","volume":"46","author":"\u0130 Ero\u011flu","year":"2023","unstructured":"Ero\u011flu \u0130, \u0130remli BG, Erko\u00e7 A, Idilman IS, Yuce D, Calik-Kutukcu E, Akata D, Erbas T (2023) Osteosarcopenia in acromegaly: reduced muscle quality and increased vertebral fat deposition. J Endocrinol Invest 46:2573\u20132582. https:\/\/doi.org\/10.1007\/s40618-023-02114-3","journal-title":"J Endocrinol Invest"},{"key":"2624_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/s0047-6374(98)00130-4","volume":"107","author":"RN Baumgartner","year":"1999","unstructured":"Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ (1999) Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 107:123\u2013136. https:\/\/doi.org\/10.1016\/s0047-6374(98)00130-4","journal-title":"Mech Ageing Dev"},{"key":"2624_CR28","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/gerona\/glu010","volume":"69","author":"SA Studenski","year":"2014","unstructured":"Studenski SA, Peters KW, Alley DE, Cawthon PM, McLean RR, Harris TB, Ferrucci L, Guralnik JM, Fragala MS, Kenny AM, Kiel DP, Kritchevsky SB, Shardell MD, Dam T-TL, Vassileva MT (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol Ser A 69:547\u2013558. https:\/\/doi.org\/10.1093\/gerona\/glu010","journal-title":"J Gerontol Ser A"},{"key":"2624_CR29","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s00223-013-9830-7","volume":"94","author":"H Gould","year":"2014","unstructured":"Gould H, Brennan SL, Kotowicz MA, Nicholson GC, Pasco JA (2014) Total and appendicular lean mass reference ranges for Australian men and women: the Geelong osteoporosis study. Calcif Tissue Int 94:363\u2013372. https:\/\/doi.org\/10.1007\/s00223-013-9830-7","journal-title":"Calcif Tissue Int"},{"key":"2624_CR30","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Sayer AA (2019) Sarcopenia. Lancet 393:2636\u20132646","journal-title":"Lancet"},{"key":"2624_CR31","doi-asserted-by":"publisher","first-page":"e7038","DOI":"10.1371\/journal.pone.0007038","volume":"4","author":"TL Kelly","year":"2009","unstructured":"Kelly TL, Wilson KE, Heymsfield SB (2009) Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS ONE 4:e7038. https:\/\/doi.org\/10.1371\/journal.pone.0007038","journal-title":"PLoS ONE"},{"key":"2624_CR32","doi-asserted-by":"publisher","first-page":"101437","DOI":"10.1016\/j.jocd.2023.101437","volume":"27","author":"D Krueger","year":"2023","unstructured":"Krueger D, Tanner SB, Szalat A, Malabanan A, Prout T, Lau A, Rosen HN, Shuhart C (2023) DXA reporting updates: 2023 official positions of the international society for clinical densitometry. J Clin Densitom 27:101437. https:\/\/doi.org\/10.1016\/j.jocd.2023.101437","journal-title":"J Clin Densitom"},{"key":"2624_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2022.866099","volume":"13","author":"AA Lopes","year":"2022","unstructured":"Lopes AA, Albuquerque L, Fontes M, Rego D, Bandeira F (2022) Body composition in acromegaly according to disease activity - performance of dual X-ray absorptiometry and multifrequency bioelectrical impedance analysis. Front Endocrinol 13:1\u20137. https:\/\/doi.org\/10.3389\/fendo.2022.866099","journal-title":"Front Endocrinol"},{"key":"2624_CR34","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1210\/jc.2009-0026","volume":"94","author":"PU Freda","year":"2009","unstructured":"Freda PU, Shen W, Reyes-Vidal CM, Geer EB, Arias-Mendoza F, Gallagher D, Heymsfield SB (2009) Skeletal muscle mass in acromegaly assessed by magnetic resonance imaging and dual-photon X-ray absorptiometry. J Clin Endocrinol Metab 94:2880\u20132886. https:\/\/doi.org\/10.1210\/jc.2009-0026","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1046\/j.1365-2265.2001.01280.x","volume":"55","author":"H Kaji","year":"2001","unstructured":"Kaji H, Sugimoto T, Nakaoka D, Okimura Y, Kaji H, Abe H, Chihara K (2001) Bone metabolism and body composition in Japanese patients with active acromegaly. Clin Endocrinol 55:175\u2013181. https:\/\/doi.org\/10.1046\/j.1365-2265.2001.01280.x","journal-title":"Clin Endocrinol"},{"key":"2624_CR36","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1530\/eje-08-0449","volume":"159","author":"N Sucunza","year":"2008","unstructured":"Sucunza N, Barahona MJ, Resmini E, Fern\u00e1ndez-Real JM, Farrerons J, Lluch P, Puig T, W\u00e4gner AM, Ricart W, Webb SM (2008) Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females. Eur J Endocrinol 159:773\u2013779. https:\/\/doi.org\/10.1530\/eje-08-0449","journal-title":"Eur J Endocrinol"},{"key":"2624_CR37","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s00198-009-1165-x","volume":"21","author":"M Madeira","year":"2010","unstructured":"Madeira M, Neto LV, de Lima GAB, Moreira RO, de Mendon\u00e7a LMC, Gadelha MR, Farias MLF (2010) Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly. Osteoporos Int 21:2019\u20132025. https:\/\/doi.org\/10.1007\/s00198-009-1165-x","journal-title":"Osteoporos Int"},{"key":"2624_CR38","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1589\/jpts.25.1497","volume":"25","author":"DP Guedes da Silva","year":"2013","unstructured":"Guedes da Silva DP, Guimar\u00e3es FS, Dias CM, Guimar\u00e3es S, de Kasuki A, Gadelha L, Camilo MR, Lopes GB AJ (2013) On the functional capacity and quality of life of patients with acromegaly: are they candidates for rehabilitation programs? J Phys Ther Sci 25:1497\u20131501. https:\/\/doi.org\/10.1589\/jpts.25.1497","journal-title":"J Phys Ther Sci"},{"key":"2624_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-024-01494-w","author":"CPS Rocha","year":"2025","unstructured":"Rocha CPS, Hupalowski NN, Andrade VFC, Boguszewski CL, Borba VZC (2025) Assessment of sarcopenic obesity in patients with acromegaly. Pituitary. https:\/\/doi.org\/10.1007\/s11102-024-01494-w","journal-title":"Pituitary"},{"key":"2624_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jendso\/bvab004","volume":"5","author":"AP Kuker","year":"2021","unstructured":"Kuker AP, Shen W, Jin Z, Singh S, Chen J, Bruce JN, Freda PU (2021) Body composition changes with long-term Pegvisomant therapy of acromegaly. J Endocr Soc 5:1\u201312. https:\/\/doi.org\/10.1210\/jendso\/bvab004","journal-title":"J Endocr Soc"},{"key":"2624_CR41","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11102-019-00979-3","volume":"22","author":"O Haliloglu","year":"2019","unstructured":"Haliloglu O, Topsakal N, Camliguney F, Polat Korkmaz O, Sahin S, Cotuk B, Kadioglu P, Erkut O (2019) Static and dynamic balances of patients with acromegaly and impact of exercise on balance. Pituitary 22:497\u2013506. https:\/\/doi.org\/10.1007\/s11102-019-00979-3","journal-title":"Pituitary"},{"key":"2624_CR42","first-page":"759","volume":"36","author":"A Atmaca","year":"2013","unstructured":"Atmaca A, Tander B, Kan EK, Ulus Y, Ecemis GC, Akyol Y, Tomak L (2013) Assessment of balance performance and fear of falling in acromegalic patients: a comparative study. J Endocrinol Invest 36:759\u2013763","journal-title":"J Endocrinol Invest"},{"key":"2624_CR43","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.gaitpost.2014.03.014","volume":"40","author":"AJ Lopes","year":"2014","unstructured":"Lopes AJ, da Silva DPG, Kasuki L, Gadelha MR, Camilo GB, Guimar\u00e3es FS (2014) Posture and balance control in patients with acromegaly: results of a cross-sectional study. Gait Posture 40:154\u2013159. https:\/\/doi.org\/10.1016\/j.gaitpost.2014.03.014","journal-title":"Gait Posture"},{"key":"2624_CR44","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/cen.12708","volume":"83","author":"E Hatipoglu","year":"2015","unstructured":"Hatipoglu E, Topsakal N, Erkut Atilgan O, Camliguney AF, Ikitimur B, Ugurlu S, Niyazoglu M, Cotuk HB, Kadioglu P (2015) Physical and cardiovascular performance in cases with acromegaly after regular short-term exercise. Clin Endocrinol 83:91\u201397. https:\/\/doi.org\/10.1111\/cen.12708","journal-title":"Clin Endocrinol"},{"key":"2624_CR45","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1046\/j.1365-2265.2002.01476.x","volume":"56","author":"SG Thomas","year":"2002","unstructured":"Thomas SG, Woodhouse LJ, Pagura SM, Ezzat S (2002) Ventilation threshold as a measure of impaired physical performance in adults with growth hormone excess. Clin Endocrinol 56:351\u2013358. https:\/\/doi.org\/10.1046\/j.1365-2265.2002.01476.x","journal-title":"Clin Endocrinol"},{"key":"2624_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2021.728734","volume":"12","author":"\u0141 Mizera","year":"2021","unstructured":"Mizera \u0141, Halupczok-\u017by\u0142a J, Kola\u010dkov K, Zembska A, Grzegrz\u00f3\u0142ka J, J\u0119drzejuk D, Bolanowski M, Daroszewski J (2021) Myokines in acromegaly: an altered Irisin profile. Front Endocrinol (Lausanne) 12:1\u20139","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2624_CR47","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1515\/hmbci-2022-0009","volume":"43","author":"SN Sendur","year":"2022","unstructured":"Sendur SN, Baykal G, Firlatan B, Aydin B, Lay I, Dagdelen S, Alikasifoglu M, Erbas T (2022) Reduced Irisin levels in patients with acromegaly. Horm Mol Biol Clin Invest 43:251\u2013261. https:\/\/doi.org\/10.1515\/hmbci-2022-0009","journal-title":"Horm Mol Biol Clin Invest"},{"key":"2624_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/2912839","volume":"2020","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Guo X, Tan G, Zhao M, Huang Y, Chen W, Shi X, Pei L, Xing B (2020) Neuromuscular Blockade correlates with hormones and body composition in acromegaly. Int J Endocrinol 2020:1\u20138. https:\/\/doi.org\/10.1155\/2020\/2912839","journal-title":"Int J Endocrinol"},{"key":"2624_CR49","doi-asserted-by":"publisher","first-page":"4218","DOI":"10.1210\/jc.2017-01210","volume":"102","author":"MA Bredella","year":"2017","unstructured":"Bredella MA, Schorr M, Dichtel LE, Gerweck AV, Young BJ, Woodmansee WW, Swearingen B, Miller KK (2017) Body composition and ectopic lipid changes with biochemical control of acromegaly. J Clin Endocrinol Metab 102:4218\u20134225. https:\/\/doi.org\/10.1210\/jc.2017-01210","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR50","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1210\/clinem\/dgad190","volume":"108","author":"MC Arlien-S\u00f8borg","year":"2023","unstructured":"Arlien-S\u00f8borg MC, Dal J, Madsen MA, H\u00f8gild ML, Pedersen SB, Jessen N, J\u00f8rgensen JOL, M\u00f8ller N (2023) Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment. J Clin Endocrinol Metab 108:671\u2013678. https:\/\/doi.org\/10.1210\/clinem\/dgad190","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR51","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1210\/jc.2006-0664","volume":"92","author":"J Gibney","year":"2007","unstructured":"Gibney J, Wolthers T, Burt MG, Leung K-C, Umpleby AM, Ho KKY (2007) Protein metabolism in acromegaly: differential effects of short- and long-term treatment. J Clin Endocrinol Metab 92:1479\u20131484. https:\/\/doi.org\/10.1210\/jc.2006-0664","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR52","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1210\/jc.2015-1917","volume":"100","author":"CM Reyes-Vidal","year":"2015","unstructured":"Reyes-Vidal CM, Mojahed H, Shen W, Jin Z, Arias-Mendoza F, Fernandez JC, Gallagher D, Bruce JN, Post KD, Freda PU (2015) Adipose tissue redistribution and ectopic lipid deposition in active acromegaly and effects of surgical treatment. J Clin Endocrinol Metab 100:2946\u20132955. https:\/\/doi.org\/10.1210\/jc.2015-1917","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR53","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1210\/jc.2007-2780","volume":"93","author":"PU Freda","year":"2008","unstructured":"Freda PU, Shen W, Heymsfield SB, Reyes-Vidal CM, Geer EB, Bruce JN, Gallagher D (2008) Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly. J Clin Endocrinol Metab 93:2334\u20132343. https:\/\/doi.org\/10.1210\/jc.2007-2780","journal-title":"J Clin Endocrinol Metab"},{"key":"2624_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jendso\/bvad028","volume":"7","author":"AP Kuker","year":"2023","unstructured":"Kuker AP, Shen W, Jin Z, Chen J, Bruce JN, Freda PU (2023) Long-term outcome of body composition, ectopic lipid, and insulin resistance changes with surgical treatment of acromegaly. J Endocr Soc 7:1\u201313. https:\/\/doi.org\/10.1210\/jendso\/bvad028","journal-title":"J Endocr Soc"},{"key":"2624_CR55","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1530\/eje-07-0838","volume":"158","author":"A Miller","year":"2008","unstructured":"Miller A, Doll H, David J, Wass J (2008) Impact of musculoskeletal disease on quality of life in long-standing acromegaly. Eur J Endocrinol 158:587\u2013593. https:\/\/doi.org\/10.1530\/eje-07-0838","journal-title":"Eur J Endocrinol"},{"key":"2624_CR56","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrendo.2012.49","volume":"8","author":"BK Pedersen","year":"2012","unstructured":"Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457\u2013465. https:\/\/doi.org\/10.1038\/nrendo.2012.49","journal-title":"Nat Rev Endocrinol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02624-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02624-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02624-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T18:50:39Z","timestamp":1757184639000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02624-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":56,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["2624"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02624-2","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"26 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have received no financial or non-financial support related to the submitted work. On behalf of all authors, the corresponding author confirms that there are no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}