{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:03:02Z","timestamp":1772204582829,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministerio de Ciencia e Innovaci\u00f3n Tecnol\u00f3gia","award":["PICT 2020-02094"],"award-info":[{"award-number":["PICT 2020-02094"]}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["10120124"],"award-info":[{"award-number":["10120124"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02667-5","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T06:44:32Z","timestamp":1754030672000},"page":"2643-2655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brachyury and IGF1R: potential opposing roles in pediatric thyroid nodular pathology"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-4870","authenticated-orcid":false,"given":"Ayelen","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Celia","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Miraglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Venara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florencia","family":"Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Papendieck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"De Matteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-7353","authenticated-orcid":false,"given":"Patricia A.","family":"Pennisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"2667_CR1","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1111\/JPC.16257","volume":"58","author":"JL Sandy","year":"2022","unstructured":"Sandy JL, Titmuss A, Hameed S et al (2022) Thyroid nodules in children and adolescents: investigation and management. J Paediatr Child Health 58:2163\u20132168. https:\/\/doi.org\/10.1111\/JPC.16257","journal-title":"J Paediatr Child Health"},{"key":"2667_CR2","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1097\/MED.0000000000000495","volume":"26","author":"AJ Bauer","year":"2019","unstructured":"Bauer AJ (2019) Thyroid nodules in children and adolescents. Curr Opin Endocrinol Diabetes Obes 26:266\u2013274. https:\/\/doi.org\/10.1097\/MED.0000000000000495","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"2667_CR3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/CCO.0b013e3282f30220","volume":"20","author":"CA Dinauer","year":"2008","unstructured":"Dinauer CA, Breuer C, Rivkees SA (2008) Differentiated thyroid cancer in children: diagnosis and management. Curr Opin Oncol 20:59\u201365. https:\/\/doi.org\/10.1097\/CCO.0b013e3282f30220","journal-title":"Curr Opin Oncol"},{"issue":"1","key":"2667_CR4","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/S00383-025-05990-3","volume":"41","author":"Y Liu","year":"2025","unstructured":"Liu Y, Meng T, Ma S et al (2025) Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study. Pediatr Surg Int 41:(1):469. https:\/\/doi.org\/10.1007\/S00383-025-05990-3","journal-title":"Pediatr Surg Int"},{"issue":"9","key":"2667_CR5","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3390\/genes10090723","volume":"10","author":"VA Paulson","year":"2019","unstructured":"Paulson VA, Rudzinski ER, Hawkins DS (2019) Thyroid cancer in the pediatric population. Genes 10(9):723. https:\/\/doi.org\/10.3390\/genes10090723","journal-title":"Genes"},{"issue":"1","key":"2667_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/S12022-025-09850-7","volume":"36","author":"Y Liu","year":"2025","unstructured":"Liu Y, Bao L, Li G et al (2025) Identification of oncogenic alterations in 124 cases of pediatric papillary thyroid carcinoma: BEND7::ALK, DLG5::RET, and CCDC30::ROS1 fusions induce MAPK pathway activation. Endocr Pathol 36(1):5. https:\/\/doi.org\/10.1007\/S12022-025-09850-7","journal-title":"Endocr Pathol"},{"key":"2667_CR7","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1089\/THY.2019.0802","volume":"30","author":"B Pekova","year":"2020","unstructured":"Pekova B, Sykorova V, Dvorakova S et al (2020) RET, NTRK, ALK, BRAF, and MET fusions in a large cohort of pediatric papillary thyroid carcinomas. Thyroid 30:1771\u20131780. https:\/\/doi.org\/10.1089\/THY.2019.0802","journal-title":"Thyroid"},{"key":"2667_CR8","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/J.CELL.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RYJ, Nieto MA (2009) Epithelial-Mesenchymal transitions in development and disease. Cell 139:871\u2013890. https:\/\/doi.org\/10.1016\/J.CELL.2009.11.007","journal-title":"Cell"},{"key":"2667_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/J.CELL.2016.06.028","volume":"166","author":"MA Nieto","year":"2016","unstructured":"Nieto MA, Huang RYYJ, Jackson RAA, Thiery JPP (2016) EMT: 2016. Cell 166:21\u201345. https:\/\/doi.org\/10.1016\/J.CELL.2016.06.028","journal-title":"Cell"},{"key":"2667_CR10","doi-asserted-by":"publisher","first-page":"2471","DOI":"10.1158\/1078-0432.CCR-06-2353","volume":"13","author":"C Palena","year":"2007","unstructured":"Palena C, Polev DE, Tsang KY et al (2007) The human T-box mesodermal transcription factor brachyury is a candidate target for T-cell-mediated cancer immunotherapy. Clin Cancer Res 13:2471\u20132478. https:\/\/doi.org\/10.1158\/1078-0432.CCR-06-2353","journal-title":"Clin Cancer Res"},{"key":"2667_CR11","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1172\/JCI38379","volume":"120","author":"RI Fernando","year":"2010","unstructured":"Fernando RI, Litzinger M, Trono P et al (2010) The T-box transcription factor brachyury promotes epithelial-mesenchymal transition in human tumor cells. J Clin Invest 120:533\u2013544. https:\/\/doi.org\/10.1172\/JCI38379","journal-title":"J Clin Invest"},{"key":"2667_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1210\/edrv-16-1-3","volume":"16","author":"JI Jones","year":"1995","unstructured":"Jones JI, Clemmons DR (1995) Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3\u201334. https:\/\/doi.org\/10.1210\/edrv-16-1-3","journal-title":"Endocr Rev"},{"key":"2667_CR13","doi-asserted-by":"publisher","first-page":"T69","DOI":"10.1530\/JME-17-0311","volume":"61","author":"F Hakuno","year":"2018","unstructured":"Hakuno F, Takahashi SI (2018) IGF1 receptor signaling pathways. J Mol Endocrinol 61:T69\u2013T86. https:\/\/doi.org\/10.1530\/JME-17-0311","journal-title":"J Mol Endocrinol"},{"key":"2667_CR14","doi-asserted-by":"publisher","first-page":"653627","DOI":"10.3389\/FENDO.2021.653627","volume":"12","author":"TJ Smith","year":"2021","unstructured":"Smith TJ (2021) Insulin-Like growth factor pathway and the thyroid. Front 497 Endocrinol 12:653627. https:\/\/doi.org\/10.3389\/FENDO.2021.653627","journal-title":"Front 497 Endocrinol"},{"key":"2667_CR15","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5152\/balkanmedj.2011.034","volume":"29","author":"E Ba\u015ft\u00fcrk","year":"2012","unstructured":"Ba\u015ft\u00fcrk E, Kement M, Yavuzer D et al (2012) The role of insulin-like growth factor 1 in the development of benign and malignant thyroid nodules. Balkan Med J 29:133\u2013138. https:\/\/doi.org\/10.5152\/balkanmedj.2011.034","journal-title":"Balkan Med J"},{"key":"2667_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12020-012-9864-z","volume":"44","author":"Y-JJ Liu","year":"2013","unstructured":"Liu Y-JJ, Qiang W, Shi J et al (2013) Expression and significance of IGF-1 and IGF-1R in thyroid nodules. Endocrine 44:158\u2013164. https:\/\/doi.org\/10.1007\/s12020-012-9864-z","journal-title":"Endocrine"},{"key":"2667_CR17","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1478-811X-9-10","volume":"9","author":"LA Walsh","year":"2011","unstructured":"Walsh LA, Damjanovski S (2011) IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-\u03b21 resulting in epithelial to mesenchymal transition. Cell Commun Signal 9:10. https:\/\/doi.org\/10.1186\/1478-811X-9-10","journal-title":"Cell Commun Signal"},{"key":"2667_CR18","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.2147\/CMAR.S196862","volume":"11","author":"XH Wang","year":"2019","unstructured":"Wang XH, Wu HY, Gao J et al (2019) IGF1R facilitates epithelial-mesenchymal transition and cancer stem cell properties in neuroblastoma via the STAT3\/AKT axis. Cancer Manag Res 11:5459\u20135472. https:\/\/doi.org\/10.2147\/CMAR.S196862","journal-title":"Cancer Manag Res"},{"key":"2667_CR19","doi-asserted-by":"publisher","first-page":"94393","DOI":"10.18632\/ONCOTARGET.21765","volume":"8","author":"BF Peake","year":"2017","unstructured":"Peake BF, Eze SM, Yang L et al (2017) Growth differentiation factor 15 mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling. Oncotarget 8:94393\u201394406. https:\/\/doi.org\/10.18632\/ONCOTARGET.21765","journal-title":"Oncotarget"},{"key":"2667_CR20","doi-asserted-by":"publisher","first-page":"111922","DOI":"10.18632\/ONCOTARGET.22952","volume":"8","author":"C Zhao","year":"2017","unstructured":"Zhao C, Wang Q, Wang B et al (2017) IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma. Oncotarget 8:111922\u2013111930. https:\/\/doi.org\/10.18632\/ONCOTARGET.22952","journal-title":"Oncotarget"},{"key":"2667_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/THY.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen BR, Alexander EK, Bible KC et al (2016) 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26:1\u2013133. https:\/\/doi.org\/10.1089\/THY.2015.0020","journal-title":"Thyroid"},{"key":"2667_CR22","unstructured":"Mete O, Asa SL, Baloch ZW et al (2021) Protocol for the Examination of Specimens From Patients With Carcinomas of the Thyroid Gland. https:\/\/documents.cap.org\/documents\/Thyroid_4.4.0.0.REL_CAPCP.pdf. Accessed 3 Jul 2025"},{"key":"2667_CR23","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.18632\/oncotarget.3086","volume":"6","author":"DH Hamilton","year":"2015","unstructured":"Hamilton DH, Fernando RI, Schlom J, Palena C (2015) Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody. Oncotarget 6:4853\u20134862. https:\/\/doi.org\/10.18632\/oncotarget.3086","journal-title":"Oncotarget"},{"issue":"3","key":"2667_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s12672-018-0328-7","volume":"9","author":"F Cl\u00e9ment","year":"2018","unstructured":"Cl\u00e9ment F, Martin A, Venara M et al (2018) Type 1 IGF receptor localization in paediatric gliomas: significant association with WHO grading and clinical outcome. Horm Cancer 9(3):205\u2013214. https:\/\/doi.org\/10.1007\/s12672-018-0328-7","journal-title":"Horm Cancer"},{"key":"2667_CR25","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3389\/FENDO.2022.849279\/BIBTEX","volume":"13","author":"A Martin","year":"2022","unstructured":"Martin A, Fernandez MC, Cattaneo ER et al (2022) Type 1 insulin-Like growth factor receptor nuclear localization in High-Grade glioma cells enhances motility, metabolism, and in vivo tumorigenesis. Front Endocrinol (Lausanne) 13:569. https:\/\/doi.org\/10.3389\/FENDO.2022.849279\/BIBTEX","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2667_CR26","doi-asserted-by":"publisher","first-page":"158573","DOI":"10.1016\/j.bbalip.2019.158573","volume":"1865","author":"S C\u00e1rdenas","year":"2020","unstructured":"C\u00e1rdenas S, Colombero C, Panelo L et al (2020) GPR75 receptor mediates 20-HETE-signaling and metastatic features of androgen-insensitive prostate cancer cells. Biochim Biophys Acta - Mol Cell Biol Lipids 1865(2):158573. https:\/\/doi.org\/10.1016\/j.bbalip.2019.158573","journal-title":"Biochim Biophys Acta - Mol Cell Biol Lipids"},{"key":"2667_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-49247-1","volume":"91 9","author":"SA Razavi","year":"2019","unstructured":"Razavi SA, Afsharpad M, Modarressi MH et al (2019) Validation of reference genes for normalization of relative qRT-PCR studies in papillary thyroid carcinoma. Sci Rep 2019 91 9:1\u201311. https:\/\/doi.org\/10.1038\/s41598-019-49247-1","journal-title":"Sci Rep 2019"},{"key":"2667_CR28","doi-asserted-by":"publisher","first-page":"E45","DOI":"10.1093\/NAR\/29.9.E45","volume":"29","author":"MW Pfaffl","year":"2001","unstructured":"Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:E45. https:\/\/doi.org\/10.1093\/NAR\/29.9.E45","journal-title":"Nucleic Acids Res"},{"key":"2667_CR29","unstructured":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals Institute for Laboratory Animal Research Division on Earth and Life Studies (2011) Guide for the care and use of of laboratory animals, 8th editio. National Academies Press, Washington DC"},{"key":"2667_CR30","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1471-2342-8-16","volume":"8","author":"MM Jensen","year":"2008","unstructured":"Jensen MM, Jorgensen JT, Binderup T, Kjaer A (2008) Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper. BMC Med Imaging 8:16. https:\/\/doi.org\/10.1186\/1471-2342-8-16","journal-title":"BMC Med Imaging"},{"issue":"7","key":"2667_CR31","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1089\/thy.2014.0460","volume":"25","author":"GL Francis","year":"2015","unstructured":"Francis GL, Waguespack SG, Bauer AJ et al (2015) Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 25(7):716\u2013759. https:\/\/doi.org\/10.1089\/thy.2014.0460","journal-title":"Thyroid"},{"key":"2667_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/DIAGNOSTICS12123136","author":"P Guleria","year":"2022","unstructured":"Guleria P, Srinivasan R, Rana C, Agarwal S (2022) Molecular Landscape of Pediatric Thyroid Cancer: A Review. Diagnostics (Basel Switzerland). https:\/\/doi.org\/10.3390\/DIAGNOSTICS12123136","journal-title":"Diagnostics (Basel Switzerland)"},{"key":"2667_CR33","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1097\/PAS.0000000000000462","volume":"39","author":"M Miettinen","year":"2015","unstructured":"Miettinen M, Wang Z, Lasota J et al (2015) NUCLEAR BRACHYURY EXPRESSION IS CONSISTENT IN CHORDOMA, COMMON IN GERM CELL TUMORS AND SMALL CELL CARCINOMAS AND RARE IN OTHER CARCINOMAS AND SARCOMAS. AN IMMUNOHISTOCHEMICAL STUDY OF 5229 CASES. Am J Surg Pathol 39:1305. https:\/\/doi.org\/10.1097\/PAS.0000000000000462","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"2667_CR34","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1016\/S1470-2045(11)70337-0","volume":"13","author":"BP Walcott","year":"2012","unstructured":"Walcott BP, Nahed BV, Mohyeldin A et al (2012) Chordoma: current concepts, management, and future directions. Lancet Oncol 13(2):e69\u201376. https:\/\/doi.org\/10.1016\/S1470-2045(11)70337-0","journal-title":"Lancet Oncol"},{"issue":"3","key":"2667_CR35","doi-asserted-by":"publisher","first-page":"565509","DOI":"10.1245\/S10434-013-2914-9","volume":"20","author":"A Haro","year":"2013","unstructured":"Haro A, Yano T, Kohno M et al (2013) Expression of brachyury gene is a significant prognostic factor for primary lung carcinoma. Ann Surg Oncol 20(3):565509\u2013565516. https:\/\/doi.org\/10.1245\/S10434-013-2914-9","journal-title":"Ann Surg Oncol"},{"key":"2667_CR36","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1093\/CARCIN\/BGZ142","volume":"41","author":"M Chen","year":"2020","unstructured":"Chen M, Zou S, He C et al (2020) Transactivation of SOX5 by brachyury promotes breast cancer bone metastasis. Carcinogenesis 41:551\u2013560. https:\/\/doi.org\/10.1093\/CARCIN\/BGZ142","journal-title":"Carcinogenesis"},{"key":"2667_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/NRUROL.2014.184","volume":"11","author":"C Thoma","year":"2014","unstructured":"Thoma C (2014) Prostate cancer: Brachyury\u2013a biomarker for progression and prognosis? Nat Rev Urol 11:485. https:\/\/doi.org\/10.1038\/NRUROL.2014.184","journal-title":"Nat Rev Urol"},{"key":"2667_CR38","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/J.EJCA.2010.11.015","volume":"47","author":"N Kilic","year":"2011","unstructured":"Kilic N, Feldhaus S, Kilic E et al (2011) Brachyury expression predicts poor prognosis at early stages of colorectal cancer. Eur J Cancer 47:1080\u20131085. https:\/\/doi.org\/10.1016\/J.EJCA.2010.11.015","journal-title":"Eur J Cancer"},{"key":"2667_CR39","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1001\/JAMAONCOL.2022.1655","volume":"8","author":"JN Gallant","year":"2022","unstructured":"Gallant JN, Chen SC, Ortega CA et al (2022) Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children. JAMA Oncol 8:1323\u20131327. https:\/\/doi.org\/10.1001\/JAMAONCOL.2022.1655","journal-title":"JAMA Oncol"},{"issue":"18","key":"2667_CR40","doi-asserted-by":"publisher","first-page":"e152696","DOI":"10.1172\/JCI152696","volume":"131","author":"AT Franco","year":"2021","unstructured":"Franco AT, Ricarte-Filho JC, Laetsch TW, Bauer AJ (2021) Oncogene-specific Inhibition in the treatment of advanced pediatric thyroid cancer. J Clin Invest 131(18):e152696. https:\/\/doi.org\/10.1172\/JCI152696","journal-title":"J Clin Invest"},{"issue":"1","key":"2667_CR41","doi-asserted-by":"publisher","first-page":"100188","DOI":"10.1016\/J.XCRM.2020.100188","volume":"2","author":"HE Sheppard","year":"2021","unstructured":"Sheppard HE, Dall\u2019Agnese A, Park WD et al (2021) Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling Chordoma cell identity. Cell Rep Med 2(1):100188. https:\/\/doi.org\/10.1016\/J.XCRM.2020.100188","journal-title":"Cell Rep Med"},{"key":"2667_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20051194","author":"G Maik-Rachline","year":"2019","unstructured":"Maik-Rachline G, Hacohen-Lev-Ran A, Seger R (2019) Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS20051194","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2667_CR43","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/GENES9040204","volume":"9","author":"KA Ely","year":"2018","unstructured":"Ely KA, Bischoff LA, Weiss VL (2018) Wnt signaling in thyroid homeostasis and carcinogenesis. Genes (Basel) 9(4):204. https:\/\/doi.org\/10.3390\/GENES9040204","journal-title":"Genes (Basel)"},{"key":"2667_CR44","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0925-4773(99)00309-3","volume":"91","author":"SJ Arnold","year":"2000","unstructured":"Arnold SJ, Stappert J, Bauer A et al (2000) Brachyury is a target gene of the Wnt\/beta-catenin signaling pathway. Mech Dev 91:249\u2013258. https:\/\/doi.org\/10.1016\/S0925-4773(99)00309-3","journal-title":"Mech Dev"},{"issue":"13","key":"2667_CR45","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.3390\/IJMS20133258","volume":"20","author":"L Manzella","year":"2019","unstructured":"Manzella L, Massimino M, Stella S et al (2019) Activation of the IGF axis in thyroid cancer: implications for tumorigenesis and treatment. Int J Mol Sci 20(13):3258. https:\/\/doi.org\/10.3390\/IJMS20133258","journal-title":"Int J Mol Sci"},{"key":"2667_CR46","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/00129039-200006000-00005","volume":"8","author":"E Maiorano","year":"2000","unstructured":"Maiorano E, Ciampolillo A, Viale G et al (2000) Insulin-like growth factor 1 expression in thyroid tumors. Appl Immunohistochem Mol Morphol AIMM 8:110\u2013119. https:\/\/doi.org\/10.1097\/00129039-200006000-00005","journal-title":"Appl Immunohistochem Mol Morphol AIMM"},{"key":"2667_CR47","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1203\/01.PDR.0000111282.98401.93","volume":"55","author":"H Gydee","year":"2004","unstructured":"Gydee H, O\u2019Neill JT, Patel A et al (2004) Differentiated thyroid carcinomas from children and adolescents express IGF-I and the IGF-I receptor (IGF-I-R). Cancers with the most intense IGF-I-R expression May be more aggressive. Pediatr Res 55:709\u2013715. https:\/\/doi.org\/10.1203\/01.PDR.0000111282.98401.93","journal-title":"Pediatr Res"},{"key":"2667_CR48","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/DVDY.10480","volume":"229","author":"C Showell","year":"2004","unstructured":"Showell C, Binder O, Conlon FL (2004) T-box genes in early embryogenesis. Dev Dyn 229:201\u2013218. https:\/\/doi.org\/10.1002\/DVDY.10480","journal-title":"Dev Dyn"},{"key":"2667_CR49","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3389\/FONC.2020.00961","volume":"10","author":"M Chen","year":"2020","unstructured":"Chen M, Wu Y, Zhang H et al (2020) The roles of embryonic transcription factor BRACHYURY in tumorigenesis and progression. Front Oncol 10:961. https:\/\/doi.org\/10.3389\/FONC.2020.00961","journal-title":"Front Oncol"},{"key":"2667_CR50","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1093\/CARCIN\/BGU014","volume":"35","author":"Y Hu","year":"2014","unstructured":"Hu Y, Mintz A, Shah SR et al (2014) The fgfr\/mek\/erk\/brachyury pathway is critical for Chordoma cell growth and survival. Carcinogenesis 35:1491. https:\/\/doi.org\/10.1093\/CARCIN\/BGU014","journal-title":"Carcinogenesis"},{"key":"2667_CR51","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/J.BBRC.2015.09.076","volume":"467","author":"C Shao","year":"2015","unstructured":"Shao C, Zhang J, Fu J, Ling F (2015) The potential role of brachyury in inducing epithelial-to-mesenchymal transition (EMT) and HIF-1\u03b1 expression in breast cancer cells. Biochem Biophys Res Commun 467:1083\u20131089. https:\/\/doi.org\/10.1016\/J.BBRC.2015.09.076","journal-title":"Biochem Biophys Res Commun"},{"key":"2667_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13046-014-0105-6","volume":"33","author":"R Du","year":"2014","unstructured":"Du R, Wu S, Lv X et al (2014) Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. J Exp Clin Cancer Res 33:1\u201311. https:\/\/doi.org\/10.1186\/S13046-014-0105-6","journal-title":"J Exp Clin Cancer Res"},{"key":"2667_CR53","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3892\/MMR.2015.3348","volume":"12","author":"K Xu","year":"2015","unstructured":"Xu K, Liu B, Liu Y (2015) Impact of brachyury on epithelial-mesenchymal transitions and chemosensitivity in non-small cell lung cancer. Mol Med Rep 12:995. https:\/\/doi.org\/10.3892\/MMR.2015.3348","journal-title":"Mol Med Rep"},{"issue":"6","key":"2667_CR54","doi-asserted-by":"publisher","first-page":"e00510","DOI":"10.1128\/MCB.00510-16","volume":"37","author":"AS Kumar","year":"2017","unstructured":"Kumar AS, Jagadeeshan S, Pitani RS et al (2017) Snail-Modulated MicroRNA 493 forms a negative feedback loop with the Insulin-Like growth factor 1 receptor pathway and blocks tumorigenesis. Mol Cell Biol 37(6):e00510\u2013e00516. https:\/\/doi.org\/10.1128\/MCB.00510-16","journal-title":"Mol Cell Biol"},{"key":"2667_CR55","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1210\/edrv.21.3.0399","volume":"21","author":"HM Khandwala","year":"2000","unstructured":"Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE (2000) The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 21:215\u2013244. https:\/\/doi.org\/10.1210\/edrv.21.3.0399","journal-title":"Endocr Rev"},{"issue":"12","key":"2667_CR56","doi-asserted-by":"publisher","first-page":"3814","DOI":"10.3390\/IJMS19123814","volume":"19","author":"V Vella","year":"2018","unstructured":"Vella V, Malaguarnera R (2018) The emerging role of insulin receptor isoforms in thyroid cancer: clinical implications and new perspectives. Int J Mol Sci 19(12):3814. https:\/\/doi.org\/10.3390\/IJMS19123814","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02667-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02667-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02667-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T17:06:47Z","timestamp":1762880807000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02667-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":56,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["2667"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02667-5","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"5 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}