{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T20:21:46Z","timestamp":1773606106389,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02684-4","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:03:42Z","timestamp":1759172622000},"page":"2933-2942","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Close relationship, similar phenotype of GATA4 and NR5A1 mutations: gonadal dysgenesis and puberty development"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-6274","authenticated-orcid":false,"given":"Sema Nilay","family":"Abseyi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"\u015e\u0131klar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"\u00d6zsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirmen","family":"K\u0131z\u0131lcan \u00c7etin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eafak","family":"Demirta\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lkyaz","family":"T\u00fcrktan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra","family":"Aycan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merih","family":"Berbero\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"2684_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2023.100991","volume":"91","author":"AN Campbell","year":"2024","unstructured":"Campbell AN et al (2024) Steroidogenic factor-1 form and function: from phospholipids to physiology. Adv Biol Regul 91:100991","journal-title":"Adv Biol Regul"},{"key":"2684_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.semcdb.2015.10.030","volume":"45","author":"A Bashamboo","year":"2015","unstructured":"Bashamboo A, McElreavey K (2015) Human sex-determination and disorders of sex-development (DSD). Semin Cell Dev Biol 45:77\u201383","journal-title":"Semin Cell Dev Biol"},{"issue":"8","key":"2684_CR3","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s40618-023-02020-8","volume":"46","author":"GY Zheng","year":"2023","unstructured":"Zheng GY et al (2023) Phenotype and genetic characteristics in 20 Chinese patients with 46,XY disorders of sex development. J Endocrinol Invest 46(8):1613\u20131622","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"2684_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000519691","volume":"96","author":"C Kouri","year":"2023","unstructured":"Kouri C, Sommer G, Fluck CE (2023) Oligogenic causes of human differences of sex development: facing the challenge of genetic complexity. Horm Res Paediatr 96(2):169\u2013179","journal-title":"Horm Res Paediatr"},{"key":"2684_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1387598","volume":"15","author":"C Jiali","year":"2024","unstructured":"Jiali C et al (2024) Worldwide cohort study of 46, XY differences\/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants. Front Genet 15:1387598","journal-title":"Front Genet"},{"issue":"5","key":"2684_CR6","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.3390\/cimb46050274","volume":"46","author":"G Luppino","year":"2024","unstructured":"Luppino G et al (2024) Role of NR5A1 gene mutations in disorders of sex development: molecular and clinical features. Curr Issues Mol Biol 46(5):4519\u20134532","journal-title":"Curr Issues Mol Biol"},{"key":"2684_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/biom13040691","author":"A Hattori","year":"2023","unstructured":"Hattori A, Fukami M (2023) Nuclear receptor gene variants underlying disorders\/differences of sex development through abnormal testicular development. Biomolecules. https:\/\/doi.org\/10.3390\/biom13040691","journal-title":"Biomolecules"},{"key":"2684_CR8","doi-asserted-by":"crossref","unstructured":"Snipes M et al (2024) Phenotype-Genotype Discordance and a Case of a Disorder of Sexual Differentiation. Case Rep Genet 2024:9936936","DOI":"10.1155\/2024\/9936936"},{"key":"2684_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.902198","volume":"13","author":"RS Viger","year":"2022","unstructured":"Viger RS, de Mattos K, Tremblay JJ (2022) Insights into the roles of GATA factors in mammalian testis development and the control of fetal testis gene expression. Front Endocrinol (Lausanne) 13:902198","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2684_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/genes14081631","author":"T Aversa","year":"2023","unstructured":"Aversa T et al (2023) A rare case of precocious puberty in a child with a novel GATA-4 gene mutation: implications for disorders of sex development (DSD) and review of the literature. Genes. https:\/\/doi.org\/10.3390\/genes14081631","journal-title":"Genes"},{"key":"2684_CR11","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fendo.2018.00142","volume":"9","author":"I de Martinez","year":"2018","unstructured":"de Martinez I et al (2018) GATA4 variants in individuals with a 46,XY disorder of sex development (DSD) May or May not be associated with cardiac defects depending on second hits in other DSD genes. Front Endocrinol (Lausanne) 9:142","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2684_CR12","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1073\/pnas.1010257108","volume":"108","author":"D Lourenco","year":"2011","unstructured":"Lourenco D et al (2011) Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Proc Natl Acad Sci U S A 108(4):1597\u20131602","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2684_CR13","doi-asserted-by":"crossref","unstructured":"Kostopoulou E et al (2024) 46,ChiUpsilon DSD in an adolescent with a novel de Novo variant of the NR5A1 gene - case report and literature review. Hormones (Athens)","DOI":"10.1007\/s42000-024-00589-0"},{"issue":"1","key":"2684_CR14","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s12887-023-03974-7","volume":"23","author":"D Zhang","year":"2023","unstructured":"Zhang D et al (2023) A novel c.64G>T (p.G22C) NR5A1 variant in a Chinese adolescent with 46,XY disorders of sex development: a case report. BMC Pediatr 23(1):182","journal-title":"BMC Pediatr"},{"issue":"52","key":"2684_CR15","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000036725","volume":"102","author":"X Wei","year":"2023","unstructured":"Wei X, Li S, He Y (2023) NR5A1-related 46,XY partial gonadal dysgenesis: a case report and literature review. Medicine (Baltimore) 102(52):e36725","journal-title":"Medicine (Baltimore)"},{"key":"2684_CR16","doi-asserted-by":"publisher","unstructured":"Bergougnoux A et al (2023) Virilization at puberty in adolescent girls May reveal a 46,XY disorder of sexual development. Endocr Connect.  https:\/\/doi.org\/10.1530\/EC-23-0267","DOI":"10.1530\/EC-23-0267"},{"issue":"3","key":"2684_CR17","doi-asserted-by":"publisher","first-page":"364","DOI":"10.4183\/aeb.2023.364","volume":"19","author":"S Gunes","year":"2023","unstructured":"Gunes S (2023) Pubertal virilization in an adolescent with 46, XY disorder of sexual development: a novel mutation in Nr5a1 gene. Acta Endocrinologica (Bucharest) 19(3):364\u2013369","journal-title":"Acta Endocrinologica (Bucharest)"},{"issue":"2","key":"2684_CR18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s12020-021-02883-y","volume":"75","author":"I Monig","year":"2022","unstructured":"Monig I et al (2022) Pubertal development in 46,XY patients with NR5A1 mutations. Endocrine 75(2):601\u2013613","journal-title":"Endocrine"},{"key":"2684_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.885589","volume":"13","author":"KM Alhamoudi","year":"2022","unstructured":"Alhamoudi KM et al (2022) Case report: severe gonadal dysgenesis causing 46,XY disorder of sex development due to a novel NR5A1 variant. Front Genet 13:885589","journal-title":"Front Genet"},{"issue":"5\u20136","key":"2684_CR20","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1159\/000507411","volume":"13","author":"MF Faienza","year":"2019","unstructured":"Faienza MF et al (2019) NR5A1 gene variants: variable phenotypes, new variants, different outcomes. Sex Dev 13(5\u20136):258\u2013263","journal-title":"Sex Dev"},{"issue":"2","key":"2684_CR21","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jpag.2013.06.006","volume":"27","author":"Z Siklar","year":"2014","unstructured":"Siklar Z et al (2014) A novel heterozygous mutation in steroidogenic factor-1 in pubertal virilization of a 46,XY female adolescent. J Pediatr Adolesc Gynecol 27(2):98\u2013101","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"1","key":"2684_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000320029","volume":"75","author":"DM Warman","year":"2011","unstructured":"Warman DM et al (2011) Three new SF-1 (NR5A1) gene mutations in two unrelated families with multiple affected members: within-family variability in 46,XY subjects and low ovarian reserve in fertile 46,XX subjects. Horm Res Paediatr 75(1):70\u201377","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"2684_CR23","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000431324","volume":"84","author":"KH Woo","year":"2015","unstructured":"Woo KH et al (2015) Novel heterozygous mutations of NR5A1 and their functional characteristics in patients with 46,XY disorders of sex development without adrenal insufficiency. Horm Res Paediatr 84(2):116\u2013123","journal-title":"Horm Res Paediatr"},{"issue":"5","key":"2684_CR24","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/gim.2015.30","volume":"17","author":"S Richards","year":"2015","unstructured":"Richards S et al (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American college of medical genetics and genomics and the association for molecular pathology. Genet Med 17(5):405\u2013424","journal-title":"Genet Med"},{"key":"2684_CR25","doi-asserted-by":"publisher","unstructured":"Eggers S et al (2016) Disorders of sex development:insights from targeted gene sequencing of a large international patient cohort. Genome Biol 17(1):243.  https:\/\/doi.org\/10.1186\/s13059-016-1105-y","DOI":"10.1186\/s13059-016-1105-y"},{"key":"2684_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.810782","volume":"13","author":"E Globa","year":"2022","unstructured":"Globa E et al (2022) Disorders of sex development in a large Ukrainian cohort: clinical diversity and genetic findings. Front Endocrinol (Lausanne) 13:810782","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"2684_CR27","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/cga.12482","volume":"62","author":"Y Shichiri","year":"2022","unstructured":"Shichiri Y et al (2022) A case of 46,XY disorders of sex development with congenital heart disease caused by a GATA4 variant. Congenit Anom (Kyoto) 62(5):203\u2013207","journal-title":"Congenit Anom (Kyoto)"},{"key":"2684_CR28","doi-asserted-by":"publisher","unstructured":"\u00c7elik N al (2022) GATA-4 Variants in Two Unrelated Cases with 46, XY Disorder of Sex Development and Review of The Literature. J Clinical Res Pediatric Endocrinol 14(4):469-474. https:\/\/doi.org\/10.4274\/jcrpe.galenos.2021.2021.0112","DOI":"10.4274\/jcrpe.galenos.2021.2021.0112"},{"key":"2684_CR29","doi-asserted-by":"publisher","unstructured":"Choi J-H et al (2019) Molecular Characteristics of Sequence Variants in GATA4 in Patients with 46,XY Disorders of Sex Development Without Cardiac Defects. Sexual Develeopment: genetics, molecular biology, evolution, endocrinology, embryology and pathology of sex determination and differentiation 13(5-6):240-245.  https:\/\/doi.org\/10.1159\/000511258","DOI":"10.1159\/000511258"},{"key":"2684_CR30","doi-asserted-by":"publisher","unstructured":"Igarashi M et el (2018) GATA4 mutations are uncommon in patients with 46, XY disorders of sex development without heart anomaly. Asian J Andrology 20(6):629-631.  https:\/\/doi.org\/10.4103\/aja.aja_20_18","DOI":"10.4103\/aja.aja_20_18"},{"key":"2684_CR31","doi-asserted-by":"publisher","unstructured":"van den Bergen J et al (2020) Analysis of variants in GATA4 and FOG2\/ ZFPM2 demonstrates benign contribution to 46, XY disrorder of sex development. Molecular Genetic Genomic Medi 9(3):e1095. https:\/\/doi.org\/10.1002\/mgg3.1095","DOI":"10.1002\/mgg3.1095"},{"key":"2684_CR32","doi-asserted-by":"publisher","unstructured":"White S et al (2011) Copy number variation in patients with disorders of sex development due to 46, XY gonadal dysgenesis. PloS one 6(3):e17793.  https:\/\/doi.org\/10.1371\/journal.pone.0017793","DOI":"10.1371\/journal.pone.0017793"},{"issue":"3","key":"2684_CR33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1159\/000454806","volume":"87","author":"K McElreavey","year":"2017","unstructured":"McElreavey K, Achermann JC (2017) Steroidogenic factor-1 (SF-1, NR5A1) and 46,XX ovotesticular disorders of sex development: one factor, many phenotypes. Horm Res Paediatr 87(3):189\u2013190","journal-title":"Horm Res Paediatr"},{"issue":"2","key":"2684_CR34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/9629","volume":"22","author":"JC Achermann","year":"1999","unstructured":"Achermann JC et al (1999) A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet 22(2):125\u2013126","journal-title":"Nat Genet"},{"issue":"5","key":"2684_CR35","doi-asserted-by":"publisher","first-page":"e0176720","DOI":"10.1371\/journal.pone.0176720","volume":"12","author":"R Werner","year":"2017","unstructured":"Werner R et al (2017) New NR5A1 mutations and phenotypic variations of gonadal dysgenesis. PLoS One 12(5):e0176720","journal-title":"PLoS One"},{"issue":"5\u20136","key":"2684_CR36","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1159\/000485868","volume":"11","author":"K Takasawa","year":"2017","unstructured":"Takasawa K et al (2017) Phenotypic variation in 46,XX disorders of sex development due to the NR5A1 p.R92W variant: a sibling case report and literature review. Sex Dev 11(5\u20136):284\u2013288","journal-title":"Sex Dev"},{"issue":"4","key":"2684_CR37","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000524956","volume":"16","author":"H Fabbri-Scallet","year":"2022","unstructured":"Fabbri-Scallet H et al (2022) Can non-coding NR5A1 gene variants explain phenotypes of disorders of sex development?? Sex Dev 16(4):252\u2013260","journal-title":"Sex Dev"},{"key":"2684_CR38","doi-asserted-by":"publisher","first-page":"104941","DOI":"10.1016\/j.ebiom.2023.104941","volume":"99","author":"C Kouri","year":"2024","unstructured":"Kouri C et al (2024) Clinical and genetic characteristics of a large international cohort of individuals with rare NR5A1\/SF-1 variants of sex development. EBioMedicine 99:104941","journal-title":"EBioMedicine"},{"issue":"7","key":"2684_CR39","doi-asserted-by":"publisher","first-page":"e0287515","DOI":"10.1371\/journal.pone.0287515","volume":"18","author":"I de Martinez","year":"2023","unstructured":"de Martinez I et al (2023) Genetic reanalysis of patients with a difference of sex development carrying the NR5A1\/SF-1 variant p.Gly146Ala has discovered other likely disease-causing variations. PLoS ONE 18(7):e0287515","journal-title":"PLoS ONE"},{"issue":"3","key":"2684_CR40","doi-asserted-by":"publisher","first-page":"e675","DOI":"10.1210\/clinem\/dgae251","volume":"110","author":"R Naamneh Elzenaty","year":"2025","unstructured":"Naamneh Elzenaty R et al (2025) Characterization of 35 novel NR5A1\/SF-1 variants identified in individuals with atypical sexual development: the SF1next study. J Clin Endocrinol Metab 110(3):e675\u2013e693","journal-title":"J Clin Endocrinol Metab"},{"key":"2684_CR41","doi-asserted-by":"publisher","unstructured":"Kouri C et al (2025) Oligogenic analysis across broad phenotypes of 46,XY differences in sex development associated with NR5A1\/SF1 variants:findings from the international SF1next study. EBioMedicine 113:105624. https:\/\/doi.org\/10.1016\/j.ebiom.2025.105624","DOI":"10.1016\/j.ebiom.2025.105624"},{"key":"2684_CR42","doi-asserted-by":"publisher","unstructured":"Sasaki T et al (2024) Case report: Rare heterozygous variant in the NR5A1 gene causing 46,XY complete gonadal dysgenesis with a non-communicating rudimentary uterus. Frontiers Medicine 11:1441990. https:\/\/doi.org\/10.3389\/fmed.2024.1441990","DOI":"10.3389\/fmed.2024.1441990"},{"key":"2684_CR43","doi-asserted-by":"publisher","unstructured":"Camats N et al (2020) Oligogenic Origin of Differences of Sex Development in Humans. Int J Molecular Sci 21(5):1809. https:\/\/doi.org\/10.3390\/ijms21051809","DOI":"10.3390\/ijms21051809"},{"issue":"1","key":"2684_CR44","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13293-024-00648-6","volume":"15","author":"H Chen","year":"2024","unstructured":"Chen H et al (2024) Application and insights of targeted next-generation sequencing in a large cohort of 46,XY disorders of sex development in Chinese. Biol Sex Differ 15(1):73","journal-title":"Biol Sex Differ"},{"issue":"1","key":"2684_CR45","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1530\/EJE-11-0944","volume":"167","author":"S Tantawy","year":"2012","unstructured":"Tantawy S et al (2012) Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations. Eur J Endocrinol 167(1):125\u2013130","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2684_CR46","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1530\/EJE-11-0392","volume":"166","author":"M Cools","year":"2012","unstructured":"Cools M et al (2012) Pubertal androgenization and gonadal histology in two 46,XY adolescents with NR5A1 mutations and predominantly female phenotype at birth. Eur J Endocrinol 166(2):341\u2013349","journal-title":"Eur J Endocrinol"},{"key":"2684_CR47","doi-asserted-by":"publisher","unstructured":"Philibert P et al (2010) Steroidogenic factor-1 (SF-1) gene mutation as a frequent cause of primary amenorrhea in 46,XY female adolescents with low testosterone concentration. Reproductive Biol Endocrinol 8:28. https:\/\/doi.org\/10.1186\/1477-7827-8-28","DOI":"10.1186\/1477-7827-8-28"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02684-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02684-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02684-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T04:51:51Z","timestamp":1763787111000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02684-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2684"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02684-4","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"26 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study protocol was reviewed and approved by, Ankara University Clinical Research Ethics Committee, approval number 2024\/790. All parents\/legal guardians of the patients gave their written informed consent per institutional procedures for the publication of medical case data and accompanying images before the Gender Assignment Committee. Following national legislation and institutional rules, parents\/legal guardians of the patients did not need to provide specific written informed consent to participate in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}