{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:12:03Z","timestamp":1769670723402,"version":"3.49.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Young Scholars Fostering Fund of the First Affiliated Hospital of Nanjing Medical University","award":["PY2022051"],"award-info":[{"award-number":["PY2022051"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20241140"],"award-info":[{"award-number":["BK20241140"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-003"],"award-info":[{"award-number":["2022-PUMCH-B-003"]}]},{"name":"Doctoral Program for Mass Entrepreneurship and Innovation in Jiangsu province","award":["JSSCBS20221836"],"award-info":[{"award-number":["JSSCBS20221836"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02706-1","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:20:01Z","timestamp":1761805201000},"page":"153-163","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide DNA methylation profiling reveals diagnostic markers in parathyroid tumours"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6047-0934","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-0270","authenticated-orcid":false,"given":"Meiping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1324-6213","authenticated-orcid":false,"given":"Quan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"2706_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12022-022-09709-1","volume":"33","author":"LA Erickson","year":"2022","unstructured":"Erickson LA, Mete O, Juhlin CC, Perren A, Gill AJ (2022) Overview of the 2022 WHO classification of parathyroid tumors. Endocr Pathol 33:64\u201389","journal-title":"Endocr Pathol"},{"key":"2706_CR2","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nrc3130","volume":"11","author":"SB Baylin","year":"2011","unstructured":"Baylin SB, Jones PA (2011) A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer 11:726\u2013734","journal-title":"Nat Rev Cancer"},{"key":"2706_CR3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.clon.2010.04.007","volume":"22","author":"B Givi","year":"2010","unstructured":"Givi B, Shah JP (2010) Parathyroid carcinoma. Clin Oncol (R Coll Radiol) 22:498\u2013507","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"2706_CR4","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.92061","volume":"2","author":"C Pandya","year":"2017","unstructured":"Pandya C, Uzilov AV, Bellizzi J, Lau CY, Moe AS, Strahl M, Hamou W, Newman LC, Fink MY, Antipin Y, Yu W, Stevenson M et al (2017) Genomic profiling reveals mutational landscape in parathyroid carcinomas. JCI Insight 2:e92061","journal-title":"JCI Insight"},{"key":"2706_CR5","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1210\/js.2018-00043","volume":"3","author":"CN Clarke","year":"2019","unstructured":"Clarke CN, Katsonis P, Hsu TK, Koire AM, Silva-Figueroa A, Christakis I, Williams MD, Kutahyalioglu M, Kwatampora L, Xi Y, Lee JE, Koptez ES et al (2019) Comprehensive genomic characterization of parathyroid cancer identifies novel candidate driver mutations and core pathways. J Endocr Soc 3:544\u2013559","journal-title":"J Endocr Soc"},{"key":"2706_CR6","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1677\/ERC-09-0134","volume":"17","author":"S Corbetta","year":"2010","unstructured":"Corbetta S, Vaira V, Guarnieri V, Scillitani A, Eller-Vainicher C, Ferrero S, Vicentini L, Chiodini I, Bisceglia M, Beck-Peccoz P, Bosari S, Spada A (2010) Differential expression of micrornas in human parathyroid carcinomas compared with normal parathyroid tissue. Endocr Relat Cancer 17:135\u2013146","journal-title":"Endocr Relat Cancer"},{"key":"2706_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1530\/ERC-18-0480","volume":"26","author":"X Zhang","year":"2019","unstructured":"Zhang X, Hu Y, Wang M, Zhang R, Wang P, Cui M, Su Z, Gao X, Liao Q, Zhao Y (2019) Profiling analysis of long non-coding RNA and mRNA in parathyroid carcinoma. Endocr Relat Cancer 26:163\u2013176","journal-title":"Endocr Relat Cancer"},{"key":"2706_CR8","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1080\/15476286.2019.1622962","volume":"16","author":"Y Hu","year":"2019","unstructured":"Hu Y, Zhang X, Cui M, Wang M, Su Z, Liao Q, Zhao Y (2019) Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs. RNA Biol 16:1228\u20131236","journal-title":"RNA Biol"},{"key":"2706_CR9","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1038\/s41467-024-46181-3","volume":"15","author":"YL Jung","year":"2024","unstructured":"Jung YL, Zhao W, Li I, Jain D, Epstein CB, Bernstein BE, Parangi S, Sherwood R, Robinson-Cohen C, Hsu YH, Park PJ, Mannstadt M (2024) Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids. Nat Commun 15:2106","journal-title":"Nat Commun"},{"key":"2706_CR10","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13148-016-0197-2","volume":"8","author":"E Barazeghi","year":"2016","unstructured":"Barazeghi E, Gill AJ, Sidhu S, Norlen O, Dina R, Palazzo FF, Hellman P, Stalberg P, Westin G (2016) 5-hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma. Clin Epigenetics 8:31","journal-title":"Clin Epigenetics"},{"key":"2706_CR11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.mce.2017.05.010","volume":"469","author":"V Guarnieri","year":"2018","unstructured":"Guarnieri V, Muscarella LA, Verdelli C, Corbetta S (2018) Alterations of DNA methylation in parathyroid tumors. Mol Cell Endocrinol 469:60\u201369","journal-title":"Mol Cell Endocrinol"},{"key":"2706_CR12","doi-asserted-by":"publisher","first-page":"646","DOI":"10.4161\/epi.24823","volume":"8","author":"L Sulaiman","year":"2013","unstructured":"Sulaiman L, Juhlin CC, Nilsson IL, Fotouhi O, Larsson C, Hashemi J (2013) Global and gene-specific promoter methylation analysis in primary hyperparathyroidism. Epigenetics 8:646\u2013655","journal-title":"Epigenetics"},{"key":"2706_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009472","volume":"5","author":"CC Juhlin","year":"2010","unstructured":"Juhlin CC, Kiss NB, Villablanca A, Haglund F, Nordenstrom J, Hoog A, Larsson C (2010) Frequent promoter hypermethylation of the APC and RASSF1A tumour suppressors in parathyroid tumours. PLoS ONE 5:e9472","journal-title":"PLoS ONE"},{"key":"2706_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1677\/ERC-09-0291","volume":"17","author":"MA Hahn","year":"2010","unstructured":"Hahn MA, Howell VM, Gill AJ, Clarkson A, Weaire-Buchanan G, Robinson BG, Delbridge L, Gimm O, Schmitt WD, Teh BT, Marsh DJ (2010) CDC73\/HRPT2 CpG island hypermethylation and mutation of 5\u2019\u2010untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors. Endocr Relat Cancer 17:273\u2013282","journal-title":"Endocr Relat Cancer"},{"key":"2706_CR15","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/gcc.20895","volume":"50","author":"LF Starker","year":"2011","unstructured":"Starker LF, Svedlund J, Udelsman R, Dralle H, Akerstrom G, Westin G, Lifton RP, Bjorklund P, Carling T (2011) The DNA methylome of benign and malignant parathyroid tumors. Genes Chromosomes Cancer 50:735\u2013745","journal-title":"Genes Chromosomes Cancer"},{"key":"2706_CR16","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1093\/bioinformatics\/btu049","volume":"30","author":"MJ Aryee","year":"2014","unstructured":"Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA (2014) Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 30:1363\u20131369","journal-title":"Bioinformatics"},{"key":"2706_CR17","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","volume":"33","author":"JP Fortin","year":"2017","unstructured":"Fortin JP, Triche TJ, Hansen KD (2017) Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi. Bioinformatics 33:558\u2013560","journal-title":"Bioinformatics"},{"key":"2706_CR18","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1093\/bioinformatics\/bts013","volume":"28","author":"D Wang","year":"2012","unstructured":"Wang D, Yan L, Hu Q, Sucheston LE, Higgins MJ, Ambrosone CB, Johnson CS, Smiraglia DJ, Liu S (2012) IMA: an R package for high-throughput analysis of Illumina\u2019s 450K Infinium methylation data. Bioinformatics 28:729\u2013730","journal-title":"Bioinformatics"},{"key":"2706_CR19","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1038\/onc.2015.38","volume":"34","author":"JT Poirier","year":"2015","unstructured":"Poirier JT, Gardner EE, Connis N, Moreira AL, de Stanchina E, Hann CL, Rudin CM (2015) DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2. Oncogene 34:5869\u20135878","journal-title":"Oncogene"},{"key":"2706_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-8-6","volume":"8","author":"TJ Peters","year":"2015","unstructured":"Peters TJ, Buckley MJ, Statham AL, Pidsley R, Samaras K, Lord RV, Clark SJ, Molloy PL (2015) De novo identification of differentially methylated regions in the human genome. Epigenetics Chromatin 8:6","journal-title":"Epigenetics Chromatin"},{"key":"2706_CR21","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature13544","volume":"511","author":"H Guo","year":"2014","unstructured":"Guo H, Zhu P, Yan L, Li R, Hu B, Lian Y, Yan J, Ren X, Lin S, Li J, Jin X, Shi X et al (2014) The DNA methylation landscape of human early embryos. Nature 511:606\u2013610","journal-title":"Nature"},{"key":"2706_CR22","doi-asserted-by":"publisher","first-page":"E1307","DOI":"10.1210\/jc.2011-3136","volume":"97","author":"J Svedlund","year":"2012","unstructured":"Svedlund J, Koskinen ES, Marquez VE, Akerstrom G, Bjorklund P, Westin G (2012) Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification. J Clin Endocrinol Metab 97:E1307\u2013E1315","journal-title":"J Clin Endocrinol Metab"},{"key":"2706_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.834362","volume":"13","author":"F Marini","year":"2022","unstructured":"Marini F, Giusti F, Palmini G, Perigli G, Santoro R, Brandi ML (2022) Genetics and epigenetics of parathyroid carcinoma. Front Endocrinol (Lausanne) 13:834362","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2706_CR24","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1002\/ijc.33166","volume":"147","author":"Y Hu","year":"2020","unstructured":"Hu Y, Zhang X, Wang O, Bi Y, Xing X, Cui M, Wang M, Tao W, Liao Q, Zhao Y (2020) The genomic profile of parathyroid carcinoma based on whole-genome sequencing. Int J Cancer 147:2446\u20132457","journal-title":"Int J Cancer"},{"key":"2706_CR25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s12935-025-03699-w","volume":"25","author":"Q Zheng","year":"2025","unstructured":"Zheng Q, Cui M, Wang O, Chang X, Xiao J, Chen T, Wang M, Hua S, Hu Y, Liao Q (2025) Primary exploration of cell-free DNA in the plasma of patients with parathyroid neoplasms using next-generation sequencing. Cancer Cell Int 25:86","journal-title":"Cancer Cell Int"},{"key":"2706_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14164004","volume":"14","author":"Y Hu","year":"2022","unstructured":"Hu Y, Cui M, Chang X, Wang O, Chen T, Xiao J, Wang M, Hua S, Liao Q (2022) Patterns and predictors of cervical lymph node metastasis in parathyroid carcinoma. Cancers (Basel) 14:4004","journal-title":"Cancers (Basel)"},{"key":"2706_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-024-03687-6","author":"Y Hu","year":"2024","unstructured":"Hu Y, Mo S, Xiao J, Cui M, Zheng Q, Chen T, Chang X, Liao Q (2024) The significance of an immunohistochemical marker-based panel in assisting the diagnosis of parathyroid carcinoma. Endocrine. https:\/\/doi.org\/10.1007\/s12020-024-03687-6","journal-title":"Endocrine"},{"key":"2706_CR28","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1210\/jc.2017-00881","volume":"102","author":"DRM Bisarro","year":"2017","unstructured":"Bisarro DRM, Barros-Filho MC, Marchi FA, Beltrami CM, Kuasne H, Pinto C, Ambatipudi S, Herceg Z, Kowalski LP, Rogatto SR (2017) Prognostic classifier based on genome-Wide DNA methylation profiling in well-differentiated thyroid tumors. J Clin Endocrinol Metab 102:4089\u20134099","journal-title":"J Clin Endocrinol Metab"},{"key":"2706_CR29","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01018-w","volume":"14","author":"T Simon","year":"2022","unstructured":"Simon T, Riemer P, Jarosch A, Detjen K, Di Domenico A, Bormann F, Menne A, Khouja S, Monje N, Childs LH, Lenze D, Leser U et al (2022) DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors. Genome Med 14:24","journal-title":"Genome Med"},{"key":"2706_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01130-5","volume":"13","author":"DW Chan","year":"2021","unstructured":"Chan DW, Lam WY, Chen F, Yung M, Chan YS, Chan WS, He F, Liu SS, Chan K, Li B, Ngan H (2021) Genome-wide DNA methylome analysis identifies methylation signatures associated with survival and drug resistance of ovarian cancers. Clin Epigenetics 13:142","journal-title":"Clin Epigenetics"},{"key":"2706_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01203-5","volume":"13","author":"J Zhou","year":"2021","unstructured":"Zhou J, Cheng T, Li X, Hu J, Li E, Ding M, Shen R, Pineda JP, Li C, Lu S, Yu H, Sun J et al (2021) Epigenetic imprinting alterations as effective diagnostic biomarkers for early-stage lung cancer and small pulmonary nodules. Clin Epigenetics 13:220","journal-title":"Clin Epigenetics"},{"key":"2706_CR32","first-page":"1161","volume":"79","author":"O Kocher","year":"1999","unstructured":"Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999) PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. Lab Invest 79:1161\u20131170","journal-title":"Lab Invest"},{"key":"2706_CR33","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ebiom.2016.12.003","volume":"15","author":"J Zheng","year":"2017","unstructured":"Zheng J, Wang L, Peng Z, Yang Y, Feng D, He J (2017) Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma. EBioMedicine 15:62\u201372","journal-title":"EBioMedicine"},{"key":"2706_CR34","doi-asserted-by":"publisher","first-page":"270","DOI":"10.2119\/molmed.2013.00166","volume":"20","author":"H Kim","year":"2014","unstructured":"Kim H, Abd EZ, Davis C, El-Bahrawy AH, Naura AS, Ekaidi I, Abdel-Mageed AB, Boulares AH (2014) Correlation between PDZK1, Cdc37, Akt and breast cancer malignancy: the role of PDZK1 in cell growth through Akt stabilization by increasing and interacting with Cdc37. Mol Med 20:270\u2013279","journal-title":"Mol Med"},{"key":"2706_CR35","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.bbrc.2011.02.076","volume":"406","author":"AJ Tennant-Eyles","year":"2011","unstructured":"Tennant-Eyles AJ, Moffitt H, Whitehouse CA, Roberts RG (2011) Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins. Biochem Biophys Res Commun 406:471\u2013477","journal-title":"Biochem Biophys Res Commun"},{"key":"2706_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066427","volume":"8","author":"M Dudkiewicz","year":"2013","unstructured":"Dudkiewicz M, Lenart A, Pawlowski K (2013) A novel predicted calcium-regulated kinase family implicated in neurological disorders. PLoS ONE 8:e66427","journal-title":"PLoS ONE"},{"key":"2706_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105644","volume":"169","author":"C Jiang","year":"2021","unstructured":"Jiang C, Liu Y, Wen S, Xu C, Gu L (2021) In silico development and clinical validation of novel 8 gene signature based on lipid metabolism related genes in colon adenocarcinoma. Pharmacol Res 169:105644","journal-title":"Pharmacol Res"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02706-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02706-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02706-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:46:55Z","timestamp":1769496415000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02706-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["2706"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02706-1","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"3 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study obtained approval from the Institutional Review Board of Peking Union Medical College Hospital and from the Institutional Review Board of the First Affiliated Hospital with Nanjing Medical University. Each patient in this study provided written informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}