{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T08:01:50Z","timestamp":1774425710788,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Luzhou Municipal People's Government Southwest Medical University Science and Technology Strategic Cooperation Project","award":["2024LZXNYDJ010"],"award-info":[{"award-number":["2024LZXNYDJ010"]}]},{"name":"Southwest Medical University Integrated Traditional Chinese and Western Medicine Special Projectine","award":["2023ZYYQ17"],"award-info":[{"award-number":["2023ZYYQ17"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02755-6","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T05:24:16Z","timestamp":1769059456000},"page":"529-545","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organoid modeling identifies EDN1 as a potential oncogenic driver in papillary thyroid carcinoma via modulation of the Hippo-YAP signaling pathway"],"prefix":"10.1007","volume":"49","author":[{"given":"Rui","family":"Hai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Singkome","family":"Tima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songyot","family":"Anuchapreeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"2755_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5821545","volume":"2022","author":"N Luo","year":"2022","unstructured":"Luo N, Tan Y, Deng H et al (2022) SRPX2 promotes tumor proliferation and migration via the FAK pathway in papillary thyroid carcinoma. J Oncol 2022:5821545","journal-title":"J Oncol"},{"key":"2755_CR2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1428411","volume":"2022","author":"R Hai","year":"2022","unstructured":"Hai R, Zhou Y, Li F et al (2022) Mir-576-5p promotes the proliferation of papillary thyroid carcinoma through the MAPK4-AKT pathway. Int J Anal Chem 2022:1428411","journal-title":"Int J Anal Chem"},{"key":"2755_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9989757","volume":"2021","author":"W Chatchomchuan","year":"2021","unstructured":"Chatchomchuan W, Thewjitcharoen Y, Karndumri K et al (2021) Recurrence factors and characteristic trends of papillary thyroid cancer over three decades. Int J Endocrinol 2021:9989757","journal-title":"Int J Endocrinol"},{"key":"2755_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1026737","volume":"13","author":"YG Sun","year":"2022","unstructured":"Sun YG, Chen F, Sun QL et al (2022) The number of metastatic lymph nodes optimizes staging in patients aged 55 years or older with papillary thyroid cancer. Front Endocrinol (Lausanne) 13:1026737","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"2755_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/jso.23967","volume":"112","author":"FH Liu","year":"2015","unstructured":"Liu FH, Kuo SF, Hsueh C et al (2015) Postoperative recurrence of papillary thyroid carcinoma with lymph node metastasis. J Surg Oncol 112(2):149\u201354","journal-title":"J Surg Oncol"},{"key":"2755_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.793997","volume":"12","author":"Y Heng","year":"2022","unstructured":"Heng Y, Feng S, Yang Z et al (2022) Features of lymph node metastasis and structural recurrence in papillary thyroid carcinoma located in the upper portion of the thyroid: a retrospective cohort study. Front Endocrinol (Lausanne) 12:793997","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"2755_CR7","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1002\/hed.26987","volume":"44","author":"HG Vuong","year":"2022","unstructured":"Vuong HG, Le MK, Hassell L et al (2022) The differences in distant metastatic patterns and their corresponding survival between thyroid cancer subtypes. Head Neck 44(4):926\u2013932","journal-title":"Head Neck"},{"issue":"1","key":"2755_CR8","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5461","volume":"62","author":"YJ Lee","year":"2023","unstructured":"Lee YJ, Jung E, Choi J et al (2023) The EDN1\/EDNRA\/\u03b2-arrestin axis promotes colorectal cancer progression by regulating STAT3 phosphorylation. Int J Oncol 62(1):13","journal-title":"Int J Oncol"},{"issue":"8","key":"2755_CR9","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","volume":"86","author":"A Inoue","year":"1989","unstructured":"Inoue A, Yanagisawa M, Kimura S et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A 86(8):2863\u20137","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2755_CR10","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nrc3546","volume":"13","author":"L Rosano","year":"2013","unstructured":"Rosano L, Spinella F, Bagnato A (2013) Endothelin 1 in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer 13:637\u2013651","journal-title":"Nat Rev Cancer"},{"key":"2755_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411295","volume":"24","author":"K Banecki","year":"2023","unstructured":"Banecki K, Dora KA (2023) Endothelin-1 in health and disease. Int J Mol Sci 24:11295","journal-title":"Int J Mol Sci"},{"issue":"19","key":"2755_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241914541","volume":"24","author":"A Berna-Erro","year":"2023","unstructured":"Berna-Erro A, Granados MP, Rosado JA et al (2023) Thrombotic alterations under perinatal hypoxic conditions: HIF and other hypoxic markers. Int J Mol Sci 24(19):14541","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2755_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00439-008-0481-0","volume":"123","author":"S Wiltshire","year":"2008","unstructured":"Wiltshire S, Powell BL, Jennens M et al (2008) Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease. Hum Genet 123(3):307\u2013313","journal-title":"Hum Genet"},{"key":"2755_CR14","doi-asserted-by":"publisher","first-page":"29877","DOI":"10.1038\/srep29877","volume":"6","author":"M Mei","year":"2016","unstructured":"Mei M, Cheng G, Sun B et al (2016) EDN1 gene variant is associated with neonatal persistent pulmonary hypertension. Sci Rep 6:29877","journal-title":"Sci Rep"},{"issue":"8","key":"2755_CR15","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1002\/jcp.23043","volume":"227","author":"MH Wu","year":"2012","unstructured":"Wu MH, Lo JF, Kuo CH et al (2012) Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK\/PI3K\/Akt\/mTOR pathways. J Cell Physiol 227(8):3016\u201326","journal-title":"J Cell Physiol"},{"issue":"26","key":"2755_CR16","doi-asserted-by":"publisher","first-page":"3432","DOI":"10.1038\/onc.2015.403","volume":"35","author":"E Semprucci","year":"2016","unstructured":"Semprucci E, Tocci P, Cianfrocca R et al (2016) Endothelin A receptor drives invadopodia function and cell motility through the \u03b2-arrestin\/PDZ-RhoGEF pathway in ovarian carcinoma. Oncogene 35(26):3432\u20133442","journal-title":"Oncogene"},{"key":"2755_CR17","first-page":"220","volume":"21","author":"ZS Razavi","year":"2021","unstructured":"Razavi ZS, Asgarpour K, Mahjoubin-Tehran M et al (2021) Angiogenesis-related non-coding RNAs and gastrointestinal cancer. Mol Ther 21:220\u2013241","journal-title":"Mol Ther"},{"issue":"6","key":"2755_CR18","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1365-2265.2006.02535.x","volume":"64","author":"JE Donckier","year":"2006","unstructured":"Donckier JE, Michel L, Delos M et al (2006) Interrelated overexpression of endothelial and inducible nitric oxide synthases, endothelin-1 and angiogenic factors in human papillary thyroid carcinoma. Clin Endocrinol (Oxf) 64(6):703\u201310","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2755_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1046\/j.1365-2265.2003.01855.x","volume":"59","author":"JE Donckier","year":"2003","unstructured":"Donckier JE, Michel L, Van Beneden R et al (2003) Increased expression of endothelin-1 and its mitogenic receptor ETA in human papillary thyroid carcinoma. Clin Endocrinol (Oxf) 59(3):354\u201360","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2755_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1158\/0008-5472.CAN-20-1674","volume":"81","author":"C Wan","year":"2021","unstructured":"Wan C, Keany MP, Dong H et al (2021) Enhanced efficacy of simultaneous PD-1 and PD-L1 immune checkpoint blockade in high-grade serous ovarian cancer. Cancer Res 81(1):158\u2013173","journal-title":"Cancer Res"},{"issue":"9","key":"2755_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105568","volume":"9","author":"J Liang","year":"2022","unstructured":"Liang J, Qian J, Yang L et al (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Adv Sci 9(9):e2105568","journal-title":"Adv Sci"},{"issue":"5","key":"2755_CR22","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1210\/clinem\/dgab020","volume":"106","author":"D Chen","year":"2021","unstructured":"Chen D, Tan Y, Li Z et al (2021) Organoid cultures derived from patients with papillary thyroid cancer. J Clin Endocrinol Metab 106(5):1410\u20131426","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2755_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12967-022-03848-z","volume":"21","author":"D Chen","year":"2023","unstructured":"Chen D, Su X, Zhu L et al (2023) Papillary thyroid cancer organoids harboring BRAFV600E mutation reveal potentially beneficial effects of BRAF inhibitor-based combination therapies. J Transl Med 21(1):9","journal-title":"J Transl Med"},{"issue":"3","key":"2755_CR24","doi-asserted-by":"publisher","first-page":"E581","DOI":"10.1152\/ajpendo.00479.2020","volume":"320","author":"H Samimi","year":"2021","unstructured":"Samimi H, Atlasi R, Parichehreh-Dizaji S et al (2021) A systematic review on thyroid organoid models: time-trend and its achievements. Am J Physiol Endocrinol Metab 320(3):E581\u2013E590","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"2755_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gad.274027.115","volume":"30","author":"Z Meng","year":"2016","unstructured":"Meng Z, Moroishi T, Guan KL (2016) Mechanisms of hippo pathway regulation. Genes Dev 30(1):1\u201317","journal-title":"Genes Dev"},{"issue":"9","key":"2755_CR26","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1158\/0008-5472.CAN-16-3229","volume":"77","author":"Z Wang","year":"2017","unstructured":"Wang Z, Liu P, Zhou X et al (2017) Endothelin promotes colorectal tumorigenesis by activating YAP\/TAZ. Cancer Res 77(9):2413\u20132423","journal-title":"Cancer Res"},{"key":"2755_CR27","doi-asserted-by":"publisher","first-page":"971416","DOI":"10.3389\/fimmu.2022.971416","volume":"13","author":"A Zheng","year":"2022","unstructured":"Zheng A, Chen Q, Zhang L (2022) The hippo-YAP pathway in various cardiovascular diseases: focusing on the inflammatory response. Front Immunol 13:971416","journal-title":"Front Immunol"},{"issue":"11","key":"2755_CR28","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/s41569-018-0063-3","volume":"15","author":"J Wang","year":"2018","unstructured":"Wang J, Liu S, Heallen T et al (2018) The hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol 15(11):672\u201384","journal-title":"Nat Rev Cardiol"},{"issue":"7675","key":"2755_CR29","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature24045","volume":"550","author":"JP Leach","year":"2017","unstructured":"Leach JP, Heallen T, Zhang M et al (2017) Hippo pathway deficiency reverses systolic heart failure after infarction. Nature 550(7675):260\u2013264","journal-title":"Nature"},{"issue":"6028","key":"2755_CR30","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1126\/science.1199010","volume":"332","author":"T Heallen","year":"2011","unstructured":"Heallen T, Zhang M, Wang J et al (2011) Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science 332(6028):458\u2013461","journal-title":"Science"},{"key":"2755_CR31","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-biochem-013118-111829","volume":"88","author":"S Ma","year":"2019","unstructured":"Ma S, Meng Z, Chen R et al (2019) The hippo pathway: biology and pathophysiology. Annu Rev Biochem 88:577\u2013604","journal-title":"Annu Rev Biochem"},{"key":"2755_CR32","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.canlet.2020.08.026","volume":"492","author":"P Tocci","year":"2020","unstructured":"Tocci P, Cianfrocca R, Sestito R et al (2020) Endothelin-1 axis fosters YAP-induced chemotherapy escape in ovarian cancer. Cancer Lett 492:84\u201395","journal-title":"Cancer Lett"},{"issue":"1","key":"2755_CR33","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s13046-022-02317-1","volume":"41","author":"R Sestito","year":"2022","unstructured":"Sestito R, Tocci P, Roman C et al (2022) Functional interaction between endothelin-1 and ZEB1\/YAP signaling regulates cellular plasticity and metastasis in high-grade serous ovarian cancer. J Exp Clin Cancer Res 41(1):157","journal-title":"J Exp Clin Cancer Res"},{"issue":"1","key":"2755_CR34","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1097\/PAI.0000000000000544","volume":"27","author":"Z Liu","year":"2019","unstructured":"Liu Z, Zeng W, Maimaiti Y et al (2019) High expression of Yes-activated protein-1 in papillary thyroid carcinoma correlates with poor prognosis. Appl Immunohistochem Mol Morphol 27(1):59\u201364","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"6163","key":"2755_CR35","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/332411a0","volume":"332","author":"M Yanagisawa","year":"1988","unstructured":"Yanagisawa M, Kurihara H, Kimura S et al (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332(6163):411\u2013415","journal-title":"Nature"},{"issue":"3","key":"2755_CR36","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/biomedicines12030511","volume":"12","author":"M Harrison","year":"2024","unstructured":"Harrison M, Zinovkin D, Pranjol MZI (2024) Endothelin-1 and its role in cancer and potential therapeutic opportunities. Biomedicines 12(3):511","journal-title":"Biomedicines"},{"issue":"Suppl 1","key":"2755_CR37","first-page":"E85","volume":"53","author":"S Nie","year":"2014","unstructured":"Nie S, Zhou J, Bai F et al (2014) Role of endothelin A receptor in colon cancer metastasis: in vitro and in vivo evidence. Mol Carcinog 53(Suppl 1):E85\u201391","journal-title":"Mol Carcinog"},{"issue":"1","key":"2755_CR38","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-025-03793-3","volume":"23","author":"J Liu","year":"2025","unstructured":"Liu J, Li H, Lin X et al (2025) Deciphering the heterogeneity of epithelial cells in pancreatic ductal adenocarcinoma: implications for metastasis and immune evasion. World J Surg Oncol 23(1):144","journal-title":"World J Surg Oncol"},{"issue":"10","key":"2755_CR39","doi-asserted-by":"publisher","first-page":"10065","DOI":"10.1007\/s11033-022-07590-z","volume":"49","author":"I Akrida","year":"2022","unstructured":"Akrida I, Bravou V, Papadaki H (2022) The deadly cross-talk between Hippo pathway and epithelial-mesenchymal transition (EMT) in cancer. Mol Biol Rep 49(10):10065\u201310076","journal-title":"Mol Biol Rep"},{"issue":"6","key":"2755_CR40","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.4161\/cc.11.6.19453","volume":"11","author":"J Avruch","year":"2012","unstructured":"Avruch J, Zhou D, Bardeesy N (2012) YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle 11(6):1090\u20131096","journal-title":"Cell Cycle"},{"key":"2755_CR41","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.semcancer.2021.07.006","volume":"85","author":"FL Li","year":"2022","unstructured":"Li FL, Guan KL (2022) The two sides of Hippo pathway in cancer. Semin Cancer Biol 85:33\u201342. https:\/\/doi.org\/10.1016\/j.semcancer.2021.07.006","journal-title":"Semin Cancer Biol"},{"issue":"1","key":"2755_CR42","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1007\/s11033-024-09868-w","volume":"51","author":"S Park","year":"2024","unstructured":"Park S, Kim J, Yang S, Kang SH, Kang W, Paik YH (2024) Exogenous S1P via S1P receptor 2 induces CTGF expression through Src-RhoA-ROCK-YAP pathway in hepatic stellate cells. Mol Biol Rep 51(1):950","journal-title":"Mol Biol Rep"},{"issue":"11","key":"2755_CR43","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.256503","volume":"134","author":"H Kim","year":"2021","unstructured":"Kim H, Son S, Ko Y et al (2021) YAP, CTGF and Cyr61 are overexpressed in tamoxifen-resistant breast cancer and induce transcriptional repression of ER\u03b1. J Cell Sci 134(11):jcs256503","journal-title":"J Cell Sci"},{"issue":"8","key":"2755_CR44","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1097\/CAD.0000000000001627","volume":"35","author":"ME Roy","year":"2024","unstructured":"Roy ME, Veilleux C, Paquin A et al (2024) Transcriptional regulation of CYR61 and CTGF by LM98: a synthetic YAP-TEAD inhibitor that targets in-vitro vasculogenic mimicry in glioblastoma cells. Anticancer Drugs 35(8):709\u2013719","journal-title":"Anticancer Drugs"},{"issue":"19","key":"2755_CR45","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1007\/s00018-011-0778-3","volume":"68","author":"LF Lau","year":"2011","unstructured":"Lau LF (2011) CCN1\/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68(19):3149\u201363. https:\/\/doi.org\/10.1007\/s00018-011-0778-3","journal-title":"Cell Mol Life Sci"},{"key":"2755_CR46","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-21-0256","author":"CY Kuo","year":"2021","unstructured":"Kuo CY, Chang YC, Chien MN et al (2021) SREBP1 promotes invasive phenotypes by upregulating CYR61\/CTGF via the Hippo-YAP pathway. Endocr Relat Cancer. https:\/\/doi.org\/10.1530\/ERC-21-0256","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"2755_CR47","doi-asserted-by":"publisher","first-page":"557","DOI":"10.33549\/physiolres.935102","volume":"72","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Fu M, Wang H et al (2023) Advances in the construction and application of thyroid organoids. Physiol Res 72(5):557\u2013564","journal-title":"Physiol Res"},{"key":"2755_CR48","doi-asserted-by":"crossref","unstructured":"Polak R, Zhang ET, Kuo CJ (2024) Cancer organoids 2.0: modeling the complexity of the tumor immune microenvironment. Nat Rev Cancer. Jul 8.24(8):523-539.","DOI":"10.1038\/s41568-024-00706-6"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02755-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02755-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02755-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:14:46Z","timestamp":1774419286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02755-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["2755"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02755-6","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"7 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Animal Experiment Ethics Committee of the Affiliated Hospital of Southwest Medical University and the Experimental Animal Center of Southwest Medical University (approval number: 20240715-013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The use of human papillary thyroid carcinoma tissue was approved by the Clinical Trial Ethics Committee of Southwest Medical University Affiliated Hospital (approval number: KY2024465), which complies with all relevant ethical regulations. All patients provided written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors of this study declare that no competing interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":".","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}