{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:52:38Z","timestamp":1792601558389,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02770-7","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:44:44Z","timestamp":1764312284000},"page":"983-995","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of thyroid disorders on flow-mediated dilation: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"49","author":[{"given":"Andrea","family":"Zaffaroni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-3048","authenticated-orcid":false,"given":"Daniela","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotiris","family":"Louka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Piantanida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Squizzato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Tanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"6","key":"2770_CR1","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1210\/jc.2003-030398","volume":"88","author":"AR Cappola","year":"2003","unstructured":"Cappola AR, Ladenson PW (2003) Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab 88(6):2438\u20132444. https:\/\/doi.org\/10.1210\/jc.2003-030398","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2770_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1001\/jama.2019.9052","volume":"322","author":"B Biondi","year":"2019","unstructured":"Biondi B, Cappola AR, Cooper DS (2019) Subclinical hypothyroidism: a review. JAMA 322(2):153\u2013160. https:\/\/doi.org\/10.1001\/jama.2019.9052","journal-title":"JAMA"},{"issue":"12","key":"2770_CR3","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1001\/jama.2010.1361","volume":"304","author":"N Rodondi","year":"2010","unstructured":"Rodondi N, den Elzen WP, Bauer DC et al (2010) Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 304(12):1365\u20131374. https:\/\/doi.org\/10.1001\/jama.2010.1361","journal-title":"JAMA"},{"issue":"16","key":"2770_CR4","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/j.jacc.2018.02.045","volume":"71","author":"S Razvi","year":"2018","unstructured":"Razvi S, Jabbar A, Pingitore A et al (2018) Thyroid hormones and cardiovascular function and diseases. J Am Coll Cardiol 71(16):1781\u20131796. https:\/\/doi.org\/10.1016\/j.jacc.2018.02.045","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2770_CR5","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1160\/TH12-07-0496","volume":"108","author":"DJ Stuijver","year":"2012","unstructured":"Stuijver DJ, van Zaane B, Romualdi E, Brandjes DP, Gerdes VE, Squizzato A (2012) The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis. Thromb Haemost 108(6):1077\u20131088. https:\/\/doi.org\/10.1160\/TH12-07-0496","journal-title":"Thromb Haemost"},{"issue":"4","key":"2770_CR6","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","volume":"118","author":"MA Gimbrone Jr","year":"2016","unstructured":"Gimbrone MA Jr, Garc\u00eda-Carde\u00f1a G (2016) Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res 118(4):620\u2013636. https:\/\/doi.org\/10.1161\/CIRCRESAHA.115.306301","journal-title":"Circ Res"},{"issue":"10","key":"2770_CR7","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","volume":"115","author":"JE Deanfield","year":"2007","unstructured":"Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115(10):1285\u20131295. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.652859","journal-title":"Circulation"},{"issue":"30","key":"2770_CR8","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1093\/eurheartj\/ehz350","volume":"40","author":"DHJ Thijssen","year":"2019","unstructured":"Thijssen DHJ, Bruno RM, van Mil ACCM et al (2019) Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J 40(30):2534\u20132547. https:\/\/doi.org\/10.1093\/eurheartj\/ehz350","journal-title":"Eur Heart J"},{"issue":"1","key":"2770_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.amjcard.2013.08.051","volume":"113","author":"M Shechter","year":"2014","unstructured":"Shechter M, Shechter A, Koren-Morag N, Feinberg MS, Hiersch L (2014) Usefulness of brachial artery flow-mediated dilation to predict long-term cardiovascular events in subjects without heart disease. Am J Cardiol 113(1):162\u2013167. https:\/\/doi.org\/10.1016\/j.amjcard.2013.08.051","journal-title":"Am J Cardiol"},{"issue":"6","key":"2770_CR10","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s10554-010-9616-1","volume":"26","author":"Y Inaba","year":"2010","unstructured":"Inaba Y, Chen JA, Bergmann SR (2010) Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis. Int J Cardiovasc Imaging 26(6):631\u2013640. https:\/\/doi.org\/10.1007\/s10554-010-9616-1","journal-title":"Int J Cardiovasc Imaging"},{"issue":"4","key":"2770_CR11","doi-asserted-by":"publisher","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","volume":"151","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151(4):W65\u2013W94. https:\/\/doi.org\/10.7326\/0003-4819-151-4-200908180-00136","journal-title":"Ann Intern Med"},{"key":"2770_CR12","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898 Published 2019 Aug 28. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"2770_CR13","unstructured":"Risk of Bias Tools. ROBINS-I V2 tool (2025) Risk of Bias Tools. https:\/\/www.riskofbias.info\/welcome\/robins-i-v2. Published 2024. Accessed April 19"},{"issue":"10","key":"2770_CR14","doi-asserted-by":"publisher","first-page":"ED000142","DOI":"10.1002\/14651858.ED000142","volume":"10","author":"M Cumpston","year":"2019","unstructured":"Cumpston M, Li T, Page MJ et al (2019) Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev 10(10):ED000142. https:\/\/doi.org\/10.1002\/14651858.ED000142","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"2770_CR15","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1002\/jrsm.12","volume":"1","author":"M Borenstein","year":"2010","unstructured":"Borenstein M, Hedges LV, Higgins JP, Rothstein HR (2010) A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods 1(2):97\u2013111. https:\/\/doi.org\/10.1002\/jrsm.12","journal-title":"Res Synth Methods"},{"key":"2770_CR16","unstructured":"Funnel plot \u2013 an overview (2025) ScienceDirect Topics. https:\/\/www.sciencedirect.com\/topics\/medicine-and-dentistry\/funnel-plot. Accessed April 19"},{"issue":"7109","key":"2770_CR17","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634. https:\/\/doi.org\/10.1136\/bmj.315.7109.629","journal-title":"BMJ"},{"key":"2770_CR18","unstructured":"Review Manager (RevMan) (2020) [Computer program]. Version 5.4. The Cochrane Collaboration"},{"issue":"1","key":"2770_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cen.13338","volume":"87","author":"X Li","year":"2017","unstructured":"Li X, Wang Y, Guan Q, Zhao J, Gao L (2017) The lipid-lowering effect of Levothyroxine in patients with subclinical hypothyroidism: a systematic review and meta-analysis of randomized controlled trials. Clin Endocrinol (Oxf) 87(1):1\u20139. https:\/\/doi.org\/10.1111\/cen.13338","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2770_CR20","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.mcna.2012.01.012","volume":"96","author":"LH Duntas","year":"2012","unstructured":"Duntas LH, Brenta G (2012) The effect of thyroid disorders on lipid levels and metabolism. Med Clin North Am 96(2):269\u2013281. https:\/\/doi.org\/10.1016\/j.mcna.2012.01.012","journal-title":"Med Clin North Am"},{"issue":"10","key":"2770_CR21","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1007\/s40618-016-0488-7","volume":"39","author":"E Piantanida","year":"2016","unstructured":"Piantanida E, Gallo D, Veronesi G et al (2016) Masked hypertension in newly diagnosed hypothyroidism: a pilot study. J Endocrinol Invest 39(10):1131\u20131138. https:\/\/doi.org\/10.1007\/s40618-016-0488-7","journal-title":"J Endocrinol Invest"},{"issue":"2","key":"2770_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102204","volume":"49","author":"B Darouei","year":"2024","unstructured":"Darouei B, Amani-Beni R, Abhari AP, Fakhrolmobasheri M, Shafie D, Heidarpour M (2024) Systematic review and meta-analysis of levothyroxine effect on blood pressure in patients with subclinical hypothyroidism. Curr Probl Cardiol 49(2):102204. https:\/\/doi.org\/10.1016\/j.cpcardiol.2023.102204","journal-title":"Curr Probl Cardiol"},{"key":"2770_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109881","volume":"124","author":"ZM Gluvic","year":"2020","unstructured":"Gluvic ZM, Obradovic MM, Sudar-Milovanovic EM et al (2020) Regulation of nitric oxide production in hypothyroidism. Biomed Pharmacother 124:109881. https:\/\/doi.org\/10.1016\/j.biopha.2020.109881","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2770_CR24","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1038\/s41598-018-22897-3","volume":"8","author":"K Yao","year":"2018","unstructured":"Yao K, Zhao T, Zeng L et al (2018) Non-invasive markers of cardiovascular risk in patients with subclinical hypothyroidism: A systematic review and meta-analysis of 27 case control studies. Sci Rep 8(1):4579. https:\/\/doi.org\/10.1038\/s41598-018-22897-3. Published 2018 Mar 15","journal-title":"Sci Rep"},{"issue":"4","key":"2770_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/20009666.2019.1625704","volume":"9","author":"B Swaid","year":"2019","unstructured":"Swaid B, Kheiri B, Sundus S et al (2019) The effect of levothyroxine treatment in individuals with subclinical hypothyroidism on surrogate markers of atherosclerosis: a meta-analysis of randomized controlled trials. J Community Hosp Intern Med Perspect 9(4):305\u2013309. https:\/\/doi.org\/10.1080\/20009666.2019.1625704","journal-title":"J Community Hosp Intern Med Perspect"},{"issue":"4","key":"2770_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000356507","volume":"2","author":"SH Pearce","year":"2013","unstructured":"Pearce SH, Brabant G, Duntas LH et al (2013) 2013 ETA guideline: management of subclinical hypothyroidism. Eur Thyroid J 2(4):215\u2013228. https:\/\/doi.org\/10.1159\/000356507","journal-title":"Eur Thyroid J"},{"key":"2770_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.591588","volume":"11","author":"LY Sue","year":"2020","unstructured":"Sue LY, Leung AM (2020) Levothyroxine for the treatment of subclinical hypothyroidism and cardiovascular disease. Front Endocrinol (Lausanne) 11:591588. https:\/\/doi.org\/10.3389\/fendo.2020.591588","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2770_CR28","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1210\/clinem\/dgaa777","volume":"106","author":"CC Peng","year":"2021","unstructured":"Peng CC, Huang HK, Wu BB, Chang RH, Tu YK, Munir KM (2021) Association of thyroid hormone therapy with mortality in subclinical hypothyroidism: a systematic review and Meta-Analysis. J Clin Endocrinol Metab 106(1):292\u2013303. https:\/\/doi.org\/10.1210\/clinem\/dgaa777","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2770_CR29","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1210\/js.2018-00207","volume":"3","author":"V Calsolaro","year":"2018","unstructured":"Calsolaro V, Niccolai F, Pasqualetti G et al (2018) Hypothyroidism in the elderly: who should be treated and how? J Endocr Soc 3(1):146\u2013158. https:\/\/doi.org\/10.1210\/js.2018-00207","journal-title":"J Endocr Soc"},{"issue":"3","key":"2770_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1159\/000438750","volume":"4","author":"B Biondi","year":"2015","unstructured":"Biondi B, Bartalena L, Cooper DS, Heged\u00fcs L, Laurberg P, Kahaly GJ (2015) The 2015 European thyroid association guidelines on diagnosis and treatment of endogenous subclinical hyperthyroidism. Eur Thyroid J 4(3):149\u2013163. https:\/\/doi.org\/10.1159\/000438750","journal-title":"Eur Thyroid J"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02770-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02770-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02770-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:11:27Z","timestamp":1776247887000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02770-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":30,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["2770"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02770-7","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"28 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Daniela Gallo, Eliana Piantanida, and Maria Laura Tanda serve on the Editorial Board of the\n                      Journal of Endocrinological Investigation\n                      . The other authors declare no relevant financial or non\u2011financial competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}