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This study aimed to describe distributions of 11-OxyA in a healthy young adult population and explore the relation between hormonal contraceptives and 11-OxyA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study utilized cross-sectional data from the third Fit Futures Study conducted in Norway. 11-OxyA in fasting blood samples were analyzed by liquid chromatography tandem mass spectrometry technique (LC-MS\/MS). Contraceptive use was registered and categorized as combined hormonal contraceptives (CHC) or gestagen-only contraceptives.\u00a0Descriptive statistics were used to report 11-OxyA distributions. Independent t-tests and ANOVA were used to compare biomarker concentrations between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 289 males and 337 females with median age of 27 years. Males had 9\u201330% higher 11-OxyA concentrations than females (all p\u2019s\u2009&lt;\u20090.01). Among the females, 25.5% used CHC, 36.7% used gestagen-only contraceptives, and 37.8% used non-hormonal contraceptives or no contraceptives. As concentrations of 11-OxyA in gestagen-only contraceptives users were similar to non-users, these groups were combined. CHC users had 25\u201329% lower concentrations of 11KT, 11OHT, and 11KA4 than non-CHC users (all p\u2019s\u2009&lt;\u20090.001). After exclusion of CHC users, sex differences attenuated and was no longer significant for 11KT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Females had lower concentrations of 11-OxyA than males, partly explained by use of CHC, as users had significantly lower concentrations of 11-OxyA than non-CHC users, except 11OHA4. These findings suggest an additional mechanism for CHC in treatment of hyperandrogenic conditions, in which 11-OxyA are elevated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40618-025-02793-0","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:53:40Z","timestamp":1770360820000},"page":"1059-1070","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["11-oxygenated androgens in healthy young adults: Does use of hormonal contraceptives matter? 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