{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:39:10Z","timestamp":1790782750195,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2016-02363260"],"award-info":[{"award-number":["RF-2016-02363260"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-025-02804-0","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T04:53:12Z","timestamp":1767934392000},"page":"1163-1172","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery"],"prefix":"10.1007","volume":"49","author":[{"given":"Michela","family":"Consonni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fresilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kotani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Bradic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mara","family":"Scandroglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian Kah","family":"Ti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Comis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Oriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Belletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Guarracino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6181-7976","authenticated-orcid":false,"given":"Rosario","family":"Losiggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Baiardo","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Pontillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Arangino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Federici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Silvetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Labanca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Ferrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pittella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ranucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cortegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Paternoster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Bove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Longhini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Piemonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"PROTECTION Study Group Collaborators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"2804_CR1","doi-asserted-by":"publisher","unstructured":"American Diabetes Association Professional Practice Committee. 16. Diabetes Care in the Hospital: Standards of Care in Diabetes-2025. Diabetes Care (2025); 48(1 Suppl 1):S321-S334. https:\/\/doi.org\/10.2337\/DC25-S016","DOI":"10.2337\/DC25-S016"},{"issue":"9","key":"2804_CR2","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/j.amjcard.2019.07.053","volume":"124","author":"JE Brush","year":"2019","unstructured":"Brush JE, Siraj ES, Kemp CD et al (2019) Effect of diabetes mellitus on complication rates of coronary artery bypass grafting. Am J Cardiol 124(9):1389\u20131396. https:\/\/doi.org\/10.1016\/j.amjcard.2019.07.053","journal-title":"Am J Cardiol"},{"issue":"1","key":"2804_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/S41572-021-00284-Z","volume":"7","author":"JA Kellum","year":"2021","unstructured":"Kellum JA, Romagnani P, Ashuntantang G, Ronco C, Zarbock A, Anders HJ (2021) Acute kidney injury. Nat Reviews Disease Primers 7(1):52. https:\/\/doi.org\/10.1038\/S41572-021-00284-Z","journal-title":"Nat Reviews Disease Primers"},{"key":"2804_CR4","unstructured":"National Diabetes Statistics Report | Diabetes | CDC. Center for Disease Control. May 15 (2024) Accessed October 4, 2025. https:\/\/www.cdc.gov\/diabetes\/php\/data-research\/index.html"},{"issue":"10","key":"2804_CR5","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.2337\/DC17-2409","volume":"41","author":"YF Lin","year":"2018","unstructured":"Lin YF, Lin SL, Huang TM et al (2018) New-Onset diabetes after acute kidney injury requiring Dialysis. Diabetes Care 41(10):2105\u20132110. https:\/\/doi.org\/10.2337\/DC17-2409","journal-title":"Diabetes Care"},{"issue":"5","key":"2804_CR6","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1097\/ALN.0000000000005336","volume":"142","author":"M Baiardo Redaelli","year":"2025","unstructured":"Baiardo Redaelli M, Monaco F, Bradic N et al (2025) Amino acid infusion for kidney protection in cardiac surgery patients with chronic kidney disease: A secondary analysis of the PROTECTION trial. Anesthesiology 142(5):818\u2013828. https:\/\/doi.org\/10.1097\/ALN.0000000000005336","journal-title":"Anesthesiology"},{"issue":"8","key":"2804_CR7","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1056\/NEJMOA2403769","volume":"391","author":"G Landoni","year":"2024","unstructured":"Landoni G, Monaco F, Ti LK et al (2024) A randomized trial of intravenous amino acids for kidney protection. N Engl J Med 391(8):687\u2013698. https:\/\/doi.org\/10.1056\/NEJMOA2403769","journal-title":"N Engl J Med"},{"issue":"2","key":"2804_CR8","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.athoracsur.2024.11.020","volume":"120","author":"R Losiggio","year":"2025","unstructured":"Losiggio R, Baiardo Redaelli M, Landoni G, Bellomo R (2025) Intravenous Amino-acid infusion to prevent acute kidney injury after cardiac surgery: A review of the evidence. Ann Thorac Surg 120(2):256\u2013266. https:\/\/doi.org\/10.1016\/j.athoracsur.2024.11.020","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"2804_CR9","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.athoracsur.2025.03.019","volume":"120","author":"R Losiggio","year":"2025","unstructured":"Losiggio R, Baiardo Redaelli M, Landoni G, Bellomo R (2025) Amino acid infusion and renal protection: beyond hemodynamic optimization in cardiac surgery. Ann Thorac Surg 120(3):614\u2013615. https:\/\/doi.org\/10.1016\/j.athoracsur.2025.03.019","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"2804_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.22514\/sv.2024.079","volume":"20","author":"R Losiggio","year":"2024","unstructured":"Losiggio R, Baiardo Redaelli M, Pruna A, Landoni G, Bellomo R (2024) The renal effects of amino acids infusion. Signa Vitae 20(7):1\u20134. https:\/\/doi.org\/10.22514\/sv.2024.079","journal-title":"Signa Vitae"},{"issue":"2","key":"2804_CR11","doi-asserted-by":"publisher","first-page":"sfae409","DOI":"10.1093\/CKJ\/SFAE409","volume":"18","author":"Y Kotani","year":"2024","unstructured":"Kotani Y, Baiardo Redaelli M, Pruna A et al (2024) Intravenous amino acid for kidney protection: current Understanding and future perspectives. Clin Kidney J 18(2):sfae409. https:\/\/doi.org\/10.1093\/CKJ\/SFAE409","journal-title":"Clin Kidney J"},{"issue":"6","key":"2804_CR12","doi-asserted-by":"publisher","first-page":"R690","DOI":"10.1152\/AJPREGU.00237.2020","volume":"319","author":"AH Jufar","year":"2020","unstructured":"Jufar AH, Lankadeva YR, May CN, Cochrane AD, Bellomo R, Evans RG (2020) Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond. Am J Physiol Regul Integr Comp Physiol 319(6):R690\u2013R702. https:\/\/doi.org\/10.1152\/AJPREGU.00237.2020","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"2804_CR13","doi-asserted-by":"publisher","first-page":"ezaf035","DOI":"10.1093\/EJCTS\/EZAF035","volume":"67","author":"A Belletti","year":"2025","unstructured":"Belletti A, Pisano A, Scandroglio AM et al (2025) Intravenous amino acids for renal protection in patients receiving temporary mechanical circulatory support: a secondary subgroup analysis of the PROTECTION study. Eur J Cardiothorac Surg 67(2):ezaf035. https:\/\/doi.org\/10.1093\/EJCTS\/EZAF035","journal-title":"Eur J Cardiothorac Surg"},{"issue":"9","key":"2804_CR14","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1053\/j.jvca.2025.05.050","volume":"39","author":"D Pontillo","year":"2025","unstructured":"Pontillo D, Rong LQ, Pruna A et al (2025) Impact of cardiopulmonary bypass duration on the renal effects of amino acids infusion in cardiac surgery patients. J Cardiothorac Vasc Anesth 39(9):2296\u20132306. https:\/\/doi.org\/10.1053\/j.jvca.2025.05.050","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"2804_CR15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/S13098-022-00971-1","volume":"14","author":"M Mo","year":"2022","unstructured":"Mo M, Huang Z, Gao T et al (2022) Development and validation of short-term renal prognosis prediction model in diabetic patients with acute kidney injury. Diabetol Metab Syndr 14(1):197. https:\/\/doi.org\/10.1186\/S13098-022-00971-1","journal-title":"Diabetol Metab Syndr"},{"key":"2804_CR16","doi-asserted-by":"publisher","first-page":"106898","DOI":"10.1016\/j.cct.2022.106898","volume":"121","author":"G Landoni","year":"2022","unstructured":"Landoni G, Brambillasca C, Baiardo Redaelli M et al (2022) Intravenous amino acid therapy for kidney protection in cardiac surgery a protocol for a multi-Centre randomized blinded placebo controlled clinical trial. The PROTECTION trial. Contemp Clin Trials 121:106898. https:\/\/doi.org\/10.1016\/j.cct.2022.106898","journal-title":"Contemp Clin Trials"},{"issue":"1","key":"2804_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/CC11454","volume":"17","author":"JA Kellum","year":"2013","unstructured":"Kellum JA, Lameire N, Aspelin P et al (2013) Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care 17(1):204. https:\/\/doi.org\/10.1186\/CC11454","journal-title":"Crit Care"},{"issue":"12","key":"2804_CR18","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1053\/J.JVCA.2024.08.033","volume":"38","author":"A Pruna","year":"2024","unstructured":"Pruna A, Losiggio R, Landoni G et al (2024) Amino acid infusion for perioperative functional renal protection: A Meta-analysis. J Cardiothorac Vasc Anesth 38(12):3076\u20133085. https:\/\/doi.org\/10.1053\/J.JVCA.2024.08.033","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"3","key":"2804_CR19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.4239\/WJD.V5.I3.393","volume":"5","author":"MB Duran-Salgado","year":"2014","unstructured":"Duran-Salgado MB, Rubio-Guerra AF (2014) Diabetic nephropathy and inflammation. World J Diabetes 5(3):393\u2013398. https:\/\/doi.org\/10.4239\/WJD.V5.I3.393","journal-title":"World J Diabetes"},{"issue":"2","key":"2804_CR20","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1053\/j.ackd.2017.12.005","volume":"25","author":"SMW Yu","year":"2018","unstructured":"Yu SMW, Bonventre JV (2018) Acute kidney injury and progression of diabetic kidney disease. Adv Chronic Kidney Dis 25(2):166\u2013180. https:\/\/doi.org\/10.1053\/j.ackd.2017.12.005","journal-title":"Adv Chronic Kidney Dis"},{"issue":"6","key":"2804_CR21","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1097\/ALN.0000000000004734","volume":"139","author":"SR Cheruku","year":"2023","unstructured":"Cheruku SR, Raphael J, Neyra JA, Fox AA (2023) Acute kidney injury after cardiac surgery: Prediction, Prevention, and management. Anesthesiology 139(6):880\u2013898. https:\/\/doi.org\/10.1097\/ALN.0000000000004734","journal-title":"Anesthesiology"},{"issue":"11","key":"2804_CR22","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/NRNEPH.2017.119","volume":"13","author":"Y Wang","year":"2017","unstructured":"Wang Y, Bellomo R (2017) Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol 13(11):697\u2013711. https:\/\/doi.org\/10.1038\/NRNEPH.2017.119","journal-title":"Nat Rev Nephrol"},{"issue":"4","key":"2804_CR23","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1213\/ANE.0000000000006068","volume":"135","author":"K Peng","year":"2022","unstructured":"Peng K, McIlroy DR, Bollen BA et al (2022) Society of cardiovascular anesthesiologists clinical practice update for management of acute kidney injury associated with cardiac surgery. Anesth Analg 135(4):744\u2013756. https:\/\/doi.org\/10.1213\/ANE.0000000000006068","journal-title":"Anesth Analg"},{"issue":"6","key":"2804_CR24","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/S40620-016-0281-X","volume":"29","author":"M Moschopoulou","year":"2016","unstructured":"Moschopoulou M, Ampatzidou FC, Loutradis C et al (2016) Diabetes mellitus does not affect the incidence of acute kidney injury after cardiac surgery; a nested case-control study. J Nephrol 29(6):835\u2013845. https:\/\/doi.org\/10.1007\/S40620-016-0281-X","journal-title":"J Nephrol"},{"issue":"5","key":"2804_CR25","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.ahj.2015.08.013","volume":"170","author":"D Hertzberg","year":"2015","unstructured":"Hertzberg D, Sartipy U, Holzmann MJ (2015) Type 1 and type 2 diabetes mellitus and risk of acute kidney injury after coronary artery bypass grafting. Am Heart J 170(5):895\u2013902. https:\/\/doi.org\/10.1016\/j.ahj.2015.08.013","journal-title":"Am Heart J"},{"key":"2804_CR26","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ijcard.2019.05.064","volume":"293","author":"Y Arbel","year":"2019","unstructured":"Arbel Y, Fuster V, Baber U, Hamza TH, Siami FS, Farkouh ME (2019) Incidence, determinants and impact of acute kidney injury in patients with diabetes mellitus and multivessel disease undergoing coronary revascularization: results from the FREEDOM trial. Int J Cardiol 293:197\u2013202. https:\/\/doi.org\/10.1016\/j.ijcard.2019.05.064","journal-title":"Int J Cardiol"},{"issue":"5","key":"2804_CR27","doi-asserted-by":"publisher","first-page":"E660","DOI":"10.1532\/HSF.4885","volume":"25","author":"R Shen","year":"2022","unstructured":"Shen R, Wang Y, Zhang B, Ge J (2022) The impact of diabetes on acute kidney injury after Off-Pump coronary artery bypass grafting. Heart Surg Forum 25(5):E660\u2013E664. https:\/\/doi.org\/10.1532\/HSF.4885","journal-title":"Heart Surg Forum"},{"issue":"1","key":"2804_CR28","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/S13019-020-01312-X","volume":"15","author":"R Wang","year":"2020","unstructured":"Wang R, Zhang H, Zhu Y, Chen W, Chen X (2020) The impact of diabetes mellitus on acute kidney injury after coronary artery bypass grafting. J Cardiothorac Surg 15(1):289. https:\/\/doi.org\/10.1186\/S13019-020-01312-X","journal-title":"J Cardiothorac Surg"},{"issue":"9","key":"2804_CR29","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/CLC.22723","volume":"40","author":"GS Mina","year":"2017","unstructured":"Mina GS, Gill P, Soliman D, Reddy P, Dominic P (2017) Diabetes mellitus is associated with increased acute kidney injury and 1-year mortality after transcatheter aortic valve replacement: A meta-analysis. Clin Cardiol 40(9):726\u2013731. https:\/\/doi.org\/10.1002\/CLC.22723","journal-title":"Clin Cardiol"},{"issue":"1","key":"2804_CR30","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3390\/NU15010184","volume":"15","author":"L Liu","year":"2022","unstructured":"Liu L, Xu J, Zhang Z et al (2022) Metabolic homeostasis of amino acids and diabetic kidney disease. Nutrients 15(1):184. https:\/\/doi.org\/10.3390\/NU15010184","journal-title":"Nutrients"},{"issue":"Suppl 1","key":"2804_CR31","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.2337\/DC22-SINT","volume":"45","author":"American Diabetes Association","year":"2022","unstructured":"American Diabetes Association (2022) Introduction: standards of medical care in Diabetes-2022. Diabetes Care 45(Suppl 1):S1\u2013S2. https:\/\/doi.org\/10.2337\/DC22-SINT","journal-title":"Diabetes Care"},{"issue":"6","key":"2804_CR32","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","volume":"23","author":"A Agus","year":"2018","unstructured":"Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of Tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716\u2013724. https:\/\/doi.org\/10.1016\/j.chom.2018.05.003","journal-title":"Cell Host Microbe"},{"issue":"1","key":"2804_CR33","doi-asserted-by":"publisher","first-page":"3294","DOI":"10.1038\/S41467-018-05470-4","volume":"9","author":"HM Roager","year":"2018","unstructured":"Roager HM, Licht TR (2018) Microbial Tryptophan catabolites in health and disease. Nat Commun 9(1):3294. https:\/\/doi.org\/10.1038\/S41467-018-05470-4","journal-title":"Nat Commun"},{"issue":"11","key":"2804_CR34","doi-asserted-by":"publisher","first-page":"e113366","DOI":"10.1371\/JOURNAL.PONE.0113366","volume":"9","author":"D Samocha-Bonet","year":"2014","unstructured":"Samocha-Bonet D, Chisholm DJ, Gribble FM et al (2014) Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PLoS ONE 9(11):e113366. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0113366","journal-title":"PLoS ONE"},{"key":"2804_CR35","doi-asserted-by":"publisher","unstructured":"Carrandi A, Faggery DM, Losiggio R et al (2025) Postoperative cost-effectiveness of prophylactic amino acid therapy for renal protection: A modelled economic evaluation. J Cardiothorac Vasc Anesth. Published online August 2025. https:\/\/doi.org\/10.1053\/j.jvca.2025.08.042","DOI":"10.1053\/j.jvca.2025.08.042"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02804-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-025-02804-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-025-02804-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T10:11:52Z","timestamp":1776247912000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-025-02804-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["2804"],"URL":"https:\/\/doi.org\/10.1007\/s40618-025-02804-0","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]},"assertion":[{"value":"21 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}