{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:01:57Z","timestamp":1779955317638,"version":"3.53.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["DFL20220505"],"award-info":[{"award-number":["DFL20220505"]}]},{"name":"Laboratory for Clinical Medicine, Capital Medical University","award":["SYJCLCSYS003"],"award-info":[{"award-number":["SYJCLCSYS003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-026-02816-4","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T05:11:05Z","timestamp":1769490665000},"page":"1285-1299","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of serum CCL18 for recurrence and invasiveness in pituitary neuroendocrine tumors"],"prefix":"10.1007","volume":"49","author":[{"given":"Yang","family":"Jiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoge","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunqing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4911-5784","authenticated-orcid":false,"given":"Guojun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"1","key":"2816_CR1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","volume":"33","author":"SL Asa","year":"2022","unstructured":"Asa SL, Mete O, Perry A, Osamura RY (2022) Overview of the 2022 WHO classification of pituitary tumors. Endocr Pathol 33(1):6\u201326. https:\/\/doi.org\/10.1007\/s12022-022-09703-7","journal-title":"Endocr Pathol"},{"key":"2816_CR2","doi-asserted-by":"publisher","unstructured":"Asioli S, Guaraldi F, Zoli M, Mazzatenta D, Villa C (2024) How to standardize the diagnostic approach to pituitary neuroendocrine tumors. Minerva Endocrinol 49(3). https:\/\/doi.org\/10.23736\/s2724-6507.24.04079-x","DOI":"10.23736\/s2724-6507.24.04079-x"},{"key":"2816_CR3","doi-asserted-by":"publisher","unstructured":"Villa C, Baussart B, Assi\u00e9 G, Raverot G, Roncaroli F (2023) The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal. Endocrine-related Cancer 30(8). https:\/\/doi.org\/10.1530\/erc-23-0021","DOI":"10.1530\/erc-23-0021"},{"issue":"1","key":"2816_CR4","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00401-013-1084-y","volume":"126","author":"J Trouillas","year":"2013","unstructured":"Trouillas J, Roy P, Sturm N et al (2013) A new prognostic clinicopathological classification of pituitary adenomas: a multicentric case\u2013control study of 410 patients with 8 years post-operative follow-up. Acta Neuropathol 126(1):123\u2013135. https:\/\/doi.org\/10.1007\/s00401-013-1084-y","journal-title":"Acta Neuropathol"},{"key":"2816_CR5","doi-asserted-by":"publisher","unstructured":"Nishioka H (2023) Aggressive pituitary tumors (PitNETs). Endocr J.70(3):241-248. } https:\/\/doi.org\/10.1507\/endocrj.EJ23-0007}","DOI":"10.1507\/endocrj.EJ23-0007"},{"key":"2816_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14174093","author":"T Feola","year":"2022","unstructured":"Feola T, Carbonara F, Verrico M et al (2022) Immunotherapy for aggressive and metastatic pituitary neuroendocrine tumors (PitNETs): state-of-the art. Cancers. https:\/\/doi.org\/10.3390\/cancers14174093","journal-title":"Cancers"},{"issue":"11","key":"2816_CR7","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1007\/s40618-023-02080-w","volume":"46","author":"CE Jimenez-Canizales","year":"2023","unstructured":"Jimenez-Canizales CE, Rojas W, Alonso D et al (2023) Clinical presentation and recurrence of pituitary neuroendocrine tumors: results from a single referral center in Colombia. J Endocrinol Invest 46(11):2275\u20132286. https:\/\/doi.org\/10.1007\/s40618-023-02080-w","journal-title":"J Endocrinol Invest"},{"key":"2816_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-023-02234-7","author":"A Taguchi","year":"2023","unstructured":"Taguchi A, Kinoshita Y, Amatya VJ et al (2023) Differences in invasiveness and recurrence rate among nonfunctioning pituitary neuroendocrine tumors depending on tumor subtype. Neurosurg Rev. https:\/\/doi.org\/10.1007\/s10143-023-02234-7","journal-title":"Neurosurg Rev"},{"key":"2816_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-025-01505-4","author":"S Chiloiro","year":"2025","unstructured":"Chiloiro S, Mattogno PP, Angelini F et al (2025) Cytokines and chemokines modulate the growth of pituitary adenoma\/neuroendocrine tumors: preliminary results of a monocenter prospective pilot study. Pituitary. https:\/\/doi.org\/10.1007\/s11102-025-01505-4","journal-title":"Pituitary"},{"issue":"2","key":"2816_CR10","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s12022-018-9521-z","volume":"29","author":"SL Asa","year":"2018","unstructured":"Asa SL, Mete O (2018) Immunohistochemical biomarkers in pituitary pathology. Endocr Pathol 29(2):130\u2013136. https:\/\/doi.org\/10.1007\/s12022-018-9521-z","journal-title":"Endocr Pathol"},{"issue":"10","key":"2816_CR11","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41574-024-01005-8","volume":"20","author":"H Butz","year":"2024","unstructured":"Butz H, Pat\u00f3cs A, Igaz P (2024) Circulating non-coding RNA biomarkers of endocrine tumours. Nat Reviews Endocrinol 20(10):600\u2013614. https:\/\/doi.org\/10.1038\/s41574-024-01005-8","journal-title":"Nat Reviews Endocrinol"},{"issue":"5","key":"2816_CR12","doi-asserted-by":"publisher","first-page":"688","DOI":"10.2967\/jnumed.123.266853","volume":"65","author":"IJ Pruis","year":"2024","unstructured":"Pruis IJ, Verburg FA, Balvers RK et al (2024) [18F]FET PET\/MRI: an accurate technique for detection of small functional pituitary tumors. J Nucl Med 65(5):688\u2013692. https:\/\/doi.org\/10.2967\/jnumed.123.266853","journal-title":"J Nucl Med"},{"key":"2816_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1426781","author":"B Zheng","year":"2024","unstructured":"Zheng B, Zhao Z, Zheng P et al (2024) The current state of MRI-based radiomics in pituitary adenoma: promising but challenging. Front Endocrinol. https:\/\/doi.org\/10.3389\/fendo.2024.1426781","journal-title":"Front Endocrinol"},{"issue":"5","key":"2816_CR14","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1002\/jmri.27930","volume":"55","author":"T Wan","year":"2021","unstructured":"Wan T, Wu C, Meng M et al (2021) Radiomic features on multiparametric MRI for preoperative evaluation of pituitary macroadenomas consistency: preliminary findings. J Magn Reson Imaging 55(5):1491\u20131503. https:\/\/doi.org\/10.1002\/jmri.27930","journal-title":"J Magn Reson Imaging"},{"key":"2816_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217955","author":"J Korbecki","year":"2020","unstructured":"Korbecki J, Olbromski M, Dzi\u0119giel P (2020) CCL18 in the progression of cancer. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21217955","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2816_CR16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/s41388-022-02540-2","volume":"42","author":"W Zeng","year":"2022","unstructured":"Zeng W, Xiong L, Wu W et al (2022) CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype. Oncogene 42(3):224\u2013237. https:\/\/doi.org\/10.1038\/s41388-022-02540-2","journal-title":"Oncogene"},{"issue":"4","key":"2816_CR17","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1111\/jcmm.14168","volume":"23","author":"Y Qin","year":"2019","unstructured":"Qin Y, Wang J, Zhu G et al (2019) CCL18 promotes the metastasis of squamous cell carcinoma of the head and neck through MTDH-NF\u2010\u03baB signalling pathway. J Cell Mol Med 23(4):2689\u20132701. https:\/\/doi.org\/10.1111\/jcmm.14168","journal-title":"J Cell Mol Med"},{"issue":"5","key":"2816_CR18","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.ccr.2014.03.021","volume":"25","author":"S Su","year":"2014","unstructured":"Su S, Liu Q, Chen J et al (2014) A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell 25(5):605\u2013620. https:\/\/doi.org\/10.1016\/j.ccr.2014.03.021","journal-title":"Cancer Cell"},{"key":"2816_CR19","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9791","author":"X Liu","year":"2018","unstructured":"Liu X, Xu X, Deng W et al (2018) CCL18 enhances migration, invasion and EMT by binding CCR8 in bladder cancer cells. Mol Med Rep. https:\/\/doi.org\/10.3892\/mmr.2018.9791","journal-title":"Mol Med Rep"},{"key":"2816_CR20","doi-asserted-by":"publisher","unstructured":"Zhao C, Zheng S, Yan Z, Deng Z, Wang R, Zhang B (2019) CCL18 promotes the invasion and metastasis of breast cancer through Annexin A2. Oncology Reports 43:571-580. https:\/\/doi.org\/10.3892\/or.2019.7426","DOI":"10.3892\/or.2019.7426"},{"key":"2816_CR21","doi-asserted-by":"publisher","unstructured":"Micko, A. S. G., W\u00f6hrer, A., Wolfsberger, S et al (2015) Invasion of the cavernous sinus space in pituitary adenomas: endoscopic verification and its correlation with an MRI-based classification. J Neurosurg122(4),803-811. https:\/\/doi.org\/10.3171\/2014.12.JNS141083","DOI":"10.3171\/2014.12.JNS141083"},{"issue":"3","key":"2816_CR22","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s12020-017-1447-6","volume":"58","author":"F Langlois","year":"2017","unstructured":"Langlois F, Lim DST, Varlamov E et al (2017) Clinical profile of silent growth hormone pituitary adenomas; higher recurrence rate compared to silent gonadotroph pituitary tumors, a large single center experience. Endocrine 58(3):528\u2013534. https:\/\/doi.org\/10.1007\/s12020-017-1447-6","journal-title":"Endocrine"},{"issue":"4","key":"2816_CR23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.ccr.2011.02.006","volume":"19","author":"J Chen","year":"2011","unstructured":"Chen J, Yao Y, Gong C et al (2011) CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3. Cancer Cell 19(4):541\u2013555. https:\/\/doi.org\/10.1016\/j.ccr.2011.02.006","journal-title":"Cancer Cell"},{"issue":"3","key":"2816_CR24","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.jhep.2015.11.020","volume":"64","author":"VK Verma","year":"2016","unstructured":"Verma VK, Li H, Wang R et al (2016) Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles. J Hepatol 64(3):651\u2013660. https:\/\/doi.org\/10.1016\/j.jhep.2015.11.020","journal-title":"J Hepatol"},{"key":"2816_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1292016","author":"J Sun","year":"2023","unstructured":"Sun J, Zhao P, Shi Y, Li Y (2023) Recent insight into the role of macrophage in alcohol-associated liver disease: a mini-review. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2023.1292016","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"2816_CR26","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s10585-019-09965-2","volume":"36","author":"Y Liu","year":"2019","unstructured":"Liu Y, Zheng H, Li Q et al (2019) Discovery of CCL18 antagonist blocking breast cancer metastasis. Clin Exp Metastasis 36(3):243\u2013255. https:\/\/doi.org\/10.1007\/s10585-019-09965-2","journal-title":"Clin Exp Metastasis"},{"issue":"6","key":"2816_CR27","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1007\/s10238-022-00906-0","volume":"23","author":"H-q Luo","year":"2022","unstructured":"Luo H-q, Huang Y-m, Li J et al (2022) DHA inhibits invasion and metastasis in NSCLC cells by interfering with CCL18\/STAT3 signaling pathway. Clin Exp Med 23(6):2311\u20132320. https:\/\/doi.org\/10.1007\/s10238-022-00906-0","journal-title":"Clin Exp Med"},{"key":"2816_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/cells14120909","author":"Y Adib","year":"2025","unstructured":"Adib Y, Serror K, Pinzon JA et al (2025) In Vitro Modulation of Macrophage Inflammatory and Pro-Repair Properties Essential for Wound Healing by Calcium and Calcium-Alginate Dressings. Cells. https:\/\/doi.org\/10.3390\/cells14120909","journal-title":"Cells"},{"key":"2816_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00456","author":"AC Little","year":"2019","unstructured":"Little AC, Pathanjeli P, Wu Z et al (2019) IL-4\/IL-13 stimulated macrophages enhance breast cancer invasion via Rho-GTPase regulation of synergistic VEGF\/CCL-18 signaling. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2019.00456","journal-title":"Front Oncol"},{"key":"2816_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112047","author":"S Yang","year":"2024","unstructured":"Yang S, Luo M, Yang S et al (2024) Relationship between chemokine\/chemokine receptor and glioma prognosis and outcomes: systematic review and meta-analysis. Int Immunopharmacol. https:\/\/doi.org\/10.1016\/j.intimp.2024.112047","journal-title":"Int Immunopharmacol"},{"key":"2816_CR31","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.2147\/jir.S357787","volume":"15","author":"W Gao","year":"2022","unstructured":"Gao W, Li Y, Zhang T et al (2022) Systematic analysis of chemokines reveals CCL18 is a prognostic biomarker in glioblastoma. J Inflamm Res 15:2731\u20132743. https:\/\/doi.org\/10.2147\/jir.S357787","journal-title":"J Inflamm Res"},{"issue":"1","key":"2816_CR32","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3322\/caac.21871","volume":"75","author":"RL Siegel","year":"2025","unstructured":"Siegel RL, Kratzer TB, Giaquinto AN, Sung H, Jemal A (2025) Cancer statistics, 2025. CA Cancer J Clin 75(1):10\u201345. https:\/\/doi.org\/10.3322\/caac.21871","journal-title":"CA Cancer J Clin"},{"key":"2816_CR33","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.msard.2018.07.009","volume":"25","author":"N Ziliotto","year":"2018","unstructured":"Ziliotto N, Bernardi F, Jakimovski D et al (2018) Increased CCL18 plasma levels are associated with neurodegenerative MRI outcomes in multiple sclerosis patients. Mult Scler Relat Disord 25:37\u201342. https:\/\/doi.org\/10.1016\/j.msard.2018.07.009","journal-title":"Mult Scler Relat Disord"},{"key":"2816_CR34","doi-asserted-by":"publisher","first-page":"e417","DOI":"10.1016\/j.wneu.2021.10.117","volume":"157","author":"J Mao","year":"2022","unstructured":"Mao J, Huang H, Liu F et al (2022) Activation of age-related nuclear factor-\u03baB signaling pathway leads to chronic inflammation and pituitary fibrosis. World Neurosurg 157:e417\u2013e423. https:\/\/doi.org\/10.1016\/j.wneu.2021.10.117","journal-title":"World Neurosurg"},{"key":"2816_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113532","author":"B Li","year":"2024","unstructured":"Li B, Cai Z, Zhang Y et al (2024) Biomarkers associated with papillary thyroid carcinoma and Hashimoto\u2019s thyroiditis: bioinformatic analysis and experimental validation. Int Immunopharmacol. https:\/\/doi.org\/10.1016\/j.intimp.2024.113532","journal-title":"Int Immunopharmacol"},{"key":"2816_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01079-x","author":"M Yang","year":"2022","unstructured":"Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W (2022) Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. Genome Med. https:\/\/doi.org\/10.1186\/s13073-022-01079-x","journal-title":"Genome Med"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-02816-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-026-02816-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-02816-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T07:04:40Z","timestamp":1779951880000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-026-02816-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["2816"],"URL":"https:\/\/doi.org\/10.1007\/s40618-026-02816-4","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"12 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All serum samples were obtained from the Beijing Tiantan Hospital, Capital Medical University, China. This study included patients who remained after their formal examination in the hospital, and no secondary trauma was caused. Personal privacy of each patient has been protected, and no identifying information is included in the article. This study was approved by the Medical Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (KY2022-172-03).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}