{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:27:54Z","timestamp":1787081274677,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"DOI":"10.1007\/s40618-026-02886-4","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:29:27Z","timestamp":1776238167000},"page":"2065-2073","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atherogenic index of plasma predicts gestational diabetes mellitus and correlates with disease severity and adverse pregnancy outcomes"],"prefix":"10.1007","volume":"49","author":[{"given":"Sha","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"2886_CR1","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12933-024-02341-9","volume":"23","author":"J Zhang","year":"2024","unstructured":"Zhang J, Suo YY, Wang L, Liu D, Jia Y, Fu YJ et al (2024) Association between atherogenic index of plasma and gestational diabetes mellitus: a prospective cohort study based on the Korean population. Cardiovasc Diabetol 23:237. https:\/\/doi.org\/10.1186\/s12933-024-02341-9","journal-title":"Cardiovasc Diabetol"},{"key":"2886_CR2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12944-021-01565-y","volume":"20","author":"Y Li","year":"2021","unstructured":"Li Y, Wang XQ, Jiang FJ, Chen WQ, Li J, Chen XT (2021) Serum lipid levels in relation to clinical outcomes in pregnant women with gestational diabetes mellitus: an observational cohort study. Lipids Health Dis 20:125. https:\/\/doi.org\/10.1186\/s12944-021-01565-y","journal-title":"Lipids Health Dis"},{"key":"2886_CR3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s13098-025-01914-2","volume":"17","author":"YW Sheng","year":"2025","unstructured":"Sheng YW, Cun DJ, Chen YQ, Hu XY, Zhang XQ, Sun XF et al (2025) Association between atherogenic index of plasma and type 2 diabetes in women with a history of gestational diabetes mellitus: a cross-sectional study. Diabetol Metab Syndr 17:344. https:\/\/doi.org\/10.1186\/s13098-025-01914-2","journal-title":"Diabetol Metab Syndr"},{"key":"2886_CR4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s13098-021-00694-9","volume":"13","author":"X Liang","year":"2021","unstructured":"Liang X, Zheng W, Liu C, Zhang LR, Zhang L, Tian ZH et al (2021) Clinical characteristics, gestational weight gain and pregnancy outcomes in women with a history of gestational diabetes mellitus. Diabetol Metab Syndr 13:73. https:\/\/doi.org\/10.1186\/s13098-021-00694-9","journal-title":"Diabetol Metab Syndr"},{"key":"2886_CR5","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1111\/jog.14629","volume":"47","author":"P Gunasegaran","year":"2020","unstructured":"Gunasegaran P, Tahmina S, Daniel M, Nanda SK (2020) Role of vitamin D-calcium supplementation on metabolic profile and oxidative stress in gestational diabetes mellitus: A randomized controlled trial. J Obstet Gynaecol Res 47:1016\u20131022. https:\/\/doi.org\/10.1111\/jog.14629","journal-title":"J Obstet Gynaecol Res"},{"key":"2886_CR6","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s12020-021-02933-5","volume":"75","author":"Y Zheng","year":"2021","unstructured":"Zheng Y, Hu Q, wu J (2021) Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation\/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity. Endocrine 75:781\u2013793. https:\/\/doi.org\/10.1007\/s12020-021-02933-5","journal-title":"Endocrine"},{"key":"2886_CR7","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.2147\/Dmso.S454826","volume":"17","author":"N Ma","year":"2024","unstructured":"Ma N, Bai LW, Lu Q (2024) First-Trimester Triglyceride-Glucose Index and Triglyceride\/High-Density Lipoprotein Cholesterol are Predictors of Gestational Diabetes Mellitus Among the Four Surrogate Biomarkers of Insulin Resistance. Diabetes Metabolic Syndrome Obes 17:1575\u20131583. https:\/\/doi.org\/10.2147\/Dmso.S454826","journal-title":"Diabetes Metabolic Syndrome Obes"},{"key":"2886_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cca.2012.12.004","volume":"418","author":"ICR dos Santos-Weiss","year":"2013","unstructured":"dos Santos-Weiss ICR, R\u00e9a RR, Fadel-Picheth CMT, Rego FGM, Pedrosa FO, Gillery P et al (2013) The plasma logarithm of the triglyceride\/HDL-cholesterol ratio is a predictor of low risk gestational diabetes in early pregnancy. Clin Chim Acta 418:1\u20134. https:\/\/doi.org\/10.1016\/j.cca.2012.12.004","journal-title":"Clin Chim Acta"},{"key":"2886_CR9","doi-asserted-by":"publisher","first-page":"147916412513802","DOI":"10.1177\/14791641251380212","volume":"22","author":"YS Liao","year":"2025","unstructured":"Liao YS, Chen LH, Huang JS, Liu HQ, Li ZH, Yan J et al (2025) Combined effect of body mass index and atherogenic index of plasma on risk of stroke among individuals with abnormal glucose metabolism: Evidence from the China health and retirement longitudinal study. Diab Vasc Dis Res 22:14791641251380212. https:\/\/doi.org\/10.1177\/14791641251380212","journal-title":"Diab Vasc Dis Res"},{"key":"2886_CR10","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s40618-025-02630-4","volume":"48","author":"LR Zhang","year":"2025","unstructured":"Zhang LR, Yan X, Zheng W, Yuan XX, Yang RH, Huang JH et al (2025) Assessment of first-trimester insulin resistance indices for gestational diabetes mellitus: a prospective cohort study. J Endocrinol Invest 48:2167\u20132176. https:\/\/doi.org\/10.1007\/s40618-025-02630-4","journal-title":"J Endocrinol Invest"},{"key":"2886_CR11","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12933-023-01886-5","volume":"22","author":"B Yin","year":"2023","unstructured":"Yin B, Wu Z, Xia Y, Xiao S, Chen L, Li Y (2023) Non-linear association of atherogenic index of plasma with insulin resistance and type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol 22:157. https:\/\/doi.org\/10.1186\/s12933-023-01886-5","journal-title":"Cardiovasc Diabetol"},{"key":"2886_CR12","doi-asserted-by":"publisher","first-page":"e70118","DOI":"10.1111\/1753-0407.70118","volume":"17","author":"JY Guo","year":"2025","unstructured":"Guo JY, Yan DD, Chen W, Wang SN, Zheng YW, Zhang WT et al (2025) Non-Traditional Lipid Parameters and Risk of Adverse Pregnancy Outcomes in Gestational Diabetes Mellitus: Mediation by Maternal Metabolites. J Diabetes 17:e70118. https:\/\/doi.org\/10.1111\/1753-0407.70118","journal-title":"J Diabetes"},{"key":"2886_CR13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5507\/bp.2021.009","volume":"165","author":"L Cibickova","year":"2021","unstructured":"Cibickova L, Schovanek J, Karasek D (2021) Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review. Biomedical Papers-Olomouc 165:8\u201312. https:\/\/doi.org\/10.5507\/bp.2021.009","journal-title":"Biomedical Papers-Olomouc"},{"key":"2886_CR14","doi-asserted-by":"publisher","first-page":"1146574","DOI":"10.3389\/fendo.2023.1146574","volume":"14","author":"F Visiedo","year":"2023","unstructured":"Visiedo F, V\u00e1zquez-Fonseca L, Abalos-Mart\u00ednez J, Broull\u00f3n-Molanes JR, Quintero-Prado R, Mateos RM et al (2023) Maternal elevated inflammation impairs placental fatty acids \u03b2-oxidation in women with gestational diabetes mellitus. Front Endocrinol (Lausanne) 14:1146574. https:\/\/doi.org\/10.3389\/fendo.2023.1146574","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2886_CR15","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ejogrb.2019.05.016","volume":"238","author":"B Manoharan","year":"2019","unstructured":"Manoharan B, Bobby Z, Dorairajan G, Jacob SE, Gladwin V, Vinayagam V et al (2019) Increased placental expressions of nuclear factor erythroid 2\u2013related factor 2 and antioxidant enzymes in gestational diabetes: Protective mechanisms against the placental oxidative stress? Eur J Obstet Gynecol Reproductive Biology 238:78\u201385. https:\/\/doi.org\/10.1016\/j.ejogrb.2019.05.016","journal-title":"Eur J Obstet Gynecol Reproductive Biology"},{"key":"2886_CR16","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/978-3-031-63657-8_14","volume":"1460","author":"D Yazici","year":"2024","unstructured":"Yazici D, Demir SC, Sezer H (2024) Insulin Resistance, Obesity, and Lipotoxicity. Adv Exp Med Biol 1460:391\u2013430. https:\/\/doi.org\/10.1007\/978-3-031-63657-8_14","journal-title":"Adv Exp Med Biol"},{"key":"2886_CR17","doi-asserted-by":"publisher","first-page":"165525","DOI":"10.1016\/j.bbadis.2019.08.001","volume":"1865","author":"T Plotz","year":"2019","unstructured":"Plotz T, von Hanstein AS, Kr\u00fcmmel B, Laporte A, Mehmeti I, Lenzen S (2019) Structure-toxicity relationships of saturated and unsaturated free fatty acids for elucidating the lipotoxic effects in human EndoC-\u03b2H1 beta-cells. Biochim Et Biophys Acta-Molecular Basis Disease 1865:165525. https:\/\/doi.org\/10.1016\/j.bbadis.2019.08.001","journal-title":"Biochim Et Biophys Acta-Molecular Basis Disease"},{"key":"2886_CR18","doi-asserted-by":"publisher","unstructured":"Sebastiani G, Guarino E, Grieco GE, Formichi C, Poggi CD, Ceccarelli E et al (2017) circulating microrna (mirna) expression Profiling in Plasma of Patients with gestational Diabetes Mellitus reveals Upregulation of mirna mir-330-3p. Front Endocrinol (Lausanne) 8345. https:\/\/doi.org\/10.3389\/fendo.2017.00345","DOI":"10.3389\/fendo.2017.00345"},{"key":"2886_CR19","doi-asserted-by":"publisher","first-page":"301","DOI":"10.11604\/pamj.2017.28.301.10773","volume":"28","author":"E Belinga","year":"2017","unstructured":"Belinga E, Foumane P, Dohbit SJ, Ngo Um EM, Kinyeck DK, Mboudou ET (2017) Pronostic des r\u00e9f\u00e9rences obst\u00e9tricales \u00e0 l\u2019H\u00f4pital Gyn\u00e9co-Obst\u00e9trique et P\u00e9diatrique de Yaound\u00e9 (HGOPY). Pan Afr Med J 28:301. https:\/\/doi.org\/10.11604\/pamj.2017.28.301.10773","journal-title":"Pan Afr Med J"},{"key":"2886_CR20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.4103\/njcp.njcp_633_23","volume":"27","author":"PU Agu","year":"2024","unstructured":"Agu PU, Egbugara MN, Ogboi JS, Ajah LO, Nwagha UI, Ugwu EO et al (2024) Atherogenic Index, Cardiovascular Risk Ratio, and Atherogenic Coefficient as Risk Factors for Cardiovascular Disease in Pre-eclampsia in Southeast Nigeria: A Cross-Sectional Study. Niger J Clin Pract 27:221\u2013227. https:\/\/doi.org\/10.4103\/njcp.njcp_633_23","journal-title":"Niger J Clin Pract"},{"key":"2886_CR21","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1080\/10641955.2021.1921790","volume":"40","author":"P Cabunac","year":"2021","unstructured":"Cabunac P, Orlic NK, Ardalic D, Banjac G, Ivanisevic J, Janac J et al (2021) Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia. Hypertens Pregnancy 40:162\u2013170. https:\/\/doi.org\/10.1080\/10641955.2021.1921790","journal-title":"Hypertens Pregnancy"},{"key":"2886_CR22","doi-asserted-by":"publisher","first-page":"795","DOI":"10.3390\/antiox12040795","volume":"12","author":"JT Stadler","year":"2023","unstructured":"Stadler JT, Scharnagl H, Wadsack C, Marsche G (2023) Preeclampsia Affects Lipid Metabolism and HDL Function in Mothers and Their Offspring. Antioxidants 12:795. https:\/\/doi.org\/10.3390\/antiox12040795","journal-title":"Antioxidants"},{"key":"2886_CR23","doi-asserted-by":"publisher","first-page":"948","DOI":"10.3390\/antiox13080948","volume":"13","author":"M Stankovic","year":"2024","unstructured":"Stankovic M, Zeljkovic A, Vekic J, Antonic T, Ardalic D, Miljkovic-Trailovic M et al (2024) Differences in HDL Remodeling during Healthy Pregnancy and Pregnancy with Cardiometabolic Complications. Antioxidants 13:948. https:\/\/doi.org\/10.3390\/antiox13080948","journal-title":"Antioxidants"},{"key":"2886_CR24","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.molmed.2022.05.013","volume":"28","author":"C Brombach","year":"2022","unstructured":"Brombach C, Tong W, Giussani DA (2022) Maternal obesity: new placental paradigms unfolded. Trends Mol Med 28:823\u2013835. https:\/\/doi.org\/10.1016\/j.molmed.2022.05.013","journal-title":"Trends Mol Med"},{"key":"2886_CR25","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1038\/s41598-025-31193-w","volume":"16","author":"RF Wang","year":"2025","unstructured":"Wang RF, Liu JY, Li Q, Yin XY, Li NN, Wang GL et al (2025) Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta. Sci Rep 16:1686. https:\/\/doi.org\/10.1038\/s41598-025-31193-w","journal-title":"Sci Rep"},{"key":"2886_CR26","doi-asserted-by":"publisher","DOI":"10.1113\/jp285943","author":"AA de Oliveira","year":"2024","unstructured":"de Oliveira AA, Spaans F, Cooke CLM, Davidge ST (2024) Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre-eclampsia. J Physiol. https:\/\/doi.org\/10.1113\/jp285943","journal-title":"J Physiol"},{"key":"2886_CR27","doi-asserted-by":"publisher","first-page":"S895","DOI":"10.1016\/j.ajog.2020.09.026","volume":"226","author":"AC Staff","year":"2022","unstructured":"Staff AC, Fjeldstad HE, Fosheim IK, Moe K, Turowski G, Johnsen GM et al (2022) Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. Am J Obstet Gynecol 226:S895\u2013S906. https:\/\/doi.org\/10.1016\/j.ajog.2020.09.026","journal-title":"Am J Obstet Gynecol"},{"key":"2886_CR28","doi-asserted-by":"publisher","first-page":"5763","DOI":"10.1002\/cphy.c230020","volume":"14","author":"C Schliefsteiner","year":"2024","unstructured":"Schliefsteiner C, Wadsack C, Allerkamp HH (2024) Exploring the Lifeline: Unpacking the Complexities of Placental Vascular Function in Normal and Preeclamptic Pregnancies. Compr Physiol 14:5763\u20135787. https:\/\/doi.org\/10.1002\/cphy.c230020","journal-title":"Compr Physiol"},{"key":"2886_CR29","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.3390\/ijms20225639","volume":"20","author":"G Moser","year":"2019","unstructured":"Moser G, Guettler J, Forstner D, Gauster M (2019) Maternal Platelets-Friend or Foe of the Human Placenta? Int J Mol Sci 20:5039. https:\/\/doi.org\/10.3390\/ijms20225639","journal-title":"Int J Mol Sci"},{"key":"2886_CR30","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1038\/s41379-021-00747-4","volume":"34","author":"RW Redline","year":"2021","unstructured":"Redline RW, Ravishankar S, Bagby CM, Saab ST, Zarei S (2021) Four major patterns of placental injury: a stepwise guide for understanding and implementing the 2016 Amsterdam consensus. Mod Pathol 34:1074\u20131092. https:\/\/doi.org\/10.1038\/s41379-021-00747-4","journal-title":"Mod Pathol"},{"key":"2886_CR31","doi-asserted-by":"publisher","first-page":"e0197593","DOI":"10.1371\/journal.pone.0197593","volume":"13","author":"M Kemppainen","year":"2018","unstructured":"Kemppainen M, Lahesmaa-Korpinen AM, Kauppi P, Virtanen M, Virtanen SM, Karikoski R et al (2018) Maternal asthma is associated with increased risk of perinatal mortality. PLoS ONE 13:e0197593. https:\/\/doi.org\/10.1371\/journal.pone.0197593","journal-title":"PLoS ONE"},{"key":"2886_CR32","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/1471-0528.70017","volume":"133","author":"RL Goldenberg","year":"2026","unstructured":"Goldenberg RL, Nausheen S, Masheer S, Uddin Z, Bann CM, Goudar SS et al (2026) Shared Placental and Asphyxial Pathways in Preterm Stillbirths and Neonatal Deaths: The Prospective Observational PURPOSe Study. Bjog-an Int J Obstet Gynecol 133:320\u2013325. https:\/\/doi.org\/10.1111\/1471-0528.70017","journal-title":"Bjog-an Int J Obstet Gynecol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-02886-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40618-026-02886-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-026-02886-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T19:02:00Z","timestamp":1787079720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40618-026-02886-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["2886"],"URL":"https:\/\/doi.org\/10.1007\/s40618-026-02886-4","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"23 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare they have no conflict of interest regarding this research study.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by Tianjin First Center Hospital, and informed written consent was waived due to the nature of a retrospective study. The study was performed in strict accordance with the Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed written consent was waived.","order":4,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}]}}